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Journal Articles

A New Promising Third Generation CAR-CD30 T-Cell Therapy for CD30+ Lymphoma

Blood (2019) 134 (Supplement_1): 2069.

https://doi.org/10.1182/blood-2019-127969

Published: 2019

Journal Articles

Academic, Phase I/II Trial on T Cells Expressing a Second Generation, CD19-Specific Chimeric Antigen Receptor (CAR) and Inducible Caspase 9 Safety Switch for the Treatment of B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) and B-Cell Non-Hodgkin Lymphoma (B-NHL) in Children

Francesca Del Bufalo, MD, Concetta Quintarelli, PhD, Biagio De Angelis, PhD, Ignazio Caruana, PhD, Matilde Sinibaldi, PhD, Luciana Vinti, MD, Pietro Merli, MD, Mattia Algeri, MD, Annalisa Ruggeri, MD, Federica Galaverna, MD, Valentina Cirillo, PhD, Maria Giuseppina Cefalo, MD, Giuseppina Li Pira, PhD, Giovanna Leone, MD, Valentina Bertaina, PhD, Franca Fassio, PhD, Monica Gunetti, PhD, Stefano Iacovelli, PhD, Franco Locatelli, MD PhD

Blood (2019) 134 (Supplement_1): 1341.

https://doi.org/10.1182/blood-2019-129821

Published: 2019

Journal Articles

Preliminary Lasso Regression Analysis Identifies DNA-Damage Gene Expression Signature Predictive of Clinical Outcomes in Patients Using Gemtuzumab Ozogamicin

Mohammed Gbadamosi, BS, Abdelrahman H. Elsayed, MSc, Rhonda E. Ries, MA, Soheil Meshinchi, MD PhD, Jatinder K Lamba, M.Sc., PhD

Blood (2019) 134 (Supplement_1): 1401.

https://doi.org/10.1182/blood-2019-131210

Published: 2019

Journal Articles

Proteomic Landscape of Acute Leukemia: A Comparison between ALL and AML in Adults

Fieke W Hoff, BSc, Yihua Qiu, Wendy Hu, PhD, Amina A Qutub, PhD, Eveline S. de Bont, MD PhD, Terzah M Horton, MD PhD, Steven M. Kornblau, MD

Blood (2019) 134 (Supplement_1): 1461.

https://doi.org/10.1182/blood-2019-123470

Published: 2019

Journal Articles

Comparative Analysis of Alpha-Beta T-Cell and B-Cell Depleted (abTCD) HLA-Haploidentical Hematopoietic Stem Cell Transplantation (haplo-HSCT) Versus Abtcd Haplo-HSCT with T-Cell Add-Back of Rivogenlecleucel Cell [Donor T Cells Transduced with the Inducible Caspase 9 (iC9) Gene Safety Switch] in Children with High-Risk Acute Leukemia (AL) in Remission

Annalisa Ruggeri, MD, Pietro Merli, MD, Mattia Algeri, MD, Marco Zecca, Franca Fagioli, MD, Giuseppina Li Pira, PhD, Valentina Bertaina, PhD, Arcangelo Prete, MD, Mauro Montanari, MD, Francesca Del Bufalo, MD, Luciana Vinti, MD, Daria Pagliara, MD PhD, Melissa Aldinger, PharmD, Kai Chan, Paul Woodard, Federica Galaverna, MD, Franco Locatelli, MD

Blood (2019) 134 (Supplement_1): 145.

https://doi.org/10.1182/blood-2019-125366

Published: 2019

Journal Articles

Enhancing the Effect of CLL-1 CAR T Cells with Interleukin-15 for Treatment of Acute Myeloid Leukemia

Pinar Ataca Atilla, MD, Haruko Tashiro, MD PhD, Mary Kathryn McKenna, PhD, Madhuwanti Srinivasan, Brian Wesley Simons, Alexandra McLean Stevens, MD PhD, Michele Redell, MD PhD, Maksim Mamonkin, PhD, Malcolm K. Brenner, MD PhD, Erden Atilla, MD

Blood (2019) 134 (Supplement_1): 3912.

https://doi.org/10.1182/blood-2019-127953

Published: 2019

Journal Articles

Identification of Dual Positive CD19+/CD3+ T Cells in an Apheresis Product Undergoing Chimeric Antigen Receptor (CAR) Transduction

Liora M Schultz, MD, Shabnum Patel, PhD, Sneha Ramakrishna, MD, Alice Bertaina, MD PhD, Neehar Bhatia, Jean Oak, MD PhD, Robbie G. Majzner, MD, Christina Baggott, RN, PhD, Kara L. Davis, DO, Crystal L. Mackall, MD, Steven A Feldman, PhD

Blood (2019) 134 (Supplement_1): 4471.

https://doi.org/10.1182/blood-2019-129436

Published: 2019

Journal Articles

HO-1 Promotes Resistance to EZH2 Inhibitor through the Prb-E2F Pathway: Corelated with the Conversion of Myelodysplastic Syndrome to Acute Myeloid Leukemia

Zhengchang He, Jishi Wang, PhD

Blood (2019) 134 (Supplement_1): 5401.

https://doi.org/10.1182/blood-2019-131573

Published: 2019

Journal Articles

Suicide Gene Therapy with a CD33 Targeted AAV6 Vector Expressing an Inducible Caspase-9 Suicide Gene Is Therapeutic in a Xenotransplantation Model of Acute Myeloid Leukemia

Nusrat Khan, MSc, Sridhar Bammidi, Jayandharan Giridhara Rao, PhD

Blood (2019) 134 (Supplement_1): 3351.

https://doi.org/10.1182/blood-2019-125222

Published: 2019

Journal Articles

CRISPR-Cas9 Screen Identifies Me2 , a Mitochondrial Malic Enzyme, As a Molecule Relevant for MCL1 Inhibitor Resistance in AML

Fumihiko Nakao, MD, Takuji Yamauchi, MD PhD, Yuichiro Semba, MD PhD, Jumpei Nogami, PhD, Koichi Akashi, MD PhD, Takahiro Maeda, MD PhD

Blood (2019) 134 (Supplement_1): 912.

https://doi.org/10.1182/blood-2019-129237

Published: 2019

Journal Articles

Targeting Oncogenic Polyamines in Refractory Pediatric Leukemias Using the Anti-Protozoan Drug Α-Difluoromethylornithine (DFMO) in Combination with GC7 and Aurothioglucose

Bradley Hofmann, MSc, Sunand Kannappan, Gupta Mehul, Chunfen Zhang, MD, Susan Chi, MD, Derek Hanson, MD, Ronald Anderson, MD FRCPC, Aru Narendran, MD PhD

Blood (2018) 132 (Supplement 1): 2725.

https://doi.org/10.1182/blood-2018-99-117229

Published: 2018

Journal Articles

Combination of Momelotinib and Citarinostat Show Strong Synergistic Effect in Lymphoid Cell Lines Co-Targeting JAK2/STAT3 and HDAC6

Maria Cosenza, MS, Monica Civallero, PhD, Stefano Sacchi, MD, Samantha Pozzi, MD

Blood (2018) 132 (Supplement 1): 3506.

https://doi.org/10.1182/blood-2018-99-116468

Published: 2018

Journal Articles

PIM Inhibitor SMI-4a Induces Cell Apoptosis and Cell Cycle Arrest in B-Cell Acute Lymphocytic Leukemia Cells Via the JAK2/STAT3 Pathway

Xingyi Kuang, Jie Xiong, Weili Wang, Xinyao Li, Tingting Lu, Jishi Wang, PhD

Blood (2018) 132 (Supplement 1): 4083.

https://doi.org/10.1182/blood-2018-99-117804

Published: 2018

Journal Articles

Inhibition of Autophagy with 3-Methyladenine Potentiates Bortezomib-Induced Apoptosis of Myeloma Cell Via up Regulation of Mitochondrial Reactive Oxygen Species

Yeung-Chul Mun, Jee Young Ahn, Eun Sun Yoo, Kyoung Eun Lee, Eunmi Nam, Soon Nam Lee, Hyun Ae Woo, Sue Goo Rhee, Chu Myong Seong

Blood (2018) 132 (Supplement 1): 4472.

https://doi.org/10.1182/blood-2018-99-117727

Published: 2018

Journal Articles

Regulated Natural Killer Cell Expansion and Anti-Tumor Activity with Inducible MyD88/CD40

Xiaomei Wang, PhD, Wei-Chun Chang, PhD, Daniel L. Jasinski, PhD, Jan L. Medina, BS, Ming Zhang, BS, Aaron Foster, PhD, David M. Spencer, PhD, J. Henri Bayle, PhD

Blood (2018) 132 (Supplement 1): 4550.

https://doi.org/10.1182/blood-2018-99-120151

Published: 2018

Journal Articles

T- and B-Cell Neogenesis Recovers Efficiently in Children with Acute Leukemia Given an Alpha-Beta T-Cell Depleted Haplo-HSCT Followed By Infusion of Donor T-Cells Genetically Modified with Inducible Caspase 9 Suicide Gene (BPX-501 cells)

Marialuigia Catanoso, MD, Emmanuel Clave, PhD, Corinne Douay, Mattia Algeri, MD, Isabelle Fournier, Valentina Bertaina, Itaua Leston Araujo, MSc, Francesca Del Bufalo, MD, Federica Galaverna, MD, Cecilia Surace, PhD, Alice Bertaina, MD PhD, Pietro Merli, MD, Aaron Foster, PhD, Antoine Toubert, MD PhD, Franco Locatelli

Blood (2018) 132 (Supplement 1): 4560.

https://doi.org/10.1182/blood-2018-99-116536

Published: 2018

Journal Articles

Characterization of Allogeneic T Cells Expressing Inducible Caspase-9 Following Adoptive Transfer in Children Receiving an HLA-Haploidentical Hematopoietic Stem Cell Transplant for the Treatment of Myeloid Malignancies

Joanne Shaw, PhD, Xiaoou Zhou, MD PhD, An Lu, Valentina Bertaina, Daria Pagliara, MD PhD, Melissa Aldinger, PharmD, David M. Spencer, PhD, Franco Locatelli, Aaron Foster, PhD

Blood (2018) 132 (Supplement 1): 4534.

https://doi.org/10.1182/blood-2018-99-119779

Published: 2018

Journal Articles

Patient-Derived Chimeric Antigen Receptor T-Cell Production Based on a Gammaretroviral Vector Platform Is Not Associated with Generation of CAR+ Leukemia Blasts

Concetta Quintarelli, PhD, Iolanda Boffa, PhDstudent, Matilde Sinibaldi, Domenico Orlando, PhDstudent, Marika Guercio, Stefano Di Cecca, PhD, Simona Caruso, PhD, Angela Pitisci, Valentina Bertaina, Francesca Del Bufalo, MD, Pietro Merli, MD, Mattia Algeri, MD, Federica Galaverna, MD, Luciana Vinti, MD, Giuseppina Li Pira, PhD, Biagio De Angelis, PhD, Franco Locatelli

Blood (2018) 132 (Supplement 1): 2204.

https://doi.org/10.1182/blood-2018-99-119413

Published: 2018

Journal Articles

Administration of BPX-501 Cells Following Αβ- T and B-Cell-Depleted HLA-Haploidentical HSCT in Children with Fanconi Anemia

Swati Naik, MBBS, Susanne H.C. Baumeister, MD, Victor Aquino, MD, Annalisa Ruggeri, MD PhD, Daria Pagliara, MD PhD, Melissa Aldinger, PharmD, Franco Locatelli

Blood (2018) 132 (Supplement 1): 4654.

https://doi.org/10.1182/blood-2018-99-119534

Published: 2018

Journal Articles

Administration of Rimiducid Following Haploidentical BPX-501 Cells in Children with Malignant or Non-Malignant Disorders Who Develop Graft-Versus-Host-Disease (GvHD)

Reem Elkeky, MBBS, David A. Jacobsohn, MD, Rajni Agarwal, MD, Swati Naik, MBBS, Neena Kapoor, MD, Lakshmanan Krishnamurti, MD, Mary Slatter, MD, Federica Galaverna, MD, Pietro Merli, MD, Melissa Aldinger, PharmD, Franco Locatelli

Blood (2018) 132 (Supplement 1): 2207.

https://doi.org/10.1182/blood-2018-99-119792

Published: 2018

NARROW

A New Promising Third Generation CAR-CD30 T-Cell Therapy for CD30+ Lymphoma

Academic, Phase I/II Trial on T Cells Expressing a Second Generation, CD19-Specific Chimeric Antigen Receptor (CAR) and Inducible Caspase 9 Safety Switch for the Treatment of B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) and B-Cell Non-Hodgkin Lymphoma (B-NHL) in Children

Preliminary Lasso Regression Analysis Identifies DNA-Damage Gene Expression Signature Predictive of Clinical Outcomes in Patients Using Gemtuzumab Ozogamicin

Proteomic Landscape of Acute Leukemia: A Comparison between ALL and AML in Adults

Enhancing the Effect of CLL-1 CAR T Cells with Interleukin-15 for Treatment of Acute Myeloid Leukemia

Identification of Dual Positive CD19+/CD3+ T Cells in an Apheresis Product Undergoing Chimeric Antigen Receptor (CAR) Transduction

HO-1 Promotes Resistance to EZH2 Inhibitor through the Prb-E2F Pathway: Corelated with the Conversion of Myelodysplastic Syndrome to Acute Myeloid Leukemia

Suicide Gene Therapy with a CD33 Targeted AAV6 Vector Expressing an Inducible Caspase-9 Suicide Gene Is Therapeutic in a Xenotransplantation Model of Acute Myeloid Leukemia

CRISPR-Cas9 Screen Identifies Me2 , a Mitochondrial Malic Enzyme, As a Molecule Relevant for MCL1 Inhibitor Resistance in AML

Targeting Oncogenic Polyamines in Refractory Pediatric Leukemias Using the Anti-Protozoan Drug Α-Difluoromethylornithine (DFMO) in Combination with GC7 and Aurothioglucose

Combination of Momelotinib and Citarinostat Show Strong Synergistic Effect in Lymphoid Cell Lines Co-Targeting JAK2/STAT3 and HDAC6

PIM Inhibitor SMI-4a Induces Cell Apoptosis and Cell Cycle Arrest in B-Cell Acute Lymphocytic Leukemia Cells Via the JAK2/STAT3 Pathway

Inhibition of Autophagy with 3-Methyladenine Potentiates Bortezomib-Induced Apoptosis of Myeloma Cell Via up Regulation of Mitochondrial Reactive Oxygen Species

Regulated Natural Killer Cell Expansion and Anti-Tumor Activity with Inducible MyD88/CD40

T- and B-Cell Neogenesis Recovers Efficiently in Children with Acute Leukemia Given an Alpha-Beta T-Cell Depleted Haplo-HSCT Followed By Infusion of Donor T-Cells Genetically Modified with Inducible Caspase 9 Suicide Gene (BPX-501 cells)

Characterization of Allogeneic T Cells Expressing Inducible Caspase-9 Following Adoptive Transfer in Children Receiving an HLA-Haploidentical Hematopoietic Stem Cell Transplant for the Treatment of Myeloid Malignancies

Patient-Derived Chimeric Antigen Receptor T-Cell Production Based on a Gammaretroviral Vector Platform Is Not Associated with Generation of CAR+ Leukemia Blasts

Administration of BPX-501 Cells Following Αβ- T and B-Cell-Depleted HLA-Haploidentical HSCT in Children with Fanconi Anemia

Administration of Rimiducid Following Haploidentical BPX-501 Cells in Children with Malignant or Non-Malignant Disorders Who Develop Graft-Versus-Host-Disease (GvHD)

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American Society of Hematology

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American Society of Hematology

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