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Journal Articles

Targeting Nicotinamide Adenine Dinucleotide (NAD) Glycohydrase Activity of CD38 Exerts Anti-Myeloma Effect Accompanying Intracellular NAD Elevation

Saki Kushima, Takayuki Sasano, Masao Matsuoka, MD PhD, Hiroyuki Hata, MD PhD, Yawara Kawano, MD PhD

Blood (2019) 134 (Supplement_1): 1810.

https://doi.org/10.1182/blood-2019-123624

Published: 2019

Journal Articles

JX06, a Novel PDK1 Inhibitor, Induces Myeloma Cell Apoptosis By Metabolic Reprogramming and Works Synergistically with Bortezomib

Takayuki Sasano, Saki Kushima, Matsushita Yutaka, Masao Matsuoka, MD PhD, Hiroyuki Hata, MD PhD, Yawara Kawano, MD PhD

Blood (2019) 134 (Supplement_1): 1814.

https://doi.org/10.1182/blood-2019-123619

Published: 2019

Journal Articles

Targeting the Plasma Cell Specific Purine Metabolic Enzyme, AMPD1, Induces Multiple Myeloma Cell Death Accompanying NAD Depletion

Yawara Kawano, MD PhD, Takayuki Sasano, Saki Kushima, Yuki Inada, Nao Nishimura, MD, Hiroyuki Hata, MD PhD, Masao Matsuoka, MD PhD

Blood (2019) 134 (Supplement_1): 3097.

https://doi.org/10.1182/blood-2019-125756

Published: 2019

Journal Articles

Curcumin Enhances the Sensitivity of Bortezomib By Inhibiting NF-Κb in ABC Diffuse Large B-Cell Lymphoma Cells

Xiaolei Wei, PhD, Jialin Song, Yongqiang Wei, PhD, Hong Zeng, Weimin Huang, PhD, Jingxia Zheng, Ru Feng, MD

Blood (2019) 134 (Supplement_1): 5237.

https://doi.org/10.1182/blood-2019-127705

Published: 2019

Journal Articles

Staurosporine Induces Caspase-Dependent Proteolysis of MEF2D-Fusion Protein and Cell Death Selective to MEF2D-Fusion-Positive ALL Cells

Naoyuki Tange, MD, Fumihiko Hayakawa, MD, PhD, Takahiko Yasuda, MD, PhD, Hideyuki Yamamoto, MD, Daiki Hirano, MD, PhD, Shinobu Tsuzuki, MD,PhD, Hitoshi Kiyoi, MD PhD

Blood (2019) 134 (Supplement_1): 1349.

https://doi.org/10.1182/blood-2019-123602

Published: 2019

Journal Articles

Inhibition of Unc-51-like Kinase 1 (ULK1) with Novel Small Molecular Inhibitor MRT68921 Preferentially Induces Apoptosis and Autophagy in FLT3-ITD- Mutated Acute Myeloid Leukemia

Jieun Jang, MD, Hoi-kyung Jeung, So-Young Seol, Haerim Chung, MD, Yu Ri Kim, MD, June-Won Cheong, MD PhD, Yoo Hong Min, MD PhD

Blood (2018) 132 (Supplement 1): 3499.

https://doi.org/10.1182/blood-2018-99-115833

Published: 2018

Journal Articles

Direct-Acting Small Molecule Activators of PP2A (SMAPs) in Myeloid Malignancies: Understanding Mechanisms of Cytotoxicity to Inform Rational Combinatorial Therapeutic Strategies

Christopher B Ryder, Goutham Narla, MD PhD

Blood (2017) 130 (Supplement 1): 2517.

https://doi.org/10.1182/blood.V130.Suppl_1.2517.2517

Published: 2017

Journal Articles

CD36 Promotes Platelet Phosphatidylserine Exposure through MAP Kinase ERK5

Moua Yang, Andaleb Kholmukhamedov, MD, Na'il O Scoggins, Brian C Cooley, PhD, Craig Morrell, DVM, PhD, Shawn M. Jobe, MD PhD, Roy L. Silverstein, MD

Blood (2017) 130 (Supplement 1): 2303.

https://doi.org/10.1182/blood.V130.Suppl_1.2303.2303

Published: 2017

Journal Articles

XIAP Knockdown Can Increase the Activity of Caspase 3 and 7, and Restore the Apoptotic Response in Cell Line Models of Rituximab Relapse/Refractory B-Cell Lymphoma

Kyle Runckel, BS, Cory Mavis, BSc, MSc, Francisco J. Hernandez-Ilizaliturri, MD

Blood (2017) 130 (Supplement 1): 1478.

https://doi.org/10.1182/blood.V130.Suppl_1.1478.1478

Published: 2017

Journal Articles

Ribosome Biogenesis Controls Erythroid Differentiation Via a p53-Dependent Transcriptional Checkpoint and Its Limitation By RPS14 Haploinsufficiency Results in Selective Defects in Translation

Ismael Boussaid, PharmD, Salome Le Goff, PhDstudent, Celia Floquet, Post-doc, Anna Raimbault, PharmD, PhD, Charlotte Andrieu-Soler, Emilie-fleur Gautier, PhD, Olivier Kosmider, Isabelle Hatin, PhD, Mohandas Narla, DSc, Eric Soler, PhD, Patrick Mayeux, PhD, Michaela Fontenay, MD PhD

Blood (2017) 130 (Supplement 1): 83.

https://doi.org/10.1182/blood.V130.Suppl_1.83.83

Published: 2017

Journal Articles

Transcriptional Response to Genome Editing Machinery in CD34+ HSPCs

Michael Kyle Cromer, BS, MPhil, PhD

Blood (2017) 130 (Supplement 1): 4621.

https://doi.org/10.1182/blood.V130.Suppl_1.4621.4621

Published: 2017

Journal Articles

Abbv-621 Is a Novel and Potent TRAIL Receptor Agonist Fusion Protein That Induces Apoptosis Alone and in Combination with Navitoclax and Venetoclax in Hematological Tumors

Stephen Kenneth Tahir, PhD, Morey L Smith, MS, Larry R Solomon, PhD, Haichao Zhang, PhD, John C Xue, MD, Yu Xiao, MS, Dong Cheng, MS, Greg Buchanan, PhD, Susan Morgan-Lappe, PhD, Darren C. Phillips, PhD

Blood (2017) 130 (Supplement 1): 2812.

https://doi.org/10.1182/blood.V130.Suppl_1.2812.2812

Published: 2017

Journal Articles

Momelotinib and Citarinostat: Co-Targeting JAK2/STAT3 and HDAC6 in Lymphoid Malignancies, a New Potential Therapeutic Combination

Maria Cosenza, MS, Monica Civallero, PhD, Stefano Sacchi, MD, Samantha Pozzi, MD

Blood (2017) 130 (Supplement 1): 5201.

https://doi.org/10.1182/blood.V130.Suppl_1.5201.5201

Published: 2017

Journal Articles

CD33 Targeted Immunoliposomal Delivery of OSU-2S, a Non-Immunosuppressive FTY720 Derivative, Mediates Selective Cytotoxicity in Acute Myeloid Leukemia

Swagata Goswami, MS, Rajeswaran Mani, DVM PhD, Chi-Ling Chiang, MS, Frank W Frissora, M.S., Xiaokui Mo, PhD MAS, Zhiliang Xie, Donna Bucci, Amber Gordon, MLS, David M. Lucas, PhD, William Blum, MD, Alison R. Walker, MD MPH, Alice S. Mims, MD MSCR, Rebecca B Klisovic, MD, Ching-Shih Chen, PhD, Robert J Lee, PhD, John C. Byrd, MD, Mitch A. Phelps, PhD, Sumithira Vasu, MBBS, Natarajan Muthusamy, DVM, PhD

Blood (2016) 128 (22): 2748.

https://doi.org/10.1182/blood.V128.22.2748.2748

Published: 2016

Journal Articles

YM155 Induces Apoptosis through Proteasome-Dependent Degradation of MCL-1 in Primary Effusion Lymphoma

Yuki Kojima, MD, Fumihiko Hayakawa, MD PhD, Takanobu Morishita, MD, Keiki Sugimoto, PhD, Mizuho Iwase, Hideyuki Yamamoto, MD, Daiki Hirano, MD, Naoto Imoto, MD, Seiji Okada, MD, PhD, Hitoshi Kiyoi, MD PhD

Blood (2016) 128 (22): 3013.

https://doi.org/10.1182/blood.V128.22.3013.3013

Published: 2016

Journal Articles

The mTOR Inhibitor Everolimus Overcomes CXCR4-Mediated Resistance to HDAC Inhibitor Panobinostat through Inhibition of p21 and Mitosis Regulators, Sensitizing MM Cells to DNA-Damaged Induced Apoptosis

Katia Beider, PhD, Valeria Voevoda, Hanna Bitner, Evgenia Rosenberg, Hila Magen, MD, Olga Ostrovsky, PhD, Merav Leiba, MD, Noya Shilo, MD, Avichai Shimoni, MD, Michael Milyavsky, PhD, Amnon Peled, PhD, Arnon Nagler

Blood (2016) 128 (22): 891.

https://doi.org/10.1182/blood.V128.22.891.891

Published: 2016

Journal Articles

Induction of Apoptosis and Autophagy By Nampt Inhibition in Adult T-Cell Leukemia/Lymphoma and Leukemic Cell Lines

Tomohiro Kozako, PhD, Makoto Yoshimitsu, MD, PhD, Naomichi Arima, MD PhD, Keisuke Sato, MS, Moe Toyoshima, Shin-ichiro Honda, PhD, Shinji Soeda, PhD

Blood (2016) 128 (22): 2327.

https://doi.org/10.1182/blood.V128.22.2327.2327

Published: 2016

Journal Articles

Estrogen Receptor Beta Is a Novel Target in Acute Myeloid Leukemia

Sara Grace Rota, MSc, Paul A Spagnuolo, PhD, Leonard Angka, Andrew Doxey, Praveen Nekkar, Mark D. Minden, MD PhD

Blood (2015) 126 (23): 1395.

https://doi.org/10.1182/blood.V126.23.1395.1395

Published: 2015

Journal Articles

Telmisartan, Angiotensin II Receptor Blocker, Induces Apoptosis and Autophagy in Adult T-Cell Leukemia Cells from Patients and Leukemia Cell Lines

Tomohiro Kozako, PhD, Makoto Yoshimitsu, MD PhD, Naomichi Arima, MD PhD, Shuhei Soeda, PhD, Shinya Hirata, MD PhD, Hiroaki Tanaka, PhD, Shin-ichiro Honda, PhD, Shinji Soeda, PhD

Blood (2015) 126 (23): 2055.

https://doi.org/10.1182/blood.V126.23.2055.2055

Published: 2015

Journal Articles

In Vitro and In Vivo Efficacy of a Novel Orally Bioavailable Beta-Catenin Inhibitor-BC2059- As Monotherapy or in Combination with Proteasome Inhibitors in Multiple Myeloma

Ioanna Savvidou, MD PhDstudent, Tiffany T. Khong, PhD, Stephen K. Horrigan, PhD, Andrew Spencer

Blood (2015) 126 (23): 1816.

https://doi.org/10.1182/blood.V126.23.1816.1816

Published: 2015

NARROW

Targeting Nicotinamide Adenine Dinucleotide (NAD) Glycohydrase Activity of CD38 Exerts Anti-Myeloma Effect Accompanying Intracellular NAD Elevation

JX06, a Novel PDK1 Inhibitor, Induces Myeloma Cell Apoptosis By Metabolic Reprogramming and Works Synergistically with Bortezomib

Targeting the Plasma Cell Specific Purine Metabolic Enzyme, AMPD1, Induces Multiple Myeloma Cell Death Accompanying NAD Depletion

Curcumin Enhances the Sensitivity of Bortezomib By Inhibiting NF-Κb in ABC Diffuse Large B-Cell Lymphoma Cells

Staurosporine Induces Caspase-Dependent Proteolysis of MEF2D-Fusion Protein and Cell Death Selective to MEF2D-Fusion-Positive ALL Cells

Inhibition of Unc-51-like Kinase 1 (ULK1) with Novel Small Molecular Inhibitor MRT68921 Preferentially Induces Apoptosis and Autophagy in FLT3-ITD- Mutated Acute Myeloid Leukemia

Direct-Acting Small Molecule Activators of PP2A (SMAPs) in Myeloid Malignancies: Understanding Mechanisms of Cytotoxicity to Inform Rational Combinatorial Therapeutic Strategies

CD36 Promotes Platelet Phosphatidylserine Exposure through MAP Kinase ERK5

XIAP Knockdown Can Increase the Activity of Caspase 3 and 7, and Restore the Apoptotic Response in Cell Line Models of Rituximab Relapse/Refractory B-Cell Lymphoma

Ribosome Biogenesis Controls Erythroid Differentiation Via a p53-Dependent Transcriptional Checkpoint and Its Limitation By RPS14 Haploinsufficiency Results in Selective Defects in Translation

Transcriptional Response to Genome Editing Machinery in CD34+ HSPCs

Abbv-621 Is a Novel and Potent TRAIL Receptor Agonist Fusion Protein That Induces Apoptosis Alone and in Combination with Navitoclax and Venetoclax in Hematological Tumors

Momelotinib and Citarinostat: Co-Targeting JAK2/STAT3 and HDAC6 in Lymphoid Malignancies, a New Potential Therapeutic Combination

CD33 Targeted Immunoliposomal Delivery of OSU-2S, a Non-Immunosuppressive FTY720 Derivative, Mediates Selective Cytotoxicity in Acute Myeloid Leukemia

YM155 Induces Apoptosis through Proteasome-Dependent Degradation of MCL-1 in Primary Effusion Lymphoma

The mTOR Inhibitor Everolimus Overcomes CXCR4-Mediated Resistance to HDAC Inhibitor Panobinostat through Inhibition of p21 and Mitosis Regulators, Sensitizing MM Cells to DNA-Damaged Induced Apoptosis

Induction of Apoptosis and Autophagy By Nampt Inhibition in Adult T-Cell Leukemia/Lymphoma and Leukemic Cell Lines

Estrogen Receptor Beta Is a Novel Target in Acute Myeloid Leukemia

Telmisartan, Angiotensin II Receptor Blocker, Induces Apoptosis and Autophagy in Adult T-Cell Leukemia Cells from Patients and Leukemia Cell Lines

In Vitro and In Vivo Efficacy of a Novel Orally Bioavailable Beta-Catenin Inhibitor-BC2059- As Monotherapy or in Combination with Proteasome Inhibitors in Multiple Myeloma

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American Society of Hematology

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American Society of Hematology

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