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Journal Articles

Differential Neutralization of Apixaban, Betrixaban, Edoxaban, and Rivaroxaban By Andexanet Alfa As Measured By Whole Blood Thromboelastographic Analysis

Siddharth Mehrotra, Debra Hoppensteadt, PhD, Walter Jeske, PhD, Omer Iqbal, MD, Alfonso J Tafur, MD MS, Bruce Lewis, Jawed Fareed, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1155.
https://doi.org/10.1182/blood-2019-131907
Published: 2019
Journal Articles

Prothrombinase Induced Clotting Time Is More Sensitive then aPTT and PT and Can be Used for the Monitoring of Anti-Xa Agents in Whole Blood and Plasma

Debra Hoppensteadt, PhD, Emily Bontekoe, Fakiha Siddiqui, Ambar Farooqui, Omer Iqbal, MD, Walter Jeske, PhD, Jeanine Walenga, PhD, Alfonso J Tafur, MD MS, Jawed Fareed, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3374.
https://doi.org/10.1182/blood-2019-131221
Published: 2019
Journal Articles

Factor Xa Inhibitory Profile of Apixaban, Betrixaban, Edoxaban and Rivaroxaban Does Not Fully Reflect Their Biologic Spectrum

Fakiha Siddiqui, Siddharth Mehrotra, Vishnu Venkitasubramony, Rithik Raina, Lorenzo Storino Ramacciotti, Jack Bontekoe, BS, Omer Iqbal, MD, Debra Hoppensteadt, PhD, Walter Jeske, PhD, Jawed Fareed, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2520.
https://doi.org/10.1182/blood-2018-99-116993
Published: 2018
Journal Articles

Efficacy and Safety of Direct Oral Anticoagulants in Patients with Cirrhosis— Single Institution Experience

Kamila I. Cisak, MD, Dennis Asante, MS, Diane E. Grill, MS, Aneel A. Ashrani, MD, M.S.
Journal: Blood
Blood (2018) 132 (Supplement 1): 2525.
https://doi.org/10.1182/blood-2018-99-117607
Published: 2018
Journal Articles

Diffuse Alveolar Hemorrhage Secondary to Direct Oral Anticoagulants: A Systematic Review of Reported Cases

Fawzi Abu Rous, MD, Abdullah al-Abcha, Layan El-khatib, Shiva Shrotriya, MD MPH, Prajwal Dhakal, MBBS
Journal: Blood
Blood (2018) 132 (Supplement 1): 5069.
https://doi.org/10.1182/blood-2018-99-115545
Published: 2018
Journal Articles

Impact of D-Dimer Assays Performed at Local Labs Vs. Central Laboratory in the Evaluation of Apex Trial Outcomes

Lisa K. Jennings, PhD, Jayaprakash Kotha, PhD MBBS, Mason Dixon, BS, Alexander Cohen, MD, John T Curnutte, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2391.
https://doi.org/10.1182/blood.V130.Suppl_1.2391.2391
Published: 2017
Journal Articles

Physiologically Based Pharmacokinetic (PBPK) Modeling for Betrixaban and the Impact of P-Glycoprotein Inhibition on Betrixaban Pharmacokinetics

Janet M. Leeds, PhD, Alice Ke, Karen Rowland Yeo, John T Curnutte, MD PhD, Pamela B. Conley, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3663.
https://doi.org/10.1182/blood.V130.Suppl_1.3663.3663
Published: 2017
Journal Articles

Reversal of Betrixaban-Induced Anticoagulation in Healthy Volunteers By Andexanet Alfa

Mark Crowther, MD, Genmin Lu, PhD, Janet M. Leeds, PhD, Joyce Lin, BS, Pamela B. Conley, PhD, Alexander Gold, MD, Stuart J. Connolly, MD, John T. Curnutte, MD PhD
Journal: Blood
Blood (2016) 128 (22): 143.
https://doi.org/10.1182/blood.V128.22.143.143
Published: 2016
Journal Articles

The Safety and Efficacy of Full Versus Reduced Dose Betrixaban in the Acute Medically Ill VTE (Venous Thromboembolism) Prevention with Extended Duration Betrixaban (APEX) Trial

Alexander T Cohen, MBBS MSc MD, Rim Halaby, MD, Serge Korjian, MD, Yazan Daaboul, MD, Donald Szlosek, Douglas Arbetter, MPH, Samuel Z. Goldhaber, MD, Russell Hull, MBBS, Adrian Hernandez, MD, Alexander Gold, MD, Brian Wiens, PhD, Robert Harrington, MD, C. Michael Gibson, MD
Journal: Blood
Blood (2016) 128 (22): 3824.
https://doi.org/10.1182/blood.V128.22.3824.3824
Published: 2016
Journal Articles

A Systematic Review Evaluating the Effects of Treatment Duration on Bleeding Due to Factor-specific Oral Anticoagulant Therapy

Natalie Chan, Chantal Li, Keith K. Lau, MD, Anthony K.C. Chan, MBBS, FRCPC, FRCPath, Howard H.W. Chan, MBChB, FRCPC, MSc
Journal: Blood
Blood (2012) 120 (21): 3417.
https://doi.org/10.1182/blood.V120.21.3417.3417
Published: 2012
Journal Articles

Metabolism and Disposition of Betrixaban and Its Lack of Interaction with Major CYP Enzymes.

Athiwat Hutchaleelaha, Ph.D., Christine Ye, Ph.D., Yonghong Song, Ph.D., Todd Lorenz, MD, Daniel Gretler, MD, Joseph L Lambing, Ph.D.
Journal: Blood
Blood (2012) 120 (21): 2266.
https://doi.org/10.1182/blood.V120.21.2266.2266
Published: 2012
Journal Articles

Recombinant Antidote for Reversal of Anticoagulation by Factor Xa Inhibitors.

Genmin Lu, PhD, Francis R. DeGuzman, Sanjay Lakhotia, PhD, Stanley J Hollenbach, David R Phillips, PhD, Uma Sinha, PhD
Journal: Blood
Blood (2008) 112 (11): 983.
https://doi.org/10.1182/blood.V112.11.983.983
Published: 2008