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Journal Articles

Two Phase I and Pharmacokinetic Studies of Darinaparsin (Organic Arsenic Compound) in Japanese and Korean Patients with Relapsed or Refractory (R/R) Peripheral T-Cell Lymphoma (PTCL)

Won-Seog Kim, MD PhD, Michinori Ogura, MD PhD, Toshiki Uchida, MD PhD, Naokuni Uike, MD, PhD, Yasunobu Abe, MD PhD, Kenichi Ishizawa, MD, PhD, Yoko Okitsu, MD PhD, Kensei Tobinai, MD PhD, Fumiko Nagahama, Yusuke Sonehara, Hirokazu Nagai, MD PhD

Blood (2015) 126 (23): 2714.

https://doi.org/10.1182/blood.V126.23.2714.2714

Published: 2015

Journal Articles

Nanoparticle Arsenic Compound Realgar Effectively Targets Myeloma Stem-Like Side Population

Jana Jakubikova, PhD, Teru Hideshima, MD, PhD, Richard W.J. Groen, PhD, Danka Cholujova, PhD, Zdenka Bujnakova, PhD, Jacob P. Laubach, MD, Nikhil C. Munshi, MD, Paul G. Richardson, MD, Constantine S. Mitsiades, MD, PhD, Peter Balaz, PhD, Jan Sedlak, PhD, Kenneth C. Anderson, MD

Blood (2013) 122 (21): 4455.

https://doi.org/10.1182/blood.V122.21.4455.4455

Published: 2013

Journal Articles

Darinaparsin in T-Cell Lymphoma (TCL) and Hodgkin Lymphoma (HL) Cells Lines and SCID Xenograft Mouse Models: Single-Agent Activity and Synergistic Cell Death Combined with a PI3K/mTOR Inhibitor

Ravi Dashnamoorthy, Ph.D., Savita Bhalla, PhD, Jennifer Crombie, Irawati Kandela, Ph.D., Andrew Mazar, Ph.D., Andrew M. Evens, DO, MSc

Blood (2012) 120 (21): 1646.

https://doi.org/10.1182/blood.V120.21.1646.1646

Published: 2012

Journal Articles

In Vitro and in Vivo Effect of Sodium Metaarsenite (KML001) in Non-Hodgkin's Lymphoma

Jinsun Yoon, Eun Shil Kim, Sujung Kim, Young Lee

Blood (2012) 120 (21): 1656.

https://doi.org/10.1182/blood.V120.21.1656.1656

Published: 2012

Journal Articles

Three Novel Clonal Non-Characteristic Chromosome Aberrations in Acute Myeloid Leukemia Resembling Acute Promyelocytic Leukemia

Hongxing Liu, MD, Wenjun Tian, MD, Fang Wang, MD, Juan Zhu, MD, Wen Teng, Hui Wang, MD, Tong Wang, MD, Ping Wu, MD, Ping Zhu, MD, Tong Wu, MD, Chunrong Tong, MD

Blood (2011) 118 (21): 4912.

https://doi.org/10.1182/blood.V118.21.4912.4912

Published: 2011

Journal Articles

Anti-Leukemic Effect of Tetra-Arsenic Oxide in Acute Promyelocytic Leukemia Cells in Vitro and In Vivo

So Young Chong, MD, PhD, Moon Ju Jang, MD, PhD, Sun Ju Lee, Ji Young Huh, MD, PhD, Jeehyeon Bae, PhD, Kwang-Hoe Chung, PhD, Doyeon Oh, MD, PhD, Hau C. Kwaan, MD, PhD

Blood (2011) 118 (21): 4306.

https://doi.org/10.1182/blood.V118.21.4306.4306

Published: 2011

Journal Articles

Targeting EVI1-Overexpressing AML with Darinaparsin

Koren K Mann, PhD, Nathalie Johnson, MD, Torsten Holm Nielsen, MD, Nicolas Garnier, MSc, Stanley Kwan, Eftihia Cocolakis, PhD, Josee Hebert, MD, Robert Morgan, MSc, Wilson H. Miller, Jr., MD, PhD

Blood (2011) 118 (21): 4269.

https://doi.org/10.1182/blood.V118.21.4269.4269

Published: 2011

Journal Articles

The Novel Organic Arsenical, Darinaparsin (ZIO-101), Induces Apoptosis through AKT and MEK/ERK Pathways In Hodgkin Lymphoma (HL) and T-Cell Lymphoma (TCL) Cell Lines

Savita Bhalla, PhD, Sheila Prachand, MS, Leo I Gordon, MD, FACP, Andrew M Evens, DO, MSc

Blood (2010) 116 (21): 2840.

https://doi.org/10.1182/blood.V116.21.2840.2840

Published: 2010

Journal Articles

Glutathione Depletion Enhances Arsenic Trioxide-Induced Apoptosis in Lymphoma Cells through Mitochondrial and Caspase-Independent Mechanisms.

Savita Bhalla, PhD, Leo I. Gordon, MD, Amareshwar Singh, PhD, Sheila Prachand, M.S., Shuo Yang, PhD, Jane N. Winter, MD, Dongsheng Guo, PhD, Thomas O'Halloran, PhD, Leonidas C Platanias, Andrew M. Evens, DO, MSc

Blood (2009) 114 (22): 2708.

https://doi.org/10.1182/blood.V114.22.2708.2708

Published: 2009

Journal Articles

Arsenic Binding to RBCC Domain Modulates Oncogenic PML-RARa and Wild-Type PML as a Key Molecular Mechanism of Arsenic Trioxide Treatment for APL.

Xiaowei Zhang, Xiaojing Yan, Feifei Yang, Ziren Zhou, Ziyu Wu, Hongbin Sun, Wenxue Liang, Aixin Song, Qiuhua Huang, Guangbiao Zhou, Jianhua Tong, Yan Zhang, Jihui Wu, Hongyu Hu, Saijuan Chen, Zhu Chen

Blood (2009) 114 (22): 592.

https://doi.org/10.1182/blood.V114.22.592.592

Published: 2009

Journal Articles

S-Dimethylarsinoglutathione (SGLU/ZIO101) Is a Novel Active Organic Arsenical That Displays a Unique Gene Expression Profile in Myeloma Cells.

Lawrence H. Boise, PhD, Alejo A. Morales, Ph.D., Claire R. Croutch, Ph.D., Delia Gutman, M.S., Robert Peter Gale, M.D./Ph.D., Kelvin P. Lee, M.D.

Blood (2006) 108 (11): 5043.

https://doi.org/10.1182/blood.V108.11.5043.5043

Published: 2006

Journal Articles

Arsenic Trioxide Induces Up-Regulation of BMF and NOXA and Overcomes an Anti-Oxidative Response To Induce Apoptosis in Myeloma Cells.

Alejo A. Morales, PhD, Delia Gutman, M.S., Pedro J. Cejas, Ph.D., Kelvin P. Lee, M.D., Lawrence H. Boise, Ph.D.

Blood (2006) 108 (11): 3419.

https://doi.org/10.1182/blood.V108.11.3419.3419

Published: 2006

Journal Articles

In Vitro Activity of a Novel Organic Arsenical (S-Dimethylarsino-Glutathione, ZIO-101) Against Multiple Myeloma.

Lawrence H. Boise, PhD, Alejo A. Morales, PhD, Delia Gutman, MS, Kelvin P. Lee, MD

Blood (2005) 106 (11): 5163.

https://doi.org/10.1182/blood.V106.11.5163.5163

Published: 2005

Journal Articles

Pharmacokinetics of Arsenic Species with Relapsed or Refractory Acute Promyelocytic Leukemia (APL) Treated with Arsenic Trioxide (ATO) in Japanese Patients.

Kazuyuki Shigeno, MD, Miki Kobayashi, MD, Naohi Sahara, MD, Satoki Nakamura, MD, Shinya Fujisawa, MD, Kensuke Naito, MD, Kaori Shinjo, MD, Akihiro Takeshita, MD, Ryuzo Ohno, MD, Kenji Kinoshita, PhD, Masahito Shimoya, PhD, Toshikazu Kaise, PhD, Kazunori Ohnishi, MD

Blood (2005) 106 (11): 4426.

https://doi.org/10.1182/blood.V106.11.4426.4426

Published: 2005

Journal Articles

Comparison of Uptake and Intracellular Induced Structural Changes of Arsenic Trioxide, an Inorganic Compound, and Organic Arsenic Derivative S-Dimethylarsino-Glutathione (SGLU; ZIO-101) in NB4 Acute Promyelocytic Leukemia (APL) Cells.

Taghi Manshouri, MS, BS, Subbarao V. Kala, PhD, Faramarz Ashoori, MD, PhD, Ralph Zingaro, PhD, Emil J. Freireich, MD, BS, Michael Andreeff, MD, PhD, Hagop M. Kantarjian, MD, Srdan Verstovsek, MD, PhD

Blood (2005) 106 (11): 4446.

https://doi.org/10.1182/blood.V106.11.4446.4446

Published: 2005

Journal Articles

Mechanism of Selectivity of Arsenic Trioxide for Acute Promyelocytic Leukemia Cells from Screening a Genome Wide Set of Saccharomyces cerevisiae Deletion Strains.

Pierre J. Dilda, Gabriel G. Perrone, Ian W. Dawes, Philip J. Hogg

Blood (2005) 106 (11): 2470.

https://doi.org/10.1182/blood.V106.11.2470.2470

Published: 2005

Journal Articles

Combined Effects of As4S4 and Imatinib on Chronic Myeloid Leukemia Cells and BCR-ABL Oncoprotein.

Tong Yin, Ying-Li Wu, Hui-Ping Sun, Guan-Lin Sun, Ji Zhang, Guo-Qiang Chen, Sai-Juan Chen, Zhu Chen

Blood (2004) 104 (11): 4651.

https://doi.org/10.1182/blood.V104.11.4651.4651

Published: 2004

Journal Articles

Arsenic Trioxide and Melarsoprol Induce Programmed Cell Death in Myeloid Leukemia Cell Lines and Function in a PML and PML-RAR Independent Manner

Zhu-Gang Wang, Roberta Rivi, Laurent Delva, Andrea König, David A. Scheinberg, Carlo Gambacorti-Passerini, Janice L. Gabrilove, Raymond P. Warrell, Jr, Pier Paolo Pandolfi

Blood (1998) 92 (5): 1497–1504.

https://doi.org/10.1182/blood.V92.5.1497

Published: 1998

NARROW

Two Phase I and Pharmacokinetic Studies of Darinaparsin (Organic Arsenic Compound) in Japanese and Korean Patients with Relapsed or Refractory (R/R) Peripheral T-Cell Lymphoma (PTCL)

Nanoparticle Arsenic Compound Realgar Effectively Targets Myeloma Stem-Like Side Population

Darinaparsin in T-Cell Lymphoma (TCL) and Hodgkin Lymphoma (HL) Cells Lines and SCID Xenograft Mouse Models: Single-Agent Activity and Synergistic Cell Death Combined with a PI3K/mTOR Inhibitor

In Vitro and in Vivo Effect of Sodium Metaarsenite (KML001) in Non-Hodgkin's Lymphoma

Three Novel Clonal Non-Characteristic Chromosome Aberrations in Acute Myeloid Leukemia Resembling Acute Promyelocytic Leukemia

Anti-Leukemic Effect of Tetra-Arsenic Oxide in Acute Promyelocytic Leukemia Cells in Vitro and In Vivo

Targeting EVI1-Overexpressing AML with Darinaparsin

The Novel Organic Arsenical, Darinaparsin (ZIO-101), Induces Apoptosis through AKT and MEK/ERK Pathways In Hodgkin Lymphoma (HL) and T-Cell Lymphoma (TCL) Cell Lines

Glutathione Depletion Enhances Arsenic Trioxide-Induced Apoptosis in Lymphoma Cells through Mitochondrial and Caspase-Independent Mechanisms.

Arsenic Binding to RBCC Domain Modulates Oncogenic PML-RARa and Wild-Type PML as a Key Molecular Mechanism of Arsenic Trioxide Treatment for APL.

S-Dimethylarsinoglutathione (SGLU/ZIO101) Is a Novel Active Organic Arsenical That Displays a Unique Gene Expression Profile in Myeloma Cells.

Arsenic Trioxide Induces Up-Regulation of BMF and NOXA and Overcomes an Anti-Oxidative Response To Induce Apoptosis in Myeloma Cells.

In Vitro Activity of a Novel Organic Arsenical (S-Dimethylarsino-Glutathione, ZIO-101) Against Multiple Myeloma.

Pharmacokinetics of Arsenic Species with Relapsed or Refractory Acute Promyelocytic Leukemia (APL) Treated with Arsenic Trioxide (ATO) in Japanese Patients.

Comparison of Uptake and Intracellular Induced Structural Changes of Arsenic Trioxide, an Inorganic Compound, and Organic Arsenic Derivative S-Dimethylarsino-Glutathione (SGLU; ZIO-101) in NB4 Acute Promyelocytic Leukemia (APL) Cells.

Mechanism of Selectivity of Arsenic Trioxide for Acute Promyelocytic Leukemia Cells from Screening a Genome Wide Set of Saccharomyces cerevisiae Deletion Strains.

Combined Effects of As4S4 and Imatinib on Chronic Myeloid Leukemia Cells and BCR-ABL Oncoprotein.

Arsenic Trioxide and Melarsoprol Induce Programmed Cell Death in Myeloid Leukemia Cell Lines and Function in a PML and PML-RAR Independent Manner

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American Society of Hematology

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American Society of Hematology

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