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Journal Articles

FLT3 Inhibitors Induce Instability of p53 By Mir-181 Mediated Downregulation of Deubiquitinase YOD1 in Acute Myeloid Leukemia

Han Zhong Pei, Yao Guo, PhD, Bo Lu, MD, Zhiguang Chang, PhD, Dengyang Zhang, PhD, Liuting Yu, Yuming Zhao, Suk-Hwan Baek, PhD, Yun Chen, PhD, Zhizhuang Joe Zhao, PhD

Blood (2020) 136 (Supplement 1): 6–7.

https://doi.org/10.1182/blood-2020-139002

Published: 2020

Journal Articles

FLT3 Ligand-DM1 Conjugate Selectively Targets Acute Myeloid Leukemia Cells with FLT3 Expression

Dengyang Zhang, PhD, Yao Guo, PhD, Yuming Zhao, MD, Liuting Yu, Zhiguang Chang, PhD, Han Zhong Pei, Junbin Huang, MDPhD, Chun Chen, MDPhD, Hongman Xue, MDPhD, Yihang Pan, MD, Ningning Li, PhD, Chengming Zhu, PhD, Zhizhuang Joe Zhao, PhD, Jian Yu, PhD, Yun Chen, PhD

Blood (2020) 136 (Supplement 1): 30–31.

https://doi.org/10.1182/blood-2020-140200

Published: 2020

Journal Articles

Tumor Associated Macrophages Express High-Levels of FLT3 Ligand, Which Induces Activation of FLT3 Signaling That Promotes Survival of Neoplastic Cells in B-Cell Acute Lymphoblastic Leukemia

Yao Guo, PhD, Junbin Huang, MDPhD, Dengyang Zhang, PhD, Liqin Zhang, Yuming Zhao, Liuting Yu, Zhiguang Chang, PhD, Han Zhong Pei, Chun Chen, MDPhD, Hongman Xue, MDPhD, Xiaojun Xu, MDPhD, Zhizhuang Joe Zhao, PhD, Yun Chen, PhD

Blood (2020) 136 (Supplement 1): 36–37.

https://doi.org/10.1182/blood-2020-142093

Published: 2020

Journal Articles

Development of Liver-Specific Thrombopoietin Targeted Sirnas: Impact on Platelet Count, Megakaryocyte Mass, and Hematopoietic Progenitors in Normal and MPN Murine Models

Dhruv Desai, MSc, Anna Borodovsky, PhD, Wendell P Davis, DVM DACVP, Rohan Degaonkar, Kristina Yucius, Kellie D'Angelo, MLS(ASCP)CM, Paul Gedman, BS, Donna Marie Williams, PhD, Ophelia Rogers, Zhizhuang Joe Zhao, PhD, Jerry L. Spivak, MD, Alison R. Moliterno, MD

Blood (2018) 132 (Supplement 1): 4329.

https://doi.org/10.1182/blood-2018-99-117142

Published: 2018

Journal Articles

High Mobility Group A1 Chromatin Remodeling Proteins Amplify Inflammatory Networks to Drive Leukemic Transformation in Chronic Myeloproliferative Neoplasia in Humans and JAK2 V617F Transgenic Mouse Models

Linda Resar, MD, Donna Marie Williams, PhD, Lingling Xian, MD PhD, Wenyan Lu, PhD, Briyana Chisholm, BS, Li Luo, PhD, Zhizhuang Joe Zhao, PhD, Ophelia Rogers, Jerry L. Spivak, MD, Alison R. Moliterno, MD

Blood (2018) 132 (Supplement 1): 102.

https://doi.org/10.1182/blood-2018-99-119549

Published: 2018

Journal Articles

Mechanism of Escape from LNK Negative Regulation: Constitutively Active JAK2V617F Retains Lysine63-Ubiquitin

Jeffrey Patterson-Fortin, MD PhD, Jerry L. Spivak, MD, Amy S. Duffield, MD PhD, Donna Marie Williams, PhD, Ophelia Rogers, Zhizhuang Joe Zhao, PhD, Alison R. Moliterno, MD

Blood (2017) 130 (Supplement 1): 2931.

https://doi.org/10.1182/blood.V130.Suppl_1.2931.2931

Published: 2017

Journal Articles

High Mobility Group A1 Chromatin Remodeling Proteins: Potential Therapeutic Targets Involved in Polycythemia Vera Transformation to Acute Leukemia in Humans and JAK2 V617F Transgenic Mouse Models

Linda Resar, MD, Donna Marie Williams, PhD, Lingling Xian, MD PhD, Zhizhuang Joe Zhao, PhD, Ophelia Rogers, Jerry L. Spivak, MD, Alison R. Moliterno, MD

Blood (2017) 130 (Supplement 1): 489.

https://doi.org/10.1182/blood.V130.Suppl_1.489.489

Published: 2017

Journal Articles

Modulating Hedgehog Signaling Reduces MAPK, TGF-β, and Marrow Fibrosis in a Transgenic Mouse Model of JAK2V617F Associated Myeloproliferative Disease

Parvesh Chaudhry, PhD, Mohan Singh, PhD, Imran Siddiqi, MDPhD, Casey L. O'Connell, MD, Zhizhuang Joe Zhao, PhD, Akil Merchant, MD

Blood (2017) 130 (Supplement 1): 4216.

https://doi.org/10.1182/blood.V130.Suppl_1.4216.4216

Published: 2017

Journal Articles

High Mobility Group A1/2 Chromatin Remodeling Proteins Associate with Polycythemia Vera Transformation to Acute Leukemia in Humans and a JAK2 V617F Transgenic Mouse Model

Linda Resar, MD, Donna Marie Williams, PhD, Zhizhuang Joe Zhao, PhD, Ophelia Rogers, Lingling Xian, MD PhD, Jerry L. Spivak, MD, Alison R Moliterno, MD

Blood (2016) 128 (22): 1958.

https://doi.org/10.1182/blood.V128.22.1958.1958

Published: 2016

Journal Articles

Preclinical Efficacy of TGF-Beta Receptor I Kinase Inhibitor, Galunisertib, in Myelofibrosis

Lanzhu Yue, PhD, Matthias Bartenstein, Wanke Zhao, Wan-Ting Ho, Ling Zhang, MD, Franck Rapaport, PhD, Ross L. Levine, MD, Zonghong Shao, Zhizhuang Joe Zhao, PhD, Amit Verma, Pearlie K Epling-Burnette, PhD

Blood (2015) 126 (23): 603.

https://doi.org/10.1182/blood.V126.23.603.603

Published: 2015

Journal Articles

MPL SV , a Unique MPN MPL Splice Variant, Provokes a Fulminant Myeloid Leukemia in a JAK2 V617F Transgenic Mouse Model of Polycythemia Vera

Jerry L. Spivak, MD, Donna Marie Williams, PhD, Zhizhuang Joe Zhao, PhD, Ophelia Rogers, Amy S. Duffield, MD PhD, W. David Hankins, PhD, Alison R Moliterno, MD

Blood (2015) 126 (23): 484.

https://doi.org/10.1182/blood.V126.23.484.484

Published: 2015

Journal Articles

HH-002 Effectively Suppresses Myeloproliferative Neoplasm Phenotypes in JAK2V617F Transgenic Mice

Wan-Ting Ho, Wanke Zhao, Paul Hallenbeck, Frank Rong, Zhizhuang Joe Zhao, PhD

Blood (2015) 126 (23): 4095.

https://doi.org/10.1182/blood.V126.23.4095.4095

Published: 2015

Journal Articles

Identification and Characterization Of a Potent FLT3 Inhibitor

Yun Chen, Yao Guo, Wanting Ho, Zhizhuang Joe, Zhao, PhD

Blood (2013) 122 (21): 5027.

https://doi.org/10.1182/blood.V122.21.5027.5027

Published: 2013

Journal Articles

The Role Of p53 In JAK2V617F-Induced Myeloproliferative Neoplasms

Wanke Zhao, Yanhong Du, Yun Chen, Wanting Ho, Zhizhuang Joe Zhao, PhD

Blood (2013) 122 (21): 4103.

https://doi.org/10.1182/blood.V122.21.4103.4103

Published: 2013

Journal Articles

CD169 + Macrophages Regulate Erythropoiesis Under Homeostasis, Recovery From Erythron Injury and in JAK2 V617F -Induced Polycythemia Vera

Andrew Chow, PhD, Matthew Huggins, Jalal Ahmed, Daniel Lucas, PhD, Daigo Hashimoto, MD, PhD, Yuya Kunisaki, MD, PhD, Sandra Pinho, PhD, Marylene Leboeuf, Clara Noizat, Nico van Rooijen, PhD, Masato Tanaka, MD, PhD, Zhizhuang Joe Zhao, PhD, Aviv Bergman, PhD, Miriam Merad, MD, PhD, Paul S. Frenette, MD, FRCPC

Blood (2012) 120 (21): 80.

https://doi.org/10.1182/blood.V120.21.80.80

Published: 2012

Journal Articles

A Functional Thrombopoietin Receptor Is Required for Full Expression of Phenotype in a JAK2 V617F Transgenic Mouse Model of Polycythemia Vera

Jerry L. Spivak, MD, Akil Merchant, MD, Donna M. Williams, PhD, Ophelia Rogers, Wanming Zhao, Alison R. Moliterno, MD, Zhizhuang Joe Zhao, PhD

Blood (2012) 120 (21): 427.

https://doi.org/10.1182/blood.V120.21.427.427

Published: 2012

Journal Articles

Aberrant Functions of Mast Cells Are Involved in Pruritus Associated with Polycythemia Vera

Xi Jin, Wanke Zhao, Annet Kirabo, Sung Park, Ph.D., Wanting Ho, Peter P. Sayeski, Ph.D., Zhizhuang Joe Zhao, PhD

Blood (2012) 120 (21): 1756.

https://doi.org/10.1182/blood.V120.21.1756.1756

Published: 2012

Journal Articles

The Jak2 Kinase Inhibitor, G6, Reduces the Mutant Burden and Reverses Marrow Fibrosis in a Mouse Model of Jak2-V617F Mediated PMF,

Peter P. Sayeski, Ph.D., Annet Kirabo, Sung Park, Ph.D., Meghanath Gali, Mary Reinhard, DVM, DACLAM, Heather L Wamsley, Zhizhuang Joe Zhao, PhD, Kirpal S Bisht, Christopher R Cogle, M.D., Gyorgy M Keseru

Blood (2011) 118 (21): 3858.

https://doi.org/10.1182/blood.V118.21.3858.3858

Published: 2011

Journal Articles

Transgene Dose- and Age-Dependent Development of Myeloproliferative Neoplasm Phenotypes In JAK2V617F Transgene Mice

Wanting Ho, Wanming Zhao, Zhizhuang Joe Zhao, PhD

Blood (2010) 116 (21): 1980.

https://doi.org/10.1182/blood.V116.21.1980.1980

Published: 2010

NARROW

FLT3 Inhibitors Induce Instability of p53 By Mir-181 Mediated Downregulation of Deubiquitinase YOD1 in Acute Myeloid Leukemia

FLT3 Ligand-DM1 Conjugate Selectively Targets Acute Myeloid Leukemia Cells with FLT3 Expression

Tumor Associated Macrophages Express High-Levels of FLT3 Ligand, Which Induces Activation of FLT3 Signaling That Promotes Survival of Neoplastic Cells in B-Cell Acute Lymphoblastic Leukemia

Development of Liver-Specific Thrombopoietin Targeted Sirnas: Impact on Platelet Count, Megakaryocyte Mass, and Hematopoietic Progenitors in Normal and MPN Murine Models

High Mobility Group A1 Chromatin Remodeling Proteins Amplify Inflammatory Networks to Drive Leukemic Transformation in Chronic Myeloproliferative Neoplasia in Humans and JAK2 V617F Transgenic Mouse Models

Mechanism of Escape from LNK Negative Regulation: Constitutively Active JAK2V617F Retains Lysine63-Ubiquitin

High Mobility Group A1 Chromatin Remodeling Proteins: Potential Therapeutic Targets Involved in Polycythemia Vera Transformation to Acute Leukemia in Humans and JAK2 V617F Transgenic Mouse Models

Modulating Hedgehog Signaling Reduces MAPK, TGF-β, and Marrow Fibrosis in a Transgenic Mouse Model of JAK2V617F Associated Myeloproliferative Disease

High Mobility Group A1/2 Chromatin Remodeling Proteins Associate with Polycythemia Vera Transformation to Acute Leukemia in Humans and a JAK2 V617F Transgenic Mouse Model

Preclinical Efficacy of TGF-Beta Receptor I Kinase Inhibitor, Galunisertib, in Myelofibrosis

MPL SV , a Unique MPN MPL Splice Variant, Provokes a Fulminant Myeloid Leukemia in a JAK2 V617F Transgenic Mouse Model of Polycythemia Vera

HH-002 Effectively Suppresses Myeloproliferative Neoplasm Phenotypes in JAK2V617F Transgenic Mice

Identification and Characterization Of a Potent FLT3 Inhibitor

The Role Of p53 In JAK2V617F-Induced Myeloproliferative Neoplasms

CD169 + Macrophages Regulate Erythropoiesis Under Homeostasis, Recovery From Erythron Injury and in JAK2 V617F -Induced Polycythemia Vera

A Functional Thrombopoietin Receptor Is Required for Full Expression of Phenotype in a JAK2 V617F Transgenic Mouse Model of Polycythemia Vera

Aberrant Functions of Mast Cells Are Involved in Pruritus Associated with Polycythemia Vera

The Jak2 Kinase Inhibitor, G6, Reduces the Mutant Burden and Reverses Marrow Fibrosis in a Mouse Model of Jak2-V617F Mediated PMF,

Transgene Dose- and Age-Dependent Development of Myeloproliferative Neoplasm Phenotypes In JAK2V617F Transgene Mice

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American Society of Hematology

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American Society of Hematology

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