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Zhimin Gu, PhD
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Journal Articles

Elucidating Mechanisms of Acquired Resistance to IDH Inhibition By Saturation Variant Screening of Base-Edited Leukemia Cells

Junhua Lyu, Yuxuan Liu, PhD, Hui Cao, MS, Mingyi Chen, MD PhD, Yazan F. Madanat, MD, Yuannyu Zhang, PhD, Zhimin Gu, PhD, Pranita Kaphle, MS, Kathryn E. Dickerson, MD, Paul Yenerall, PhD, Rahul Kollipara, PhD, Ralf Kittler, PhD, John Minna, MD, Weina Chen, MD PhD, Stephen Chung, MD, Robert H. Collins, MD, Xin Liu, PhD, Jian Xu, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 3.
https://doi.org/10.1182/blood-2020-141433
Published: 2020
Journal Articles

The Interaction of NEK2 with USP7 Causes Resistance to Proteasome Inhibitor in Multiple Myeloma

Reinaldo Franqui-Machin, Mu Hao, PhD, Bai Hua, Zhimin Gu, PhD, Xin Zhan, Hongwei Xu, Hasem Habelhah, Yogesh Jethava, MBBS,MDFRCPath,MRCP, Lugui Qiu, MD, Ivana Frech, DSc, PhD MBA, Guido J. Tricot, MD PhD, Fenghuang Zhan, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 593.
https://doi.org/10.1182/blood.V130.Suppl_1.593.593
Published: 2017
Journal Articles

Targeting the Epigenetic and Metabolic Vulnerabilities of Ezh2-Deficiency-Induced Myeloid Neoplasms

Zhimin Gu, PhD, Yuxuan Liu, PhD, Hui Cao, MS, Mingyi Chen, MD PhD, Yuannyu Zhang, PhD, Le Qi, Xin Liu, PhD, Kailong Li, PhD, Kathryn Dickerson, MD, Feng Cai, PhD, Weina Chen, MD PhD, Min Ni, PhD, Ralph Deberardinis, MD PhD, Jian Xu, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 380.
https://doi.org/10.1182/blood.V130.Suppl_1.380.380
Published: 2017
Journal Articles

Mitochondria Coordinate Intracellular Metabolism and Epigenetic Gene Regulation during Erythropoiesis

Xin Liu, PhD, Yuannyu Zhang, PhD, Min Ni, PhD, Hui Cao, M.S., Robert Signer, PhD, Dan Li, B.S., Zhimin Gu, PhD, Zeping Hu, PhD, Navdeep Chandel, Ralph DeBerardinis, MD PhD, Feng Zhou, PhD, Zhen Shao, PhD, Jian Xu, PhD
Journal: Blood
Blood (2016) 128 (22): 1038.
https://doi.org/10.1182/blood.V128.22.1038.1038
Published: 2016
Journal Articles

Drug Resistant Myeloma Cells Cause More Severe Bone Destruction in Myeloma

Mu Hao, MD PhD, Zhimin Gu, PhD, Reinaldo Franqui Machin, Hongwei Xu, Gregory S. Thomas, PhD, Lugui Qiu, MD PhD, Guido J Tricot, MD PhD, Fenghuang Zhan, MD PhD
Journal: Blood
Blood (2015) 126 (23): 839.
https://doi.org/10.1182/blood.V126.23.839.839
Published: 2015
Journal Articles

Targeting Neddylation to Overcome Drug Resistance in Multiple Myeloma

Gregory S Thomas, PhD, Junwei Huang, MD, Yi Zhou, PhD, Zhimin Gu, PhD, Ye Yang, PhD, Hongwei Xu, Guido J Tricot, MD PhD, Fenghuang Zhan, MD PhD
Journal: Blood
Blood (2015) 126 (23): 1804.
https://doi.org/10.1182/blood.V126.23.1804.1804
Published: 2015
Journal Articles

Hypermethylation of TAp73 Suppresses ABL1-Involved DNA Damage Response in Multiple Myeloma

Mu Hao, PhD, Yu Qin, PhD, Meirong Zang, PhD, Yan Xu, MD PhD, Gang An, MD PhD, Changhong Li, MD, Ye Yang, PhD, Zhimin Gu, PhD, Fenghuang Zhan, MD PhD, Lugui Qiu, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3374.
https://doi.org/10.1182/blood.V124.21.3374.3374
Published: 2014
Journal Articles

Decreased FPN1 in Myeloma Promotes Malignant Cell Growth and Osteoclast Differentiation

Zhimin Gu, PhD, He Wang, PhD, Jiliang Xia, MS, Ivana De Domenico, PhD, Ye Yang, PhD, Junwei Huang, MD, Hongwei Xu, DDS, Zhengdong Jin, PhD, Guido J. Tricot, MD, PhD, Fenghuang Zhan, MD PhD
Journal: Blood
Blood (2014) 124 (21): 2017.
https://doi.org/10.1182/blood.V124.21.2017.2017
Published: 2014
Journal Articles

NEK2 Suppresses Cellular Senescence through Regulation of the β-Catenin/CCND2/RB Axis in Multiple Myeloma

Ye Yang, PhD, Guido J. Tricot, MD, PhD, Xia Jiliang, Zhimin Gu, PhD, Hongwei Xu, DDS, Mu Hao, PhD, Fenghuang Zhan, MD PhD
Journal: Blood
Blood (2014) 124 (21): 2024.
https://doi.org/10.1182/blood.V124.21.2024.2024
Published: 2014
Journal Articles

Elevated Expression Of CKS1B Inhibits Senescence Thorough Enhanced Degradation Of p21 In Multiple Myeloma

Zhimin Gu, PhD, Yi Zhou, PhD, He Wang, MD, Ye Yang, PhD, Hongwei Xu, DDS, Junwei Huang, MD, Jie He, MD, Yi Tao, MD&PhD, Guido J. Tricot, M.D., Ph.D., Fenghuang Zhan, MD&PhD
Journal: Blood
Blood (2013) 122 (21): 1882.
https://doi.org/10.1182/blood.V122.21.1882.1882
Published: 2013
Journal Articles

RARα2 Expression Confers Myeloma Stem Cell Features

Guido J. Tricot, M.D., Ph.D., Ye Yang, PhD, Zhimin Gu, PhD, Hongwei Xu, DDS, Junwei Huang, MD, Jie He, MD, Yi Tao, MD&PhD, Fenghuang Zhan, MD&PhD
Journal: Blood
Blood (2013) 122 (21): 5404.
https://doi.org/10.1182/blood.V122.21.5404.5404
Published: 2013
Journal Articles

High Trip13 and Low P31 Comet Cause Drug Resistance and Poor Prognosis In Multiple Myeloma

Yi Tao, MD&PhD, Zhimin Gu, PhD, Ye Yang, PhD, Hongwei Xu, DDS, Xiaojing Hu, Guido J. Tricot, M.D., Ph.D., Fenghuang Zhan, MD&PhD, Jumei Shi, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 3820.
https://doi.org/10.1182/blood.V122.21.3820.3820
Published: 2013
Journal Articles

Targeting BTK As a Treatment For Multiple Myeloma Stem Cells

Ye Yang, PhD, Zhimin Gu, PhD, Hongwei Xu, DDS, Junwei Huang, MD, Jie He, MD, Yi Tao, MD&PhD, Guido J. Tricot, M.D., Ph.D., Fenghuang Zhan, MD&PhD
Journal: Blood
Blood (2013) 122 (21): 271.
https://doi.org/10.1182/blood.V122.21.271.271
Published: 2013
Journal Articles

Next-Generation STAT3 Inhibitors As Targeted Therapeutics in Chronic Myeloid Leukemia.

Ira L Kraft, BS, Anna M. Eiring, PhD, Brent DG Page, BS, Clinton C Mason, PhD, Zhimin Gu, PhD, Jamshid S Khorashad, MD, PhD, David J Anderson, BA, Anthony D Pomicter, MS, Kimberly R Reynolds, MS, Johanna Estrada, Matthew S Zabriskie, BS, Patrick T Gunning, PhD, Thomas O'Hare, PhD, Michael W Deininger, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 2445.
https://doi.org/10.1182/blood.V120.21.2445.2445
Published: 2012
Journal Articles

Suppression of CML Progenitor but Not Stem Cells Requires Simultaneous Inhibition of KIT and BCR-ABL1.

Zhimin Gu, PhD, Amie S. Corbin, Thomas O'Hare, PhD, Anna M. Eiring, PhD, Tian yi Zhang, Brian J. Druker, Michael W. Deininger, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 2778.
https://doi.org/10.1182/blood.V120.21.2778.2778
Published: 2012
Journal Articles

STAT3 Inhibition Synergizes with BCR-ABL1 Inhibition to Overcome Kinase-Independent TKI Resistance in Chronic Myeloid Leukemia (CML)

Anna M. Eiring, PhD, Ira L Kraft, BS, Brent DG Page, BS, David J Anderson, BA, Zhimin Gu, PhD, Jamshid S Khorashad, MD, PhD, Anthony D Pomicter, MS, Kimberly R Reynolds, MS, Matthew S Zabriskie, BS, Richard Moriggl, PhD, Patrick T Gunning, PhD, Thomas O'Hare, PhD, Michael W Deininger, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 31.
https://doi.org/10.1182/blood.V120.21.31.31
Published: 2012