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Zhengshan Chen, MDPhD
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Journal Articles

CD25-Dependent Feedback Control of the B-Cell Receptor and Its Oncogenic Mimics in B-Cell Malignancies

Jae-Woong Lee, PhD, Kohei Kume, PhD, Zhengshan Chen, MDPhD, Gang Xiao, PhD, Kadriye Nehir Cosgun, PhD, Lai N Chan, Chun-Wei Chen, PhD, Raju Pillai, MD, Wing C Chan, MD, Stephen J Forman, Larry W Kwak, MD PhD, Francesca Zammarchi, PhD, Patrick Van Berkel, PhD, David M Weinstock, MD, Ari M Melnick, MD, Vu N Ngo, PhD, Huimin Geng, PhD, Selina Luger, MD, Mark R. Litzow, MD, Alexandre Belot, MDPhD, Gulbu Uzel, MD, Michael T McManus, PhD, Elisabeth M. Paietta, PhD, Eric Meffre, PhD, Markus Muschen, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 776.
https://doi.org/10.1182/blood-2018-99-117553
Published: 2018
Journal Articles

Ras-Driven B-Cell Transformation Targets Developmental Rewiring of Cytokine to Pre-B Cell Receptor Signaling

Lai N Chan, Christian Hurtz, PhD, Huimin Geng, PhD, Franziska Auer, PhD, Zhengshan Chen, MDPhD, Gang Xiao, PhD, Jae-Woong Lee, PhD, Kadriye Nehir Cosgun, PhD, B Hilda Ye, PhD, Markus Muschen, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1336.
https://doi.org/10.1182/blood-2018-99-115514
Published: 2018
Journal Articles

Divergent Evolutionary Trajectories of Erk- and Stat5-Activating Lesions in Acute Lymphoblastic Leukemia

Lai N Chan, Seyedmehdi Shojaee, PhD, Christian Hurtz, PhD, Franziska Auer, PhD, Zhengshan Chen, MDPhD, Kadriye Nehir Cosgun, PhD, Huimin Geng, PhD, Teresa Sadras, PhD, Deborah L White, PhD, Markus Muschen, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 568.
https://doi.org/10.1182/blood-2018-99-115536
Published: 2018
Journal Articles

IFITM3-Mediated Regulation of Cell Membrane Dynamics Is Essential for Malignant B-Cell Transformation

Jae-Woong Lee, PhD, Huimin Geng, PhD, Derek S Dinson, Gang Xiao, PhD, Kadriye Nehir Cosgun, PhD, Lai N Chan, Zhengshan Chen, MDPhD, Michael Farzan, MDPhD, Jae U Jung, PhD, Arun P Wiita, MDPhD, Markus Muschen, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 552.
https://doi.org/10.1182/blood-2018-99-117472
Published: 2018
Journal Articles

Autoimmunity Checkpoints As Therapeutic Targets in B-Cell Malignancies

Zhengshan Chen, MDPhD, Markus Muschen, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1587.
https://doi.org/10.1182/blood-2018-99-113674
Published: 2018
Journal Articles

Autoimmunity Checkpoints As Therapeutic Targets in B- and T-Cell Malignancies

Zhengshan Chen, MDPhD, Anna Hecht, MD, Markus Muschen, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 718.
https://doi.org/10.1182/blood.V130.Suppl_1.718.718
Published: 2017
Journal Articles

Stat5 Feedback Control Switches MYC- and BCL6-Dependent Cell Fates in Normal and Transformed B Cells

Zhengshan Chen, MDPhD, Lai N Chan, Huimin Geng, PhD, Merja Heinäniemi, PhD, Olli Lohi, MD PhD, Cheryl L. Willman, MD, Markus Muschen, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1440.
https://doi.org/10.1182/blood.V130.Suppl_1.1440.1440
Published: 2017
Journal Articles

CD25 Enables Oncogenic BCR-Signaling and Represents a Therapeutic Target in B Cell Malignancies

Jaewoong Lee, PhD, Huimin Geng, PhD, Zhengshan Chen, MDPhD, Gang Xiao, PhD, Kadriye Nehir Nehir Cosgun, PhD, Francesca Zammarchi, PhD, Patrick Van Berkel, PhD, Ari Melnick, MD, Elisabeth Paietta, PhD, Markus Muschen, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3834.
https://doi.org/10.1182/blood.V130.Suppl_1.3834.3834
Published: 2017
Journal Articles

Lgr5 Functions As Negative Regulator of Wnt Signaling in B Cells and Is Critical for Self-Renewal of Normal and Transformed B Cells

Kadriye Nehir Nehir Cosgun, PhD, Anna Hecht, MD, Xin Yang, MD, Maurizio Mangolini, PhD, Ali Aghajanirefah, PhD, Zhengshan Chen, MDPhD, Gang Xiao, PhD, Lars Klemm, Msc, Chao Hong, PhD, Huimin Geng, PhD, Hassan Jumaa, PhD, Hans Clevers, MD PhD, Markus Muschen, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3989.
https://doi.org/10.1182/blood.V130.Suppl_1.3989.3989
Published: 2017
Journal Articles

PP2A Is Required for B Cell Survival and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia

Xiao Gang, PhD, Huimin Geng, PhD, Lai N Chan, PhD, Zhengshan Chen, MDPhD, Xiaoyan Jiang, MDPhD, Markus Muschen, MDPhD
Journal: Blood
Blood (2015) 126 (23): 902.
https://doi.org/10.1182/blood.V126.23.902.902
Published: 2015
Journal Articles

CD25 (IL2RA) Orchestrates Negative Feedback Control and Stabilizes Oncogenic Signaling Strength in Acute Lymphoblastic Leukemia

Jae-Woong Lee, PhD, Zhengshan Chen, MDPhD, Huimin Geng, PhD, Gang Xiao, PhD, Eugene PARK, PhD, Samir Parekh, MD, Steven M. Kornblau, MD, Ari Melnick, MD, Abul Abbas, Elisabeth Paietta, Markus Muschen, MD PhD
Journal: Blood
Blood (2015) 126 (23): 1434.
https://doi.org/10.1182/blood.V126.23.1434.1434
Published: 2015
Journal Articles

Identification of BCL6 As a Therapeutic Target in RAS -Driven Acute Lymphoblastic Leukemia

Qiang Li, PhD, Christian Hurtz, PhD, Seyedmehdi Shojaee, PhD, Zhengshan Chen, MDPhD, Huimin Geng, PhD, Gang Xiao, PhD, Mignon L. Loh, MD, B. Hilda Ye, PhD, Ari Melnick, MD, Markus Muschen, MDPhD
Journal: Blood
Blood (2015) 126 (23): 556.
https://doi.org/10.1182/blood.V126.23.556.556
Published: 2015
Journal Articles

IFITM3 (CD225) Links the B Cell Antigen CD19 to PI3K-AKT Signaling in Human ALL Cells

Jae-Woong Lee, PhD, Huimin Geng, PhD, Zhengshan Chen, MDPhD, Eugene PARK, PhD, Lars Klemm, BSc, MSc, Charles C. Bailey, Markus Muschen, MD PhD
Journal: Blood
Blood (2015) 126 (23): 1325.
https://doi.org/10.1182/blood.V126.23.1325.1325
Published: 2015
Journal Articles

Targeted Activation of B Cell Autoimmunity Checkpoints in Acute Lymphoblastic Leukemia

Zhengshan Chen, MDPhD, Huimin Geng, PhD, Clifford A. Lowell, MD PhD, Arthur Weiss, MDPhD, Stephen P. Hunger, Ari Melnick, MD, Markus Muschen, MD PhD
Journal: Blood
Blood (2015) 126 (23): 3716.
https://doi.org/10.1182/blood.V126.23.3716.3716
Published: 2015