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Yoshiyuki Kosaka, MD, PhD
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Journal Articles

Outcome of Hematopoietic Stem Cell Transplantation in the Patients with Pediatric Acute Lymphoblastic Leukemia Enrolled in the Japan Association of Childhood Leukemia Study (JACLS) ALL-02

Mio Yano, MD, Hisashi Ishida, MD PhD, Yoshiko Hashii, MD PhD, Asahito Hama, MD PhD, Yoshiyuki Kosaka, MD PhD, Tsukasa Hori, MD PhD, Junichi Hara, MD, PhD, Hiroshi Kawaguchi, MD PhD, Etsuro Ito, MD PhD, Akiko M Saito, MD PhD, Atsushi Sato, MD PhD, Hiroki Hori, MD PhD, Keizo Horibe, MD PhD, Toshihiko Imamura, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4605.
https://doi.org/10.1182/blood-2019-122224
Published: 2019
Journal Articles

Coagulation and Fibrinolysis Imbalance Demonstrated By Novel Simultaneous Thrombin and Plasmin Generation Assay during L-Asparaginase Treatment Phase of Induction Therapy in Pediatric Acute Lymphoblastic Leukemia

Takashi Ishihara, MD, Keiji Nogami, MD PhD, Satoshi Ochi, MD, Toshiaki Ishida, MD PhD, Yoshiyuki Kosaka, MD PhD, Akihisa Sawada, MD PhD, Masami Inoue, MD, Shinya Osone, MD PhD, Toshihiko Imamura, MD PhD, Hajime Hosoi, MD PhD, Midori Shima, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3972.
https://doi.org/10.1182/blood-2018-99-110411
Published: 2018
Journal Articles

The Prognostic Value of TP53 Mutations Depends on Clinical Backgrounds in Pediatric Patients with Acute Lymphoblastic Leukemia

Hiroo Ueno, MD, Kenichi Yoshida, MD PhD, Yusuke Shiozawa, MD, PhD, Yasuhito Nannya, MD PhD, Yuka Iijima-Yamashita, PhD, Nobutaka Kiyokawa, MD PhD, Yuichi Shiraishi, PhD, Kenichi Chiba, PhD, Hiroko Tanaka, BA, Tomoya Isobe, MD, Masafumi Seki, MD,PhD, Shunsuke Kimura, MD, Hideki Makishima, MD PhD, Nobuyuki Kakiuchi, MD, Keisuke Kataoka, MD PhD, Tetsuichi Yoshizato, MD PhD, Hiroyuki Tsukamoto, MD PhD, Dai Nishijima, PhD, Takao Deguchi, MD PhD, Kentaro Ohki, MD PhD, Atsushi Sato, MD, Hiroyuki Takahashi, Yoshiko Hashii, MD, PhD, Sadao Tokimasa, MD, PhD, Junichi Hara, MD, PhD, Yoshiyuki Kosaka, MD PhD, Koji Kato, MD PhD, Takeshi Inukai, MD, Junko Takita, MD, PhD, Toshihiko Imamura, MD PhD, Satoru Miyano, PhD, Atsushi Manabe, MD PhD, Keizo Horibe, MD PhD, Seishi Ogawa, MD PhD, Masashi Sanada, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4077.
https://doi.org/10.1182/blood-2018-99-115617
Published: 2018
Journal Articles

Programmed Death-1 and Programmed Death-Ligand 1 Expression Patterns in Pediatric Lymphoma

Akihiro Tamura, MD PhD, Makiko Yoshida, MD PhD, Nobuyuki Yamamoto, MD PhD, Nanako Nino, MD, Naoko Nakatani, MD, Takayuki Ichikawa, MD, Sayaka Nakamura, MD, Atsuro Saito, MD, Aiko Kozaki, MD, Kenji Kishimoto, MD, Toshiaki Ishida, MD PhD, Daiichiro Hasegawa, MD PhD, Yoshiyuki Kosaka, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5316.
https://doi.org/10.1182/blood-2018-99-110732
Published: 2018
Journal Articles

Molecular Diagnosis of Hemophilia B Leyden in Japanese Brothers Reveals Spontaneous Amelioration in Early Childhood with c. -35 G>A Onecut Binding Site Mutation

Akihiro Tamura, MD, Daiichiro Hasegawa, MD PhD, Sayaka Nakamura, MD, Takahiro Fujiwara, MD, Teppei Tahara, MD, Nobuyuki Yamamoto, MD PhD, Atsuro Saito, MD, Aiko Kozaki, MD, Kenji Kishimoto, MD, Toshiaki Ishida, MD PhD, Keiko Shinozawa, PhD, Kagehiro Amano, MD PhD, Katsuyuki Fukutake, MD PhD, Yoshiyuki Kosaka, MD, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3680.
https://doi.org/10.1182/blood.V130.Suppl_1.3680.3680
Published: 2017
Journal Articles

Clinical Effect of Genetic Alterations in Pediatric Patients with B-Progenitor Acute Lymphoblastic Leukemia

Hiroo Ueno, MD, Kenichi Yoshida, MD PhD, Yasuhito Nannya, MD PhD, Yuka Iijima-Yamashita, M.S., Yusuke Shiozawa, MD , PhD, Yuichi Shiraishi, PhD, Tomomi Ishida, Keisuke Kataoka, MD PhD, Tetsuichi Yoshizato, MD,PhD, Hideki Makishima, MD PhD, Nobuyuki Kakiuchi, MD, Masafumi Seki, MD,PhD, Hiroko Tanaka, B.A., Kenichi Chiba, B.A., Takao Deguchi, MD PhD, Atsushi Sato, MD, Yoshiko Hashii, MD, PhD, Sadao Tokimasa, MD, PhD, Junichi Hara, MD, PhD, Yoshiyuki Kosaka, MD, PhD, Koji Kato, MD, PhD, Toshihiko Imamura, MD, PhD, Satoru Miyano, PhD, Keizo Horibe, Seishi Ogawa, MD PhD, Masashi Sanada, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3979.
https://doi.org/10.1182/blood.V130.Suppl_1.3979.3979
Published: 2017
Journal Articles

Low Incidence of Osteonecrosis in Childhood Acute Lymphoblastic Leukemia Treated with ALL-97 and ALL-02 Study of Japan Association of Childhood Leukemia Study Group

Kenichi Sakamoto, MD, Toshihiko Imamura, MD PhD, Kentaro Kihira, MD, Hisashi Ishida, MD, Suzuki Kouji, MD, Hiromi Morita, MD, Kanno Miyako, MD, Takeshi Mori, MD, Hidefumi Hiramatsu, MD PhD, Kousaku Matsubara, MD, Kiminori Terui, MD PhD, Yoshihiro Takahashi, MD PhD, So-ichi Suenobu, MD PhD, Daiichiro Hasegawa, MD PhD, Yoshiyuki Kosaka, MD, PhD, Koji Kato, Saito-Moriya Akiko, MD, Atsushi Sato, MD, Hirohide Kawasaki, MD, Keiko Yumura Yagi, MD PhD, Jun-ichi Hara, MD PhD, Hiroki Hori, MD PhD, Keizo Horibe
Journal: Blood
Blood (2017) 130 (Supplement 1): 1286.
https://doi.org/10.1182/blood.V130.Suppl_1.1286.1286
Published: 2017
Journal Articles

The Outcome of Low-Risk Childhood B-Cell Precursor ALL Treated with the Japan Association of Childhood Leukemia Study (JACLS) ALL-02 Trial

Yoshihiro Takahashi, MD PhD, Toshihiko Imamura, MD PhD, Ikuya Usami, MD PhD, Keiko Yumura-Yagi, Soichi Suenobu, Daiichiro Hasegawa, MD PhD, Shinichiro Nishimura, MD PhD, Nobuhiro Suzuki, MDPhD, Yoshiko Hashii, MD PhD, Takao Deguchi, MD PhD, Akiko M. Saito, MD PhD, Yoshihiro Komada, MD PhD, Yoshiyuki Kosaka, MD PhD, Koji Kato, MD PhD, Ryoji Kobayashi, MD PhD, Hirohide Kawasaki, MD PhD, Hiroki Hori, MD PhD, Atsushi Sato, MD PhD, Tooru Kudo, MD PhD, Tatsutoshi Nakahata, MD PhD, Megumi Oda, MD PhD, Junichi Hara, MD PhD, Keizo Horibe, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1604.
https://doi.org/10.1182/blood.V128.22.1604.1604
Published: 2016
Journal Articles

Shift to Anti-Fibrinolysis on the Administration of L-Asparaginase (L-Asp) during Induction Therapy for Pediatric Acute Lymphoblastic Leukemia (ALL)

Takashi Ishihara, MD, Keiji Nogami, MD PhD, Tomoko Matsumoto, PhD, Yasufumi Takeshita, MD, Akitaka Nomura, MD, Satoshi Ochi, MD, Toshiaki Ishida, MD PhD, Yoshiyuki Kosaka, MD PhD, Akihisa Sawada, PhD MD, Masami Inoue, MD, Midori Shima, MD PhD
Journal: Blood
Blood (2016) 128 (22): 5156.
https://doi.org/10.1182/blood.V128.22.5156.5156
Published: 2016
Journal Articles

Congenital Undifferentiated Pure Erythroid Leukemia

Akihiro Tamura, MD PhD, Daiichiro Hasegawa, MD PhD, Suguru Uemura, MD, Atsuro Saito, MD, Emiko Takeoka, MD, Saki Okubo, MD, Nanako Nino, MD, Takehito Yokoi, MD, Teppei Tahara, MD, Aiko Kozaki, MD, Kenji Kishimoto, MD, Toshiaki Ishida, MD PhD, Seiji Yoshimoto, MD PhD, Keiichiro Kawasaki, MD PhD, Hideto Nakao, MD PhD, Makiko Yoshida, MD, Naoya Morisada, MD PhD, Yoshiyuki Kosaka, MD PhD
Journal: Blood
Blood (2016) 128 (22): 5231.
https://doi.org/10.1182/blood.V128.22.5231.5231
Published: 2016
Journal Articles

Continuous Cytarabine Plus Dexamethasone in Consolidation Phase to Patients with Childhood ALL: Result from Japan Association of Childhood Leukemia Study - JACLS ALL02 Protocol -

So-ichi Suenobu, MD PhD, Ikuya Usami, MD PhD, Toshihiko Imamura, MD PhD, Hirohide Kawasaki, MD PhD, Keiko Yumura Yagi, MD PhD, Shinichiro Nishimura, MD PhD, Makoto Kaneda, MD PhD, Yoshihiro Takahashi, MD PhD, Daiichiro Hasegawa, MD PhD, Nobuhiro Suzuki, MD PhD, Yoshiko Hashii, MD PhD, Takao Deguchi, MD PhD, Saito Akiko, MD PhD, Koji Kato, MD PhD, Yoshiyuki Kosaka, MD PhD, Mikiya Endo, MD PhD, Akihiro Iguchi, MD PhD, Megumi Oda, MD PhD, Hiroki Hori, MD PhD, Atsushi Sato, MD PhD, Tatsutoshi Nakahata, MD PhD, Tooru Kudoh, MD PhD, Junichi Hara, MD PhD, Keizo Horibe, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2802.
https://doi.org/10.1182/blood.V128.22.2802.2802
Published: 2016
Journal Articles

Risk-Adjusted Therapy of Acute Lymphoblastic Leukemia Can Optimize the Indication of Stem Cell Transplantation and Cranial Irradiation: Results of Japan Association Childhood Leukemia Study Group (JACLS) Protocol ALL-02

Daiichiro Hasegawa, MD PhD, Toshihiko Imamura, MD PhD, Keiko Yagi, MD PhD, Yoshihiro Takahashi, MD PhD, Ikuya Usami, MD PhD, So-ichi Suenobu, MD PhD, Nishimura Shinichiro, MD PhD, Nobuhiro Suzuki, MD PhD, Yoshiko Hashii, MD PhD, Takao Deguchi, MD PhD, Akiko M. Saito, MD PhD, Koji Kato, MD PhD, Yoshiyuki Kosaka, MD PhD, Yoshihiro Komada, MD PhD, Akihiro Iguchi, MD PhD, Hirohide Kawasaki, MD, Hiroki Hori, MD PhD, Atsushi Sato, MD PhD, Tooru Kudo, MD PhD, Tatsutoshi Nakahata, MD PhD, Megumi Oda, MD PhD, Junichi Hara, MD PhD, Keizo Horibe, MD PhD
Journal: Blood
Blood (2016) 128 (22): 3973.
https://doi.org/10.1182/blood.V128.22.3973.3973
Published: 2016
Journal Articles

Landscape of Driver Mutations and Their Clinical Impacts in Pediatric Acute Lymphoblastic Leukemia

Hiroo Ueno, MD, Kenichi Yoshida, MD PhD, Yuka Yamashita, MS, Yusuke Shiozawa, MD, Tomomi Ishida, Hiroyuki Tsukamoto, MD, Yuichi Shiraishi, PhD, Hiroko Tanaka, BA, Kenichi Chiba, BA, Takao Deguchi, MD PhD, Atsushi Sato, MD, Yoshiko Hashii, MD PhD, Sadao Tokimasa, PhD MD, Junichi Hara, MD PhD, Yoshiyuki Kosaka, MD PhD, Koji Kato, MD PhD, Toshihiko Imamura, MD PhD, Satoru Miyano, PhD, Seishi Ogawa, MD PhD, Keizo Horibe, MD PhD, Masashi Sanada, MD PhD
Journal: Blood
Blood (2016) 128 (22): 912.
https://doi.org/10.1182/blood.V128.22.912.912
Published: 2016
Journal Articles

Risk Factors For Clonal Evolution Of Acquired Bone Marrow Failure After Immunosuppressive Therapy In Children

Asahito Hama, MD, PhD, Hideki Muramatsu, MD, PhD, Masafumi Ito, MD, PhD, Yoshiyuki Kosaka, MD, PhD, Masahiro Tsuchida, MD, PhD, Yoshiyuki Takahashi, MD, PhD, Ryoji Kobayashi, MD, PhD, Etsuro Ito, MD, PhD, Hiromasa Yabe, MD, Shouichi Ohga, MD, PhD, Akira Ohara, MD, PhD, Seiji Kojima, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 2473.
https://doi.org/10.1182/blood.V122.21.2473.2473
Published: 2013
Journal Articles

Poor Prognosis With Different Induction Rate Was Observed In Children With Acute Myeloid Leukemia and FLT3 -ITD According To The ITD/WT Allelic Ratio: A Result From The Japanese Pediatric Leukemia/Lymphoma Study Group

Akira Shimada, MD., PhD, Yuka Yamashita, MS, Daisuke Tomizawa, MD, PhD, Akio Tawa, MD, PhD, Tomoyuki Watanabe, PhD, Toshiya Yokozawa, MD, PhD, Kazuko Kudo, MD, PhD, Takashi Taga, MD, PhD, Shotaro Iwamoto, MD, PhD, Kiminori Terui, MD, PhD, Hiroshi Moritake, MD, PhD, Akitoshi Kinoshita, MD, PhD, Hiroyuki Takahashi, MD, PhD, Hideki Nakayama, MD., PhD, Katsuyoshi Koh, MD, Hiroaki Goto, MD., PhD, Yoshiyuki Kosaka, MD, PhD, Akiko Moriya Saito, MD, PhD, Junichiro Fujimoto, MD, PhD, Keizo Horibe, MD, PhD, Kentaro Oki, MD, PhD, Yasuhide Hayashi, MD, PhD, Souichi Adachi, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 3891.
https://doi.org/10.1182/blood.V122.21.3891.3891
Published: 2013
Journal Articles

Prognostic Significance Of CRLF2 Over-Expression In Pediatric Acute Lymphoblastic Leukemia

Mio Yano, MD, Toshihiko Imamura, MD, Daisuke Asai, MD, Akiko Moriya Saito, MD, PhD, So-ichi Suenobu, MD, PhD, Daiichiro Hasegawa, MD, PhD, Takao Deguchi, MD, Yoshiko Hashii, MD, PhD, Hirohide Kawasaki, MD, Hiroki Hori, MD, Yoshiyuki Kosaka, MD, PhD, Koji Kato, MD, PhD, Keizo Horibe, MD, PhD, Keiko Yagi, MD, Junichi Hara, MD, PhD, Kenji Matsumoto, Nobutaka Kiyokawa, MD, PhD, Megumi Oda, MD, Atsushi Sato, MD
Journal: Blood
Blood (2013) 122 (21): 1368.
https://doi.org/10.1182/blood.V122.21.1368.1368
Published: 2013
Journal Articles

Attempts to Optimize Post-Induction Treatment in Childhood Acute Myeloid Leukemia without Core Binding Factors: A Report From the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG)

Daiichiro Hasegawa, MD, PhD, Akio Tawa, MD, PhD, Daisuke Tomizawa, Tomoyuki Watanabe, PhD, Akiko Saito, MD, PhD, Kazuko Kudo, Takashi Taga, MD, Shotaro Iwamoto, MD, PhD, Akira Shimada, MD, PhD, Kiminori Terui, MD, PhD, Hiroshi Moritake, MD, PhD, Akitoshi Kinoshita, MD, Hiroyuki Takahashi, MD, PhD, Hideki Nakayama, MD, Katsuyoshi Koh, MD, PhD, Hisato Kigasawa, MD, Yoshiyuki Kosaka, MD, PhD, Hayato Miyachi, MD, PhD, Keizo Horibe, MD, Tatsutoshi Nakahata, MD, PhD, Souichi Adachi, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 3545.
https://doi.org/10.1182/blood.V120.21.3545.3545
Published: 2012
Journal Articles

Excess Reduction of Anthracyclines Results in Inferior Event-Free Survival in Core Binding Factor Acute Myeloid Leukemia in Children; A Report From the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG)

Daisuke Tomizawa, Akio Tawa, MD, PhD, Tomoyuki Watanabe, PhD, Akiko Moriya Saito, MD, Kazuko Kudo, Takashi Taga, MD, Shotaro Iwamoto, MD, PhD, Akira Shimada, MD, PhD, Kiminori Terui, MD, PhD, Hiroshi Moritake, MD, PhD, Akitoshi Kinoshita, MD, Hiroyuki Takahashi, MD, PhD, Hideki Nakayama, MD, Katsuyoshi Koh, MD, PhD, Hisato Kigasawa, MD, Yoshiyuki Kosaka, MD, PhD, Hayato Miyachi, MD, PhD, Keizo Horibe, MD, Tatsutoshi Nakahata, MD, PhD, Souichi Adachi, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 409.
https://doi.org/10.1182/blood.V120.21.409.409
Published: 2012
Journal Articles

Appropriate Dose Modification in Induction Therapy Is Essential for the Treatment of Infants with Acute Myeloid Leukemia; A Report From the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG).

Daisuke Tomizawa, Akio Tawa, MD, PhD, Tomoyuki Watanabe, PhD, Akiko Moriya Saito, MD, Kazuko Kudo, Takashi Taga, MD, Shotaro Iwamoto, MD, PhD, Akira Shimada, MD, PhD, Kiminori Terui, MD, PhD, Hiroshi Moritake, MD, PhD, Akitoshi Kinoshita, MD, Hiroyuki Takahashi, MD, PhD, Hideki Nakayama, MD, Katsuyoshi Koh, MD, PhD, Hisato Kigasawa, MD, Yoshiyuki Kosaka, MD, PhD, Hayato Miyachi, MD, PhD, Keizo Horibe, MD, Tatsutoshi Nakahata, MD, PhD, Souichi Adachi, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 2615.
https://doi.org/10.1182/blood.V120.21.2615.2615
Published: 2012
Journal Articles

JAK2 mutations and CRLF2 rearrangements in Down Syndrome-Associated Acute Lymphoblastic Leukemia in Japan

Isamu Hanada, MD, Kiminori Terui, MD, PhD, Tsutomu Toki, PhD, Ko Kudo, MD, Tomohiko Sato, MD, PhD, Takuya Kamio, MD, PhD, Shinya Sasaki, MD, PhD, Yoshihiro Takahashi, MD, PhD, Yasuhide Hayashi, MD, PhD, Kanji Sugita, MD, PhD, Seiji Kojima, MD, PhD, Kenichi Koike, MD, PhD, Yoshiyuki Kosaka, MD, PhD, Masao Kobayashi, MD, PhD, Etsuro Ito, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 1451.
https://doi.org/10.1182/blood.V118.21.1451.1451
Published: 2011