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Yoshiko Hashii, MD, PhD
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Journal Articles

Post-Induction Minimal Residual Disease Measured By Flow Cytometry and Deep Sequencing of Mutant GATA1 Are Both Significant Prognostic Factors for Children with Myeloid Leukemia and Down Syndrome: A Nationwide Prospective Study of the Japanese Pediatric Leukemia/Lymphoma Study Group

Takashi Taga, MD PhD, Shiro Tanaka, PhD, Kiminori Terui, MD PhD, Shotaro Iwamoto, MD, Hidefumi Hiramatsu, MD PhD, Takako Miyamura, MD PhD, Yoshiko Hashii, MD PhD, Daisuke Hasegawa, MD PhD, Hiroshi Moritake, MD PhD, Hideki Nakayama, MD, Hiroyuki Takahashi, MD PhD, Akira Shimada, MD PhD, Tomohiko Taki, MD PhD, Tsutomu Toki, PhD, Etsuro Ito, MD PhD, Katsuyoshi Koh, MD, Daiichiro Hasegawa, MD PhD, Asahito Hama, MD PhD, Akiko M Saito, MD PhD, Souichi Adachi, MD PhD, Daisuke Tomizawa, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3848.
https://doi.org/10.1182/blood-2019-123302
Published: 2019
Journal Articles

Outcome of Hematopoietic Stem Cell Transplantation in the Patients with Pediatric Acute Lymphoblastic Leukemia Enrolled in the Japan Association of Childhood Leukemia Study (JACLS) ALL-02

Mio Yano, MD, Hisashi Ishida, MD PhD, Yoshiko Hashii, MD PhD, Asahito Hama, MD PhD, Yoshiyuki Kosaka, MD PhD, Tsukasa Hori, MD PhD, Junichi Hara, MD, PhD, Hiroshi Kawaguchi, MD PhD, Etsuro Ito, MD PhD, Akiko M Saito, MD PhD, Atsushi Sato, MD PhD, Hiroki Hori, MD PhD, Keizo Horibe, MD PhD, Toshihiko Imamura, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4605.
https://doi.org/10.1182/blood-2019-122224
Published: 2019
Journal Articles

The Prognostic Value of TP53 Mutations Depends on Clinical Backgrounds in Pediatric Patients with Acute Lymphoblastic Leukemia

Hiroo Ueno, MD, Kenichi Yoshida, MD PhD, Yusuke Shiozawa, MD, PhD, Yasuhito Nannya, MD PhD, Yuka Iijima-Yamashita, PhD, Nobutaka Kiyokawa, MD PhD, Yuichi Shiraishi, PhD, Kenichi Chiba, PhD, Hiroko Tanaka, BA, Tomoya Isobe, MD, Masafumi Seki, MD,PhD, Shunsuke Kimura, MD, Hideki Makishima, MD PhD, Nobuyuki Kakiuchi, MD, Keisuke Kataoka, MD PhD, Tetsuichi Yoshizato, MD PhD, Hiroyuki Tsukamoto, MD PhD, Dai Nishijima, PhD, Takao Deguchi, MD PhD, Kentaro Ohki, MD PhD, Atsushi Sato, MD, Hiroyuki Takahashi, Yoshiko Hashii, MD, PhD, Sadao Tokimasa, MD, PhD, Junichi Hara, MD, PhD, Yoshiyuki Kosaka, MD PhD, Koji Kato, MD PhD, Takeshi Inukai, MD, Junko Takita, MD, PhD, Toshihiko Imamura, MD PhD, Satoru Miyano, PhD, Atsushi Manabe, MD PhD, Keizo Horibe, MD PhD, Seishi Ogawa, MD PhD, Masashi Sanada, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4077.
https://doi.org/10.1182/blood-2018-99-115617
Published: 2018
Journal Articles

Distribution and Clinical Features of NOTCH1 Signaling Activating Alterations in Pediatric T-Cell Acute Lymphoblastic Leukemia (T-ALL)

Shunsuke Kimura, MD, Masafumi Seki, MD, PhD, Kenichi Yoshida, MD PhD, Hiroo Ueno, MD, Yasuhito Nannya, MD PhD, Kentaro Ohki, MD PhD, Motohiro Kato, MD PhD, Katsuyoshi Koh, MD, Ryoji Kobayashi, MD, Takao Deguchi, MD PhD, Yoshiko Hashii, MD PhD, Toshihiko Imamura, MD PhD, Atsushi Sato, MD, Nobutaka Kiyokawa, MD PhD, Atsushi Manabe, MD PhD, Keizo Horibe, MD PhD, Akira Ohara, MD, Masashi Sanada, MD PhD, Mitsuteru Hiwatari, MD PhD, Masao Kobayashi, MD PhD, Akira Oka, MD PhD, Satoru Miyano, PhD, Seishi Ogawa, MD PhD, Junko Takita, MD, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4089.
https://doi.org/10.1182/blood-2018-99-111092
Published: 2018
Journal Articles

Negative CD19 Expression Is Associated with Inferior Relapse-Free Survival in RUNX1-RUNX1T1 -Positive Acute Myeloid Leukemia; The Japanese Pediatric Leukemia/Lymphoma Study Group Experience from the AML-05 Study

Toshihiko Imamura, MD PhD, Kenichi Sakamoto, MD PhD, Norio Shiba, MD PhD, Takao Deguchi, MD PhD, Nobutaka Kiyokawa, MD PhD, Yoshiko Hashii, MD, PhD, Akiko Saito, MD, Daisuke Tomizawa, MD PhD, Takashi Taga, MD PhD, Souichi Adachi, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2810.
https://doi.org/10.1182/blood-2018-99-115553
Published: 2018
Journal Articles

Hematopoietic Stem Cell Transplantation in Children with Refractory Langerhans Cell Histiocytosis

Kazuko Kudo, MD PhD, Miho Maeda, MD, Nobuhiro Suzuki, MD PhD, Hirokazu Kanegane, MD PhD, Shouichi Ohga, MD PhD, Eiichi Ishii, MD PhD, Yoko Shioda, MD, Toshihiko Imamura, MD PhD, Shinsaku Imashuku, MD PhD, Yukiko Tsunematsu, MD, Mikiya Endo, MD, Akira Shimada, MD PhD, Yuuki Koga, MD PhD, Yoshiko Hashii, MD PhD, Jiro Inagaki, MD, Masami Inoue, MD, Ken Tabuchi, MD, Akira Morimoto, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4657.
https://doi.org/10.1182/blood-2018-99-110711
Published: 2018
Journal Articles

Hematopoietic Stem Cell Transplantation in Children with Refractory Acute Lymphoblastic Leukemia

Yasuhiro Okamoto, MD, Yozo Nakazawa, MD, PhD, Masami Inoue, MD, Kenichiro Watanabe, MD PhD, Hiroaki Goto, MD, Nao Yoshida, MD PhD, Maiko Noguchi, MD, Atsushi Kikuta, MD, Koji Kato, MD PhD, Yoshiko Hashii, MD PhD, Yoshiko Atsuta, MD PhD, Motohiro Kato, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2173.
https://doi.org/10.1182/blood-2018-99-111301
Published: 2018
Journal Articles

Clinical Significance of Natural Killer Cell-Mediated Alloreactivity in Unrelated Cord Blood Transplantation for Children with Acute Leukemia: A Japanese National Registry Study

Hirotoshi Sakaguchi, MD PhD, Nobuyoshi Arima, MD PhD, Atsushi Narita, MD PhD, Sae Ishimaru, MD, Daisuke Tomizawa, MD PhD, Daiichiro Hasegawa, MD PhD, Motohiro Kato, MD, Hiroyuki Ishida, MD PhD, Junya Kanda, MD, Masami Inoue, MD PhD, Nao Yoshida, MD PhD, Katsuyoshi Koh, MD, Jiro Inagaki, MD PhD, Atsushi Ogawa, MD PhD, Tsukasa Hori, MD PhD, Yoshiko Hashii, MD, PhD, Koji Kato, MD, PhD, Yoshiko Atsuta, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3315.
https://doi.org/10.1182/blood.V130.Suppl_1.3315.3315
Published: 2017
Journal Articles

Clinical Effect of Genetic Alterations in Pediatric Patients with B-Progenitor Acute Lymphoblastic Leukemia

Hiroo Ueno, MD, Kenichi Yoshida, MD PhD, Yasuhito Nannya, MD PhD, Yuka Iijima-Yamashita, M.S., Yusuke Shiozawa, MD , PhD, Yuichi Shiraishi, PhD, Tomomi Ishida, Keisuke Kataoka, MD PhD, Tetsuichi Yoshizato, MD,PhD, Hideki Makishima, MD PhD, Nobuyuki Kakiuchi, MD, Masafumi Seki, MD,PhD, Hiroko Tanaka, B.A., Kenichi Chiba, B.A., Takao Deguchi, MD PhD, Atsushi Sato, MD, Yoshiko Hashii, MD, PhD, Sadao Tokimasa, MD, PhD, Junichi Hara, MD, PhD, Yoshiyuki Kosaka, MD, PhD, Koji Kato, MD, PhD, Toshihiko Imamura, MD, PhD, Satoru Miyano, PhD, Keizo Horibe, Seishi Ogawa, MD PhD, Masashi Sanada, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3979.
https://doi.org/10.1182/blood.V130.Suppl_1.3979.3979
Published: 2017
Journal Articles

The Epigenetic and Genetic Landscapes of Pediatric T-Cell Acute Lymphoblastic Leukemia (T-ALL)

Shunsuke Kimura, Masafumi Seki, MD,PhD, Tomoko Kawai, PhD, Kenichi Yoshida, MD PhD, Tomoya Isobe, Hiroo Ueno, MD, Yusuke Shiozawa, MD , PhD, Hiromichi Suzuki, MD , PhD, Yuichi Shiraishi, PhD, Kenichi Chiba, B.A., Hiroko Tanaka, B.A., Kentaro Ohki, MD PhD, Motohiro Kato, MD, Katsuyoshi Koh, MD, Ryoji Hanada, MD, Ryoji Kobayashi, MD, Takao Deguchi, MD PhD, Yoshiko Hashii, MD, PhD, Toshihiko Imamura, MD, PhD, Atsushi Sato, MD, Nobutaka Kiyokawa, MD PhD, Atushi Manabe, MD PhD, Keizo Horibe, Akira Ohara, MD, Masashi Sanada, MD PhD, Masao Kobayashi, MD PhD, Akira Oka, MD PhD, Yasuhide Hayashi, MD PhD, Satoru Miyano, PhD, Kenichiro Hata, MD PhD, Seishi Ogawa, MD PhD, Junko Takita, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1444.
https://doi.org/10.1182/blood.V130.Suppl_1.1444.1444
Published: 2017
Journal Articles

Comprehensive Immunophenotyping Panel in Japan Enables to Detect Rare Subtypes in Childhood Leukemia

Takao Deguchi, MD PhD, Nobutaka Kiyokawa, MD PhD, Kentaro Ohki, MD PhD, Yoshiko Hashii, MD, PhD, Atsushi Manabe, Souichi Adachi, MD PhD, Akiko Moriya Saito, MD PhD, Keizo Horibe
Journal: Blood
Blood (2017) 130 (Supplement 1): 5112.
https://doi.org/10.1182/blood.V130.Suppl_1.5112.5112
Published: 2017
Journal Articles

The Outcome of Childhood B-Cell Precursor ALL with ETV6-RUNX1 Treated with Japan Association of Childhood Leukemia Study (JACLS) ALL-02 Trial

Ikuya Usami, Toshihiko Imamura, MD, PhD, Yoshihiro Takahashi, MD PhD, So-ichi Suenobu, MD PhD, Daiichiro Hasegawa, MD PhD, Yoshiko Hashii, MD, PhD, Takao Deguchi, MD PhD, Tsukasa Hori, MD PhD, Akira Shimada, MDPhD, Koji Kato, MD, PhD, Etsuro Ito, MD PhD, Akiko Moriya Saito, MD PhD, Hirohide Kawasaki, MD, Hiroki Hori, MD PhD, Keiko Yumura Yagi, MD PhD, Jun-ichi Hara, MD PhD, Atsushi Sato, MD, Keizo Horibe
Journal: Blood
Blood (2017) 130 (Supplement 1): 2565.
https://doi.org/10.1182/blood.V130.Suppl_1.2565.2565
Published: 2017
Journal Articles

Continuous Cytarabine Plus Dexamethasone in Consolidation Phase to Patients with Childhood ALL: Result from Japan Association of Childhood Leukemia Study - JACLS ALL02 Protocol -

So-ichi Suenobu, MD PhD, Ikuya Usami, MD PhD, Toshihiko Imamura, MD PhD, Hirohide Kawasaki, MD PhD, Keiko Yumura Yagi, MD PhD, Shinichiro Nishimura, MD PhD, Makoto Kaneda, MD PhD, Yoshihiro Takahashi, MD PhD, Daiichiro Hasegawa, MD PhD, Nobuhiro Suzuki, MD PhD, Yoshiko Hashii, MD PhD, Takao Deguchi, MD PhD, Saito Akiko, MD PhD, Koji Kato, MD PhD, Yoshiyuki Kosaka, MD PhD, Mikiya Endo, MD PhD, Akihiro Iguchi, MD PhD, Megumi Oda, MD PhD, Hiroki Hori, MD PhD, Atsushi Sato, MD PhD, Tatsutoshi Nakahata, MD PhD, Tooru Kudoh, MD PhD, Junichi Hara, MD PhD, Keizo Horibe, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2802.
https://doi.org/10.1182/blood.V128.22.2802.2802
Published: 2016
Journal Articles

The Outcome of Low-Risk Childhood B-Cell Precursor ALL Treated with the Japan Association of Childhood Leukemia Study (JACLS) ALL-02 Trial

Yoshihiro Takahashi, MD PhD, Toshihiko Imamura, MD PhD, Ikuya Usami, MD PhD, Keiko Yumura-Yagi, Soichi Suenobu, Daiichiro Hasegawa, MD PhD, Shinichiro Nishimura, MD PhD, Nobuhiro Suzuki, MDPhD, Yoshiko Hashii, MD PhD, Takao Deguchi, MD PhD, Akiko M. Saito, MD PhD, Yoshihiro Komada, MD PhD, Yoshiyuki Kosaka, MD PhD, Koji Kato, MD PhD, Ryoji Kobayashi, MD PhD, Hirohide Kawasaki, MD PhD, Hiroki Hori, MD PhD, Atsushi Sato, MD PhD, Tooru Kudo, MD PhD, Tatsutoshi Nakahata, MD PhD, Megumi Oda, MD PhD, Junichi Hara, MD PhD, Keizo Horibe, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1604.
https://doi.org/10.1182/blood.V128.22.1604.1604
Published: 2016
Journal Articles

Improved Outcome of Unrelated Cord Blood Transplantation in Children with Severe Aplastic Anemia

Kazuko Kudo, MD PhD, Hideki Muramatsu, MD PhD, Nao Yoshida, MD PhD, Ryoji Kobayashi, MD PhD, Hiromasa Yabe, MD, Mikiya Endo, MD PhD, Masami Inoue, MD PhD, Yozo Nakazawa, MD PhD, Jun-ichi Hara, MD, Shinji Kaminami, MD, Jiro Inagaki, MD, Yoshiko Hashii, MD PhD, Koji Kato, MD PhD, Ken Tabuchi, MD, Seiji Kojima, MD PhD
Journal: Blood
Blood (2016) 128 (22): 3503.
https://doi.org/10.1182/blood.V128.22.3503.3503
Published: 2016
Journal Articles

Risk-Adjusted Therapy of Acute Lymphoblastic Leukemia Can Optimize the Indication of Stem Cell Transplantation and Cranial Irradiation: Results of Japan Association Childhood Leukemia Study Group (JACLS) Protocol ALL-02

Daiichiro Hasegawa, MD PhD, Toshihiko Imamura, MD PhD, Keiko Yagi, MD PhD, Yoshihiro Takahashi, MD PhD, Ikuya Usami, MD PhD, So-ichi Suenobu, MD PhD, Nishimura Shinichiro, MD PhD, Nobuhiro Suzuki, MD PhD, Yoshiko Hashii, MD PhD, Takao Deguchi, MD PhD, Akiko M. Saito, MD PhD, Koji Kato, MD PhD, Yoshiyuki Kosaka, MD PhD, Yoshihiro Komada, MD PhD, Akihiro Iguchi, MD PhD, Hirohide Kawasaki, MD, Hiroki Hori, MD PhD, Atsushi Sato, MD PhD, Tooru Kudo, MD PhD, Tatsutoshi Nakahata, MD PhD, Megumi Oda, MD PhD, Junichi Hara, MD PhD, Keizo Horibe, MD PhD
Journal: Blood
Blood (2016) 128 (22): 3973.
https://doi.org/10.1182/blood.V128.22.3973.3973
Published: 2016
Journal Articles

Clusters of Childhood Mixed Phenotype Acute Leukemia Diagnosed By Nation-Wide Immunophenotyping in Japan

Takao Deguchi, MD PhD, Nobutaka Kiyokawa, MD PhD, Kentaro Ohki, MD PhD, Yoshiko Hashii, MD PhD, Atsushi Manabe, MD PhD, Souichi Adachi, MD, PhD, Akiko M. Saito, MD PhD, Keizo Horibe, MD PhD, Yoshihiro Komada, MD PhD
Journal: Blood
Blood (2016) 128 (22): 5277.
https://doi.org/10.1182/blood.V128.22.5277.5277
Published: 2016
Journal Articles

Adolescents and Young Adults with Acute Myeloid Leukemia Are Associated with Higher Treatment-Related Mortality and Inferior Overall Survival after Allogeneic Hematopoietic Cell Transplantation Compared with Children

Daisuke Tomizawa, MD, PhD, Shiro Tanaka, PhD, Tadakazu Kondo, MD PhD, Yoshiko Hashii, MD PhD, Yasuyuki Arai, MD PhD, Kazuko Kudo, MD PhD, Takashi Taga, MD PhD, Jiro Inagaki, MD, Katsuyoshi Koh, MD, Masami Inoue, MD, Junji Tanaka, MD PhD, Koji Kato, MD PhD, Yoshiko Atsuta, MD PhD, Souichi Adachi, MD, PhD, HIroyuki Ishida, MD
Journal: Blood
Blood (2016) 128 (22): 4702.
https://doi.org/10.1182/blood.V128.22.4702.4702
Published: 2016
Journal Articles

Landscape of Driver Mutations and Their Clinical Impacts in Pediatric Acute Lymphoblastic Leukemia

Hiroo Ueno, MD, Kenichi Yoshida, MD PhD, Yuka Yamashita, MS, Yusuke Shiozawa, MD, Tomomi Ishida, Hiroyuki Tsukamoto, MD, Yuichi Shiraishi, PhD, Hiroko Tanaka, BA, Kenichi Chiba, BA, Takao Deguchi, MD PhD, Atsushi Sato, MD, Yoshiko Hashii, MD PhD, Sadao Tokimasa, PhD MD, Junichi Hara, MD PhD, Yoshiyuki Kosaka, MD PhD, Koji Kato, MD PhD, Toshihiko Imamura, MD PhD, Satoru Miyano, PhD, Seishi Ogawa, MD PhD, Keizo Horibe, MD PhD, Masashi Sanada, MD PhD
Journal: Blood
Blood (2016) 128 (22): 912.
https://doi.org/10.1182/blood.V128.22.912.912
Published: 2016
Journal Articles

Identifications of Highly Aggressive Phenotype with SPI1 Overexpression in Pediatric T Cell Acute Lymphoblastic Leukemia/Lymphoma

Masafumi Seki, MD PhD, Shunsuke Kimura, MD, Kenichi Yoshida, MD PhD, Tomoya Isobe, MD, Hiroo Ueno, MD, Hiromichi Suzuki, MD PhD, Yusuke Shiozawa, MD, Keisuke Kataoka, MD PhD, Yoichi Fujii, MD, Yuichi Shiraishi, PhD, Kenichi Chiba, BA, Hiroko Tanaka, BA, Masatoshi Takagi, MD PhD, Atsushi Iwama, MD PhD, Kentaro Oki, MDPhD, Motohiro Kato, MD PhD, Katsuyoshi Koh, MD, Ryoji Hanada, MD, Hiroshi Moritake, MD PhD, Ryoji Kobayashi, MD PhD, Takao Deguchi, MD PhD, Yoshiko Hashii, MD PhD, Toshihiko Imamura, MD PhD, Atsushi Sato, MD, Keizo Horibe, MD PhD, Nobutaka Kiyokawa, MD PhD, Atsushi Manabe, MD PhD, Akira Ohara, MD PhD, Masashi Sanada, MD PhD, Yasuhide Hayashi, MD PhD, Hiroyuki Mano, MDPhD, Satoru Miyano, PhD, Akira Oka, MD PhD, Seishi Ogawa, MD PhD, Junko Takita, MD PhD
Journal: Blood
Blood (2016) 128 (22): 909.
https://doi.org/10.1182/blood.V128.22.909.909
Published: 2016