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Journal Articles

T Cells Bearing Anti-CD19- and/or Anti-CD38-Chimeric Antigen Receptors Effectively Abrogate Primary Double-Hit Lymphoma Cells

Keichiro Mihara, MD PhD, Tetsumi Yoshida, MD, Yoshifumi Takei, MD PhD, Naomi Sasaki, MD PhD, Yoshihiro Takihara, MD PhD, Tatsuo Ichinohe, MD PhD

Blood (2016) 128 (22): 4182.

https://doi.org/10.1182/blood.V128.22.4182.4182

Published: 2016

Journal Articles

All-Trans Retinoic Acid and Interferon-Alpha Increase CD38 Expression on Adult T-Cell Leukemia Cells and Sensitize Them to T Cells Bearing Anti-CD38 Chimeric Antigen Receptors

Keichiro Mihara, MD PhD, Tetsumi Yoshida, MD, Seiko Ishida, MD PhD, Yoshifumi Takei, MD PhD, Akira Kitanaka, MD PhD, Kazuya Shimoda, MD PhD, Kazuhiro Morishita, MD PhD, Yoshihiro Takihara, MD PhD, Tatsuo Ichinohe, MD

Blood (2015) 126 (23): 591.

https://doi.org/10.1182/blood.V126.23.591.591

Published: 2015

Journal Articles

Adult T-Cell Leukemia/Lymphoma Cells Were Eliminated By T Cells With Anti-CD38 Chimeric Antigen Receptor Through CD38 Expression Induced By All-Trans Retinoic Acid

Tetsumi Yoshida, MD, Keichiro Mihara, MD, PhD, Akira Kitanaka, MD, PhD, Kazuya Shimoda, MD, PhD, Kazuhiro Morishita, MD, PhD, Yoshihiro Takihara, MD, PhD, Tatsuo Ichinohe, MD, PhD

Blood (2013) 122 (21): 1824.

https://doi.org/10.1182/blood.V122.21.1824.1824

Published: 2013

Journal Articles

All-Trans Retinoic Acid Enhances the Cytotoxic Effect of T Cells with Anti-CD38 Chimeric Receptor in Acute Myeloid Leukemia

Keichiro Mihara, MD, PhD, Joyeeta Bhattacharyya, MD, PhD, Yoshihiro Takihara, MD, PhD, Akiro Kimura, MD

Blood (2012) 120 (21): 1901.

https://doi.org/10.1182/blood.V120.21.1901.1901

Published: 2012

Journal Articles

T-Cell Immunotherapy with a Chimeric Receptor Against CD38 Is Effective in Eliminating Myeloma Cells

Keichiro Mihara, MD, PhD, Joyeeta Bhattacharyya, MD, PhD, Akira Kitanaka, MD, PhD, Akihiro Ihara, MD, PhD, Akira Sakai, MD, PhD, Yoshiaki Kuroda, MD, PhD, Hideki Asaoku, MD, Yoshihiro Takihara, MD, PhD, Akiro Kimura, MD

Blood (2011) 118 (21): 885.

https://doi.org/10.1182/blood.V118.21.885.885

Published: 2011

Journal Articles

B-Cell Lymphoma Cells Overexpressing BMI-1 Are Correlated with Drug Resistance through Enhanced Expression of Survivin and Are Effectively Eliminated by T Cells with Anti-CD38 Chimeric Receptor

Joyeeta Bhattacharyya, Keichiro Mihara, MD, PhD, Motoaki Ohtsubo, Shin'ichiro Yasunaga, MD, PhD, Yoshihiro Takihara, MD, PhD, Masaharu Hoshi, Akiro Kimura, MD, PhD

Blood (2010) 116 (21): 3613.

https://doi.org/10.1182/blood.V116.21.3613.3613

Published: 2010

Journal Articles

Decreased Expression In NF-κB Essential Modulator Due to a Novel Splice-Site Mutation Causes Ectodermal Dysplasia with Immunodeficiency

Shuhei Karakawa, M.D, Satoshi Okada, MD, Miyuki Tsumura, BSc, Yoko Mizoguchi, MD, Norioki Ohno, MD, Shin'ichiro Yasunaga, MD, Motoaki Ohtsubo, PhD, Tomoki Kawai, MD, Ryuta Nishikomori, MD, Yoshihiro Takihara, MD, Masao Kobayashi, MD

Blood (2010) 116 (21): 1732.

https://doi.org/10.1182/blood.V116.21.1732.1732

Published: 2010

Journal Articles

A Novel Mutation K673R In STAT1 Impaired the STAT1 Signal Transduction In a dominant– Negative Manner Identified In a Japanese Boy with MSMD

Yoko Mizoguchi, MD, Miyuki Tsumura, B.Sc., Satoshi Okada, MD, Hidemasa Sakai, MD, Ryuta Nishikomori, MD, Shin'ichiro Yasunaga, MD, Motoaki Ohtsubo, PhD, Takuji Murata, MD, Hideto Obata, MD, Takahiro Yasumi, MD, Toshio Heike, MD, Tatsutoshi Nakahata, MD, Yoshihiro Takihara, MD, Masao Kobayashi, MD

Blood (2010) 116 (21): 1734.

https://doi.org/10.1182/blood.V116.21.1734.1734

Published: 2010

Journal Articles

A Novel Splicing Mutation in NEMO Gene in a Patient with X-Linked Ectodermal Dysplasia with Immunodeficiency.

Syuhei Karakawa, MD, Satoshi Okada, MD, Miyuki Tsumura, MA, Yoko Mizoguchi, MD, Tomoki Kawai, MD, Ryota Nishikomori, MD, Shin'ichiro Yasunaga, MD, Yoshihiro Takihara, MD, Masao Kobayashi, MD, PhD

Blood (2009) 114 (22): 2665.

https://doi.org/10.1182/blood.V114.22.2665.2665

Published: 2009

Journal Articles

Synergistic and Persistent Effect of T-Cell Immunotherapy with Anti-CD19 or Anti-CD38 Chimeric Receptor on B-Cell Lymphoma in Conjunction with Rituximab

Keichiro Mihara, MD, PhD, Kazuyoshi Yanagihara, PhD, Misato Takigahira, PhD, Yoshihiro Takihara, MD, PhD, Akiro Kimura, MD, PhD

Blood (2008) 112 (11): 2610.

https://doi.org/10.1182/blood.V112.11.2610.2610

Published: 2008

Journal Articles

Novel Heterozygous Mutation 572insA in TACI Identified in a Patient with Selective IgA Deficiency.

Satoshi Okada, MD, PhD, Teruyuki Kajiume, MD, PhD, Miyuki Tsumura, MSc, Kenichiro Shirao, MD, Yoshinori Ohno, MSc, Shin’ichiro Yasunaga, MD, PhD, Motoaki Ohtsubo, PhD, Mostafa Mofamed Sira, Hirokazu Kanegane, MD, PhD, Toshio Miyawaki, MD, PhD, Yoshihiro Takihara, MD, PhD, Masao Kobayashi, MD, PhD

Blood (2008) 112 (11): 1473.

https://doi.org/10.1182/blood.V112.11.1473.1473

Published: 2008

Journal Articles

Activated T Cell-Mediated Immunotherapy with a Chimeric Receptor Against CD38 in B-Cell Malignancies.

Keichiro Mihara, MD, PhD, Kazuyoshi Yanagihara, Ph.D, Misato Takigahira, Takahiro Ochiya, Ph.D, Chihaya Imai, M.D., Ph.D, Akira Kitanaka, M.D., Ph.D, Yoshihiro Takihara, M.D., Ph.D, Akiro Kimura, M.D., Ph.D

Blood (2007) 110 (11): 2356.

https://doi.org/10.1182/blood.V110.11.2356.2356

Published: 2007

Journal Articles

Association of Neurodevelopmental Abnormalities Is a Common Clinical Character in Japanese Patients with Severe Congenital Neutropenia Due to HAX1 Deficiency.

Satoshi Okada, MD, Nobutsune Ishikawa, M.D., Kenichiro Shirao, M.D., Miyuki Tsumura, M.Sc., Takashi Satoh, M.D., Yoshinori Ohno, M.Sc., Shin’ichiro Yasunaga, Ph.D., Motoaki Ohtsubo, Ph.D., Yoshihiro Takihara, Ph.D., Masao Kobayashi, M.D.

Blood (2007) 110 (11): 665.

https://doi.org/10.1182/blood.V110.11.665.665

Published: 2007

Journal Articles

A Novel Mutation 774del4 in IFNGR1 , Which Produces Truncated Form of Interferon γ Receptor 1, Causes a Dominant-Negative Effect on Interferon γ Signal Transduction.

Satoshi Okada, MD, Nobutsune Ishikawa, M.D., Kenichirou Shirao, M.D., Hiroshi Kawaguchi, M.D., Miyuki Tsumura, Ph.D., Yoshinori Ohno, Ph.D., Shin’ichiro Yasunaga, Ph.D., Motoaki Ohtsubo, Ph.D., Yoshihiro Takihara, Ph.D., Masao Kobayashi, M.D.

Blood (2006) 108 (11): 1246.

https://doi.org/10.1182/blood.V108.11.1246.1246

Published: 2006

Journal Articles

Bmi-1 is useful as a novel molecular marker for predicting progression of myelodysplastic syndrome and patient prognosis

Keichiro Mihara, Moniruddin Chowdhury, Nanae Nakaju, Sachiko Hidani, Akihiro Ihara, Hideo Hyodo, Shin'ichiro Yasunaga, Yoshihiro Takihara, Akiro Kimura

Blood (2006) 107 (1): 305–308.

https://doi.org/10.1182/blood-2005-06-2393

Published: 2006

Journal Articles

Compound Heterozygosity for a Novel Mutation Combined with G Insertion in Exon 13 Causes Severe Factor XI Deficiency in Patients of Japanese Origin.

Nobutsune Ishikawa, Shinichiro Yasunaga, Motoaki Ohtsubo, Yoshihiro Takihara, Takashi Sato, Masao Kobayashi

Blood (2005) 106 (11): 4087.

https://doi.org/10.1182/blood.V106.11.4087.4087

Published: 2005

Journal Articles

Bmi-1 Expression Is Useful To Design Therapy and To Predict Prognosis in Patients with Acute Myeloid Leukemia.

Moniruddin Chowdhury, Keichiro Mihara, MD, Nanae Nakaju, Sachiko Fukumoto-Hidani, Yoshihiro Takihara, MD, Akiro Kimura, MD

Blood (2005) 106 (11): 3296.

https://doi.org/10.1182/blood.V106.11.3296.3296

Published: 2005

NARROW

T Cells Bearing Anti-CD19- and/or Anti-CD38-Chimeric Antigen Receptors Effectively Abrogate Primary Double-Hit Lymphoma Cells

All-Trans Retinoic Acid and Interferon-Alpha Increase CD38 Expression on Adult T-Cell Leukemia Cells and Sensitize Them to T Cells Bearing Anti-CD38 Chimeric Antigen Receptors

Adult T-Cell Leukemia/Lymphoma Cells Were Eliminated By T Cells With Anti-CD38 Chimeric Antigen Receptor Through CD38 Expression Induced By All-Trans Retinoic Acid

All-Trans Retinoic Acid Enhances the Cytotoxic Effect of T Cells with Anti-CD38 Chimeric Receptor in Acute Myeloid Leukemia

T-Cell Immunotherapy with a Chimeric Receptor Against CD38 Is Effective in Eliminating Myeloma Cells

B-Cell Lymphoma Cells Overexpressing BMI-1 Are Correlated with Drug Resistance through Enhanced Expression of Survivin and Are Effectively Eliminated by T Cells with Anti-CD38 Chimeric Receptor

Decreased Expression In NF-κB Essential Modulator Due to a Novel Splice-Site Mutation Causes Ectodermal Dysplasia with Immunodeficiency

A Novel Mutation K673R In STAT1 Impaired the STAT1 Signal Transduction In a dominant– Negative Manner Identified In a Japanese Boy with MSMD

A Novel Splicing Mutation in NEMO Gene in a Patient with X-Linked Ectodermal Dysplasia with Immunodeficiency.

Synergistic and Persistent Effect of T-Cell Immunotherapy with Anti-CD19 or Anti-CD38 Chimeric Receptor on B-Cell Lymphoma in Conjunction with Rituximab

Novel Heterozygous Mutation 572insA in TACI Identified in a Patient with Selective IgA Deficiency.

Activated T Cell-Mediated Immunotherapy with a Chimeric Receptor Against CD38 in B-Cell Malignancies.

Association of Neurodevelopmental Abnormalities Is a Common Clinical Character in Japanese Patients with Severe Congenital Neutropenia Due to HAX1 Deficiency.

A Novel Mutation 774del4 in IFNGR1 , Which Produces Truncated Form of Interferon γ Receptor 1, Causes a Dominant-Negative Effect on Interferon γ Signal Transduction.

Bmi-1 is useful as a novel molecular marker for predicting progression of myelodysplastic syndrome and patient prognosis

Compound Heterozygosity for a Novel Mutation Combined with G Insertion in Exon 13 Causes Severe Factor XI Deficiency in Patients of Japanese Origin.

Bmi-1 Expression Is Useful To Design Therapy and To Predict Prognosis in Patients with Acute Myeloid Leukemia.

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American Society of Hematology

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American Society of Hematology

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