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Journal Articles

RUNX1 Mutation Leads to Megakaryocyte-Primed Hematopoietic Stem Cell Expansion and Familial Platelet Disorder

Chen Wang, MD, Weinan Wang, BS, Lei Huang, PhD, Yoshihiro Hayashi, MD PhD, Xiongwei Cai, PhD, Xiaomei Yan, MD PhD, Gang Huang, PhD, Yi Zheng, PhD

Blood (2020) 136 (Supplement 1): 8–9.

https://doi.org/10.1182/blood-2020-140769

Published: 2020

Journal Articles

C/EBPβ Isoforms Regulate Proliferation and Differentiation of Regenerating Hematopoietic Stem/Progenitor Cells

Atsushi Sato, MD, Asumi Yokota, PhD, Yoshihiro Hayashi, MD PhD, Naoka Kamio, MD, Satoshi Sagai, Taira Maekawa, MD PhD, Hideyo Hirai, MD PhD

Blood (2019) 134 (Supplement_1): 3713.

https://doi.org/10.1182/blood-2019-128026

Published: 2019

Journal Articles

Inducible Correction of a RUNX1 Mutation of Human AML Causes a Switch of AML to B-ALL

Chen Wang, PhDcandidate, Yoshihiro Hayashi, MD PhD, Xiongwei Cai, PhD, Xiaomei Yan, MD PhD, Gang Huang, PhD, Yi Zheng, PhD

Blood (2018) 132 (Supplement 1): 1325.

https://doi.org/10.1182/blood-2018-99-116919

Published: 2018

Journal Articles

Myc Regulates the Development and Anti-Tumor Immunity of Natural Killer Cells

Yuting Tang, MD PhD, Xiaomei Yan, MD PhD, Di Zhan, PhD, Lijun Wen, MS, Rui Huang, MD PhD, Yue Zhang, MD PhD, Yoshihiro Hayashi, MD PhD, Qianfei Wang, PhD, Jianfeng Zhou, MD PhD, Gang Huang, PhD

Blood (2018) 132 (Supplement 1): 1113.

https://doi.org/10.1182/blood-2018-99-114180

Published: 2018

Journal Articles

Mll -Partial Tandem Duplication ( Mll -PTD) Causes Pseudohypoxia and Hypermethylation of the Epigenome through Suppression of Mitochondrial Complex II

Asumi Yokota, PhD, Lulu Zhang, PhD, Xiaomei Yan, MD PhD, Xiaomin Feng, MD PhD, Lijun Wen, MS, George Freudiger, Maria Rife, Ally Woeste, Yoshihiro Hayashi, MD PhD, Gang Huang, PhD

Blood (2018) 132 (Supplement 1): 1311.

https://doi.org/10.1182/blood-2018-99-112529

Published: 2018

Journal Articles

Essential Role of c-MYC for Natural Killer Cell Development, Proliferation and Anti-Tumor Activity

Yuting Tang, MD, Xiaomei Yan, Rui Huang, MD PhD, Yoshihiro Hayashi, MD PhD, Yue Zhang, Wang Qianfei, PhD, Jianfeng Zhou, MD PhD, Gang Huang, PhD

Blood (2017) 130 (Supplement 1): 786.

https://doi.org/10.1182/blood.V130.Suppl_1.786.786

Published: 2017

Journal Articles

IFN-α Upregulates the Expression of C/EBPβ and Induces Myeloid Differentiation and Exhaustion of CD34 + CML Stem Cells

Asumi Yokota, PhD, Hideyo Hirai, MD, Atsushi Sato, MD, Naoka Kamio, MD, Yoshihiro Hayashi, MD PhD, Yasuo Miura, MD PhD, Shinya Kimura, MD, PhD, Taira Maekawa, MD PhD

Blood (2017) 130 (Supplement 1): 2863.

https://doi.org/10.1182/blood.V130.Suppl_1.2863.2863

Published: 2017

Journal Articles

Monotcytes/Macrophages Are Involved in Erythrocytosis Caused By Both EPO-Dependent and -Independent Activation of EPOR

Asumi Yokota, PhD, Yoshihiro Hayashi, MD PhD, Jieyu Wang, MD PhD, Rui Huang, MD PhD, Xiaomei Yan, Yue Zhang, MD PhD, Gang Huang, PhD

Blood (2017) 130 (Supplement 1): 449.

https://doi.org/10.1182/blood.V130.Suppl_1.449.449

Published: 2017

Journal Articles

HIF1A Is a Critical Downstream Mediator for Hemophagocytic Lymphohistiocytosis

Blood (2017) 130 (Supplement 1): 3565.

https://doi.org/10.1182/blood.V130.Suppl_1.3565.3565

Published: 2017

Journal Articles

SETD2, a H3K36 Lysine Methyltransferase, Is Essential for Adult Normal Hematopoiesis and Leukemia Stem Cells

Yile Zhou, Yunzhu Dong, Jiachen Bu, Xiaomei Yan, MD PhD, Yoshihiro Hayashi, MD PhD, Qianfei Wang, PhD, Jie Jin, MD PhD, Gang Huang, PhD

Blood (2016) 128 (22): 1055.

https://doi.org/10.1182/blood.V128.22.1055.1055

Published: 2016

Journal Articles

C/EBPβ Is a Critical Regulator of CML Stem Cell Differentiation and Exhaustion Induced By Interferon-α

Asumi Yokota, PhD, Hideyo Hirai, MD PhD, Yoshihiro Hayashi, MD PhD, Ryuichi Sato, Hiroko Adachi, Fumiko Sato, Atsushi Sato, MD, Akihiro Tamura, MD PhD, Masaki Iwasa, MD, Aya Fujishiro, MD, Tsukimi Shoji, Takahiro Kashiwagi, Naoka Kamio, MD, Yusuke Torikoshi, MD, Yasuo Miura, MD PhD, Masakazu Nakano, PhD, Kei Tashiro, MD PhD, Taira Maekawa, MD PhD

Blood (2016) 128 (22): 1120.

https://doi.org/10.1182/blood.V128.22.1120.1120

Published: 2016

Journal Articles

Loss of Function RUNX1 Mutations Restrict Protein Biosynthesis during Pre-Leukemia and MDS Transition but Not after Leukemic Transformation

Xiongwei Cai, PhD, Yoshihiro Hayashi, MD PhD, Mark Wunderlich, MS, Nancy A. Speck, PhD, James C. Mulloy, PhD, Gang Huang, PhD, Yi Zheng, PhD

Blood (2016) 128 (22): 3860.

https://doi.org/10.1182/blood.V128.22.3860.3860

Published: 2016

Journal Articles

EPO Signaling Triggers Erythrocytosis By Expanding Erythrocytes and Also Subsets of Macrophages

Yoshihiro Hayashi, MD PhD, Jieyu Wang, MD, Zefeng Xu, MD, Xiaomei Yan, MD PhD, Yue Zhang, MD, Theodosia A Kalfa, MD PhD, Zhijian Xiao, MD, Gang Huang, PhD

Blood (2016) 128 (22): 542.

https://doi.org/10.1182/blood.V128.22.542.542

Published: 2016

Journal Articles

Downregulation of SETD2-H3K36me3 Tumor Suppression Axis Promotes MLL Leukemia through Activation of DOT1L-H3K79me2 Axis

Jiachen Bu, Aili Chen, PhD, Yunzhu Dong, PhD, Fuhong He, PhD, Xiaomei Yan, MD PhD, Yile Zhou, Di Zhan, Yoshihiro Hayashi, MD PhD, Qianfei Wang, PhD, Gang Huang, PhD

Blood (2016) 128 (22): 435.

https://doi.org/10.1182/blood.V128.22.435.435

Published: 2016

Journal Articles

HIF-1a Pathway, As a Signal Funnel for Genetic, Epigenetic, and Metabolic Aberrations, Is Sufficient and Essential for MDS Development

Blood (2015) 126 (23): 303.

https://doi.org/10.1182/blood.V126.23.303.303

Published: 2015

Journal Articles

Activation of HIF-2a-EPO Axis in Kidney or Liver Is Sufficient to Drive Erythrocytosis in a Novel Inducible HIF-2a Transgenic Mouse Model

Jieyu Wang, MD, Yoshihiro Hayashi, MD PhD, Zefeng Xu, MD, Lingyun Wu, MD PhD, Xiaomei Yan, MD PhD, Theodosia A. Kalfa, MD PhD, Zhijian Xiao, MD, Gang Huang, PhD

Blood (2015) 126 (23): 931.

https://doi.org/10.1182/blood.V126.23.931.931

Published: 2015

Journal Articles

Two Novel Knock-in and Knock-out of Setd2 Alleles Cooperate with Mll-Af9 Knock-in Allele to Accelerate Leukemia Development

Yunzhu Dong, Yoshihiro Hayashi, MD PhD, Xiaomei Yan, MD PhD, Feng Xue, PhD, Wei Chen, PhD, Gang Huang, PhD

Blood (2015) 126 (23): 555.

https://doi.org/10.1182/blood.V126.23.555.555

Published: 2015

Journal Articles

RUNX1/CBFβ Dosage Is Critical for MLL Leukemias Development

Blood (2014) 124 (21): 2187.

https://doi.org/10.1182/blood.V124.21.2187.2187

Published: 2014

Journal Articles

Novel Myelodysplastic Syndromes-like Mouse Models By Cooperating Genetic/Epigenetic Mutations Reveal the Critical Role of HIF-1α for Disease Development

Yoshihiro Hayashi, MD PhD, Yue Zhang, MD, Xiaomei Yan, MD PhD, Goro Sashida, MD PhD, Zefeng Xu, MD, Yunzhu Dong, Hironori Harada, MD PhD, Zhijian Xiao, MD, Gang Huang, PhD

Blood (2014) 124 (21): 362.

https://doi.org/10.1182/blood.V124.21.362.362

Published: 2014

Journal Articles

C/EBPβ Promotes Initial Expansion and Exhaustion of Hematopoietic Stem and Progenitor Cells in Response to Hematopoietic Stresses

Atsushi Sato, MD, Hideyo Hirai, MD PhD, Akihiro Tamura, MD, Asumi Yokota, PhD, Yoshihiro Hayashi, MD PhD, Hisayuki Yao, MD PhD, Masaki Iwasa, MD, Aya Fujishiro, MD, Eishi Ashihara, MD PhD, Yasuo Miura, MD PhD, Taira Maekawa, MD PhD

Blood (2014) 124 (21): 5126.

https://doi.org/10.1182/blood.V124.21.5126.5126

Published: 2014

NARROW

RUNX1 Mutation Leads to Megakaryocyte-Primed Hematopoietic Stem Cell Expansion and Familial Platelet Disorder

C/EBPβ Isoforms Regulate Proliferation and Differentiation of Regenerating Hematopoietic Stem/Progenitor Cells

Inducible Correction of a RUNX1 Mutation of Human AML Causes a Switch of AML to B-ALL

Myc Regulates the Development and Anti-Tumor Immunity of Natural Killer Cells

Mll -Partial Tandem Duplication ( Mll -PTD) Causes Pseudohypoxia and Hypermethylation of the Epigenome through Suppression of Mitochondrial Complex II

Essential Role of c-MYC for Natural Killer Cell Development, Proliferation and Anti-Tumor Activity

IFN-α Upregulates the Expression of C/EBPβ and Induces Myeloid Differentiation and Exhaustion of CD34 + CML Stem Cells

Monotcytes/Macrophages Are Involved in Erythrocytosis Caused By Both EPO-Dependent and -Independent Activation of EPOR

HIF1A Is a Critical Downstream Mediator for Hemophagocytic Lymphohistiocytosis

SETD2, a H3K36 Lysine Methyltransferase, Is Essential for Adult Normal Hematopoiesis and Leukemia Stem Cells

C/EBPβ Is a Critical Regulator of CML Stem Cell Differentiation and Exhaustion Induced By Interferon-α

Loss of Function RUNX1 Mutations Restrict Protein Biosynthesis during Pre-Leukemia and MDS Transition but Not after Leukemic Transformation

EPO Signaling Triggers Erythrocytosis By Expanding Erythrocytes and Also Subsets of Macrophages

Downregulation of SETD2-H3K36me3 Tumor Suppression Axis Promotes MLL Leukemia through Activation of DOT1L-H3K79me2 Axis

HIF-1a Pathway, As a Signal Funnel for Genetic, Epigenetic, and Metabolic Aberrations, Is Sufficient and Essential for MDS Development

Activation of HIF-2a-EPO Axis in Kidney or Liver Is Sufficient to Drive Erythrocytosis in a Novel Inducible HIF-2a Transgenic Mouse Model

Two Novel Knock-in and Knock-out of Setd2 Alleles Cooperate with Mll-Af9 Knock-in Allele to Accelerate Leukemia Development

RUNX1/CBFβ Dosage Is Critical for MLL Leukemias Development

Novel Myelodysplastic Syndromes-like Mouse Models By Cooperating Genetic/Epigenetic Mutations Reveal the Critical Role of HIF-1α for Disease Development

C/EBPβ Promotes Initial Expansion and Exhaustion of Hematopoietic Stem and Progenitor Cells in Response to Hematopoietic Stresses

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American Society of Hematology

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ASH Publications

American Society of Hematology

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