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Yong Zhang, PhD
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Journal Articles

Treatment of High Risk (HR) Smoldering Multiple Myeloma (SMM) with Carfilzomib, Lenalidomide, and Dexamethasone (KRd) Followed By Lenalidomide Maintenance (-R): A Phase 2 Clinical and Correlative Study

Dickran Kazandjian, MD, Elizabeth Hill, MD, Candis Morrison, CNP, PhD, Alexander Dew, DO, MS, Neha Korde, MD, Sham Mailankody, MBBS, Elisabet E. Manasanch, MD, Mary L. Kwok, MD, Manisha Bhutani, MD, Nishant Tageja, MD, Yong Zhang, PhD, Ashley Carpenter, RN, Monica Epstein, RN, Michael Emanuel, BSN, RN, Crystal Lu, PharmD, BCOP, Raul C. Braylan, MD, Katherine R. Calvo, MD PhD, Peter Choyke, MD, Alina Dulau-Florea, MD, Esther Mena, MD, Liza Lindenberg, MD, Irina Maric, MD MSci, Nisha Patel, DO, Maryalice Stetler-Stevenson, MD PhD, Hao-Wei Wang, MD PhD, Constance M. Yuan, MD PhD, Seth M. Steinberg, PhD, William D. Figg, PhD, Mark Roschewski, MD, Ola Landgren, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 43–45.
https://doi.org/10.1182/blood-2020-136148
Published: 2020
Journal Articles

Developing a Genomics Model to Predict Failure of Isocitrate Dehydrogenase (IDH) Inhibitors for Treatment of Patients with IDH1- or IDH2-Mutated Acute Myeloid Leukemia

Tigran Ghazanchyan, MS, Dickran Kazandjian, MD, Donna Przepiorka, MD PhD, Kelly J. Norsworthy, MD, Emma Scott, PhD, Luis Santana-Quintero, PhD, Svetlana Petrovskaya, PhD, Yong Zhang, PhD, Amy Rosenberg, MD, Ashutosh Rao, PhD, Richard Pazdur, MD, Ann T. Farrell, MD, Julia A. Beaver, MD, Vahan Simonyan, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2815.
https://doi.org/10.1182/blood-2018-99-116870
Published: 2018
Journal Articles

A Phase 2 Study of Carfilzomib, Lenalidomide, and Dexamethasone with Lenalidomide Maintenance (KRd-r) in Newly Diagnosed Multiple Myeloma (NDMM): Sustained Long Term Deep Remissions and Prolonged Progression-Free Duration Regardless of Age or Cytogenetic Risk after 5 Years of Follow up

Dickran Kazandjian, MD, Neha Korde, MD, Sham Mailankody, MBBS, Yong Zhang, PhD, Jennifer Hsu, RN, Elizabeth Hill, MD, Candis Morrison, CNP, PhD, Sneha Divakarla, MHA, Mary L. Kwok, MD, Elisabet E. Manasanch, MD, Manisha Bhutani, MD, Nishant Tageja, MD, Pallavi Galera, Alina Dulau-Florea, MD, Dalia Salem, MD, Esther Gonzalez, MD, Liza Lindenberg, MD, Irina Maric, MD MSci, Katherine R. Calvo, MD PhD, Raul C. Braylan, MD, Constance Yuan, MD PhD, Wyndham H. Wilson, MD PhD, Peter Choyke, MD, Maryalice Stetler-Stevenson, MD PhD, Seth M. Steinberg, PhD, William Figg, PharmD, Mark Roschewski, MD, Ola Landgren, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1957.
https://doi.org/10.1182/blood-2018-99-111712
Published: 2018
Journal Articles

Blockade of IL-2 and IL-15 Gamma Chain Receptor Signaling Decreases Leukemic Cell Viability in T-Cell Large Granular Lymphocyte Leukemia and Adult T-Cell Leukemia

Tracy Tiffany Wang, BS, Jun Yang, MD, Yong Zhang, PhD, Meili Zhang, PhD, Kevin C Conlon, MD, Yutaka Tagaya, B.M., PhD, Thomas L Olson, PhD, David J Feith, PhD, Nazli Azimi, Pharm.D., PhD, Thomas A. Waldmann, MD, Thomas P Loughran, Jr., MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3585.
https://doi.org/10.1182/blood.V130.Suppl_1.3585.3585
Published: 2017
Journal Articles

Sustained High Rates of Complete Response and Minimal Residual Disease Negativity after 8 Cycles of Carfilzomib (CFZ), Lenalidomide (LEN), and Dexamethasone (DEX) Followed By 2 Years of Lenalidomide Maintenance (CRd-R) in Patients with High-Risk Smoldering Multiple Myeloma: Updated Results of Clinical and Correlative Phase 2 Study

Dickran Kazandjian, MD, Neha S Korde, MD, Mark Roschewski, MD, Sham Mailankody, MD, Candis Morrison, RN, PhD, Elisabet E. Manasanch, MD, Mary L Kwok, MD, Nishant Tageja, MD, Manisha Bhutani, MD, Adriana Zingone, PhD, Rene Costello, Yong Zhang, PhD, Marcia Mulquin, Liz Lamping, Ashley Carpenter, Brenda Roberson, Irina Maric, MD, Katherine R. Calvo, MD PhD, Raul C Braylan, MD, Constance M. Yuan, MD PhD, Maryalice Stetler-Stevenson, MD PhD, Diane C. Arthur, MD, Liza Lindenberg, Karen A. Kurdziel, MD, Peter Choyke, Seth M. Steinberg, PhD, William Figg, Wyndham H. Wilson, MD PhD, Ola Landgren, MD PhD
Journal: Blood
Blood (2016) 128 (22): 3339.
https://doi.org/10.1182/blood.V128.22.3339.3339
Published: 2016
Journal Articles

Sustained Minimal Residual Disease Negativity in Newly Diagnosed Multiple Myeloma (NDMM) Patients Treated with Carfilzomib (CFZ), Lenalidomide (LEN), and Dexamethasone (DEX) Followed By 2 Years of Lenalidomide Maintenance (CRd-R): Updated Results of a Phase 2 Study

Dickran Kazandjian, MD, Neha S Korde, MD, Mark Roschewski, MD, Sham Mailankody, MD, Candis Morrison, RN, PhD, Elisabet E. Manasanch, MD, Mary L Kwok, MD, Nishant Tageja, MD, Manisha Bhutani, MD, Adriana Zingone, PhD, Rene Costello, Yong Zhang, PhD, Marcia Mulquin, Liz Lamping, Ashley Carpenter, Brenda Roberson, Irina Maric, MD, Katherine R. Calvo, MD PhD, Raul C Braylan, MD, Constance M. Yuan, MD PhD, Maryalice Stetler-Stevenson, MD PhD, Diane C. Arthur, MD, Liza Lindenberg, Karen A. Kurdziel, MD, Peter Choyke, Seth M. Steinberg, PhD, William Figg, Wyndham H. Wilson, MD PhD, Ola Landgren, MD PhD
Journal: Blood
Blood (2016) 128 (22): 4527.
https://doi.org/10.1182/blood.V128.22.4527.4527
Published: 2016
Journal Articles

Proline-Rich Tyrosine Kinase (Pyk2) Promotes Tumor Progression in Multiple Myeloma (MM) and Represents a Novel Target for Therapy in MM

Yu Zhang, MD, Yong Zhang, PhD, Yuji Mishima, PhD, Michele Moschetta, MD, Wenjing Zhang, MD, Patricia Maiso, PhD, Antonio Sacco, BS, Yosra Aljawai, MS, Ilyas Sahin, MD, Michaela R. Reagan, PhD, Jennifer E. Ring, Winnie F. Tam, PhD, Qunli Xu, PhD, Jonathan A. Pachter, PhD, Aldo M Roccaro, MD PhD, Irene M. Ghobrial, MD
Journal: Blood
Blood (2014) 124 (21): 2101.
https://doi.org/10.1182/blood.V124.21.2101.2101
Published: 2014
Journal Articles

Methylation-Dependent Epigenetic Silencing Of Mir-152 and Mir-10b-5p Plays a Crucial Role In Modulating Tumor Progression In Multiple Myeloma

Wenjing Zhang, MD, Yu Zhang, MD, Yong Zhang, PhD, Yuji Mishima, PhD, Michaela Reagan, PhD, Siobhan Glavey, MD, Antonio Sacco, BS, Aldo M Roccaro, MD, PhD, Irene M Ghobrial, MD
Journal: Blood
Blood (2013) 122 (21): 3751.
https://doi.org/10.1182/blood.V122.21.3751.3751
Published: 2013
Journal Articles

Evaluation Of Circulating Cell-Free VDJ DNA As a Marker For Monitoring Patients With Multiple Myeloma (MM) During Treatment With Carfilzomib, Lenalidomide and Dexamethasone,

Roger Kurlander, MD, Yixin LI, Ph.D., Maryalice Stetler-Stevenson, MD, PhD, Constance Yuan, MD, PhD, Neha Korde, MD, Sham Mailankody, MD, Mary Kwok, MD, Elisabet E. Manasanch, MD, Manisha Bhutani, MD, Nishant Tageja, MD, Dickran Kazandjian, MD, Rene Costello, Yong Zhang, PhD, Adriana Zingone, MD, PhD, Peter Wu, Marcia Mulquin, RN, Diamond Zuchlinski, RN, Irina Maric, MD, Katherine R Calvo, MD, PhD, Raul C. Braylan, Mark Roschewski, MD, Ola Landgren, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 1868.
https://doi.org/10.1182/blood.V122.21.1868.1868
Published: 2013
Journal Articles

Clinical and Correlative Pilot Study Of Carfilzomib, Lenalidomide, and Dexamethasone Followed By Lenalidomide Extended Dosing (CRd – R) In High Risk Smoldering Multiple Myeloma Patients

Ola Landgren, MD, PhD, Sham Mailankody, MD, Mary Kwok, MD, Elisabet E. Manasanch, MD, Manisha Bhutani, MD, Nishant Tageja, MD, Dickran Kazandjian, MD, Adriana Zingone, MD, PhD, Rene Costello, Debra Burton, Yong Zhang, PhD, Peter Wu, George Carter, PA, Marcia Mulquin, RN, Diamond Zuchlinski, RN, Irina Maric, MD, Katherine R Calvo, MD, PhD, Raul C. Braylan, Constance Yuan, MD, PhD, Maryalice Stetler-Stevenson, MD, PhD, Diane C Arthur, M.D., Liza Lindenberg, MD, Karen Kurdziel, MD, Peter Choyke, MD, Seth M. Steinberg, PhD, Mark Roschewski, MD, Neha Korde, MD
Journal: Blood
Blood (2013) 122 (21): 1939.
https://doi.org/10.1182/blood.V122.21.1939.1939
Published: 2013
Journal Articles

Mirna Expression Profiling and Proteomic Analysis Of Circulating Exosomes From Multiple Myeloma Patients

Salomon Manier, MD, Erica N Boswell, BS, Siobhan Glavey, MD, Antonio Sacco, BS, Patricia Maiso, PhD, Yuji Mishima, PhD, Yosra Aljaway, BS, Ranjit Banwait, MA, Wenjing Zhang, MD, Yu Zhang, MD, Ilyas Sahin, MD, Michele Moschetta, MD, Yong Zhang, PhD, Michaela R Reagan, PhD, John M. Asara, PhD, Xavier Leleu, MD, PhD, Aldo M Roccaro, MD, PhD, Irene M. Ghobrial, MD
Journal: Blood
Blood (2013) 122 (21): 3086.
https://doi.org/10.1182/blood.V122.21.3086.3086
Published: 2013
Journal Articles

Microrna-Dependent Modulation Of Osteogenesis In a 3D In Vitro Bone Marrow Model System Of Multiple Myeloma

Michaela R Reagan, PhD, Yuji Mishima, PhD, Yong Zhang, PhD, Patricia Maiso, PhD, Salomon Manier, MD, Yu-Tzu Tai, PhD, Priya Dhir, Zhi Ning Lu, Masoumeh Memarzadeh, Antonio Sacco, BS, Yosra Aljawai, MS, Susanna Santos, PA-C, John Ready, MD, David L. Kaplan, PhD, Aldo M Roccaro, MD, PhD, Irene M. Ghobrial, MD
Journal: Blood
Blood (2013) 122 (21): 3093.
https://doi.org/10.1182/blood.V122.21.3093.3093
Published: 2013
Journal Articles

Proline-Rich Tyrosine Kinase (Pyk2) Promotes Tumor Progression In Multiple Myeloma Through Modulation Of Wnt/β-Catenin Signaling Pathway

Yu Zhang, MD, Yong Zhang, PhD, Yuji Mishima, PhD, Michele Moschetta, MD, Wenjing Zhang, MD, Patricia Maiso, PhD, Antonio Sacco, BS, Yosra Aljawai, MS, Ilyas Sahin, MD, Michaela Reagan, PhD, Aldo M Roccaro, MD, PhD, Irene M. Ghobrial, MD
Journal: Blood
Blood (2013) 122 (21): 3094.
https://doi.org/10.1182/blood.V122.21.3094.3094
Published: 2013
Journal Articles

CXCR4 Is a Regulator Of Disease Involvement Of Extramedullary Myeloma Confirmed By a Novel Mouse Model For Extramedullary Disease

Yuji Mishima, Ph. D., Michele Moschetta, MD, Michaela R Reagan, PhD, Yong Zhang, PhD, Ilyas Sahin, MD, Niraj Maulkhan, Aldo M Roccaro, MD, PhD, Irene M. Ghobrial, MD
Journal: Blood
Blood (2013) 122 (21): 5320.
https://doi.org/10.1182/blood.V122.21.5320.5320
Published: 2013
Journal Articles

Minimal Residual Disease (MRD) Detection By Deep Sequencing In Newly Diagnosed Multiple Myeloma Patients Treated With Carfilzomib, Lenalidomide and Dexamethasone

Sham Mailankody, MD, Neha Korde, MD, Malek Faham, MD, PhD, Mary Kwok, MD, Elisabet E. Manasanch, MD, Manisha Bhutani, MD, Nishant Tageja, MD, Dickran Kazandjian, Li Weng, PhD, Martin Moorhead, PhD, Rene Costello, Yong Zhang, PhD, Adriana Zingone, MD, PhD, Debbie Burton, Peter Wu, Marcia Mulquin, RN, Diamond Zuchlinski, RN, Roger Kurlander, MD, Irina Maric, MD, Katherine R Calvo, MD, PhD, Raul C. Braylan, Constance Yuan, MD, PhD, Maryalice Stetler-Stevenson, MD, PhD, Diane C Arthur, M.D., Mark Roschewski, MD, Ola Landgren, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 1902.
https://doi.org/10.1182/blood.V122.21.1902.1902
Published: 2013
Journal Articles

Phase II Clinical and Correlative Study Of Carfilzomib, Lenalidomide, and Dexamethasone Followed By Lenalidomide Extended Dosing (CRD-R) Induces High Rates Of MRD Negativity In Newly Diagnosed Multiple Myeloma (MM) Patients

Neha Korde, MD, Adriana Zingone, MD, PhD, Mary L Kwok, MD, Elisabet E. Manasanch, MD, Manisha Bhutani, MD, Nishant Tageja, MD, Dickran Kazandjian, MD, Sham Mailankody, MD, Rene Costello, Yong Zhang, PhD, Debra Burton, George Carter, PA, Peter Wu, Marcia Mulquin, RN, Diamond Zuchlinski, RN, Irina Maric, MD, Katherine R Calvo, MD, PhD, Raul C. Braylan, Mark Roschewski, MD, Constance Yuan, MD, PhD, Maryalice Stetler-Stevenson, MD, PhD, Diane C Arthur, M.D., Liza Lindenberg, MD, Karen Kurdziel, MD, Pete Choyke, MD, Seth M. Steinberg, PhD, Ola Landgren, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 538.
https://doi.org/10.1182/blood.V122.21.538.538
Published: 2013
Journal Articles

Silencing The Sialyltransferase Gene ST3GAL6 Inhibits Adhesion and Migration Of Myeloma Cells In Vitro and Reduces The Homing and Proliferation Of Tumor Cells In Vivo

Siobhan Glavey, MD, Salomon Manier, MD, Antonio Sacco, BS, Michaela R Reagan, PhD, Yuji Mishima, PhD, Yong Zhang, PhD, Ilyas Sahin, MD, Yu Zhang, MD, Wenjing Zhang, MD, Laura S Murillo, PhD, Catherine Loughrey, MSc, Alessandro Natoni, PhD, Katarzyna Kazlowska, Lokesh Joshi, PhD, Aldo M Roccaro, MD, PhD, Irene M. Ghobrial, MD, Michael E O'Dwyer, MD, FRCPI, FRCPath
Journal: Blood
Blood (2013) 122 (21): 275.
https://doi.org/10.1182/blood.V122.21.275.275
Published: 2013
Journal Articles

Multiple Myeloma-Derived Bone-Marrow Mesenchymal Stem Cells: Microrna-, Gene Expression-Profiling and Functional Characterization

Michaela R Reagan, PhD, Aldo M Roccaro, MD, PhD, AbdelKareem Azab, PhD, Yong Zhang, PhD, Grace B O'Callaghan, PhD, Patricia Maiso, PhD, Salomon Manier, MD, David L. Kaplan, PhD, Irene M. Ghobrial, MD
Journal: Blood
Blood (2012) 120 (21): 1837.
https://doi.org/10.1182/blood.V120.21.1837.1837
Published: 2012
Journal Articles

Let-7 Microrna Family Members Regulate Cell Proliferation in Multiple Myeloma

Salomon Manier, MD, Antonio Sacco, BS, Patricia Maiso, PhD, Yong Zhang, PhD, Yang Liu, PhD, Yosra Aljawai, BS, Weixin Wang, PhD, Meghan Corrigan-Cummins, Xavier Leleu, MD, PhD, Katherine R. Calvo, MD, PhD, Ola Landgren, M.D., Ph.D., Aldo M. Roccaro, MD, PhD, Irene Ghobrial, MD
Journal: Blood
Blood (2012) 120 (21): 570.
https://doi.org/10.1182/blood.V120.21.570.570
Published: 2012
Journal Articles

Deregulation of TNFRSF18 (GITR) Through Promoter CpG Island Methylation Induces Tumor Proliferation in Multiple Myeloma

Yang Liu, PhD, Yong Zhang, PhD, Phong Quang, BS, Hai T Ngo, BS, Feda Azab, BPharm, Abdel Kareem Azab, PhD, BSPharm, Brittany Morgan, Patricia Maiso, PhD, Michaela Reagan, PhD, Christopher P. Rombaoa, Antonio Sacco, BS, Aldo M Roccaro, MD, PhD, Ruben Carrasco, MD, PhD, Irene M. Ghobrial, MD
Journal: Blood
Blood (2011) 118 (21): 2424.
https://doi.org/10.1182/blood.V118.21.2424.2424
Published: 2011