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Journal Articles

Manufacture of Platelets from Human Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells: Functional Comparison to Concentrate Platelets

Keiichi Tozawa, MD, Yukako Ono-Uruga, MD PhD, Masaki Yazawa, MD PhD, Taisuke Mori, PhD, Noriko Takizawa, Mitsuru Murata, MD PhD, Shinichiro Okamoto, MD PhD, Yasuo Ikeda, MD PhD, Yumiko Matsubara, PhD

Blood (2016) 128 (22): 1028.

https://doi.org/10.1182/blood.V128.22.1028.1028

Published: 2016

Journal Articles

Establishment of Human Adipose Tissue-Derived Stromal Cell Lines: A Culture System to Manufacture Megakaryocytes Releasing Functional Platelets

Keiichi Tozawa, MD, Yukako Ono-Uruga, MD PhD, Noriko Takizawa, Tadashi Horiuchi, Shin-ichiro Okamoto, MD PhD, Mitsuru Murata, MD PhD, Yasuo Ikeda, MD PhD, Yumiko Matsubara, PhD

Blood (2015) 126 (23): 656.

https://doi.org/10.1182/blood.V126.23.656.656

Published: 2015

Journal Articles

Effects of Daily Aspirin on Cancer Incidence and Mortality in the Japanese

Kenji Yokoyama, MD PhD, Naoki Ishizuka, PhD, Naomi Uemura, MD PhD, Yuji Mizokami, MD PhD, Hideyuki Hiraishi, MD PhD, Tamio Teramoto, MD PhD, Kazuyuki Shimada, MD PhD, Yasuo Ikeda, MD PhD

Blood (2015) 126 (23): 2322.

https://doi.org/10.1182/blood.V126.23.2322.2322

Published: 2015

Journal Articles

A Novel Mechanism of Megakaryopoiesis from Pre-Adipocytes: Involvement of Transferrin/ CD71/ TPO Pathways

Yukako Ono-Uruga, Keiichi Tozawa, MD, Sahoko Matsuoka, MD PhD, Tadashi Horiuchi, PhD, Shinichiro Okamoto, MD PhD, Mitsuru Murata, MD PhD, Yasuo Ikeda, MD PhD, Toshio Suda, MD PhD, Yumiko Matsubara, PhD

Blood (2014) 124 (21): 4306.

https://doi.org/10.1182/blood.V124.21.4306.4306

Published: 2014

Journal Articles

Rituximab As Second-Line Treatment For Chronic Immune Thrombocytopenia: Investigator-Initiated Clinical Trial In Japan

Yoshitaka Miyakawa, MD, PhD, Shinya Katsutani, MD, PhD, Takahiro Yano, MD, PhD, Shosaku Nomura, MD, PhD, Kaichi Nishiwaki, MD, Yoshiaki Tomiyama, MD, PhD, Masaaki Higashihara, MD, PhD, Yukari Shirasugi, MD, PhD, Masakatsu Nishikawa, MD, PhD, Katsutoshi Ozaki, MD, PhD, Kayoko Kikuchi, Takayuki Abe, PhD, Yuji Sato, MD, PhD, Yuzuru Kanakura, Kingo Fujimura, MD, PhD, Yasuo Ikeda, MD, PhD, Shinichiro Okamoto, MD, PhD

Blood (2013) 122 (21): 3554.

https://doi.org/10.1182/blood.V122.21.3554.3554

Published: 2013

Journal Articles

Subcutaneous Preadipocytes Are Ideal Candidate To Produce A Large Number Of Functional Platelets In a Culture System

Yukako Ono-Uruga, MD, PhD, Tatsuya Tanaka, Atsuko Igari, Takanori Moriki, MD, PhD, Kenji Yokoyama, MD, PhD, Takeru Zama, MD, PhD, Tadashi Horiuchi, PhD, Mitsuru Murata, MD, PhD, Yasuo Ikeda, MD, PhD, Toshio Suda, MD, PhD, Yumiko Matsubara, PhD

Blood (2013) 122 (21): 3271.

https://doi.org/10.1182/blood.V122.21.3271.3271

Published: 2013

Journal Articles

Divalent Cations Define the Structural Requirements for αIIbβ3 Integrin Activation

Tetsuji Kamata, MD, Makoto Handa, MD, Yohko Kawai, MD, Yasuo Ikeda, MD, Sadakazu Aiso, MD

Blood (2012) 120 (21): 260.

https://doi.org/10.1182/blood.V120.21.260.260

Published: 2012

Journal Articles

Tet2 Uniquely Regulates Self-Renewal and Long Term Repopulating Capacity of Fetal Liver and Bone Marrow Hematopoietic Stem Cells

Hiroyoshi Kunimoto, MD, Yumi Fukuchi, PhD, Masatoshi Sakurai, MD, Daichi Abe, MD, Ken Sadahira, MD, Yasuo Ikeda, MD, PhD, Shinichiro Okamoto, MD, PhD, Hideaki Nakajima, MD, PhD

Blood (2012) 120 (21): 4739.

https://doi.org/10.1182/blood.V120.21.4739.4739

Published: 2012

Journal Articles

Pre-Adipocytes Differentiate Into Megakaryocytes (MK) by a Paracrine Thrombopoietin (TPO) Loop

Yukako Ono, MD, Yumiko Matsubara, PhD, Tatsuya Tanaka, Shinichiro Okamoto, MD, PhD, Yasuo Ikeda, MD, Mitsuru Murata, MD, PhD

Blood (2012) 120 (21): 4742.

https://doi.org/10.1182/blood.V120.21.4742.4742

Published: 2012

Journal Articles

Disruption of Tet2 Leads to Enhanced Self-Renewal and Competitive Repopulating Capacity of Fetal Liver Hematopoietic Stem Cells

Hiroyoshi Kunimoto, MD, Yumi Fukuchi, PhD, Masatoshi Sakurai, MD, Ken Sadahira, MD, Yasuo Ikeda, MD, PhD, Shinichiro Okamoto, MD, PhD, Hideaki Nakajima, MD, PhD

Blood (2011) 118 (21): 2331.

https://doi.org/10.1182/blood.V118.21.2331.2331

Published: 2011

Journal Articles

Induction of Megakaryocytes From Fibroblasts by p45NF-E2/Maf

Yuhuan Wang, PhD, Yukako Ono, MD, Yasuo Ikeda, MD, Shinichiro Okamoto, MD, PhD, Mitsuru Murata, MD, Mortimer Poncz, MD, Yumiko Matsubara, PhD

Blood (2011) 118 (21): 908.

https://doi.org/10.1182/blood.V118.21.908.908

Published: 2011

Journal Articles

A Critical Role of CD4 + CD25 + Regulatory T Cells In Prevention of Murine Autoantibody-Mediated Thrombocytopenia

Tetsuya Nishimoto, Takashi Satoh, Ph.D, Yasuo Ikeda, MD, Masataka Kuwana, MD, Ph.D

Blood (2010) 116 (21): 381.

https://doi.org/10.1182/blood.V116.21.381.381

Published: 2010

Journal Articles

Impact of Factor × Mutations on the Activity of Edoxaban

Kengo Noguchi, Shin-ichi Takahashi, PhD, Hiroaki Ishihara, PhD, Yoshiyuki Morishima, PhD, Toshiro Shibano, PhD, Yasuo Ikeda, MD, PhD, Mitsuru Murata, MD, PhD

Blood (2010) 116 (21): 3321.

https://doi.org/10.1182/blood.V116.21.3321.3321

Published: 2010

Journal Articles

Regulatory Role of the Extracellular α-Tail/β-Tail Interaction in αIIbβ3 Integrin Activation

Tetsuji Kamata, MD, Makoto Handa, MD, Yohko Kawai, MD, Yasuo Ikeda, MD, Sadakazu Aiso, MD

Blood (2010) 116 (21): 3199.

https://doi.org/10.1182/blood.V116.21.3199.3199

Published: 2010

Journal Articles

Six Month Treatment of Low Dose Eltrombopag Is Efficacious in Japanese Patients with Refractory Chronic Immune Thrombocytopenic Purpura (ITP).

Yoshiaki Tomiyama, MD, Yoshitaka Miyakawa, MD, PhD, Shinichiro Okamoto, MD, PhD, Shinya Katsutani, MD, Akiro Kimura, MD, Yasushi Okoshi, MD, PhD, Haruhiko Ninomiya, MD, PhD, Hiroshi Kosugi, MD, PhD, Shosaku Nomura, MD, Katsutoshi Ozaki, MD, Yasuo Ikeda, MD, Nobuyuki Koh, Koichi Katsura, MD, PhD, Yuzuru Kanakura, MD, PhD

Blood (2009) 114 (22): 1324.

https://doi.org/10.1182/blood.V114.22.1324.1324

Published: 2009

Journal Articles

Megakaryocytes and Functional Platelets Obtained from Human Subcutaneous Adipocytes in an In Vitro Differentiation System.

Emi Saito, Yumiko Matsubara, PhD, Hidenori Suzuki, PhD, Yasuo Ikeda, MD, Mitsuru Murata, MD

Blood (2007) 110 (11): 3702.

https://doi.org/10.1182/blood.V110.11.3702.3702

Published: 2007

Journal Articles

A Novel, Small Non-Peptidyl Butyzamide Activates Human Thrombopoietin Receptor and Promotes Megakaryopoiesis.

Wataru Nogami, Hiroshi Yoshida, Kenzo Koizumi, Hajime Yamada, PhD, Kenji Abe, Akinori Arimura, PhD, Noriko Yamane, Koji Takahashi, Yoshikazu Tanaka, PhD, Akiko Yamane, Hiroshi Takemoto, PhD, Yasuyuki Ohnishi, PhD, Yasuo Ikeda, MD, Yoshitaka Miyakawa, MD

Blood (2007) 110 (11): 2201.

https://doi.org/10.1182/blood.V110.11.2201.2201

Published: 2007

Journal Articles

Interferon-α2b-Induced Thrombocytopenia Is Caused by Inhibition of Cytoplasmic Maturation and Platelet Production, but Not Proliferation and Endomitosis in Human Megakaryocytes.

Akiko Yamane, MD, Takanori Nakamura, Mamoru Ito, Yasuyuki Ohnishi, Yasuo Ikeda, MD, PhD, Yoshitaka Miyakawa, MD, PhD

Blood (2007) 110 (11): 2195.

https://doi.org/10.1182/blood.V110.11.2195.2195

Published: 2007

Journal Articles

Characterization of Cancer Stem Cells in Human B-Cell Lymphoid Hematologic Malignancies.

Hiroko Nishida, MD, Hiroto Yamazaki, MD, PhD, Yasuo Ikeda, MD, PhD, Chikao Morimoto, MD, PhD

Blood (2007) 110 (11): 3384.

https://doi.org/10.1182/blood.V110.11.3384.3384

Published: 2007

Journal Articles

Natural History of 33 Patients with Upshaw-Schulman Syndrome Has Revealed That All the Gravida Develop Thrombocytopenia, Often Followed by Thrombotic Microangiopathy with Stillbirth.

Blood (2007) 110 (11): 3211.

https://doi.org/10.1182/blood.V110.11.3211.3211

Published: 2007

NARROW

Manufacture of Platelets from Human Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells: Functional Comparison to Concentrate Platelets

Establishment of Human Adipose Tissue-Derived Stromal Cell Lines: A Culture System to Manufacture Megakaryocytes Releasing Functional Platelets

Effects of Daily Aspirin on Cancer Incidence and Mortality in the Japanese

A Novel Mechanism of Megakaryopoiesis from Pre-Adipocytes: Involvement of Transferrin/ CD71/ TPO Pathways

Rituximab As Second-Line Treatment For Chronic Immune Thrombocytopenia: Investigator-Initiated Clinical Trial In Japan

Subcutaneous Preadipocytes Are Ideal Candidate To Produce A Large Number Of Functional Platelets In a Culture System

Divalent Cations Define the Structural Requirements for αIIbβ3 Integrin Activation

Tet2 Uniquely Regulates Self-Renewal and Long Term Repopulating Capacity of Fetal Liver and Bone Marrow Hematopoietic Stem Cells

Pre-Adipocytes Differentiate Into Megakaryocytes (MK) by a Paracrine Thrombopoietin (TPO) Loop

Disruption of Tet2 Leads to Enhanced Self-Renewal and Competitive Repopulating Capacity of Fetal Liver Hematopoietic Stem Cells

Induction of Megakaryocytes From Fibroblasts by p45NF-E2/Maf

A Critical Role of CD4 + CD25 + Regulatory T Cells In Prevention of Murine Autoantibody-Mediated Thrombocytopenia

Impact of Factor × Mutations on the Activity of Edoxaban

Regulatory Role of the Extracellular α-Tail/β-Tail Interaction in αIIbβ3 Integrin Activation

Six Month Treatment of Low Dose Eltrombopag Is Efficacious in Japanese Patients with Refractory Chronic Immune Thrombocytopenic Purpura (ITP).

Megakaryocytes and Functional Platelets Obtained from Human Subcutaneous Adipocytes in an In Vitro Differentiation System.

A Novel, Small Non-Peptidyl Butyzamide Activates Human Thrombopoietin Receptor and Promotes Megakaryopoiesis.

Interferon-α2b-Induced Thrombocytopenia Is Caused by Inhibition of Cytoplasmic Maturation and Platelet Production, but Not Proliferation and Endomitosis in Human Megakaryocytes.

Characterization of Cancer Stem Cells in Human B-Cell Lymphoid Hematologic Malignancies.

Natural History of 33 Patients with Upshaw-Schulman Syndrome Has Revealed That All the Gravida Develop Thrombocytopenia, Often Followed by Thrombotic Microangiopathy with Stillbirth.

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American Society of Hematology

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American Society of Hematology

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