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Journal Articles

Generating a Model of Human CD8 + T-Cell Lymphoma from Genetically Modified Normal T-Cells

Xuxiang Liu, Pin Yu Hou, Krystie Chew, Ruimeng Yang, Anurag Kumar, Jaehyuk Choi, Javeed Iqbal, Wing Chung Chan

Blood (2024) 144 (Supplement 1): 1358.

https://doi.org/10.1182/blood-2024-210915

Published: 2024

Journal Articles

Tet2 Loss and IDH2 R172 K Mutation Develop T FH -Cell-like Lymphoma with Restricted T H 1 Differentiation Program and Cognate Interaction with B Cells

Waseem Gul Lone, Alyssa Bouska, Tayla B Heavican-Foral, Tyler A Herek, Ab Rauf Shah, Abdul Rouf Mir, Mahfuza Afroz Soma, Dylan T. Jochum, Ruimeng Yang, Xuxiang Liu, Jeffrey Cannatella, Catalina Amador, Andrew L. Feldman, Wing Chung Chan, Javeed Iqbal

Blood (2024) 144 (Supplement 1): 1357.

https://doi.org/10.1182/blood-2024-210833

Published: 2024

Journal Articles

Complementary Roles of DNMT3A and TET2 KO in Sculpting CD4-T Cells for Sustained Proliferation without Exhaustion to Promote Lymphomagenesis

Ruimeng Yang, Xuxiang Liu, Jibin Zhang, Abdul Rouf Mir, Waseem Gul Lone, Yuping Li, Krystie Chew, Claire Wu, Jasmine Zain, Joo Y Song, Javeed Iqbal, Wing Chung Chan

Blood (2024) 144 (Supplement 1): 1362.

https://doi.org/10.1182/blood-2024-211750

Published: 2024

Journal Articles

RHOA G17V Mutation Exhibits Markedly Different Functions in the Presence of TET2 Loss in T-Cells

Anurag Kumar, Qi Wei, Ruimeng Yang, Xuxiang Liu, Jibin Zhang, Alyssa Bouska, Javeed Iqbal, Wing Chung Chan

Blood (2024) 144 (Supplement 1): 1360.

https://doi.org/10.1182/blood-2024-211029

Published: 2024

Journal Articles

The Influence of TET2 and/or DNMT3A Knockout on the 5hmC Levels and Growth Characteristics of Modified Human Primary CD4 T Cells after Activation

Ruimeng Yang, Xuxiang Liu, Jibin Zhang, Yuping Li, Krystie Chew, Claire Wu, Jasmine M. Zain, Joo Y. Song, Waseem Gul Lone, Javeed Iqbal, Wing C. Chan

Blood (2023) 142 (Supplement 1): 2775.

https://doi.org/10.1182/blood-2023-187176

Published: 2023

Journal Articles

PRDM1 Promotes Primary Human Circulating CD56 dim NK-Cell Differentiation

Xuxiang Liu, Jibin Zhang, Yunfei Shi, Kunal Shetty, Can Kucuk, Esra Esmeray, Wing C. Chan

Blood (2023) 142 (Supplement 1): 1177.

https://doi.org/10.1182/blood-2023-180323

Published: 2023

Journal Articles

Co-Occurrence of TP53/PTEN and CCR4 genetic Alteration Deregulates T H -Cell Differentiation and Drives T H 2-like Lymphomagenesis and T-Cell Signaling

Dylan T. Jochum, Waseem G. Lone, Alyssa C. Bouska, Xuxiang Liu, Jiayu Yu, Catalina Amador, Sunandini Sharma, Tyler A. Herek, Wing C. Chan, Javeed Iqbal

Blood (2022) 140 (Supplement 1): 2040–2041.

https://doi.org/10.1182/blood-2022-169804

Published: 2022

Journal Articles

PRDM1 Deletion and STAT3 Mutations Cooperatively Promote CD8 + T-Cell and NK-Cell Growth in Vitro

Xuxiang Liu, Kunal Shetty, Yuping Li, Jibin Zhang, Alyssa C. Bouska, Javeed Iqbal, Giorgio Inghirami, Wing C. Chan

Blood (2022) 140 (Supplement 1): 5913.

https://doi.org/10.1182/blood-2022-168184

Published: 2022

Journal Articles

Single-Cell Transcriptomics of Human TET2 Knockout CD4 T-Cells and Their Clonal Evolution

Yuping Li, PhD, Xiaoqian Liu, MD PhD, Xuxiang Liu, PhD, Xiwei Wu, PhD, Alyssa Bouska, PhD, Waseem G. Lone, PhD, Chan-Wang J. Lio, PhD, Tyler Herek, BS,MS, Logan Lee, BS, Gehong Dong, MD PhD, Jinhui Wang, PhD, Chih-Hong Lou, PhD, Wei Qi, MD, Kunal Shetty, BS, Timothy W. McKeithan, MD PhD, Javeed Iqbal, PhD, Wing (John) C. Chan, MD

Blood (2020) 136 (Supplement 1): 22–23.

https://doi.org/10.1182/blood-2020-143113

Published: 2020

Journal Articles

VAV1-GFP Fusion Protein Generated By Intron-Based Genome Editing through CRISPR/Cas9 Leads to Spontaneous Activation in TCR Signaling

Xiaoqian Liu, MD PhD, Yuping Li, PhD, Xuxiang Liu, PhD, Wei Qi, MD, Jibin Zhang, Kunal Shetty, BS, Javeed Iqbal, PhD, Wing C. Chan, MD

Blood (2020) 136 (Supplement 1): 27–28.

https://doi.org/10.1182/blood-2020-143052

Published: 2020

Journal Articles

PRDM1 Binds an Extensive Network of Genes to Regulate Human Natural Killer Cell Homeostasis

Xuxiang Liu, PhD, Yunfei Shi, MD PhD, Yuping Li, PhD, Ru Chen, PhD, Sheng Pan, PhD, Gehong Dong, MD PhD, Qiang Gong, PhD, Javeed Iqbal, PhD, Haiqing Li, PhD, Jinhui Wang, PhD, Shuhua Yi, MD, Timothy McKeithan, MD PhD, Wing C. Chan, MD

Blood (2019) 134 (Supplement_1): 2536.

https://doi.org/10.1182/blood-2019-129270

Published: 2019

NARROW

Generating a Model of Human CD8 + T-Cell Lymphoma from Genetically Modified Normal T-Cells

Tet2 Loss and IDH2 R172 K Mutation Develop T FH -Cell-like Lymphoma with Restricted T H 1 Differentiation Program and Cognate Interaction with B Cells

Complementary Roles of DNMT3A and TET2 KO in Sculpting CD4-T Cells for Sustained Proliferation without Exhaustion to Promote Lymphomagenesis

RHOA G17V Mutation Exhibits Markedly Different Functions in the Presence of TET2 Loss in T-Cells

The Influence of TET2 and/or DNMT3A Knockout on the 5hmC Levels and Growth Characteristics of Modified Human Primary CD4 T Cells after Activation

PRDM1 Promotes Primary Human Circulating CD56 dim NK-Cell Differentiation

Co-Occurrence of TP53/PTEN and CCR4 genetic Alteration Deregulates T H -Cell Differentiation and Drives T H 2-like Lymphomagenesis and T-Cell Signaling

PRDM1 Deletion and STAT3 Mutations Cooperatively Promote CD8 + T-Cell and NK-Cell Growth in Vitro

Single-Cell Transcriptomics of Human TET2 Knockout CD4 T-Cells and Their Clonal Evolution

VAV1-GFP Fusion Protein Generated By Intron-Based Genome Editing through CRISPR/Cas9 Leads to Spontaneous Activation in TCR Signaling

PRDM1 Binds an Extensive Network of Genes to Regulate Human Natural Killer Cell Homeostasis

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American Society of Hematology

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ASH Publications

American Society of Hematology

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