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Xiaorui Zhang, BS
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Journal Articles

AXL/Mertk Inhibitor ONO-7475 Potently Synergizes with BCL2 Inhibitor ABT-199, Overcomes ABT-199 Resistance Mechanisms, and Kills FLT3 ITD AML Cells

Sean M Post, PhD, Huaxian Ma, MS, Vivian Ruvolo, Xiaorui Zhang, BS, Tomoko Yasuhiro, Kohei Tanaka, Ryohei Kozaki, Toshio Yoshizawa, PhD, Jorge E. Cortes, MD, Courtney D. DiNardo, MDMSc, Marina Y Konopleva, MD PhD, Steven M. Kornblau, MD, Joseph D. Khoury, MD, Michael Andreeff, MD PhD, Peter P. Ruvolo, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2550.
https://doi.org/10.1182/blood-2019-128626
Published: 2019
Journal Articles

Combination Therapy with BTK Inhibitor Plus Anti-PD-1 Antibody Results in a Hyperprogressor Phenotype in a Mouse Model of CLL

Aidi Gu, PhD, Huaxian Ma, MS, Xiaorui Zhang, BS, Prerna Malaney, PhD, Miguel Gallardo, PhD, Jingwei Liu, MD, Sattva S. Neelapu, MD, Sean M Post, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4416.
https://doi.org/10.1182/blood-2018-99-118773
Published: 2018
Journal Articles

hnRNP K Overexpression Drives Myeloid Malignancy Via Interaction with RUNX1

Marisa J Hornbaker, BS, Prerna Malaney, PhD, Xiaorui Zhang, BS, Ruizhi Duan, M.Sc., Vrutant Shah, PhD, Shelley Herbrich, MS, Miguel Gallardo, PhD, Rodrigo Jacamo, PhD, Todd Link, PhD, Huaxian Ma, MS, Sanzhar Alybayev, MS, Steven M. Kornblau, MD, Peter Hu, PhD, Dos Sarbassov, PhD, Rashmi Kanagal-Shamanna, MD, Carlos E. Bueso-Ramos, MD PhD, Sean M Post, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2622.
https://doi.org/10.1182/blood-2018-99-117387
Published: 2018
Journal Articles

TAM Inhibitor ONO-7475 Combination with Sorafenib Is Effective Using in Vitro and In Vivo Models of FLT3 ITD Acute Myeloid Leukemia

Peter P. Ruvolo, PhD, Huaxian Ma, MS, Vivian Ruvolo, MS, Xiaorui Zhang, BS, Hong Mu, MD PhD, Tomoko Yasuhiro, Kohei Tanaka, Toshio Yoshizawa, PhD, Weiguo Zhang, MD PhD, Jorge E. Cortes, MD, Michael Andreeff, MD PhD, Sean M Post, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2642.
https://doi.org/10.1182/blood-2018-99-112211
Published: 2018
Journal Articles

hnRNP K: A Regulator of Global Transcription and Translation That Drives Lymphomagenesis

Prerna Malaney, PhD, Miguel Gallardo, PhD, Marisa J Hornbaker, BS, Xiaorui Zhang, BS, Todd Link, PhD, Vrutant Shah, PhD, Sanzhar Alybayev, MS, Meng-Han Wu, Laura R Pageon, DVM, Huaxian Ma, MS, Rodrigo Jacamo, PhD, Li Yu, MD, Zijun Yidan Xu-Monette, PhD, Haley Steinman, BS, Hun Ju Lee, MD, Dos Sarbassov, PhD, Inmaculada Rapado, Michelle Barton, PhD, Joaquin Martinez-Lopez, MDPhD, Carlos E. Bueso-Ramos, MD PhD, Ken H. Young, MD PhD, Sean M Post, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1346.
https://doi.org/10.1182/blood-2018-99-116163
Published: 2018
Journal Articles

hnRNP K: A Driver of Myeloid Malignancy

Marisa J Hornbaker, BS, Miguel Gallardo, PhD, Xiaorui Zhang, BS, Prerna Malaney, PhD, Shelley Herbrich, MS, Huaxian Ma, Peter Hu, PhD, Steven Kornblau, MD, Carlos E. Bueso-Ramos, MD PhD, Sean M Post, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2511.
https://doi.org/10.1182/blood.V130.Suppl_1.2511.2511
Published: 2017
Journal Articles

AXL Inhibitor ONO-9330547 Suppresses PLK1 Gene and Protein Expression and Effectively Induces Growth Arrest and Apoptosis in FLT3 ITD Acute Myeloid Leukemia Cells

Peter Ruvolo, PhD, Huaxian Ma, BS, Vivian Ruvolo, MS, Hong Mu, MD PhD, Wendy Schober, Tomoko Yasuhiro, Toshio Yoshizawa, PhD, Miguel Gallardo, PhD, Xiaorui Zhang, BS, Joseph D Khoury, MD, Jorge Cortes, MD, Michael Andreeff, MD PhD, Sean M. Post, PhD
Journal: Blood
Blood (2016) 128 (22): 3939.
https://doi.org/10.1182/blood.V128.22.3939.3939
Published: 2016
Journal Articles

hnRNP K Overexpression Drives AML Progression By Altering Pathways Critical for Myeloid Proliferation and Differentiation

Marisa J Hornbaker, BS, Miguel Gallardo, PhD, Xiaorui Zhang, BS, Huaxian Ma, BS, Peter Hu, PhD, Joseph D Khoury, MD, Steven M. Kornblau, MD, Carlos E Bueso-Ramos, MD PhD, Sean M. Post, PhD
Journal: Blood
Blood (2016) 128 (22): 744.
https://doi.org/10.1182/blood.V128.22.744.744
Published: 2016
Journal Articles

Developing Therapeutic Strategies for CLL with Mutant p53

Hun Ju Lee, MD, Miguel Gallardo, PhD, Xiaorui Zhang, BS, Huaxian Ma, BS, Alfonso Quintas-Cardama, MD, Yuan Qi, Xiaoping Su, PhD, Sean M. Post, PhD
Journal: Blood
Blood (2015) 126 (23): 2476.
https://doi.org/10.1182/blood.V126.23.2476.2476
Published: 2015
Journal Articles

Amplification of hnRNP K Drives c-Myc-Dependent Malignancies and Represent a Novel Therapeutic Opportunity for Hematologic Malignancies

Miguel Gallardo, PhD, Xiaorui Zhang, BS, Mark McArthur, Taghi Manshouri, PhD, Sean M. Post, PhD
Journal: Blood
Blood (2015) 126 (23): 468.
https://doi.org/10.1182/blood.V126.23.468.468
Published: 2015
Journal Articles

Ruxolitinib Treatment Induces a Transition of Classical to Non-Classical Monocytes in Patients with Myelofibrosis

Sanja Prijic, PhD, Taghi Manshouri, PhD, Ying Zhang, MD MS, Ivo Veletic, MD, Xiaorui Zhang, BS, Joseph E Bove, IV, BS, Zeev Estrov, MD, Srdan Verstovsek, MD
Journal: Blood
Blood (2015) 126 (23): 2838.
https://doi.org/10.1182/blood.V126.23.2838.2838
Published: 2015
Journal Articles

hnRNP K Is a Novel Haploinsufficient Tumor Suppressor at the 9q21.32 Locus That Defines a Subset of AML

Miguel Gallardo, PhD, Hun Ju Lee, MD, Xiaorui Zhang, BS, Carlos E. Bueso-Ramos, MD, Laura Pageon, Mark McArthur, Asha Multani, Aziz Nazha, MD, Taghi Manshouri, PhD, Jan Parker-Thornburg, Peter Hu, Yuan Qi, Xiaoping Su, PhD, Inmaculada Rapado, Alfonso Quintás-Cardama, Steven M. Kornblau, MD, Joaquin Martinez-López, MDPhD, Sean M. Post, PhD
Journal: Blood
Blood (2015) 126 (23): 439.
https://doi.org/10.1182/blood.V126.23.439.439
Published: 2015