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Journal Articles

Pathophysiology of Obstructive Sleep Apnea (OSA) - Blood Cells’ Reactive Oxygen Species and Inflammation Prevent Polycythemia

Jihyun Song, PhD, Krishna M Sundar, MD, Christensen Robert, MD, Monika Horvathova, MSc, PhD, Barbora Kralova, MSc, Vladimir Divoky, PhD, Tomas Ganz, MD PhD, Josef T. Prchal, MD

Blood (2018) 132 (Supplement 1): 1028.

https://doi.org/10.1182/blood-2018-99-116658

Published: 2018

Journal Articles

JAK2 R1063H Variant Enhances V617F Constitutive Signaling and Favors Development of Essential Thrombocythemia with Increased Hemoglobin and Neutrophils

Cristina Mambet, MD, Jean-Philippe Defour, BPharm, PhD, Olga Babosova, M.Sc., Emilie Leroy, Laura Necula, PhD, Oana Stanca, MD, Aurelia Tatic, MD, Daniel Coriu, MD, Monika Belickova, PhD, Barbora Kralova, MSc, Lucie Lanikova, PhD, Pascale Saussoy, Violaine Havelange, Carmen C. Diaconu, PhD, Vladimir Divoky, PhD, Stefan N Constantinescu, MD

Blood (2018) 132 (Supplement 1): 3066.

https://doi.org/10.1182/blood-2018-99-117019

Published: 2018

Journal Articles

Inflammatory Signature, Oxidative Stress, and DNA Damage Response in DBA Pathogenesis

Katarina Kapralova, MSc, Zuzana Saxova, PhD, Barbora Kralova, MSc, Lucie Lanikova, PhD, Dagmar Pospisilova, Prof. MD PhD, Vladimir Divoky, PhD, Monika Horvathova, MSc, PhD

Blood (2017) 130 (Supplement 1): 2452.

https://doi.org/10.1182/blood.V130.Suppl_1.2452.2452

Published: 2017

Journal Articles

The Role of Egln2/Proline Hydroxylase 1 in Regulation of Cyclin D1 in Mantle Cell Lymphoma

Olga Babosova, M.Sc., Lucie Lanikova, PhD, Katarina Kapralova, MSc, Vladimir Divoky, PhD, Vladimir Korinek, PhD, Josef T. Prchal, MD

Blood (2017) 130 (Supplement 1): 5141.

https://doi.org/10.1182/blood.V130.Suppl_1.5141.5141

Published: 2017

Journal Articles

Characterization of Iron Metabolism in Mouse Model of Congenital Polycythemia with Human Gain-of-Function Erythropoietin Receptor

Barbora Kralova, MSc, Jihyun Song, PhD, Vladimir Divoky, PhD, Josef T. Prchal, MD, Monika Horvathova, MSc, PhD

Blood (2017) 130 (Supplement 1): 170.

https://doi.org/10.1182/blood.V130.Suppl_1.170.170

Published: 2017

Journal Articles

JAK2 V617F Progenitors Utilize Adaptations to Cell-Autonomous and Microenvironment-Dependent Inflammatory Stress in Polycythemia Vera, Likely Exhibiting Barrier Against Rapid Transformation to Myelofibrosis

Jan Stetka, MSc, Pavla Luzna, PhD, Lucie Lanikova, PhD, Pavla Koralkova, MSc, Jan Gursky, PhD, Zdenek Hodny, MD PhD, Jiri Bartek, MD, Vladimir Divoky, PhD

Blood (2017) 130 (Supplement 1): 1667.

https://doi.org/10.1182/blood.V130.Suppl_1.1667.1667

Published: 2017

Journal Articles

A Novel Dual Class III/Src Family Tyrosine Kinase Inhibitor Is Highly Active Against FLT3-ITD Leukemia Cells In Vivo

Tereza Radosova Muchova, Eva Reznickova, Zuzana Somikova, Tomas Gucky, Miroslav Strnad, DSc, Vladimir Krystof, PhD, Vladimir Divoky, PhD

Blood (2016) 128 (22): 1569.

https://doi.org/10.1182/blood.V128.22.1569.1569

Published: 2016

Journal Articles

Sickle Cell Anemia in a Child with Three β-Globin Clusters (β-S/β-S, β-A): Loss of LCR and 3' HS1 in the Duplicated Wild-Type β-Globin Cluster Does Not Fully Abrogate Its Transcript

N. Scott Reading, PhD, Barnaby E. Clark, PhD, Jihyun Song, MS, Claire C. Shooter, Robin E. Miller, MD, Archana M Agarwal, MD, Swee Lay Thein, MD, Vladimir Divoky, PhD, Josef T. Prchal, MD

Blood (2015) 126 (23): 3371.

https://doi.org/10.1182/blood.V126.23.3371.3371

Published: 2015

Journal Articles

Polycythemia of Mice with Human Gain-of-Function EPOR (mtH EPOR ) Is Transiently Corrected in Perinatal Life in Association with Low Epo and Increased Erythrocyte Phosphatidylserine Exposure

Jihyun Song, MS, Barbora Kralova, Monika Horvathova, PhD, Donghoon Yoon, PhD, Josef T. Prchal, MD, Vladimir Divoky, PhD

Blood (2015) 126 (23): 3335.

https://doi.org/10.1182/blood.V126.23.3335.3335

Published: 2015

Journal Articles

Iron Chelation Reinforces DNA Damage Response and Leads to G2/M Checkpoint Activation and Autophagy in Myeloid Bone Marrow Cells of Preleukemia Mouse Model

Leona Raskova Kafkova, Zuzana Somikova, Jana Kucerova, MSc, Lenka Calabkova, Pavla Luzna, Jan Stetka, Dana Simkova, Dalibor Dolezal, Vladimir Divoky, PhD

Blood (2015) 126 (23): 3351.

https://doi.org/10.1182/blood.V126.23.3351.3351

Published: 2015

Journal Articles

Oxidative Stress and Increased Destruction of Red Blood Cells Contribute to the Pathophysiology of Anemia Caused By DMT1 Deficiency

Zuzana Zidova, MSc, Daniel Garcia-Santos, PhD, Katarina Kapralova, MSc, Pavla Koralkova, MSc, Renata Mojzikova, PhD, Dalibor Dolezal, DVM, Prem Ponka, MD PhD FCMA, Vladimir Divoky, PhD, Monika Horvathova, PhD

Blood (2014) 124 (21): 4027.

https://doi.org/10.1182/blood.V124.21.4027.4027

Published: 2014

Journal Articles

JAK2 E846D Germline Mutation Associated with Erythrocytosis Causes Increased and Prolonged Epo-Induced Activation of STAT5

Katarina Kapralova, MSc, Monika Horvathova, PhD, Jana Kucerova, PhD, Dagmar Pospisilova, MD PhD, Emilie Leroy, Stefan N. Constantinescu, MD PhD, Vladimir Divoky, PhD

Blood (2014) 124 (21): 4008.

https://doi.org/10.1182/blood.V124.21.4008.4008

Published: 2014

Journal Articles

RUNX1 and NF-E2 Transcriptional Upregulation Is Not Specific For Myeloproliferative Neoplasms But Is Seen In Those Polycythemic Disorders With Augmented HIFs Signaling

Katarina Kapralova, MSc, Lucie Lanikova, PhD, Felipe R Lorenzo V, PhD, Monika Horvathova, PhD, Vladimir Divoky, PhD, Josef T. Prchal, MD

Blood (2013) 122 (21): 2177.

https://doi.org/10.1182/blood.V122.21.2177.2177

Published: 2013

Journal Articles

Mutation Of The Divalent Metal Transporter (Dmt1) Gene Results In Inefficient Induction Of The Erythroid Transcriptional Program Due To Latter Onset Of GATA-1 and Epor Expression

Nikola Curik, PhD, Pavel Burda, PhD, Tomas Zikmund, MSc., Filipp Savvulidi, Monika Horvathova, PhD, John Strouboulis, PhD, Vladimir Divoky, PhD, Tomas Stopka, MD, PhD

Blood (2013) 122 (21): 2197.

https://doi.org/10.1182/blood.V122.21.2197.2197

Published: 2013

Journal Articles

Erythropoiesis and Iron Metabolism In Diamond-Blackfan Anemia

Dagmar Pospisilova, MD, PhD, Dusan Holub, Zuzana Zidova, MSc, Barbora Ludikova, Lucie Sulovska, Vladimir Divoky, PhD, Monika Horvathova, PhD

Blood (2013) 122 (21): 2478.

https://doi.org/10.1182/blood.V122.21.2478.2478

Published: 2013

Journal Articles

DMT1-Mutant Erythrocytes Have Shortened Life Span, Accelerated Glycolysis and Increased Oxidative Stress

Zuzana Zidova, MSc, Pavla Pospisilova, MSc, Renata Mojzikova, PhD, Katarina Kapralova, MSc, Dalibor Dolezal, DVM, Vladimir Divoky, PhD, Monika Horvathova, PhD

Blood (2013) 122 (21): 957.

https://doi.org/10.1182/blood.V122.21.957.957

Published: 2013

Journal Articles

Decreased Rate of β-Globin L1 Allele Transcription Due to Intronic LINE-1 Insertion In the β-Globin gene Is Associated with β-globin L1 Promoter and Enhancer Hypermethylation Which Is Not Reverted by Decitabine

Lucie Piterkova, Ing, Jana Kucerova, MSc, Karel Indrak, MD, PhD, Vladimir Divoky, PhD

Blood (2010) 116 (21): 2073.

https://doi.org/10.1182/blood.V116.21.2073.2073

Published: 2010

Journal Articles

DNA Damage Response Is a Barrier in the Mixed Lineage Leukemia Development.

Sylvia Takacova, PhD, Jiri Zavadil, PhD, MSC, Jiri Bartek, MD, PhD, Vladimir Divoky, PhD

Blood (2009) 114 (22): 2399.

https://doi.org/10.1182/blood.V114.22.2399.2399

Published: 2009

Journal Articles

New Mutation in ALAS2 as the Cause of X-Linked Sideroblastic Anemia Responsive to Pyridoxine: Comparison of ALAS2-Defective and DMT1-Defective BFU-E Growth.

Jana Kucerova, MSc, Monika Horvathova, MSc, PhD, Petra Belohlavkova, MD, Jaroslav Cermak, M.D., Ph.D., Vladimir Divoky, PhD

Blood (2009) 114 (22): 4051.

https://doi.org/10.1182/blood.V114.22.4051.4051

Published: 2009

Journal Articles

Bcr-Abl-Independent Activation of Src Kinases Associated with Development of Dasatinib Resistance in a CML Patient.

Jitka Veselovska, MSc, Renata Solna, PhD, Marie Jarosova, PhD, Edgar Faber, MD, PhD, Helena Urbankova, MSc, Milena Holzerova, MSc, Jana Balcarkova, MSc, Karel Indrak, MD, PhD, Vladimir Divoky, PhD

Blood (2008) 112 (11): 1624.

https://doi.org/10.1182/blood.V112.11.1624.1624

Published: 2008

NARROW

Pathophysiology of Obstructive Sleep Apnea (OSA) - Blood Cells’ Reactive Oxygen Species and Inflammation Prevent Polycythemia

JAK2 R1063H Variant Enhances V617F Constitutive Signaling and Favors Development of Essential Thrombocythemia with Increased Hemoglobin and Neutrophils

Inflammatory Signature, Oxidative Stress, and DNA Damage Response in DBA Pathogenesis

The Role of Egln2/Proline Hydroxylase 1 in Regulation of Cyclin D1 in Mantle Cell Lymphoma

Characterization of Iron Metabolism in Mouse Model of Congenital Polycythemia with Human Gain-of-Function Erythropoietin Receptor

JAK2 V617F Progenitors Utilize Adaptations to Cell-Autonomous and Microenvironment-Dependent Inflammatory Stress in Polycythemia Vera, Likely Exhibiting Barrier Against Rapid Transformation to Myelofibrosis

A Novel Dual Class III/Src Family Tyrosine Kinase Inhibitor Is Highly Active Against FLT3-ITD Leukemia Cells In Vivo

Sickle Cell Anemia in a Child with Three β-Globin Clusters (β-S/β-S, β-A): Loss of LCR and 3' HS1 in the Duplicated Wild-Type β-Globin Cluster Does Not Fully Abrogate Its Transcript

Polycythemia of Mice with Human Gain-of-Function EPOR (mtH EPOR ) Is Transiently Corrected in Perinatal Life in Association with Low Epo and Increased Erythrocyte Phosphatidylserine Exposure

Iron Chelation Reinforces DNA Damage Response and Leads to G2/M Checkpoint Activation and Autophagy in Myeloid Bone Marrow Cells of Preleukemia Mouse Model

Oxidative Stress and Increased Destruction of Red Blood Cells Contribute to the Pathophysiology of Anemia Caused By DMT1 Deficiency

JAK2 E846D Germline Mutation Associated with Erythrocytosis Causes Increased and Prolonged Epo-Induced Activation of STAT5

RUNX1 and NF-E2 Transcriptional Upregulation Is Not Specific For Myeloproliferative Neoplasms But Is Seen In Those Polycythemic Disorders With Augmented HIFs Signaling

Mutation Of The Divalent Metal Transporter (Dmt1) Gene Results In Inefficient Induction Of The Erythroid Transcriptional Program Due To Latter Onset Of GATA-1 and Epor Expression

Erythropoiesis and Iron Metabolism In Diamond-Blackfan Anemia

DMT1-Mutant Erythrocytes Have Shortened Life Span, Accelerated Glycolysis and Increased Oxidative Stress

Decreased Rate of β-Globin L1 Allele Transcription Due to Intronic LINE-1 Insertion In the β-Globin gene Is Associated with β-globin L1 Promoter and Enhancer Hypermethylation Which Is Not Reverted by Decitabine

DNA Damage Response Is a Barrier in the Mixed Lineage Leukemia Development.

New Mutation in ALAS2 as the Cause of X-Linked Sideroblastic Anemia Responsive to Pyridoxine: Comparison of ALAS2-Defective and DMT1-Defective BFU-E Growth.

Bcr-Abl-Independent Activation of Src Kinases Associated with Development of Dasatinib Resistance in a CML Patient.

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American Society of Hematology

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American Society of Hematology

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