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Journal Articles

Super-Enhancer-Driven TOX2 Mediates Oncogenesis in Natural Killer/T Cell Lymphoma

Jianbiao Zhou, MDPhD, Sabrina Hui Min Toh, BSc, Kalpnaa Balan, BSc, Tze King Tan, PhD, Yunlu Jia, MD, Jing Quan Lim, PhD, Choon Kiat Ong, PhDBSc, Soon Thye Lim, MBBS, MRCP, Tuan Zea Tan, Siok-Bian Ng, Takaomi Sanda, MD PhD, Wee-Joo Chng, MBBS, PhD FRCPath, FRCP

Blood (2020) 136 (Supplement 1): 17.

https://doi.org/10.1182/blood-2020-136244

Published: 2020

Journal Articles

Development of the First Transgenic Animal Model for IRF4-Induced Lymphoid Malignancy

Stella Amanda, MSc, BSc, Regina Wong, Tze King Tan, PhD, Muhammad Zulfaqar Ali, MSc, BSc, Yan Li, PhD, Zhi Yuan Gong, PhD, Shinsuke Iida, MD PhD, Takaomi Sanda, MD PhD

Blood (2019) 134 (Supplement_1): 1242.

https://doi.org/10.1182/blood-2019-129714

Published: 2019

Journal Articles

Super-Enhancer Profiling Identifies Novel Oncogenes and Therapeutic Targets in Multiple Myeloma

Jianbiao Zhou, MD PhD, Yunlu Jia, MD, Tze King Tan, PhD, Tae-Hoon Chung, PhD, Takaomi Sanda, MD PhD, Wee Joo Chng, MB ChB, PhD FRCP(UK), FRCPath, FAMS

Blood (2019) 134 (Supplement_1): 362.

https://doi.org/10.1182/blood-2019-124252

Published: 2019

Journal Articles

Identification of Long Non-Coding RNAs Regulated By the TAL1 Complex in T-Cell Acute Lymphoblastic Leukemia

Shi Hao Tan, PhD, Phuong Cao Thi Ngoc, PhD, Wei Zhong Leong, BSc, Daniel G. Tenen, MD, Takaomi Sanda, MD PhD

Blood (2017) 130 (Supplement 1): 1201.

https://doi.org/10.1182/blood.V130.Suppl_1.1201.1201

Published: 2017

Journal Articles

ARID5B Activates the TAL1-Induced Core Regulatory Circuit and the MYC Oncogene in T-Cell Acute Lymphoblastic Leukemia

Wei Zhong Leong, BSc, Shi Hao Tan, PhD, Phuong Cao Thi Ngoc, PhD, Stella Amanda, Alice Wei Yee Yam, Wei-Siang Liau, Zhiyuan Gong, Lee N. Lawton, PhD, Daniel G. Tenen, MD, Takaomi Sanda, MD PhD

Blood (2017) 130 (Supplement 1): 2502.

https://doi.org/10.1182/blood.V130.Suppl_1.2502.2502

Published: 2017

Journal Articles

Identification of Super-Enhancer-Associated Cancer Genes Provides Novel Therapeutic Targets in Adult T-Cell Leukemia/Lymphoma

Regina Wan Ju Wong, BSc, Phuong Thi Ngoc Cao, PhD, Wei Zhong Leong, BSc, Alice Wei Yee Yam, Bsc, Tinghu Zhang, PhD, Shinsuke Iida, MD PhD, Takashi Okamoto, MD PhD, Ryuzo Ueda, MD PhD, Nathanael S. Grey, PhD, Takashi Ishida, MD PhD, Takaomi Sanda, MD PhD

Blood (2016) 128 (22): 2720.

https://doi.org/10.1182/blood.V128.22.2720.2720

Published: 2016

Journal Articles

Anti-Leukemic Activity of the TYK2 Selective Inhibitor Ndi-031301 in T-Cell Acute Lymphoblastic Leukemia

Koshi Akahane, MD PhD, Zhaodong Li, PhD, Julia Etchin, PhD, Alla Berezovskaya, Evisa Gjini, PhD, Craig E Masse, PhD, Wenyan Miao, PhD, Jennifer Rocnik, PhD, Rosana Kapeller, MD PhD, Jeremy R Greenwood, PhD, Hong Tiv, Takaomi Sanda, MD PhD, David M Weinstock, MD, A. Thomas Look, MD

Blood (2016) 128 (22): 1596.

https://doi.org/10.1182/blood.V128.22.1596.1596

Published: 2016

Journal Articles

The KDM3A-KLF2-IRF4 Axis Maintains Myeloma Cell Survival

Hiroto Ohguchi, MD PhD, Teru Hideshima, MDPhD, Manoj Bhasin, PhD, Gullu Gorgun, PhD, Loredana Santo, MD, Michele Cea, MD, Naoya Mimura, MD PhD, Rikio Suzuki, MDPhD, Yu-Tzu Tai, PhD, Ruben D. Carrasco, MD PhD, Noopur S. Raje, MD, Paul G. Richardson, MD, Hideo Harigae, MD PhD, Takaomi Sanda, MD PhD, Kenneth C. Anderson, MD

Blood (2015) 126 (23): 3633.

https://doi.org/10.1182/blood.V126.23.3633.3633

Published: 2015

Journal Articles

The TAL1 Complex Represses the FBXW7 Tumor Suppressor Through Mir-223 in Human T-Cell Acute Lymphoblastic Leukemia

Marc R Mansour, MD FRCPath, Takaomi Sanda, MD, PhD, Lee N Lawton, PhD, Xiaoyu Li, MD, PhD, Taras Kreslavsky, PhD, Carl Novina, MD PhD, Harald von Boehmer, MD PhD, Richard Young, PhD, A. Thomas Look, M.D.

Blood (2012) 120 (21): 1296.

https://doi.org/10.1182/blood.V120.21.1296.1296

Published: 2012

Journal Articles

TYK2-STAT1 Pathway Positively Regulates BCL2 Gene Expression in T-Cell Acute Lymphoblastic Leukemia

Blood (2012) 120 (21): 1470.

https://doi.org/10.1182/blood.V120.21.1470.1470

Published: 2012

Journal Articles

Mutationally Activated TYK2 From T-ALL Specimens Exhibits Tranformative Capacity in Cell Lines and Primary Cell Models and T-Lineage Expansion in Mice

Angela G. Fleischman, MD, PhD, Takaomi Sanda, MD, PhD, Alejandro Gutierrez, MD, Samuel B Luty, Stephanie G Willis, A. Thomas Look, M.D., Brian J. Druker, Jeffrey W Tyner, PhD

Blood (2011) 118 (21): 74.

https://doi.org/10.1182/blood.V118.21.74.74

Published: 2011

Journal Articles

KPT-SINE, a Potent, Small Molecule Inhibitor of CRM1-Dependent Nuclear-Cytoplasmic Shuttling, with Potent Activity Against T-ALL and AML

Julia Etchin, PhD, Alex Kentsis, MD, PhD, Takaomi Sanda, MD, PhD, Andrew L. Kung, MD, PhD, Richard M. Stone, MD, Dilara McCauley, Michael Kauffman, MD, Ph.D., Sharon Shacham, PhD, Thomas Look, MD

Blood (2011) 118 (21): 2622.

https://doi.org/10.1182/blood.V118.21.2622.2622

Published: 2011

Journal Articles

Combined Targeting of the MET and FGF Receptor Tyrosine Kinases Induces Sustained AML Cell Death by Preventing Compensatory Upregulation of HGF in Response to MET Kinase Inhibition

Alex Kentsis, MD, PhD, Takaomi Sanda, MD, PhD, Casie Reed, BS, Scott J. Rodig, MD, PhD, Eleni Tholouli, PhD, MRCPath, Vu Ngo, PhD, Jeffery Lorne Kutok, MD, PhD, Suzanne E. Dahlberg, PhD, Lisa A Moreau, PhD, George Vande Woude, PhD, James Christensen, MD, Richard Byers, PhD, MBChB, FRCPath, Andrew L. Kung, MD, PhD, Louis M. Staudt, MD., Ph.D., Thomas Look, MD

Blood (2011) 118 (21): 1405.

https://doi.org/10.1182/blood.V118.21.1405.1405

Published: 2011

Journal Articles

Pathway Dependence on the Tyrosine Kinase TYK2 and Its Mediator STAT1 In T-Cell Acute Lymphoblastic Leukemia

Takaomi Sanda, MD, PhD, Jeffrey W Tyner, PhD, Alejandro Gutierrez, MD, Vu N Ngo, PhD, Richard Moriggl, Yebin Ahn, Jason M Glover, MD, Bill H Chang, MD, PhD, Stephanie G Willis, Louis M. Staudt, MD, PhD, Brian J Druker, MD, A. Thomas Look, MD

Blood (2010) 116 (21): 3155.

https://doi.org/10.1182/blood.V116.21.3155.3155

Published: 2010

Journal Articles

The BCL11B Tumor Suppressor Is Mutated In Human T-Cell Acute Lymphoblastic Leukemia

Alejandro Gutierrez, MD, Alex Kentsis, MD, PhD, Takaomi Sanda, MD, PhD, Julia Etchin, PhD, Alexei Protopopov, PhD, Jianhua Zhang, PhD, Lynda Chin, MD, Lewis B. Silverman, MD, Stuart Winter, MD, Stephen Hunger, MD, Stephen E. Sallan, MD, Shan Zha, PhD, Frederick Alt, PhD, A. Thomas Look, MD

Blood (2010) 116 (21): 4177.

https://doi.org/10.1182/blood.V116.21.4177.4177

Published: 2010

Journal Articles

RNAi Screen Reveals TYK2 as a Novel Therapeutic Gene Target In T-Cell Acute Lymphoblastic Leukemia

Jeffrey W Tyner, PhD, Takaomi Sanda, MD, PhD, Alejandro Gutierrez, MD, Jason M Glover, MD, Bill H Chang, MD, PhD, Stephanie G Willis, Yebin Ahn, A. Thomas Look, MD, Brian J Druker, MD

Blood (2010) 116 (21): 1001.

https://doi.org/10.1182/blood.V116.21.1001.1001

Published: 2010

Journal Articles

Aberrant Expression of Hepatocyte Growth Factor Induces Autocrine MET Activation Providing a Novel Therapeutic Target In Acute Myeloid Leukemia.

Alex Kentsis, MD, PhD, Takaomi Sanda, MD, PhD, Vu Ngo, PhD, Scott J. Rodig, MD, PhD, Jeffery Kutok, MD, PhD, Eleni Tholouli, PhD, MRCPath, Richard Byers, PhD, MBChB, FRCPath, George Vande Woude, PhD, Andrew L. Kung, MD, PhD, Louis M. Staudt, MD, PhD, A. Thomas Look, MD

Blood (2010) 116 (21): 1042.

https://doi.org/10.1182/blood.V116.21.1042.1042

Published: 2010

Journal Articles

LEF1 Is a Tumor Suppressor in T Cell Acute Lymphoblastic Leukemia

Alejandro Gutierrez, MD, Takaomi Sanda, MD, PhD, Stuart Winter, MD, Richard S. Larson, MD, PhD, Lewis B. Silverman, MD, Stephen P. Hunger, MD, Stephen E. Sallan, MD, A. Thomas Look, MD

Blood (2008) 112 (11): 3802.

https://doi.org/10.1182/blood.V112.11.3802.3802

Published: 2008

NARROW

Super-Enhancer-Driven TOX2 Mediates Oncogenesis in Natural Killer/T Cell Lymphoma

Development of the First Transgenic Animal Model for IRF4-Induced Lymphoid Malignancy

Super-Enhancer Profiling Identifies Novel Oncogenes and Therapeutic Targets in Multiple Myeloma

Identification of Long Non-Coding RNAs Regulated By the TAL1 Complex in T-Cell Acute Lymphoblastic Leukemia

ARID5B Activates the TAL1-Induced Core Regulatory Circuit and the MYC Oncogene in T-Cell Acute Lymphoblastic Leukemia

Identification of Super-Enhancer-Associated Cancer Genes Provides Novel Therapeutic Targets in Adult T-Cell Leukemia/Lymphoma

Anti-Leukemic Activity of the TYK2 Selective Inhibitor Ndi-031301 in T-Cell Acute Lymphoblastic Leukemia

The KDM3A-KLF2-IRF4 Axis Maintains Myeloma Cell Survival

The TAL1 Complex Represses the FBXW7 Tumor Suppressor Through Mir-223 in Human T-Cell Acute Lymphoblastic Leukemia

TYK2-STAT1 Pathway Positively Regulates BCL2 Gene Expression in T-Cell Acute Lymphoblastic Leukemia

Mutationally Activated TYK2 From T-ALL Specimens Exhibits Tranformative Capacity in Cell Lines and Primary Cell Models and T-Lineage Expansion in Mice

KPT-SINE, a Potent, Small Molecule Inhibitor of CRM1-Dependent Nuclear-Cytoplasmic Shuttling, with Potent Activity Against T-ALL and AML

Combined Targeting of the MET and FGF Receptor Tyrosine Kinases Induces Sustained AML Cell Death by Preventing Compensatory Upregulation of HGF in Response to MET Kinase Inhibition

Pathway Dependence on the Tyrosine Kinase TYK2 and Its Mediator STAT1 In T-Cell Acute Lymphoblastic Leukemia

The BCL11B Tumor Suppressor Is Mutated In Human T-Cell Acute Lymphoblastic Leukemia

RNAi Screen Reveals TYK2 as a Novel Therapeutic Gene Target In T-Cell Acute Lymphoblastic Leukemia

Aberrant Expression of Hepatocyte Growth Factor Induces Autocrine MET Activation Providing a Novel Therapeutic Target In Acute Myeloid Leukemia.

LEF1 Is a Tumor Suppressor in T Cell Acute Lymphoblastic Leukemia

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American Society of Hematology

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American Society of Hematology

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