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Suzan Imren, MD
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Journal Articles

Safety and Efficacy of CTX001 in Patients with Transfusion-Dependent β-Thalassemia and Sickle Cell Disease: Early Results from the Climb THAL-111 and Climb SCD-121 Studies of Autologous CRISPR-CAS9-Modified CD34+ Hematopoietic Stem and Progenitor Cells

Haydar Frangoul, MD, Yael Bobruff, PhD, Maria Domenica Cappellini, Selim Corbacioglu, MD, Christine Marie Fernandez, RN,MSN, Josu de la Fuente, Stephan A Grupp, MD PhD, Rupert Handgretinger, MD, Tony W. Ho, MD, Suzan Imren, MD, Antonis Kattamis, Julie Lekstrom-Himes, MD, Franco Locatelli, MD PhD, Yimeng Lu, PhD, Markus Y Mapara, MD PhD, Mariane de Montalembert, MD PhD, Sarah D. Mulcahey, MS, Damiano Rondelli, MD, Niraj Shanbhag, MD PhD, Sujit Sheth, MD, Sandeep Soni, MBBS, Martin H. Steinberg, MD, Michael J. Weinstein, John K. Wu, MBBS, FRCPC, MS, Donna Wall, MDCCPE
Journal: Blood
Blood (2020) 136 (Supplement 1): 3–4.
https://doi.org/10.1182/blood-2020-139575
Published: 2020
Journal Articles

CBFA2T3-GLIS2 induces Malignant Transformation of Primitive CD34+ Cord Blood Cells and Recapitulates Infant Megakaryocytic Leukemia

Tiffany A. Hylkema, BS, Laura Pardo, Keith R. Loeb, MD, Quy Le, PhD, Suzan Imren, MD, Lisa Eidenschink Brodersen, PhD, Michael R. Loken, PhD, Soheil Meshinchi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1444.
https://doi.org/10.1182/blood-2019-126185
Published: 2019
Journal Articles

Serially Transplantable Patient-Derived Xenograft Model of Chronic Myelomonocytic Leukemia (CMML)

Arnold Kloos, PhD, Felicitas Thol, MD, Lina Winckler, Razif Gabdoulline, PhD, Konstantinos Mintzas, Nidhi Jyotsana, PhD, Renate Schottmann, Felix F. Adams, Adrian Schwarzer, MD PhD, Dirk Heckl, PhD, Suzan Imren, MD, R. Keith Humphries, Arnold Ganser, MD, Michael Heuser, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4236.
https://doi.org/10.1182/blood.V130.Suppl_1.4236.4236
Published: 2017
Journal Articles

Demonstration of Rapid Functional Myeloid Cell Recovery after Infusion of a Universal Donor Ex Vivo Expanded Progenitor Cell Therapy As a Bridging Graft Source

Fabiola V. Merriam, PhD DVM, Suzan Imren, MD, Robert A Landeros, Colleen Delaney, MD MSc
Journal: Blood
Blood (2016) 128 (22): 3348.
https://doi.org/10.1182/blood.V128.22.3348.3348
Published: 2016
Journal Articles

Distinct Patterns of Early Hematopoietic Reconstitution in Patients Receiving Notch Expanded Non HLA-Matched Off-the-Shelf Cord Blood Derived Hematopoietic Stem and Progenitor Cells

Jianqiang Li, PhD MSc, Allen Jiang, Filippo Milano, MD PhD, Suzan Imren, MD, David Charles Keahi Oliver, BS, Joseph Blake, Colleen Delaney, MD MSc
Journal: Blood
Blood (2015) 126 (23): 379.
https://doi.org/10.1182/blood.V126.23.379.379
Published: 2015
Journal Articles

Short Term Signalling Responses of the Most Primitive Subsets of Human Hematopoietic Cells Stimulated in Vitro Correlate with Their Subsequent Self-Renewal Behaviour.

David J.H.F. Knapp, Sean C. Bendall, PhD, Paul H. Miller, Alice M.S. Cheung, PhD, Suzan Imren, MD, R. Keith Humphries, MD, PhD, Ryan R. Brinkman, Robert A.J. Oostendorp, BSc, MSc, PhD, Garry P. Nolan, PhD, Connie J. Eaves, PhD
Journal: Blood
Blood (2012) 120 (21): 2341.
https://doi.org/10.1182/blood.V120.21.2341.2341
Published: 2012
Journal Articles

In Vitro Expansion of Human Hematopoietic Cells with Delayed but Sustained Multi-Lineage Repopulating Activity

Alice M.S. Cheung, PhD, Stefan Wohrer, MD, Paul H. Miller, Suzan Imren, MD, Shabnam Rostamirad, Kiran Dhillon, David Knapp, Robert A.J. Oostendorp, BSc, MSc, PhD, R. Keith Humphries, MD, PhD, Connie J. Eaves, PhD
Journal: Blood
Blood (2011) 118 (21): 1270.
https://doi.org/10.1182/blood.V118.21.1270.1270
Published: 2011
Journal Articles

Distinct Human Cell Populations Produce Rapidly Detectable Levels of Neutrophils and Platelets in NOD/SCID-IL-2Receptor Gamma Chain Null Mice Transgenically Engineered to Produce Human Myeloid Growth Factors

Paul H. Miller, Alice M.S. Cheung, PhD, Suzan Imren, MD, Philip A Beer, BM, MRCP, MRCPath, Shabnam Rostamirad, Kiran Dhillon, R. Keith Humphries, MD, PhD, Connie J. Eaves, PhD
Journal: Blood
Blood (2011) 118 (21): 1892.
https://doi.org/10.1182/blood.V118.21.1892.1892
Published: 2011
Journal Articles

Enhancement of Soluble Transcription Factor (TAT-HOXB4 and TAT-NUP98HOXA10HD) - Mediated Human Hematopoietic Stem Cell Self-Renewal by Minimizing Inhibitory Endogenous Signalling.

Elizabeth Csaszar, Daniel Kirouac, Genevieve Gavigan, Suzan Imren, MD, Michelle Miller, R. Keith Humphries, MD, PhD, Peter W. Zandstra, PhD
Journal: Blood
Blood (2009) 114 (22): 1493.
https://doi.org/10.1182/blood.V114.22.1493.1493
Published: 2009
Journal Articles

A Novel Strategy for Expanding Primitive Leukemic Cells from Chronic Phase CML Patients by Forced Overexpression of a NUP98-HOXA10 Homeodomain Fusion Gene.

Ivan Sloma, PhD, Suzan Imren, MD, Yun Zhao, PhD, Keith Humphries, MD, PhD, Connie J. Eaves, PhD
Journal: Blood
Blood (2008) 112 (11): 1078.
https://doi.org/10.1182/blood.V112.11.1078.1078
Published: 2008
Journal Articles

MN1 Overexpression Promotes Proliferation and Self-Renewal of Primitive Normal Human Hematopoietic Cells

Suzan Imren, MD, Michael Heuser, MD, Ling-Yi Chen, Glen Edin, Connie J. Eaves, PhD, R. Keith Humphries, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 681.
https://doi.org/10.1182/blood.V112.11.681.681
Published: 2008
Journal Articles

A NUP98-HOX Fusion Gene Containing the Homeodomain of HOXA10 Promotes Significant Expansion of Primitive Human Hematopoietic Cells in Extended Cultures.

Suzan Imren, MD, Guy Sauvageau, MD PhD, Connie J. Eaves, PhD, R. Keith Humphries, MD PhD
Journal: Blood
Blood (2006) 108 (11): 1351.
https://doi.org/10.1182/blood.V108.11.1351.1351
Published: 2006