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Steven P Treon, MDPhDFRCP
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Journal Articles

Application and Outcomes of Bendamustine- or Bortezomib-Based Therapy for Waldenstrom's Macroglobulinemia

Adam J Olszewski, MD, Steven P Treon, MDPhDFRCP, Jorge J. Castillo, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 348.
https://doi.org/10.1182/blood.V130.Suppl_1.348.348
Published: 2017
Journal Articles

Acquired Von Willebrand Disease in Patients with Waldenström Macroglobulinemia

Jorge J. Castillo, MD, Joshua Gustine, Kirsten Meid, MPH, Toni Dubeau, NP, Patricia Severns, NP, Steven P Treon, MDPhDFRCP
Journal: Blood
Blood (2017) 130 (Supplement 1): 1088.
https://doi.org/10.1182/blood.V130.Suppl_1.1088.1088
Published: 2017
Journal Articles

Modeling Lymphoplasmacytic Lymphoma/Waldenström Macroglobulinemia in Transgenic Mice Using Human MYD88 L256P Mutated Protein

Tomasz Sewastianik, MSc,PhD, Maria Luisa Guerrera, MD, Meng Jiang, MD, Peter S. Dennis, Jianjun Zhao, MD, Guang Yang, PhD, Zachary Hunter, PhD, Geraldine S. Pinkus, Petr Jarolim, MD PhD, Wong Kwok-Kin, MD PhD, Steven P Treon, MDPhDFRCP, Ruben D. Carrasco, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2510.
https://doi.org/10.1182/blood.V130.Suppl_1.2510.2510
Published: 2017
Journal Articles

Aberrant HCK Survival Signaling By Mutated MYD88 Requires PAX5 in Waldenstrom's Macroglobulinemia and ABC DLBCL Cells

Xia Liu, MD, Jiaji Chen, BS, Manit Munshi, MS, Lian Xu, Nickolas Tsakmaklis, BA, Maria Demos, BS, Amanda Kofides, BS, Maria Luisa Guerrera, MD, Gloria Chan, MS, Christopher Patterson, MAcc, Joshua Gustine, Jorge J. Castillo, MD, Zachary Hunter, PhD, Steven P Treon, MDPhDFRCP, Guang Yang, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1199.
https://doi.org/10.1182/blood.V130.Suppl_1.1199.1199
Published: 2017
Journal Articles

Ibrutinib Discontinuation in Waldenström Macroglobulinemia: Etiologies, Outcomes, and IgM Rebound

Joshua Gustine, Kirsten Meid, MPH, Toni Dubeau, NP, Patricia Severns, NP, Lian Xu, Zachary Hunter, PhD, Steven P Treon, MDPhDFRCP, Jorge J. Castillo, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 802.
https://doi.org/10.1182/blood.V130.Suppl_1.802.802
Published: 2017
Journal Articles

BTK Cys481Ser Mutation Drives Ibrutinib Resistance through ERK1/2 Hyperactivation, and Can Confer a Protective Effect on Bystander Waldenstrom's Macroglobulinemia and ABC DLBCL Cells through Paracrine Mediated Pro-Survival Signaling

Jiaji Chen, BS, Xia Liu, MD, Manit Munshi, MS, Lian Xu, Nickolas Tsakmaklis, BA, Maria Demos, BS, Amanda Kofides, BS, Maria Luisa Guerrera, MD, Gloria Chan, MS, Zachary Hunter, PhD, Christopher Patterson, MAcc, Joshua Gustine, Jorge J. Castillo, MD, Steven P Treon, MDPhDFRCP, Guang Yang, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 803.
https://doi.org/10.1182/blood.V130.Suppl_1.803.803
Published: 2017
Journal Articles

A Novel, Highly Selective IRAK1 Inhibitor Jh-X-119-01 Shows Synergistic Tumor Cell Killing with Ibrutinib in MYD88 Mutated B-Cell Lymphoma Cells

Guang Yang, PhD, John Hatcher, PhD, Jinhua Wang, PhD, Xia Liu, MD, Manit Munshi, MS, Jiaji Chen, BS, Lian Xu, Nickolas Tsakmaklis, BA, Maria Demos, BS, Amanda Kofides, BS, Gloria Chan, MS, Zachary Hunter, PhD, Christopher Patterson, MAcc, Joshua Gustine, Jorge J. Castillo, MD, Nathanael Gray, PhD, Steven P Treon, MDPhDFRCP, Sara Buhrlage, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 719.
https://doi.org/10.1182/blood.V130.Suppl_1.719.719
Published: 2017
Journal Articles

PAK4 Inhibition Impacts Growth and Survival, and Increases Sensitivity to DNA-Damaging Agents in Waldestrostom Macroglobulinemia

Na Li, MD, Mariateresa Fulciniti, PhD, Michael A Lopez, BS, Tommaso Perini, MD, Raphael Szalat, MD, Subodh Kumar, PhD, Mehmet Kemal Samur, PhD, Lian Xu, Yan Xu, MD, William Senapedis, PhD, Erkan Baloglu, Stefania Oliva, MD, Masood A. Shammas, PhD, Zachary Hunter, PhD, Kenneth C Anderson, MD, Steven P Treon, MDPhDFRCP, Nikhil Munshi, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 648.
https://doi.org/10.1182/blood.V130.Suppl_1.648.648
Published: 2017
Journal Articles

Abnormal Splicing Patterns and Novel Intron Retentions Affect Genes Regulating Splicing, NF-Kb, ERK1/2, and TP53 in Waldenstrom's Macroglobulinemia

Zachary Hunter, PhD, Nickolas Tsakmaklis, BA, Lian Xu, Maria Demos, BS, Amanda Kofides, BS, Jiaji Chen, BS, Gloria Chan, MS, Manit Munshi, MS, Xia Liu, MD, Joshua Gustine, Kirsten Meid, MPH, Christopher Patterson, MAcc, Toni Dubeau, NP, Patricia Severns, NP, Jorge J. Castillo, MD, Guang Yang, PhD, Nikhil Munshi, MD, Kenneth C Anderson, MD, Steven P Treon, MDPhDFRCP
Journal: Blood
Blood (2017) 130 (Supplement 1): 3812.
https://doi.org/10.1182/blood.V130.Suppl_1.3812.3812
Published: 2017
Journal Articles

MYD88 Mutation Status Impacts Overall Survival and Risk of Histological Transformation in Waldenstrom's Macroglobulinemia

Steven P Treon, MDPhDFRCP, Zachary Hunter, PhD, Joshua Gustine, Kirsten Meid, MPH, Lian Xu, Xia Liu, MD, Guang Yang, PhD, Manit Munshi, MS, Robert Manning, Nickolas Tsakmaklis, BA, Maria Demos, BS, Amanda Kofides, BS, Maria Luisa Guerrera, MD, Jiaji Chen, BS, Gloria Chan, MS, Christopher Patterson, MAcc, Toni Dubeau, NP, Patricia Severns, NP, Jorge J. Castillo, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4006.
https://doi.org/10.1182/blood.V130.Suppl_1.4006.4006
Published: 2017
Journal Articles

The Genomic Landscape of MYD88 Wild-Type WaldenströM's Macroglobulinemia Ischaracterized By Somatic Mutations in TBL1XR1, the CBM Complex, and NFKB2

Zachary Hunter, PhD, Nickolas Tsakmaklis, BA, Maria Demos, BS, Amanda Kofides, BS, Lian Xu, Gloria Chan, MS, Jiaji Chen, BS, Manit Munshi, MS, Xia Liu, MD, Joshua Gustine, Christopher Patterson, MAcc, Toni Dubeau, NP, Patricia Severns, NP, Jorge J. Castillo, MD, Guang Yang, PhD, Steven P Treon, MDPhDFRCP
Journal: Blood
Blood (2017) 130 (Supplement 1): 4011.
https://doi.org/10.1182/blood.V130.Suppl_1.4011.4011
Published: 2017
Journal Articles

Patient-Reported Symptoms during Ibrutinib Holds: A Withdrawal Syndrome

Jorge J. Castillo, MD, Joshua Gustine, Kirsten Meid, MPH, Toni Dubeau, NP, Patricia Severns, NP, Steven P Treon, MDPhDFRCP
Journal: Blood
Blood (2017) 130 (Supplement 1): 4058.
https://doi.org/10.1182/blood.V130.Suppl_1.4058.4058
Published: 2017
Journal Articles

Mutated MYD88 Activates the BCR Component SYK and Provides a Rationale Therapeutic Target in Waldenstrom's Macroglobulinemia

Manit Munshi, MS, Xia Liu, MD, Jiaji Chen, BS, Lian Xu, Nickolas Tsakmaklis, BA, Maria Demos, BS, Amanda Kofides, BS, Maria Luisa Guerrera, MD, Gloria Chan, MS, Zachary Hunter, PhD, Christopher Patterson, MAcc, Joshua Gustine, Jorge J. Castillo, MD, Steven P Treon, MDPhDFRCP, Guang Yang, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2539.
https://doi.org/10.1182/blood.V130.Suppl_1.2539.2539
Published: 2017
Journal Articles

Long-Term Follow-up of Previously Treated Patients Who Received Ibrutinib for Symptomatic Waldenstrom's Macroglobulinemia: Update of Pivotal Clinical Trial

Steven P Treon, MDPhDFRCP, Kirsten Meid, MPH, Joshua Gustine, Kurt S. Bantilan, MPH, Toni Dubeau, NP, Patricia Severns, NP, Guang Yang, PhD, Lian Xu, Christopher Patterson, MAcc, Irene M Ghobrial, MD, Jacob Laubach, MD, Zachary Hunter, PhD, Jorge J. Castillo, MD, Maria L. Palomba, MD, Ranjana H. Advani, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2766.
https://doi.org/10.1182/blood.V130.Suppl_1.2766.2766
Published: 2017
Journal Articles

Ibrutinib Is Highly Active As First Line Therapy in Symptomatic Waldenstrom's Macroglobulinemia

Steven P Treon, MDPhDFRCP, Joshua Gustine, Kirsten Meid, MPH, Toni Dubeau, NP, Patricia Severns, NP, Christopher Patterson, MAcc, Lian Xu, Guang Yang, PhD, Xia Liu, MD, Maria Demos, BS, Amanda Kofides, BS, Jiaji Chen, BS, Manit Munshi, MS, Nickolas Tsakmaklis, BA, Gloria Chan, MS, Andrew J Yee, MD, Noopur Raje, MD, Elizabeth O'Donnell, MD, Zachary Hunter, PhD, Jorge J. Castillo, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2767.
https://doi.org/10.1182/blood.V130.Suppl_1.2767.2767
Published: 2017
Journal Articles

Long-Term Follow-up of a Prospective Clinical Trial of Carfilzomib, Rituximab and Dexamethasone (CaRD) in Waldenstrom's Macroglobulinemia

Kirsten Meid, MPH, Toni Dubeau, NP, Patricia Severns, NP, Joshua Gustine, Irene M Ghobrial, MD, Jorge J. Castillo, MD, Steven P Treon, MDPhDFRCP
Journal: Blood
Blood (2017) 130 (Supplement 1): 2772.
https://doi.org/10.1182/blood.V130.Suppl_1.2772.2772
Published: 2017
Journal Articles

Prospective Phase II Study of Ixazomib, Dexamethasone and Rituximab in Previously Untreated Patients with Waldenström Macroglobulinemia

Jorge J. Castillo, MD, Kirsten Meid, MPH, Joshua Gustine, Toni Dubeau, NP, Patricia Severns, NP, Steven P Treon, MDPhDFRCP
Journal: Blood
Blood (2017) 130 (Supplement 1): 1487.
https://doi.org/10.1182/blood.V130.Suppl_1.1487.1487
Published: 2017
Journal Articles

Bendamustine and Bortezomib-Containing Regimens Produce Higher Response Rates and More Durable Responses Versus Cyclophosphamide-Based Therapy in Frontline Waldenstrom Macroglobulinemia

Jorge J. Castillo, MD, Joshua Gustine, Kirsten Meid, MPH, Toni Dubeau, NP, Patricia Severns, NP, Steven P Treon, MDPhDFRCP
Journal: Blood
Blood (2017) 130 (Supplement 1): 1488.
https://doi.org/10.1182/blood.V130.Suppl_1.1488.1488
Published: 2017
Journal Articles

Mutated MYD88 Homozygosity Is Increased in Previously Treated Patients with Waldenstrom's Macroglobulinemia, and Associates with CXCR4 Mutation Status and Ibrutinib Exposure

Nickolas Tsakmaklis, BA, Lian Xu, Robert Manning, Guang Yang, PhD, Xia Liu, MD, Jiaji Chen, BS, Maria Demos, BS, Amanda Kofides, BS, Gloria Chan, MS, Maria Luisa Guerrera, MD, Christopher Patterson, MAcc, Jorge J. Castillo, MD, Steven P Treon, MDPhDFRCP, Zachary Hunter, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1462.
https://doi.org/10.1182/blood.V130.Suppl_1.1462.1462
Published: 2017
Journal Articles

Dysregulation of MYD88 Regulatory Isoforms in Waldenstrom's Macroglobulinemia

Amanda Kofides, BS, Maria Demos, BS, Nickolas Tsakmaklis, BA, Lian Xu, Xia Liu, MD, Guang Yang, PhD, Manit Munshi, MS, Jiaji Chen, BS, Christopher Patterson, MAcc, Maria Luisa Guerrera, MD, Jorge J. Castillo, MD, Steven P Treon, MDPhDFRCP, Zachary Hunter, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4967.
https://doi.org/10.1182/blood.V130.Suppl_1.4967.4967
Published: 2017