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Stephen M. Sykes, PhD
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Journal Articles

Pkcε Is a Central Regulator of Mitochondrial Function and Metabolism in Acute Myeloid Leukemia

Daniela Di Marcantonio, PhD, Elena Masselli, MD, Esteban Martinez, BS, Daniela Araiza-Olivera, MD PhD, Giuliana Gobbi, PhD, Prisco Mirandola, PhD, Marco Vitale, MD, Stephen M. Sykes, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3926.
https://doi.org/10.1182/blood-2018-99-119758
Published: 2018
Journal Articles

JUN and ATF3 Regulate the Transcriptional Output of the Unfolded Protein Response to Support Acute Myeloid Leukemia

Stephen M. Sykes, PhD, Daniela Di Marcantonio, PhD, Esteban Martinez, BS, Jacqueline Huhn, BS, Anushk Gupta, Ritika Mistry
Journal: Blood
Blood (2018) 132 (Supplement 1): 1327.
https://doi.org/10.1182/blood-2018-99-119742
Published: 2018
Journal Articles

The RET Receptor Tyrosine Kinase Promotes Acute Myeloid Leukemia through Protection of FLT3-ITD Mutants from Autophagic Degradation

Saskia Rudat, MSc, Anja Pfaus, MSc, Claudia Bühler, MD, Sophie Rabe, MSc, Lars Bullinger, MD, Stefan Gröschel, MD, Stephen M. Sykes, PhD, Michael D. Milsom, PhD, Jana M. Ellegast, MD, Stefan Fröhling, MD, Claudia Scholl, MD
Journal: Blood
Blood (2016) 128 (22): 2849.
https://doi.org/10.1182/blood.V128.22.2849.2849
Published: 2016
Journal Articles

Ribosomal Protein L22 Loss Predisposes Stem Cells to Transformation By Altering Metabolism

Bryan Harris, BS, Shawn Fahl, Jaqueline Perrigoue, Stephen M. Sykes, PhD, Amit Verma, MD, David L Wiest, PhD
Journal: Blood
Blood (2016) 128 (22): 2733.
https://doi.org/10.1182/blood.V128.22.2733.2733
Published: 2016
Journal Articles

Gene Expression and Mutation Analysis (GEMA) –Guided Precision Medicine Targeting PARP1 to Induce Synthetic Lethality in DNA-PK –Deficient Quiescent and BRCA-Deficient Proliferating Leukemia Stem and Progenitor Cells

Margaret Nieborowska-Skorska, MD PhD, Katherine Sullivan, Paulina Podszywalow-Bartnicka, Grazyna Hoser, PhD, Elisabeth Bolton-Gillespie, Kimberly Cramer-Morales, Artur Slupianek, PhD, Chun Zhou, PhD, Sabine Cerny-Reiterer, DVM, Tomasz Stoklosa, MD PhD, Stephen M. Sykes, PhD, Peter Valent, MD, Curt I. Civin, MD, Markus Muschen, MD PhD, Mark D. Minden, MD PhD, Kolja Eppert, PhD, Tomasz Skorski, MD PhD
Journal: Blood
Blood (2014) 124 (21): 480.
https://doi.org/10.1182/blood.V124.21.480.480
Published: 2014
Journal Articles

Requirement For CDK6 In MLL-Rearranged Acute Myeloid Leukemia

Theresa Placke, PhD, Katrin Faber, PhD, Atsushi Nonami, MD, Helmut R. Salih, MD, Stephen M. Sykes, PhD, David E. Root, PhD, David A. Barbie, MD, William C. Hahn, MD, PhD, Michael D. Milsom, PhD, Claudia Scholl, MD, Stefan Fröhling, MD
Journal: Blood
Blood (2013) 122 (21): 3782.
https://doi.org/10.1182/blood.V122.21.3782.3782
Published: 2013
Journal Articles

Oncogene-Induced DNA Repair Defects Promote PARP1-Mediated “Dual Synthetic Lethality” To Eradicate Quiescent and Proliferating Leukemia Stem and Progenitor Cells

Margaret Nieborowska-Skorska, MD, PhD, Artur Slupianek, PhD, Grazyna Hoser, PhD, Elisabeth Bolton-Gillespie, PhD, Alexei Tulin, Sabine Cerny-Reiterer, D.V.M, Peter Valent, Markus Muschen, Stephen M. Sykes, PhD, Tomasz Skorski, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 810.
https://doi.org/10.1182/blood.V122.21.810.810
Published: 2013
Journal Articles

Aldehyde Dehydrogenase 3a2 (Aldh3a2) Represents a Distinct Metabolic Vulnerability in MLL-AF9 AML Leukemia Initiating Cells

Rushdia Z. Yusuf, MBBS, MPH, Sanket S. Acharya, BA, MBS, Vionnie W.C. Yu, PhD, Borja Saez, PhD, Julien M Cobert, BA, John Doench, PhD, Lars Bullinger, MD, PhD, Dana S'aulis, BA, Dongjun Lee, PhD, Rahul Palchaudhuri, PhD, Akachimere C. Uzosike, Mildred Duvet, BA, David J. Logan, PhD, Sudeshna Das, PhD, Colleen M Cook, BA, Michael Churchill, BS, Elizabeth Scadden, BA, Gohar Warraich, Hao Liu, BA, Shrikanta Chattopadhyay, MD, Adam Brown, PhD, Stephen M. Sykes, PhD, David B. Sykes, MD, PhD, Francois Mercier, MD, Anne E. Carpenter, PhD, Scott A. Armstrong, MD, PhD, Matthew Vander Heiden, MD, PhD, Benjamin L. Ebert, Andrew L. Kung, MD, PhD, William B. Rizzo, MD, Siddhartha Mukherjee, MD, PhD, David T. Scadden, MD
Journal: Blood
Blood (2012) 120 (21): 208.
https://doi.org/10.1182/blood.V120.21.208.208
Published: 2012
Journal Articles

Hematopoietic Stem/Progenitor Cell Retention in the Bone Marrow Depends On Tissue Specific Heparan Sulfate Proteoglycans

Borja Saez, PhD, Francesca Ferraro, MD, Rushdia Z. Yusuf, MBBS, MPH, Colleen M Cook, BA, Stephen M. Sykes, PhD, Ana Pardo, PhD, Vionnie W.C. Yu, PhD, Sutada Lotinun, Rahul Palchaudhuri, PhD, Dongjun Lee, PhD, Stefania Lymperi, BSc, MSc, PhD, Robyn Day, Radovan Vasic, Sanket S. Acharya, BA, MBS, Roland Baron, Amy J. Wagers, PhD, David T. Scadden, MD
Journal: Blood
Blood (2012) 120 (21): 637.
https://doi.org/10.1182/blood.V120.21.637.637
Published: 2012