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Journal Articles

Treatment of Myelofibrosis Using I.V. Treosulfan and Autologous Peripheral Blood Progenitor Cell Transplantation Is Feasible and Results in Hematologic Responses – Long-Term Follow-up and Final Analysis of a One-Armed Clinical Study and of Individual Cases

Eike C. Buss, MD, Julian Topaly, MD, Hans H. Kreipe, MD, Stefan Fruehauf, MD, Anthony D. Ho, MD

Blood (2011) 118 (21): 4514.

https://doi.org/10.1182/blood.V118.21.4514.4514

Published: 2011

Journal Articles

Gene Therapy of Chronic Myelogenous Leukemia Using Pseudotyped Recombinant Adeno-Associated Viral Vectors.

Leopold Sellner, MD, Marlon R Veldwijk, PhD, Jürgen A. Kleinschmidt, PhD, Stephanie Laufs, PhD, Julian Topaly, MD, W. Jens Zeller, MD, Frederik Wenz, MD, Stefan Fruehauf, MD

Blood (2009) 114 (22): 4506.

https://doi.org/10.1182/blood.V114.22.4506.4506

Published: 2009

Journal Articles

In Vivo Mobilization of Leukemic Human Precursor-B-ALL Cells by the CXCR4-Antagonist AMD3100 Is Via Secretion of SDF-1 and Synergistically by Catecholamine Action.

Eike C. Buss, MD, Alexander Kalinkovich, MD, PhD, Amir Schajnovitz, MSc, Orit Kollet, PhD, Ayelet Dar, PhD, Melania Tesio, PhD, Stefan Fruehauf, MD, Marc Hotfilder, PhD, Anthony D. Ho, MD, Leonard D. Shultz, Tsvee Lapidot, PhD

Blood (2008) 112 (11): 1920.

https://doi.org/10.1182/blood.V112.11.1920.1920

Published: 2008

Journal Articles

Impact of Chemoselective Pressure on Integration Site Patterns of Lentivirally Transduced Human Hematopoietic Stem Cells

Nadja Grund, Patrick Maier, Uwe Appelt, Heike Allgayer, Frederik Wenz, W. Jens Zeller, Stefan Fruehauf, MD, Stefanie Laufs

Blood (2008) 112 (11): 4622.

https://doi.org/10.1182/blood.V112.11.4622.4622

Published: 2008

Journal Articles

Efficient Gene Transfer into Human CD34 + Peripheral Blood Progenitor Cells Using Pseudotyped Recombinant Adeno-Associated Viral Vectors

Leopold Sellner, Marlon Veldwijk, PhD, Marius Stiefelhagen, Jurgen A. Kleinschmidt, PhD, Stephanie Laufs, PhD, Julian Topaly, MD, W. Jens Zeller, MD, Frederik Wenz, MD, Stefan Fruehauf, MD

Blood (2008) 112 (11): 4627.

https://doi.org/10.1182/blood.V112.11.4627.4627

Published: 2008

Journal Articles

Genes Involved in Acute Leukemias Are Favored Targets of HIV Vector Integration

Jens U. Appelt, Frank A. Giordano, Marcel Zimmermann, Stephan Weinhard, Ph.D., Nadja Grund, Agnes Hotz-Wagenblatt, Ph.D., W. Jens Zeller, M.D., Heike Allgayer, M.D., Ph.D., Stefan Fruehauf, MD, Stephanie Laufs, Ph.D.

Blood (2007) 110 (11): 3738.

https://doi.org/10.1182/blood.V110.11.3738.3738

Published: 2007

Journal Articles

Novel Efficient Primary Human Peripheral Blood Progenitor Cell-Targeted Recombinant Adeno-Associated Viral Vectors.

Marlon R. Veldwijk, Ph.D., Leopold Sellner, Marius Stiefelhagen, Jürgen A. Kleinschmidt, Ph.D., Stephanie Laufs, Ph.D., Julian Topaly, M.D., Frederik Wenz, M.D., W. Jens Zeller, M.D., Stefan Fruehauf, MD

Blood (2007) 110 (11): 5144.

https://doi.org/10.1182/blood.V110.11.5144.5144

Published: 2007

Journal Articles

Drug Resistance Gene Therapy by Simultaneous Lentiviral Overexpression of MDR1 in Combination with the MGMT P140K Mutant in Human Hematopoietic Stem Cells.

Isabel Spier, Patrick Maier, Ph.D., Stephanie Laufs, Ph.D., Marlon R. Veldwijk, Ph.D., Frederik Wenz, M.D., W. Jens Zeller, M.D., Stefan Fruehauf, MD

Blood (2007) 110 (11): 5146.

https://doi.org/10.1182/blood.V110.11.5146.5146

Published: 2007

Journal Articles

Highly Efficient Peripheral Blood Progenitor Cell Mobilization in Myeloma Patients by Single-Dose Application of 12 mg Pegylated G-CSF.

Stefan Fruehauf, MD, Timon Seeger, Julian Topaly, MD, Anthony D. Ho, MD, Hartmut Goldschmidt, MD

Blood (2005) 106 (11): 5264.

https://doi.org/10.1182/blood.V106.11.5264.5264

Published: 2005

Journal Articles

Myeloablative Conditioning of Patients with Myelofibrosis with Myeloid Metaplasia Using i.v. Treosulfan and Autologous Peripheral Blood Progenitor Cell Transplantation (PBPCT) with High Doses of CD34+ Cells Results in Hematologic Responses - 32 Months Follow-Up of Three Patients and Short-Term Results of a New Study.

Stefan Fruehauf, MD, Eike C. Buss, MD, Julian Toplay, MD, Hans H. Kreipe, MD, Anthony D. Ho, MD

Blood (2005) 106 (11): 5515.

https://doi.org/10.1182/blood.V106.11.5515.5515

Published: 2005

Journal Articles

Microarray Analysis of Differentially Expressed Genes in Response to Retrovirally Mediated Overexpression of MDR1.

Patrick Maier, PhD, Carsten Herskind, PhD, Li Li, PhD, Stephanie Laufs, PhD, Jens W. Zeller, Katharina Fleckenstein, MD, Frederik Wenz, Stefan Fruehauf, MD

Blood (2005) 106 (11): 1519.

https://doi.org/10.1182/blood.V106.11.1519.1519

Published: 2005

Journal Articles

CD34+ Cells Mobilized with the New CXCR4 Antagonist AMD3100 + G-CSF Show Increased Anti-Apoptotic, Cell Cycle, DNA Repair and Cell Motility-Associated Gene Expression When Compared to G-CSF Mobilization Alone.

Timon Seeger, Patrick Maier, PhD, Li Li, PhD, Stephanie Laufs, PhD, Volker Eckstein, PhD, Gary Bridger, PhD, Gary Calandra, MD, PhD, Frederik Wenz, MD, Hartmut Goldschmidt, MD, Anthony D. Ho, MD, Stefan Fruehauf, MD

Blood (2005) 106 (11): 4264.

https://doi.org/10.1182/blood.V106.11.4264.4264

Published: 2005

Journal Articles

Treatment of Imatinib-Sensitive and -Resistant Chronic Myelogenous Leukemia Cells with a Combination of Imatinib and Farnesyltransferase Inhibitors.

Aleksandar Radujkovic, Julian Topaly, MD, W. Jens Zeller, MD, Anthony D. Ho, MD, Stefan Fruehauf, MD

Blood (2005) 106 (11): 4881.

https://doi.org/10.1182/blood.V106.11.4881.4881

Published: 2005

Journal Articles

Combination Treatment with Imatinib and Mitoxantrone/Etoposide Is a Suitable Preparative Regimen before Allogeneic Transplantation in Patients with Myeloid Blast Crisis of Chronic Myeloid Leukemia.

Stefan Fruehauf, MD, Julian Topaly, MD, Eike C. Buss, MD, Tanja Lahaye, MD, Oliver G. Ottmann, MD, Thomas Fischer, MD, Bertold Emmerich, MD, Ulrike Haus, Rudiger Hehlmann, MD, Anthony D. Ho, MD, Andreas Hochhaus, MD

Blood (2005) 106 (11): 1105.

https://doi.org/10.1182/blood.V106.11.1105.1105

Published: 2005

Journal Articles

Generation and Application of a CML-Specific Recombinant Adeno-Associated Virus (rAAV) Vector.

Marius Stiefelhagen, Marlon R. Veldwijk, PhD, Anna Jauch, PhD, Volker Eckstein, PhD, Stephanie Laufs, PhD, Juergen A. Kleinschmidt, PhD, Frederik Wenz, Jens W. Zeller, Anthony D. Ho, Stefan Fruehauf, MD

Blood (2005) 106 (11): 4417.

https://doi.org/10.1182/blood.V106.11.4417.4417

Published: 2005

Journal Articles

Quantitative Real Time PCR Analysis of MDR1 Transduced Rhesus Macaque Hematopoietic Stem Cells Shows No Indication for Proliferative Advantage after Long-Term Follow-Up.

Farastuk Bozorgmehr, Stephanie Laufs, PhD, Eike C. Buss, MD, Katalina Z. Nagy, Stephanie E. Sellers, PhD, W. Jens Zeller, MD, Cynthia E. Dunbar, MD, Stefan Fruehauf, MD

Blood (2005) 106 (11): 2198.

https://doi.org/10.1182/blood.V106.11.2198.2198

Published: 2005

Journal Articles

The CXCR4-Antagonist AMD3100 Augments the Number of Mobilized Peripheral Blood Progenitor Cells (PBPC) When Added to a G-CSF Standard Mobilization Regime and AMD3100-Mobilized PBPC Result in Rapid Hematopoietic Reconstitution after Autologous Transplantation.

Stefan Fruehauf, MD, Timon Seeger, Julian Topaly, MD, Doris Herrmann, PhD, Falk Dillmann, Per Humpert, MD, Gary Calandra, MD, PhD, Stephanie Laufs, PhD, Hartmut Goldschmidt, MD, Anthony D. Ho, MD

Blood (2005) 106 (11): 1961.

https://doi.org/10.1182/blood.V106.11.1961.1961

Published: 2005

Journal Articles

The CXCR4 Antagonist AMD3100 Mobilizes a More Primitive Subset of CD34+ Cells Than G-CSF.

Timon Seeger, Marlon Veldwijk, PhD, Gary Bridger, PhD, Gary Calandra, MD, PhD, Hartmut Goldschmidt, MD, Anthony Ho, MD, Stefan Fruehauf, MD

Blood (2005) 106 (11): 1969.

https://doi.org/10.1182/blood.V106.11.1969.1969

Published: 2005

Journal Articles

Functional Activity of Granulocytes Primed In Vivo with Glycosylated Granulocyte Colony-Stimulating Factor (G-CSF) Is Superior To Priming with Non-Glycosylated G-CSF.

Daniel Ribeiro, Stephanie Laufs, PhD, Marlon R. Veldwijk, PhD, Jens W. Zeller, Anthony D. Ho, Stefan Fruehauf, MD

Blood (2005) 106 (11): 3865.

https://doi.org/10.1182/blood.V106.11.3865.3865

Published: 2005

Journal Articles

Functional Activity of In Vivo Primed Granulocytes: A Comparative Study.

Daniel Ribeiro, Stephanie Laufs, Phd, Eike B. Buss, MD, W. Jens Zeller, MD, Anthony D. Ho, MD, Stefan Fruehauf, MD

Blood (2004) 104 (11): 3818.

https://doi.org/10.1182/blood.V104.11.3818.3818

Published: 2004

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Treatment of Myelofibrosis Using I.V. Treosulfan and Autologous Peripheral Blood Progenitor Cell Transplantation Is Feasible and Results in Hematologic Responses – Long-Term Follow-up and Final Analysis of a One-Armed Clinical Study and of Individual Cases

Gene Therapy of Chronic Myelogenous Leukemia Using Pseudotyped Recombinant Adeno-Associated Viral Vectors.

In Vivo Mobilization of Leukemic Human Precursor-B-ALL Cells by the CXCR4-Antagonist AMD3100 Is Via Secretion of SDF-1 and Synergistically by Catecholamine Action.

Impact of Chemoselective Pressure on Integration Site Patterns of Lentivirally Transduced Human Hematopoietic Stem Cells

Efficient Gene Transfer into Human CD34 + Peripheral Blood Progenitor Cells Using Pseudotyped Recombinant Adeno-Associated Viral Vectors

Genes Involved in Acute Leukemias Are Favored Targets of HIV Vector Integration

Novel Efficient Primary Human Peripheral Blood Progenitor Cell-Targeted Recombinant Adeno-Associated Viral Vectors.

Drug Resistance Gene Therapy by Simultaneous Lentiviral Overexpression of MDR1 in Combination with the MGMT P140K Mutant in Human Hematopoietic Stem Cells.

Highly Efficient Peripheral Blood Progenitor Cell Mobilization in Myeloma Patients by Single-Dose Application of 12 mg Pegylated G-CSF.

Microarray Analysis of Differentially Expressed Genes in Response to Retrovirally Mediated Overexpression of MDR1.

CD34+ Cells Mobilized with the New CXCR4 Antagonist AMD3100 + G-CSF Show Increased Anti-Apoptotic, Cell Cycle, DNA Repair and Cell Motility-Associated Gene Expression When Compared to G-CSF Mobilization Alone.

Treatment of Imatinib-Sensitive and -Resistant Chronic Myelogenous Leukemia Cells with a Combination of Imatinib and Farnesyltransferase Inhibitors.

Combination Treatment with Imatinib and Mitoxantrone/Etoposide Is a Suitable Preparative Regimen before Allogeneic Transplantation in Patients with Myeloid Blast Crisis of Chronic Myeloid Leukemia.

Generation and Application of a CML-Specific Recombinant Adeno-Associated Virus (rAAV) Vector.

Quantitative Real Time PCR Analysis of MDR1 Transduced Rhesus Macaque Hematopoietic Stem Cells Shows No Indication for Proliferative Advantage after Long-Term Follow-Up.

The CXCR4-Antagonist AMD3100 Augments the Number of Mobilized Peripheral Blood Progenitor Cells (PBPC) When Added to a G-CSF Standard Mobilization Regime and AMD3100-Mobilized PBPC Result in Rapid Hematopoietic Reconstitution after Autologous Transplantation.

The CXCR4 Antagonist AMD3100 Mobilizes a More Primitive Subset of CD34+ Cells Than G-CSF.

Functional Activity of Granulocytes Primed In Vivo with Glycosylated Granulocyte Colony-Stimulating Factor (G-CSF) Is Superior To Priming with Non-Glycosylated G-CSF.

Functional Activity of In Vivo Primed Granulocytes: A Comparative Study.

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