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Sin Tiong Ong
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Journal Articles

Somatic mutations at diagnosis in patients with chronic Phase CML receiving frontline imatinib are associated with a higher rate of treatment failure: First analysis from the international CML foundation (iCMLf) genomics alliance on the harmony platform

Free
Susan Branford, Ali Albeer, Ángela Villaverde Ramiro, Joe McConnell, María Abáigar, Jenny Rinke, Katerina Machova Polakova, Jiri Mayer, Ruth Stuckey, Mohamed Yassin, Lee-Yung Shih, Ahmad Alhuraiji, Carlo Gambacorti-Passerini, Dennis Kim, Sin Tiong Ong, Tomasz Stoklosa, Jitka Krizkova, Adam Laznicka, Ivana Jeziskova, María Teresa Gómez Casares, Susanna Akiki, Mahmoud Hasaneen, Federica Colombo, Charles Chuah, Monika Pępek, Ángela Rodríguez, Ana Garcia, Markus Pfirrmann, Nicola Evans, Andreas Hochhaus, Timothy Hughes, Chung Hoow Kok, Thomas Ernst
Journal: Blood
Blood (2025) 146 (Supplement 1): 75.
https://doi.org/10.1182/blood-2025-75
Published: 2025
Journal Articles

A single-cell atlas of diagnostic bone marrow to uncover the origins of CML relapse following therapy cessation

Free
Vaidehi Krishnan, Xi Ren, Kian Leong Lee, Radhika Sonthalia, Prasanna Venkatesh, Mengge Yu, Pavithra Shyamsunder, John Ouyang, Xinyi Yang, Florian Schmidt, Verity Saunders, Naranie Shanmuganathan, Charles Chuah, Naoto Takahashi, Susan Branford, Timothy Hughes, Shyam Prabhakar, Sin Tiong Ong
Journal: Blood
Blood (2025) 146 (Supplement 1): 74.
https://doi.org/10.1182/blood-2025-74
Published: 2025
Journal Articles

Single-cell chromatin profiling reveals early epigenetic reprogramming, subtype-specific regulatory networks, and JAK/STAT–IRF vulnerabilities in high-risk chronic myeloid leukemia

Free
Sin Tiong Ong, Pavithra Shyamsunder, Beijun Chen, Zahid Nawaz, Prasanna Venkatesh, Xinyi Yang, Yiyang Lim, Charles Chuah, Shyam Prabhakar, Vaidehi Krishnan, John Ouyang
Journal: Blood
Blood (2025) 146 (Supplement 1): 5012.
https://doi.org/10.1182/blood-2025-5012
Published: 2025
Journal Articles

Imatinib-Sensitive Chronic Myeloid Leukaemia Is Associated with mtDNA Mutations and Reduced Oxphos Capacity

Free
Ilaria Stefania Pagani, Vaidehi Krishnan, John Ouyang, Chung How Kok, BeiJun Chen, Elyse C Page, Phuong Dang, Verity A Saunders, Jane James, Kelly Lim, Naranie Shanmuganathan, Susan Branford, Charles Chuah, David T Yeung, Daniel Thomas, Timothy P Hughes, Sin Tiong Ong, David M Ross
Journal: Blood
Blood (2024) 144 (Supplement 1): 2715.
https://doi.org/10.1182/blood-2024-206591
Published: 2024
Journal Articles

A Single-Cell Atlas Identifies Pretreatment Features of Primary Imatinib Resistance in Chronic Myeloid Leukemia

Free
Vaidehi Krishnan, Florian Schmidt, Zahid Nawaz, Kian Leong Lee, Prasanna Nori Venkatesh, Meera Makheja, Zhu En Chan, Mengge Yu, Nirmala Arul Rayan, Michelle Gek Liang Lim, Alice Cheung, Sudipto Bari, John Ouyang, Owen Rackham, Tuan Zea Tan, William YK Hwang, Charles Chuah, Shyam Prabhakar, Sin Tiong Ong
Journal: Blood
Blood (2022) 140 (Supplement 1): 792–794.
https://doi.org/10.1182/blood-2022-165758
Published: 2022
Journal Articles

PML-RAR Binds to the +7kb Enhancer of CEBPE and Inhibits Its Expression

Free
Pavithra Shyamsunder, Shree Pooja Sridharan, Pushkar Dakle, Zeya Cao, Vikas Madan, PhD, Sin Tiong Ong, MD, H. Phillip Koeffler, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 43.
https://doi.org/10.1182/blood-2020-136230
Published: 2020
Journal Articles

Physiologic Hypoxia Promotes Maintenance of CML Stem Cells Despite Effective BCR-ABL Inhibition

Free
King-Pan Ng, PhD, Kian Leong Lee, PhD, Weijie Huang, B.Sc, Lorenz Poellinger, PhD, MD, Charles Chuah, MBChB, FRCPE, MD, Sin Tiong Ong, M.A., M.B.B.Ch., M.R.C.P., (UK)
Journal: Blood
Blood (2011) 118 (21): 450.
https://doi.org/10.1182/blood.V118.21.450.450
Published: 2011