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Journal Articles

Casein Kinase 1 Delta Is a Novel Regulator of mRNA Translation and Druggable Target in Aggressive Lymphomas

Ipsita Pal, PhD, Sohani Das Sharma, PhD, Andre M. Grilo, PhD, Prabhjot S. Mundi, MD, Luigi Scotto, PhD, Abdullah Mahmood Ali, PhD, Luke E Berchowitz, PhD, Siddhartha Mukherjee, MD PhD, Owen O'Connor, MD PhD, Marko Jovanovic, PhD, Changchun Deng, MD PhD

Blood (2019) 134 (Supplement_1): 2864.

https://doi.org/10.1182/blood-2019-129528

Published: 2019

Journal Articles

Rigosertib Oral in Transfusion Dependent Lower Risk Myelodysplastic Syndromes (LR-MDS): Optimization of Dose and Rate of Transfusion Independence (TI) or Transfusion Reduction (TR) in a Single-Arm Phase 2 Study

Azra Raza, MD, Aref Al-Kali, MD, Raoul Tibes, MD PhD, Gary Spitzer, MD, Manila Gaddh, MD, Benjamin Tycko, MD PhD, Sangmin Lee, MD, Naomi Galili, PhD, Abdullah Mahmood Ali, PhD, John G. Mears, MD, Siddhartha Mukherjee, MD PhD, Ryan Shelton, BS, Steven M. Fruchtman, MD, Michael E. Petrone, MD MPH, Patrick S. Zbyszewski, MBA, Mark Lawrence Heaney, MD PhD

Blood (2017) 130 (Supplement 1): 1689.

https://doi.org/10.1182/blood.V130.Suppl_1.1689.1689

Published: 2017

Journal Articles

Umbralisib/TGR-1202 As a Novel Dual PI3K/CK1 Inhibitor Has a Unique Therapeutic Role in Silencing Oncogenes in Aggressive Lymphomas

Ipsita Pal, PhD, Yu Ri Kim, MD, Luigi Scotto, PhD, Mark R Lipstein, PhD, Abdullah Mahmood Ali, PhD, Siddhartha Mukherjee, MD PhD, Susan E. Bates, MDPhD, Owen A. O'Connor, MD, PhD, Changchun Deng, MD PhD

Blood (2017) 130 (Supplement 1): 2809.

https://doi.org/10.1182/blood.V130.Suppl_1.2809.2809

Published: 2017

Journal Articles

Myelodysplastic Syndrome Marrow Stroma Shows Widespread Aberrant Hypermethylation That Is Abrogated By Treatment with Dnmt Inhibitors

Tushar D Bhagat, PhD, Matthias Bartenstein, MD, Yiting Yu, PhD, A. Mario Q. Marcondes, MD PhD, Britta Will, PhD, Orsolya Giricz, PhD, Davendra P. Sohal, MD MPH, Ioannis Mantzaris, MD, Amittha Wickrema, PhD, Christine Mcmahon, MD, Yeung Cecilia, MD, John Greally, MB, PhD, Siddhartha Mukherjee, MD PhD, Ulrich Steidl, MD PhD, H. Joachim Deeg, MD, Amit Verma, MD

Blood (2014) 124 (21): 4379.

https://doi.org/10.1182/blood.V124.21.4379.4379

Published: 2014

Journal Articles

Molecular Genetic Analysis of Myelodysplastic Syndromes (MDS) Patients with Ring Sideroblasts (RS); Independent Confirmation of Association of SF3B1 Mutations with Better Prognosis

Abdullah Mahmood Ali, PhD, Nicholas Iverson, Alexander Penson, PhD, Allison Scott, Tabish Riaz, Raul Rabadan, PhD, Siddhartha Mukherjee, MD PhD, Azra Raza, MD

Blood (2014) 124 (21): 3237.

https://doi.org/10.1182/blood.V124.21.3237.3237

Published: 2014

Journal Articles

Conditional Loss of Dnmt3a Results in Myeloproliferation and Liver-Specific Myeloid Expansion

Olga A Guryanova, MD PhD, Yen Lieu, PhD, Kaitlyn R Shank, B.S., Sharon Rivera, PhD, Francine E Garrett-Bakelman, MD PhD, Jacob Glass, MD PhD, Matthew D Keller, B.S., Suveg Pandey, B.S., Daniel Tovbin, Abby R Weinstein, Julie Teruya-Feldstein, MD, Omar Abdel-Wahab, MD, Christopher E Mason, PhD, Ari M Melnick, MD, Siddhartha Mukherjee, MD PhD, Ross L. Levine, MD

Blood (2014) 124 (21): 364.

https://doi.org/10.1182/blood.V124.21.364.364

Published: 2014

Journal Articles

Ex Vivo expansion Of Umbilical Cord Blood CD34+ Cells Under Hypoxic Conditions Using Novel Compound#999 With Cytokines

Saadiya Khan, MD, Alison L. Stewart, PhD, Siddhartha Mukherjee, MD, PhD, Stuart L. Scheiber, Benjamin L. Ebert, MD, DPhil, Todd R. Golub, MD, David T. Scadden, M.D., Malcolm A.S. Moore, D.Phil

Blood (2013) 122 (21): 4508.

https://doi.org/10.1182/blood.V122.21.4508.4508

Published: 2013

Journal Articles

Oral Rigosertib (ON 01910.Na) Treatment Produces An Encouraging Rate Of Transfusion Independence In Lower Risk Myelodysplastic Syndromes (MDS) Patients; A Genomic Methylation Profile Is Associated With Responses

Azra Raza, MD, Benjamin Tycko, M.D., Ph.D., Sangmin Lee, MD, Naomi Galili, Ph.D., Abdullah Ali, Andrew Eisenberger, MD, John G. Mears, MD, Aref Al-Kali, MD, Raoul Tibes, MD, PhD, Gary Spitzer, MD, Francois Wilhelm, MD, PhD., Siddhartha Mukherjee, MD, PhD

Blood (2013) 122 (21): 2745.

https://doi.org/10.1182/blood.V122.21.2745.2745

Published: 2013

Journal Articles

Niche-Based Screening Identifies Novel Small Molecules That Overcome Stromal Effects in Multiple Myeloma

Blood (2012) 120 (21): 571.

https://doi.org/10.1182/blood.V120.21.571.571

Published: 2012

Journal Articles

Aldehyde Dehydrogenase 3a2 (Aldh3a2) Represents a Distinct Metabolic Vulnerability in MLL-AF9 AML Leukemia Initiating Cells

Blood (2012) 120 (21): 208.

https://doi.org/10.1182/blood.V120.21.208.208

Published: 2012

Journal Articles

Identification of Dido1 Mutation Associated with Familial Myelodysplastic Syndrome (MDS)/Acute Myeloid Leukemia (AML)

Naomi Galili, Ph.D., Vladimir Trifonov, PhD, Mark Ewalt, MD, Siddhartha Mukherjee, MD, PhD, Raul Rabadan, Azra Raza, MD

Blood (2012) 120 (21): 169.

https://doi.org/10.1182/blood.V120.21.169.169

Published: 2012

Journal Articles

In Vivo RNA Interference Screening Identifies a Leukemia-Specific Dependence on Integrin Beta 3 Signaling

Blood (2011) 118 (21): 758.

https://doi.org/10.1182/blood.V118.21.758.758

Published: 2011

Journal Articles

Distinct Metabolic Dependency of Normal and Leukemic Cells in a Mouse Model

Blood (2011) 118 (21): 759.

https://doi.org/10.1182/blood.V118.21.759.759

Published: 2011

Journal Articles

Niche-Based Screening Reveals Leukemia Stem Cell Specific Therapeutics

Blood (2011) 118 (21): 760.

https://doi.org/10.1182/blood.V118.21.760.760

Published: 2011

Journal Articles

CCR1 Inhibition Targets Osteoclast-Myeloma Adhesion and Exerts in Vivo Anti-Osteoclast Activity

Soni a Vallet, MD, Nileshwari Vaghela, Mariateresa Fulciniti, PhD, Petter Veiby, Teru Hideshima, MD, PhD, Samantha Pozzi, MD, Loredana Santo, MD, Siddhartha Mukherjee, MD, Diana Cirstea, MD, David T. Scadden, MD, Kenneth C. Anderson, MD, Noopur Raje, MD

Blood (2008) 112 (11): 2757.

https://doi.org/10.1182/blood.V112.11.2757.2757

Published: 2008

Journal Articles

Promoting Osteoblastogenesis Using a Novel Dkk-1 Neutralizing Antibody in the Treatment of Multiple Myeloma Related Bone Disease

Samantha Pozzi, MD, Hua Yan, MD, Sonia Vallet, M.D., Nileshwari Vaghela, MS, Mariateresa Fulciniti, PhD, Diana Cirstea, MD, Loredana Santo, M.D., Siddhartha Mukherjee, MD, Teru Hideshima, M.D., Ph.D., Linda Schirtzinger, M.S., Stuart Kuhstoss, Nikhil C. Munshi, MD, Kenneth C Anderson, MD, David Scadden, MD, Noopur Raje, MD

Blood (2008) 112 (11): 2739.

https://doi.org/10.1182/blood.V112.11.2739.2739

Published: 2008

Journal Articles

Restoration of Bone Balance Via Activin a Inhibition Results in Anti-Myeloma Activity

Blood (2008) 112 (11): 645.

https://doi.org/10.1182/blood.V112.11.645.645

Published: 2008

Journal Articles

Targeting CCR1 for the Treatment of Osteolytic Bone Disease in Multiple Myeloma.

Sonia Vallet, MD, Noopur Raje, MD, MariaTeresa Fulciniti, Kenji Ishitsuka, MD, Teru Hideshima, MD, Klaus Podar, MD, Samantha Pozzi, MD, Iris Breitkreutz, MD, Tanyel Kiziltepe, PhD, Yutaka Okawa, MD, Hiroshi Ikeda, MD, Loredana Santo, MD, Siddhartha Mukherjee, MD, Nileshwari Vaghela, Diana Cirstea, MD, Mario Boccadoro, MD, Kenneth C. Anderson, MD

Blood (2007) 110 (11): 2503.

https://doi.org/10.1182/blood.V110.11.2503.2503

Published: 2007

Journal Articles

Preclinical Validation of a Clinical Grade Novel Specific Small Molecule Cyclin D1 Inhibitor, P276-00 for the Treatment of Multiple Myeloma.

Blood (2007) 110 (11): 256.

https://doi.org/10.1182/blood.V110.11.256.256

Published: 2007

Journal Articles

In Vivo Effects of Zoledronic Acid on Bone Remodeling.

Samantha Pozzi, MD, Teru Hideshima, MD, Sonia Vallet, MD, Siddhartha Mukherjee, MD, Shweta Chhetri, Diana Cirstea, MD, Nileshwari Vaghela, Clare Thomas, Dilani Rosa, Hiroshi Ikeda, MD, Yutaka Okawa, MD, Tanyel Kiziltepe, PhD, Jesse Schoonmaker, Ernestina Schipani, MD, Mary Bouxsein, PhD, Kenneth C. Anderson, MD, Noopur Raje, MD

Blood (2007) 110 (11): 3520.

https://doi.org/10.1182/blood.V110.11.3520.3520

Published: 2007

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Casein Kinase 1 Delta Is a Novel Regulator of mRNA Translation and Druggable Target in Aggressive Lymphomas

Rigosertib Oral in Transfusion Dependent Lower Risk Myelodysplastic Syndromes (LR-MDS): Optimization of Dose and Rate of Transfusion Independence (TI) or Transfusion Reduction (TR) in a Single-Arm Phase 2 Study

Umbralisib/TGR-1202 As a Novel Dual PI3K/CK1 Inhibitor Has a Unique Therapeutic Role in Silencing Oncogenes in Aggressive Lymphomas

Myelodysplastic Syndrome Marrow Stroma Shows Widespread Aberrant Hypermethylation That Is Abrogated By Treatment with Dnmt Inhibitors

Molecular Genetic Analysis of Myelodysplastic Syndromes (MDS) Patients with Ring Sideroblasts (RS); Independent Confirmation of Association of SF3B1 Mutations with Better Prognosis

Conditional Loss of Dnmt3a Results in Myeloproliferation and Liver-Specific Myeloid Expansion

Ex Vivo expansion Of Umbilical Cord Blood CD34+ Cells Under Hypoxic Conditions Using Novel Compound#999 With Cytokines

Oral Rigosertib (ON 01910.Na) Treatment Produces An Encouraging Rate Of Transfusion Independence In Lower Risk Myelodysplastic Syndromes (MDS) Patients; A Genomic Methylation Profile Is Associated With Responses

Niche-Based Screening Identifies Novel Small Molecules That Overcome Stromal Effects in Multiple Myeloma

Aldehyde Dehydrogenase 3a2 (Aldh3a2) Represents a Distinct Metabolic Vulnerability in MLL-AF9 AML Leukemia Initiating Cells

Identification of Dido1 Mutation Associated with Familial Myelodysplastic Syndrome (MDS)/Acute Myeloid Leukemia (AML)

In Vivo RNA Interference Screening Identifies a Leukemia-Specific Dependence on Integrin Beta 3 Signaling

Distinct Metabolic Dependency of Normal and Leukemic Cells in a Mouse Model

Niche-Based Screening Reveals Leukemia Stem Cell Specific Therapeutics

CCR1 Inhibition Targets Osteoclast-Myeloma Adhesion and Exerts in Vivo Anti-Osteoclast Activity

Promoting Osteoblastogenesis Using a Novel Dkk-1 Neutralizing Antibody in the Treatment of Multiple Myeloma Related Bone Disease

Restoration of Bone Balance Via Activin a Inhibition Results in Anti-Myeloma Activity

Targeting CCR1 for the Treatment of Osteolytic Bone Disease in Multiple Myeloma.

Preclinical Validation of a Clinical Grade Novel Specific Small Molecule Cyclin D1 Inhibitor, P276-00 for the Treatment of Multiple Myeloma.

In Vivo Effects of Zoledronic Acid on Bone Remodeling.

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