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Robert A.J. Oostendorp, PhD
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Journal Articles

GATA2 Zinc Finger Mutations Affect DNA-Binding and Promote Granulopoietic Differentiation

Georg Leubolt, MSc, Belay Tizazu, Sayantanee Dutta, PhD, Monica Cusan, MD, Theresa Sippenauer, Rouzanna Istvanffy, PhD, Robert A.J. Oostendorp, PhD, Wolfgang Hiddemann, Philipp A. Greif, MD PD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2779.
https://doi.org/10.1182/blood-2018-99-115976
Published: 2018
Journal Articles

Data Driven Computational Modeling of Hematopoiesis in Myelodysplastic Syndromes Unveils Differences in Hematopoietic Stem Cell Kinetics Compared to Age-Matched Healthy Controls

Michèle Kyncl, MSc, Lisa Bast, MSc, Lynette Henkel, Fabian Theis, PhD, Robert A.J. Oostendorp, PhD, Carsten Marr, PhD, Katharina S. Götze, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4354.
https://doi.org/10.1182/blood-2018-99-115942
Published: 2018
Journal Articles

Azacitidine Directly Acts on the Mesenchymal Stromal Cell Compartment in Myelodysplastic Syndromes to Alter Niche Function and Suppress Malignant Hematopoeitic Stem/Progenitor Cells

Catharina Wenk, MD, Anne-Kathrin Garz, MSc, Christina Huberle, MD, Sonja Grath, PhD, Denis Witham, Marie Weickert, Msc, Julia Niggemeyer, Msc, Judith Hecker, MD, Michele Kyncl, MSc, Catharina Müller-Thomas, MD, Christopher Mulholland, MSc, Robert A.J. Oostendorp, PhD, Klaus H. Metzeler, MD, Christian Peschel, MD, Katharina S Götze, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1683.
https://doi.org/10.1182/blood.V130.Suppl_1.1683.1683
Published: 2017
Journal Articles

Azacitidine in Combination with the Selective FLT3 Kinase Inhibitor Crenolanib Effectively Disrupts Stromal Protection of CD34+ Leukemia-Initiating Cells (LIC) in FLT3-ITD+ Acute Myeloid Leukemia (AML)

Anne-Kathrin Garz, M.Sc., Stefan Habringer, Saskia Wolf, Binje Vick, PhD, Marie-Theresa Weickert, M.Sc., Irmela Jeremias, MD, Karsten Spiekermann, MD, Christian Peschel, MD, Robert A.J. Oostendorp, PhD, Ulrich Keller, Katharina S. Götze, MD
Journal: Blood
Blood (2015) 126 (23): 676.
https://doi.org/10.1182/blood.V126.23.676.676
Published: 2015
Journal Articles

Depletion of Ptch2 Activates Canonical and Non-Canonical HH Signaling within the Niche Leading to Myeloproliferation, Stem Cell Exhaustion and Accelerates JAK2V617F Driven Disease

Claudius Klein, Anabel Kuhn, Sandra Kissel, Marie Follo, PhD, Anna Lena Illert, MD, Dietmar Pfeifer, Heike L Pahl, PhD, Robert A.J. Oostendorp, PhD, Justus Duyster, MD, Christine Dierks, MD
Journal: Blood
Blood (2015) 126 (23): 3593.
https://doi.org/10.1182/blood.V126.23.3593.3593
Published: 2015
Journal Articles

Connective Tissue Growth Factor (Ctgf/Ccn2) Is a Novel Extrinsic Niche-Derived Regulator Of Hematopoietic Stem Cells

Baiba Vilne, MSc, Rouzanna Istvanffy, PhD, Christina Eckl, MSc, Franziska Bock, MSc, Sandra Grziwok, MSc, Prazeras da Costa Olivia, PhD, Matthias Schiemann, PhD, Christian Peschel, H. Werner Mewes, PhD, Robert A.J. Oostendorp, PhD
Journal: Blood
Blood (2013) 122 (21): 3688.
https://doi.org/10.1182/blood.V122.21.3688.3688
Published: 2013
Journal Articles

Protein Kinase C-β Dependent Activation of NF-κB in Stromal Cells Is Indispensable for the Survival of Chronic Lymphocytic Leukemia B-Cells in Vivo

Gloria Lutzny, Thomas Kocher, MSc, Martina Rudelius, Marc Schmidt-Supprian, Ludger Klein-Hitpass, Jan Dürig, Robert A.J. Oostendorp, PhD, Christian Peschel, MD, Alexander Egle, Ingo Ringshausen
Journal: Blood
Blood (2012) 120 (21): 314.
https://doi.org/10.1182/blood.V120.21.314.314
Published: 2012
Journal Articles

Lentivirally Transduced Human Cord Blood CD34 + FLT3-ITD + Cells Induce Murine Acute Leukemia in the NOD/SCID Transplantation Model.

Pawan Kaur Bollinger, PhD, Doris Steinemann, PhD, Rama Krishna Kancha, PhD, Leticia Quantanilla-Fend, MD, Stefan K Bohlander, MD, Christian Peschel, MD, Robert A.J. Oostendorp, PhD, Christopher Baum, MD, Katharina S. Goetze, MD
Journal: Blood
Blood (2012) 120 (21): 2984.
https://doi.org/10.1182/blood.V120.21.2984.2984
Published: 2012
Journal Articles

Secreted Mediators of Self-Renewal of Hematopoietic Stem Cells Identified Using Bio-Informatic Analysis of Co-Cultures of HSC and Stromal Cells.

Baiba Vilne, MSc, Rouzanna Istvanffy, PhD, Christina Eckl, MSc, Franziska Bock, MSc, Olivia Prazeres da Costa, PhD, Volker Stümpflen, PhD, Christian Peschel, MD, Hans-Werner Mewes, PhD, Robert A.J. Oostendorp, PhD
Journal: Blood
Blood (2012) 120 (21): 2353.
https://doi.org/10.1182/blood.V120.21.2353.2353
Published: 2012
Journal Articles

The Combination of Stem Cell Factor and Oncostatin M Maintains Cord Blood-Derived NOD/SCID-Repopulating Cells.

Siv Gilfillan, PhD, Simone Kraner, PhD, Katharina S. Goetze, MD, Matthias Schiemann, PhD, Stefanie Marz, Christian Peschel, MD, PhD, Robert A.J. Oostendorp, PhD
Journal: Blood
Blood (2005) 106 (11): 4267.
https://doi.org/10.1182/blood.V106.11.4267.4267
Published: 2005
Journal Articles

Frequency of Mesenchymal Colony-Forming Cells (CFU-F) from Human Cord Blood and the Umbilical Vein.

Robert A.J. Oostendorp, PhD, Nicole Mohaupt, PhD, Nikolas Kaltz, Sandra Hippauf, Christian Peschel, MD, PhD
Journal: Blood
Blood (2005) 106 (11): 4309.
https://doi.org/10.1182/blood.V106.11.4309.4309
Published: 2005