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Ramasamy Santhanam, PhD
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Journal Articles

Targeting Mir-155 via The NEDD8-Activating Enzyme Inhibitor MLN4924: A Novel Therapeutic Approach For Acute Myeloid Leukemia (AML)

Jihane C Khalife, MS, Hanna S Radomska, PhD, Jennifer Saultz, MD, Ramasamy Santhanam, PhD, Xiaomeng Huang, Hongyan Wang, PhD, John P. Curfman, Yue-Zhong Wu, MS, Pia Hoellerbauer, Houda Alachkar, PharmD, PhD, Adrienne M Dorrance, Ph.D, Michael A. Caligiuri, MD, Ramiro Garzon, MD, Jason H. Mendler, MD, PhD, Guido Marcucci, MD
Journal: Blood
Blood (2013) 122 (21): 3804.
https://doi.org/10.1182/blood.V122.21.3804.3804
Published: 2013
Journal Articles

Translational Research From the Tropical Forest: Silvestrol, a Natural Product From the Plant Aglaia Foveolata inhibits the Expression of Tyrosine Kinases and Shows a Significant In Vivo Activity in Acute Myeloid Leukemia (AML)

Houda Alachkar, PharmD, M.S, Ramasamy Santhanam, PhD, David M. Lucas, PhD, Sebastian Schwind, MD, Christopher Hickey, M.S, Jiuxia Pang, Danilo Perrotti, MD, PhD, Li Pan, PhD, A Douglas Kinghorn, Ph.D., D.Sc, Guido Marcucci, MD, Michael R Grever, MD
Journal: Blood
Blood (2011) 118 (21): 2616.
https://doi.org/10.1182/blood.V118.21.2616.2616
Published: 2011
Journal Articles

FTY720 Restores PP2A Tumor Suppressor Activity in Polycythemia Vera CD34 + Progenitors Through Inhibition of Jak2 V617F- and PI-3Kγ-Dependent SET Serine Phosphorylation and Enhancement of NOS-Dependent PP2A Tyrosine Nitration

Joshua J Oaks, A. Mukhopadhyay, Ramasamy Santhanam, PhD, S. A Saddoughi, Paolo Neviani, PhD, Jason G Harb, Ph.D, Besim Ogretmen, PhD, Robert Bittman, Ph.D, Ross L Levine, MD, Alfonso Quintás-Cardama, MD, Guido Marcucci, MD, Danilo Perrotti, MD, Ph.D
Journal: Blood
Blood (2011) 118 (21): 2494.
https://doi.org/10.1182/blood.V118.21.2494.2494
Published: 2011
Journal Articles

Interleukin-15 Is a Proto-Oncogene In Acute Large Granular Lymphocyte Leukemia

Anjali Mishra, Ph.D., Shujun Liu, Ph.D., Gregory H Sams, Douglas P Curphey, Ramasamy Santhanam, PhD, Laura J Rush, DVM, PhD, Deanna Schaefer, DVM, Lauren G Falkenberg, Laura Sullivan, Laura Jaroncyk, Xunchang Zou, MS, Harold Fisk, PhD, Jadwiga Labanowska, MS, Enrico Caserta, PhD, Lai-Chu Wu, MD, PhD, Heiko Becker, MD, Sebastian Schwind, MD, Jason C. Chandler, MD, Yue-Zhong Wu, MS, Nyla A. Heerema, Ph.D., Pierluigi Porcu, MD, Ramiro Garzon, MD, Guido Marcucci, MD, Michael A. Caligiuri, MD
Journal: Blood
Blood (2010) 116 (21): 704.
https://doi.org/10.1182/blood.V116.21.704.704
Published: 2010
Journal Articles

Suppression of RISC-Independent Decoy and RISC-Mediated mRNA Base-Pairing Activities of MicroRNA-328 Is Required for Differentiation-Arrest and Enhanced Survival of Blast Crisis CML Progenitors.

Anna M Eiring, PhD, Jason Harb, PhD, Paolo Neviani, PhD, Joshua Oaks, BS, Shujun Liu, PhD, Riccardo Spizzo, Sebastian Schwind, MD, Ramasamy Santhanam, PhD, Christopher Hickey, MS, Heiko Becker, MD, Jason C. Chandler, MD, Raul Andino, PhD, Jorge Cortes, MD, Peter Hokland, Sr., M.D., D., Med., Sci., Claudia Huettner, PhD, Ravi Bhatia, MD, Denis-Claude Roy, MD, Stephen Liebhaber, MD, Michael A. Caligiuri, M.D., Guido Marcucci, MD, Ramiro Garzon, MD, Carlo M. Croce, MD, George A Calin, MD, PhD, Danilo Perrotti, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 855.
https://doi.org/10.1182/blood.V114.22.855.855
Published: 2009
Journal Articles

Evidence of MicroRNA-29b and Sp1/NFκB-HDAC Regulatory Network for KIT Expression in KIT-Driven Acute Myeloid Leukemia (AML): Biologic and Therapeutic Implications.

Shujun Liu, PhD, Lai Chu Wu, PhD, Jiuxia Pang, BS, Ramasamy Santhanam, PhD, Sebastian Schwind, MD, Yue-Zhong Wu, MS, Christopher Hickey, MS, Jianhua Yu, PhD, Anjali Mishra, PhD, Heiko Becker, MD, Chenglong Li, PhD, Roger Briesewitz, PhD, Robert A. Baiocchi, MD, Kenneth K. Chan, PhD, Michael A. Caligiuri, MD, John C. Byrd, MD, Danilo Perrotti, MD, PhD, Ramiro Garzon, MD, Guido Marcucci, MD
Journal: Blood
Blood (2009) 114 (22): 938.
https://doi.org/10.1182/blood.V114.22.938.938
Published: 2009
Journal Articles

FTY720 but Not Its Immunosuppressive Phosphorylated Form FTY720-P Exerts Anti-Leukemic Activity towards Ph(+) and Ph(−) Myeloproliferative Disorders through Reactivation of the PP2A Tumor Suppressor.

Joshua Oaks, BS, Paolo Neviani, PhD, A. Mukhopadhyay, Ramasamy Santhanam, PhD, Y. Ma, Charlene Mao, Guido Marcucci, MD, Ching-Shih Chen, Jorge Cortes, MD, Michael A. Caligiuri, M.D., Peter Hokland, Sr., Claudia Huettner, PhD, Steffen Koschmieder, MD, Jose Cancelas, MD, PhD, Roger Briesewitz, PhD, Ravi Bhatia, MD, Denis-Claude Roy, MD, Besim Ogretmen, PhD, Danilo Perrotti, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 3259.
https://doi.org/10.1182/blood.V114.22.3259.3259
Published: 2009
Journal Articles

FTY720, a New and Alternative Strategy for Treating Blast Crisis CML and Ph 1 ALL Patients.

Ramasamy Santhanam, PhD, Paolo Neviani, D.Sci, Anna Eiring, B.S., Joshua Oaks, B.S., Mario Notari, D.Sci, Bradley W. Blaser, Ph.D., Shujun Liu, Ph.D, Rossana Trotta, Ph.D, Natarajan Muthusamy, Ph.D, Guido Marcucci, M.D., Carlo Gambacorti, M.D., Denis-Claude Roy, M.D., Michael A. Caligiuri, M.D., Clara D. Bloomfield, M.D., Ching-Shih Chen, Ph.D, John C. Byrd, M.D., Danilo Perrotti, MD, PhD
Journal: Blood
Blood (2006) 108 (11): 288.
https://doi.org/10.1182/blood.V108.11.288.288
Published: 2006
Journal Articles

In Vitro and In Vivo Evidence That the PP2A Inhibitor SET Regulates IFN-γ Production in Monokine-Stimulated Natural Killer Cells.

Rossana Trotta, PhD, Jessica Dal Col, PhD, Jeffrey Allard, II, BS, Paolo Neviani, PhD, Ramasamy Santhanam, PhD, Hsiaoyin Mao, MS, Brian Becknell, PhD, Jianhua Yu, PhD, Aalok Modi, BS, Bradley W. Blaser, PhD, Danilo Perrotti, MD PhD, Michael A. Caligiuri, MD
Journal: Blood
Blood (2006) 108 (11): 928.
https://doi.org/10.1182/blood.V108.11.928.928
Published: 2006