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Journal Articles

Optimising the Duration of Therapy for Newly Diagnosed Transplant Ineligible Patients - Analysis of Long Term Follow up Data from the UK MRA Myeloma XI Trial

Charlotte Pawlyn, Faith E Davies, Gordon Cook, Heather McIntyre, Jeanine Richards, Sharon Jackson, Elizabeth Hodson, Catherine Olivier, Anna Hockaday, John R Jones, Martin F Kaiser, Matthew W. Jenner, Walter Martin Gregory, Ruth M de Tute, Roger G Owen, Mark Drayson, David A. Cairns, Gareth Morgan, Graham Jackson
Journal: Blood
Blood (2024) 144 (Supplement 1): 1987.
https://doi.org/10.1182/blood-2024-205788
Published: 2024
Journal Articles

MRD and Molecular Risk Status Help to Define Optimal Maintenance Delivery Strategies after ASCT: Long Term Outcomes of the UK MRA Myeloma XI Trial Comparing Lenalidomide to Observation

Graham Jackson, Charlotte Pawlyn, Faith E Davies, Martin F Kaiser, Ruth M de Tute, Heather McIntyre, Jeanine Richards, Sharon Jackson, Elizabeth Hodson, Anna Hockaday, Catherine Olivier, John R Jones, Matthew W. Jenner, Gordon Cook, Walter Martin Gregory, Mark Drayson, Roger G Owen, David A. Cairns, Gareth Morgan
Journal: Blood
Blood (2024) 144 (Supplement 1): 3375.
https://doi.org/10.1182/blood-2024-205871
Published: 2024
Journal Articles

Final Analysis of the Randomised UK MRA Myeloma XI+ Trial Examining Krdc (carfilzomib, lenalidomide, dexamethasone and cyclophosphamide) As Induction Therapy for Newly Diagnosed Multiple Myeloma Patients

Charlotte Pawlyn, Faith E Davies, Martin F Kaiser, Ruth M de Tute, Heather McIntyre, Jeanine Richards, Sharon Jackson, Elizabeth Hodson, Anna Hockaday, Catherine Olivier, John R Jones, Matthew W. Jenner, Gordon Cook, Walter Martin Gregory, Mark Drayson, Roger G Owen, Gareth Morgan, David A. Cairns, Graham Jackson
Journal: Blood
Blood (2024) 144 (Supplement 1): 771.
https://doi.org/10.1182/blood-2024-208255
Published: 2024
Journal Articles

Cost-Effectiveness of Frailty-Adjusted Therapy in Transplant Non-Eligible Patients with Newly Diagnosed Multiple Myeloma - an Economic Evaluation of the Fitness Trial

Bryony Dawkins, Georgios Gkountouras, David Meads, Charlotte Pawlyn, Kara-Louise Royle, Ethan R Senior, Dax Everritt, Jenny Bird, Stella Bowcock, Mark Drayson, Sharon Gillson, Catherine Olivier, Matthew W. Jenner, John R Jones, Martin F Kaiser, Bhuvan Kishore, Neil Rabin, Roger G Owen, Ruth M de Tute, Christopher Parrish, David A. Cairns, Alan Chant, Graham Jackson, Gordon Cook
Journal: Blood
Blood (2024) 144 (Supplement 1): 385.
https://doi.org/10.1182/blood-2024-209720
Published: 2024
Journal Articles

4D intravital imaging studies identify platelets as the predominant cellular procoagulant surface in a mouse hemostasis model

Abigail Ballard-Kordeliski, Robert H. Lee, Ellen C. O’Shaughnessy, Paul Y. Kim, Summer R. Jones, Rafal Pawlinski, Matthew J. Flick, David S. Paul, Nigel Mackman, David A. Adalsteinsson, Wolfgang Bergmeier
Journal: Blood
Blood (2024) 144 (10): 1116–1126.
https://doi.org/10.1182/blood.2023022608
Published: 2024
Includes: Multimedia, Supplemental data
Journal Articles

Health-Related Quality of Life (HRQoL) in Fit, Unfit and Frail Patients Enrolled in Fitness (UK-MRA Myeloma XIV): A Cross Sectional Study

Orla McCourt, David Allan Cairns, Sally Moore, Christopher Parrish, Charlotte Pawlyn, Frances Seymour, Ethan R Senior, Kara-Louise Royle, Jennifer Bird, Stella J. Bowcock, Alan Chant, Mark Drayson, Hayley Gardner, Matthew W. Jenner, John R Jones, Martin F. Kaiser, Bhuvan Kishore, Roger Owen, Neil Rabin, Ruth M de Tute, Bryony Dawkins, David Meads, Sharon Gillson, Sharon Jackson, Catherine Olivier, Graham Jackson, Gordon Cook
Journal: Blood
Blood (2023) 142 (Supplement 1): 3368.
https://doi.org/10.1182/blood-2023-187202
Published: 2023
Journal Articles

The Impact of Epstein-Barr Virus Infection on Second Cancer Development in Newly Diagnosed Myeloma Patients Treated with Lenalidomide in the UK NCRI Myeloma XI Trial

Molly Reed, David Allan Cairns, Charlotte Pawlyn, Faith E. Davies, Rachel Sigsworth, Annamaria Brioli, Matthew W. Jenner, Martin F. Kaiser, Catherine Olivier, Roger Owen, Kevin Boyd, Gordon Cook, Gareth J. Morgan, Graham Jackson, Mark Drayson, John R Jones
Journal: Blood
Blood (2023) 142 (Supplement 1): 3366.
https://doi.org/10.1182/blood-2023-181939
Published: 2023
Journal Articles

The Impact of Lymphocyte Composition in the Stem Cell Harvest on Blood Lymphocytes 1-2 Weeks Post-Autologous Stem Cell Transplant for Newly Diagnosed Myeloma

Benjamin Dimbleby, Tatiana Zhelezniakova, Alex G Richter, Charlotte Pawlyn, John R Jones, Matthew W Jenner, David Cairns, Tom Menzies, Walter Martin Gregory, Martin F. Kaiser, Gordon Cook, Roger G Owen, Graham Jackson, Faith E Davies, Gareth J. Morgan, Mark T Drayson
Journal: Blood
Blood (2022) 140 (Supplement 1): 4299–4300.
https://doi.org/10.1182/blood-2022-169774
Published: 2022
Journal Articles

Age of Packed Red Blood Cells Transfused to Patients with Acute Leukemia: A Descriptive Analysis

Omer H Jamy, Allison R Jones, Peng Li, Rakesh P. Patel, Ellen M. Lavoie Smith
Journal: Blood
Blood (2022) 140 (Supplement 1): 13125–13126.
https://doi.org/10.1182/blood-2022-169606
Published: 2022
Journal Articles

Second Primary Malignancy Incidence in Patients Receiving Lenalidomide at Induction and Maintenance; Long-Term Follow up of 4358 Patients Enrolled to the Myeloma XI Trial

John R Jones, David Cairns, Tom Menzies, Charlotte Pawlyn, Faith E. Davies, Rachel Sigsworth, Matthew W Jenner, Martin F. Kaiser, Rebecca Mottram, Mark T Drayson, Walter Martin Gregory, Roger G Owen, Kevin Boyd, Gordon Cook, Graham Jackson, Gareth J. Morgan
Journal: Blood
Blood (2022) 140 (Supplement 1): 1823–1825.
https://doi.org/10.1182/blood-2022-168723
Published: 2022
Journal Articles

The Impact of Autologous Stem Cell Transplantation on the Genetics of High-Risk Relapsed Multiple Myeloma

Mohamed Shahin, Charlotte Pawlyn, Niels Weinhold, Timothy Cody Ashby, Brian A. Walker, Christopher P. Wardell, David Cairns, Tom Menzies, Walter Martin Gregory, Martin F. Kaiser, Gordon Cook, Mark T Drayson, Roger G Owen, Graham Jackson, Faith E Davies, Gareth J. Morgan, John R Jones
Journal: Blood
Blood (2022) 140 (Supplement 1): 4232–4233.
https://doi.org/10.1182/blood-2022-169628
Published: 2022
Journal Articles

Defining the Optimal Duration of Lenalidomide Maintenance after Autologous Stem Cell Transplant - Data from the Myeloma XI Trial

Charlotte Pawlyn, Tom Menzies, Faith E Davies, Ruth M. de Tute, Rowena Henderson, Gordon Cook, Matthew W Jenner, John R Jones, Martin F. Kaiser, Mark T Drayson, Roger G Owen, David Cairns, Gareth J. Morgan, Graham Jackson
Journal: Blood
Blood (2022) 140 (Supplement 1): 1371–1372.
https://doi.org/10.1182/blood-2022-165376
Published: 2022
Journal Articles

Fitness, a UK Myeloma Research Alliance (UK-MRA) Frailty-Adjusted Therapy Study, Supports the Feasibility of Recruiting Frail Newly Diagnosed Myeloma Patients to Large Clinical Trials

Gordon Cook, Charlotte Pawlyn, Kara-Louise Royle, Amy Beth Coulson, Jennifer Bird, Stella Bowcock, Matthew W Jenner, Bhuvan Kishore, Christopher Parrish, Neil K Rabin, Phillip Best, Sharon Gillson, Rowena Henderson, Catherine Olivier, Martin F. Kaiser, Ruth M. de Tute, Roger G Owen, Mark T Drayson, John R Jones, Bryony Dawkins, David Meads, David Cairns, Graham Jackson
Journal: Blood
Blood (2021) 138 (Supplement 1): 81.
https://doi.org/10.1182/blood-2021-146650
Published: 2021
Journal Articles

The Impact of gain1q on Mutational Structure and Clonal Evolution in a Uniformly Treated High-Risk Series of Patients at First Relapse

John R Jones, Charlotte Pawlyn, Niels Weinhold, Timothy Cody Ashby, Brian A Walker, Christopher P. Wardell, David Cairns, Walter Martin Gregory, Martin F. Kaiser, Gordon Cook, Mark T Drayson, Roger G Owen, Graham Jackson, Faith E Davies, Gareth J. Morgan
Journal: Blood
Blood (2021) 138 (Supplement 1): 2683.
https://doi.org/10.1182/blood-2021-152123
Published: 2021
Journal Articles

Phenotypic High-Risk Disease in the Context of Carfilzomib and Lenalidomide Combination Induction Therapy for Newly Diagnosed Transplant-Eligible Myeloma Patients

Charlotte Pawlyn, Faith E Davies, Tom Menzies, Rowena Henderson, Gordon Cook, Matthew W Jenner, John R Jones, Martin F. Kaiser, Roger G Owen, Mark T Drayson, David Cairns, Gareth J. Morgan, Graham Jackson
Journal: Blood
Blood (2021) 138 (Supplement 1): 2907.
https://doi.org/10.1182/blood-2021-151102
Published: 2021
Journal Articles

Multistate Models Demonstrate That Lenalidomide Maintenance Enhances Survival By Prolonging Time in First Remission for Patients Treated in the UK NCRI Myeloma XI Randomised Trial

Zoe Craig, Christopher Parrish, Charlotte Pawlyn, Martin F. Kaiser, Catherine Olivier, John R Jones, Mark T Drayson, Roger G Owen, Matthew W Jenner, Gordon Cook, Walter Martin Gregory, Faith E Davies, Gareth J. Morgan, Graham Jackson, David Cairns
Journal: Blood
Blood (2021) 138 (Supplement 1): 3758.
https://doi.org/10.1182/blood-2021-150631
Published: 2021
Journal Articles

Mutations in CRBN and Other Cereblon Pathway Genes Are Only Associated with Acquired Resistance to Immunomodulatory Drugs in a Subset of Patients and Cell Line Models

Amy Barber, PhD, John R Jones, MD, Harvey Che, Yann-Vai Le Bihan, Niels Weinhold, PhD, Cody Ashby, PhD, Brian A Walker, PhD, Christopher P. Wardell, PhD MSc, BSc, Hannah Wang, PhD, Martin F. Kaiser, MD FRCP, FRCPath, Graham H Jackson, MD MA, MB BS, FRCP, FRCPath, Faith E. Davies, Rajesh Chopra, MD, Gareth Morgan, MD PhD, Charlotte Pawlyn, BA,PhDMBBChir,MRCP,FRCPath
Journal: Blood
Blood (2020) 136 (Supplement 1): 6–7.
https://doi.org/10.1182/blood-2020-140024
Published: 2020
Journal Articles

The Addition of Carfilzomib to a Lenalidomide-Based Triplet Improves Outcomes in Newly Diagnosed Transplant Eligible Myeloma Patients with Renal Impairment: A Subgroup Analysis of the Myeloma XI Trial

Charlotte Pawlyn, BA,PhDMBBChir,MRCP,FRCPath, Tom Menzies, Faith E. Davies, Ritika Rana, Jennifer Pinney, Gordon Cook, MD, Walter Martin Gregory, PhD, Matthew W Jenner, John R Jones, MD, Martin F. Kaiser, MD FRCP, FRCPath, Roger G Owen, MD, Gareth Morgan, MD PhD, Graham H Jackson, MD MA, MB BS, FRCP, FRCPath, David Cairns, MSc, PhD, Mark T Drayson, MB ChB, PhD FRCPath
Journal: Blood
Blood (2020) 136 (Supplement 1): 40–43.
https://doi.org/10.1182/blood-2020-139238
Published: 2020
Journal Articles

Thrombosis in patients with myeloma treated in the Myeloma IX and Myeloma XI phase 3 randomized controlled trials

Charlotte A. Bradbury, Zoe Craig, Gordon Cook, Charlotte Pawlyn, David A. Cairns, Anna Hockaday, Andrea Paterson, Matthew W. Jenner, John R. Jones, Mark T. Drayson, Roger G. Owen, Martin F. Kaiser, Walter M. Gregory, Faith E. Davies, J. Anthony Child, Gareth J. Morgan, Graham H. Jackson
Journal: Blood
Blood (2020) 136 (9): 1091–1104.
https://doi.org/10.1182/blood.2020005125
Published: 2020
Includes: Supplemental data
Journal Articles

Morphological changes in a case of SARS-CoV-2 infection

John R. Jones, Robin Ireland
Journal: Blood
Blood (2020) 135 (25): 2324.
https://doi.org/10.1182/blood.2020006665
Published: 2020