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Journal Articles

Inhibition of PIM Kinases in Diffuse Large B-Cell Lymphoma Cells Targets MYC-Dependent Transcriptional Program, Increases CD20 Expression and Augments the Efficacy of Anti-CD20 Antibodies

Blood (2020) 136 (Supplement 1): 33–34.

https://doi.org/10.1182/blood-2020-134778

Published: 2020

Journal Articles

SIRT1 and HSP90alpha Are Functionally Linked and Control Mitotic Chromosome Segregation and Cell Viability in a Subset of Dlbcls

Emilia Bialopiotrowicz, PhD, Monika Noyszewska-Kania, MSc, Ewa Jabłońska, PhD, Tomasz Sewastianik, PhD, Monika Stańczak, Msc, Anna Szumera-Ciećkiewicz, MD PhD, Katarzyna Borg, PhD, Aleksandra Bluszcz, Msc, Sonia Dębek, MSc, Monika Prochorec-Sobieszek, MD PhD, Anna Polak, PhD, Patryk Górniak, PhD, Maciej Szydlowski, PhD, Przemyslaw Juszczynski, MD PhD

Blood (2020) 136 (Supplement 1): 28–29.

https://doi.org/10.1182/blood-2020-139319

Published: 2020

Journal Articles

Hodgkin Lymphoma Reed-Sternberg Cells Induce Immunosuppressive and Pro-Angiogenic Phenotype of Tumor-Associated Macrophages in a Paracrine Manner

Maciej Szydlowski, PhD, Michał Pawlak, PhD, Filip Garbicz, MD, Patryk Górniak, PhD, Justyna Żurańska, PhD, Magdalena Król, PhD, Bartłomiej Taciak, Maciej Białasek, Anna Szumera-Ciećkiewicz, MD PhD, Kamil Sokół, Monika Stańczak, Msc, Daria Owczarek, Monika Prochorec-Sobieszek, MD PhD, Anna Polak, PhD, Emilia Bialopiotrowicz, PhD, Michał Kurlapski, Jan Zaucha, MDPhD, Paweł Wołkow, PhD, Przemyslaw Juszczynski, MD PhD

Blood (2020) 136 (Supplement 1): 30.

https://doi.org/10.1182/blood-2020-134886

Published: 2020

Journal Articles

PIM Kinase Inhibition Decreases the Proangiogenic Properties of Multiple Myeloma Cells and Affects the Metabolic State of the Vascular Endothelium

Filip Garbicz, MD, Anna Szumera-Ciećkiewicz, MD PhD, Joanna Barankiewicz, MD, Dorota Komar, PhD, Michał Pawlak, PhD, Sonia Dębek, MSc, Aleksandra Matrejek, MSc, Thorsten Stuehmer, PhD, Aleksander Salomon-Perzynski, MD, Agata Malenda, MD PhD, Krzysztof Brzózka, PhD, Tomasz Rzymski, PhD, Andrea Massimiliano Tomirotti, PhD, Ewa Lech-Marańda, MD PhD, Monika Prochorec-Sobieszek, MD PhD, Maciej Szydlowski, PhD, Przemyslaw Juszczynski, MD PhD

Blood (2020) 136 (Supplement 1): 16–17.

https://doi.org/10.1182/blood-2020-134979

Published: 2020

Journal Articles

CDK8 Inhibitor SEL120-34A Has Therapeutic Efficacy in Murine and Human Acute Myeloid Leukemia Models

Blood (2018) 132 (Supplement 1): 1520.

https://doi.org/10.1182/blood-2018-99-111859

Published: 2018

Journal Articles

Functional Link Between Heat Shock Protein HSP90alpha and Sirtuin 1 (SIRT1) in the Pathogenesis of Diffuse Large B Cell Lymphoma

Emilia Bialopiotrowicz, PhD, Tomasz Sewastianik, PhD, Monika Noyszewska-Kania, MSc, Maciej Szydlowski, PhD, Ewa Jablonska, PhD, Patryk Gorniak, PhD, Anna Polak, PhD, Przemyslaw Kiliszek, PhD, Krzysztof Warzocha, Przemyslaw Juszczynski, MD PhD

Blood (2016) 128 (22): 4120.

https://doi.org/10.1182/blood.V128.22.4120.4120

Published: 2016

Journal Articles

Downregulation of Deptor By MiR-155 Promotes Cell Survival through Activation of PI3K/AKT and NFkB Signaling in ABC-Type Diffuse Large B-Cell Lymphomas

Ewa Jablonska, PhD, Patryk Gorniak, PhD, Weronika Prusisz, MSc, Przemyslaw Kiliszek, PhD, Maciej Szydlowski, PhD, Tomasz Sewastianik, PhD, Emilia Bialopiotrowicz, PhD, Anna Polak, PhD, Monika Prochorec-Sobieszek, MD PhD Prof, Anna Szumera-Cieckiewicz, MD PhD, Krzysztof Warzocha, Przemyslaw Juszczynski, MD PhD

Blood (2016) 128 (22): 1761.

https://doi.org/10.1182/blood.V128.22.1761.1761

Published: 2016

Journal Articles

Microenvironment-Induced Expression of PIM Kinases Supports Chronic Lymphocytic Leukemia Cells Survival and Promotes CXCR4-mTOR Pathway Dependent Migration

Blood (2016) 128 (22): 3239.

https://doi.org/10.1182/blood.V128.22.3239.3239

Published: 2016

Journal Articles

MiR-155 Amplifies AKT and NFkB Signaling By Targeting Multiple Regulators of BCR Signal in DLBCL

Ewa Jablonska, PhD, Patryk Gorniak, PhD, Weronika Prusisz, MSc, Przemyslaw Kiliszek, MSc, Maciej Szydlowski, PhD, Tomasz Sewastianik, MSc, Emilia Bialopiotrowicz, PhD, Anna Polak, MSc, Monika Prochorec-Sobieszek, MD PhD, Anna Szumera-Cieckiewicz, MD PhD, Krzysztof Warzocha, MD PhD, Przemyslaw Juszczynski, MD PhD

Blood (2015) 126 (23): 2455.

https://doi.org/10.1182/blood.V126.23.2455.2455

Published: 2015

Journal Articles

MEK1 Inhibitor Selumetinib Sensitizes Precursor B-Cell Acute Lymphoblastic Leukemia Cells (B-ALL) to Dexamethasone through Modulation of mTOR Activity and Stimulation of Autophagy

Anna Polak, MSc, Przemyslaw Kiliszek, MSc, Tomasz Sewastianik, MSc, Maciej Szydlowski, PhD, Ewa Jablonska, PhD, Emilia Bialopiotrowicz, PhD, Patryk Gorniak, PhD, Sergiusz Markowicz, PhD, Eliza Nowak, MSc, Monika A. Grygorowicz, MSc, Dominika Nowis, MDPhD, Jakub Golab, MD PhD, Sebastian Giebel, MD PhD, Ewa Lech-Maranda, MD PhD, Krzysztof Warzocha, MD PhD, Przemyslaw Juszczynski, MD PhD

Blood (2015) 126 (23): 4917.

https://doi.org/10.1182/blood.V126.23.4917.4917

Published: 2015

Journal Articles

FOXO1-p300-Txn Circuit Regulates Oxidative Stress Responses in Diffuse Large B-Cell Lymphomas Characterized By Enhanced Oxidative Phosphorylation

Tomasz Sewastianik, MSc, Maciej Szydlowski, PhD, Emilia Bialopiotrowicz, PhD, Ewa Jablonska, PhD, Przemyslaw Kiliszek, MSc, Anna Polak, MSc, Monika Prochorec-Sobieszek, MD PhD, Anna Szumera-Cieckiewicz, MD PhD, Tomasz S. Kaminski, MSc, Patryk Gorniak, PhD, Sergiusz Markowicz, PhD, Eliza Nowak, MSc, Monika A. Grygorowicz, MSc, Krzysztof Warzocha, MD PhD, Przemyslaw Juszczynski, MD PhD

Blood (2015) 126 (23): 466.

https://doi.org/10.1182/blood.V126.23.466.466

Published: 2015

Journal Articles

FOXO1 Activation Is an Effector of SYK and AKT Inhibition in Tonic BCR Signal-Dependent Diffuse Large B-Cell Lymphomas

Przemyslaw Kiliszek, MSc, Maciej Szydlowski, PhD, Tomasz Sewastianik, MSc, Ewa Jablonska, PhD, Emilia Bialopiotrowicz, PhD, Patryk Gorniak, PhD, Anna Polak, MSc, Sergiusz Markowicz, PhD, Eliza Nowak, MSc, Monika A. Grygorowicz, MSc, Monika Prochorec-Sobieszek, MD PhD, Anna Szumera-Cieckiewicz, MD PhD, Agata Malenda, MD PhD, Ewa Lech-Maranda, MD PhD, Krzysztof Warzocha, MD PhD, Przemyslaw Juszczynski, MD PhD

Blood (2015) 126 (23): 314.

https://doi.org/10.1182/blood.V126.23.314.314

Published: 2015

Journal Articles

Expression of PIM Kinases in Reed-Sternberg Cells Fosters Immune Privilege and Tumor Cell Survival in Classical Hodgkin Lymphoma

Maciej Szydlowski, PhD, Monika Prochorec-Sobieszek, MD PhD, Anna Szumera-Cieckiewicz, MD PhD, Grazyna Hoser, PhD, Ewa Jablonska, PhD, Emilia Bialopiotrowicz, PhD, Przemyslaw Kiliszek, MSc, Tomasz Sewastianik, MSc, Anna Polak, MSc, Wojciech Czardybon, PhD, Michal Galezowski, PhD, Renata Windak, PhD, Krzysztof Brzozka, PhD, Krzysztof Warzocha, MD PhD, Jan Maciej Zaucha, MD PhD, Przemyslaw Juszczynski, MD PhD

Blood (2015) 126 (23): 819.

https://doi.org/10.1182/blood.V126.23.819.819

Published: 2015

Journal Articles

Activity of PIM Kinases in Chronic Lymphocytic Leukemia Modulates Tumor Cell Survival and Stromal Interactions through a Pleiotropic Mechanism Involving Modulation of CXCR4 - mTOR Pathway

Blood (2015) 126 (23): 1549.

https://doi.org/10.1182/blood.V126.23.1549.1549

Published: 2015

Journal Articles

HIF1-Alpha and MYC Transcription Factor Signatures in B-Cell Acute Lymphoblastic Leukemia Are Associated with Positive Minimal Residual Disease Status: Therapeutic Implications

Tomasz Sewastianik, MSc, Patryk Gorniak, PhD, Przemyslaw Kiliszek, MSc, Anna Polak, MSc, Emilia Bialopiotrowicz, PhD, Ewa Jablonska, PhD, Maciej Szydlowski, PhD, Ewa Lech-Maranda, MD PhD, Katarzyna Borg, PhD, Hanna Makuch-Lasica, MSc, Adam Zabek, MSc, Piotr Mlynarz, PhD, Tomasz Stoklosa, MD PhD, Sebastian Giebel, MD PhD, Krzysztof Warzocha, MD PhD, Przemyslaw Juszczynski, MD PhD

Blood (2015) 126 (23): 1436.

https://doi.org/10.1182/blood.V126.23.1436.1436

Published: 2015

Journal Articles

A Novel Pan-PIM Kinase Inhibitor, SEL24-B489, Induces Apoptosis and Inhibits Proliferation of Diffuse Large B-Cell Lymphoma Cells through Inhibition of Protein Translation and Attenuation of Myc and NFkB Activity

Ewa Jablonska, PhD, Maciej Szydlowski, PhD, Emilia Bialopiotrowicz, PhD, Przemyslaw Kiliszek, MSc, Tomasz Sewastianik, MSc, Anna Polak, MSc, Krzysztof Warzocha, MD PhD, Wojciech Czardybon, PhD, Michal Galezowski, PhD, Renata Windak, PhD, Aniela Golas, PhD, Krzysztof Brzozka, PhD, Przemyslaw Juszczynski, MD PhD

Blood (2015) 126 (23): 706.

https://doi.org/10.1182/blood.V126.23.706.706

Published: 2015

Journal Articles

CXCR4 Upregulation Is a Biomarker Of Sensitivity To Targeted Inhibition Of B-Cell Receptor Signaling In Diffuse Large B-Cell Lymphoma

Linfeng Chen, PhD, Yansheng Hao, MD, PhD, Jing Ouyang, PhD, Bjoern Chapuy, MD, PhD, Donna S. Neuberg, ScD, Thomas M Habermann, MD, Przemyslaw Juszczynski, MD, PhD, Scott J Rodig, MD, PhD, Stefano Monti, PhD, Margaret A Shipp, MD

Blood (2013) 122 (21): 631.

https://doi.org/10.1182/blood.V122.21.631.631

Published: 2013

Journal Articles

The BBAP E3 Ligase Monoubiquitylates Histone H4 at Lysine 91 and Selectively Modulates the DNA Damage Response in Chemotherapy-Resistant Lymphomas.

Qingsheng Yan, PH.D., Shilpee Dutt, Ph.D., Rong Xu, Katherine Graves, Przemyslaw Juszczynski, MD, PhD, John Manis, MD, Margaret A. Shipp, MD

Blood (2009) 114 (22): 3958.

https://doi.org/10.1182/blood.V114.22.3958.3958

Published: 2009

Journal Articles

Expression and Targeted Inhibition of the Immunoregulatory Carbohydrate-Binding Lectin, Galectin 1, in EBV-Driven Post-Transplant Lymphoproliferative Disorders.

Jing Ouyang, PhD, Przemyslaw Juszczynski, MD, PhD, Evan O'Donnell, Myriam Armant, PhD, Scott J. Rodig, MD, PhD, Kunihiko Takeyama, MD, PhD, Stefano Monti, PhD, Gabriel Rabinovich, PhD, Jeffery Lorne Kutok, MD, PhD, Jerome Ritz, MD, Margaret A. Shipp, MD

Blood (2009) 114 (22): 96.

https://doi.org/10.1182/blood.V114.22.96.96

Published: 2009

Journal Articles

Selective Expression of the Immunoregulatory Lectin, Galectin-1, in Precursor B Cell Acute Lymphoblastic Leukemias (ALLs) with MLL Rearrangements

Przemyslaw Juszczynski, MD, PhD, Scott J. Rodig, MD, PhD, Kunihiko Takeyama, MD, PhD, Jing Ouyang, PhD, Jorg Faber, MD, PhD, Scott Armstrong, MD, PhD, Jeffery L. Kutok, MD, PhD, Margaret A. Shipp, MD

Blood (2008) 112 (11): 2539.

https://doi.org/10.1182/blood.V112.11.2539.2539

Published: 2008

NARROW

Inhibition of PIM Kinases in Diffuse Large B-Cell Lymphoma Cells Targets MYC-Dependent Transcriptional Program, Increases CD20 Expression and Augments the Efficacy of Anti-CD20 Antibodies

SIRT1 and HSP90alpha Are Functionally Linked and Control Mitotic Chromosome Segregation and Cell Viability in a Subset of Dlbcls

Hodgkin Lymphoma Reed-Sternberg Cells Induce Immunosuppressive and Pro-Angiogenic Phenotype of Tumor-Associated Macrophages in a Paracrine Manner

PIM Kinase Inhibition Decreases the Proangiogenic Properties of Multiple Myeloma Cells and Affects the Metabolic State of the Vascular Endothelium

CDK8 Inhibitor SEL120-34A Has Therapeutic Efficacy in Murine and Human Acute Myeloid Leukemia Models

Functional Link Between Heat Shock Protein HSP90alpha and Sirtuin 1 (SIRT1) in the Pathogenesis of Diffuse Large B Cell Lymphoma

Downregulation of Deptor By MiR-155 Promotes Cell Survival through Activation of PI3K/AKT and NFkB Signaling in ABC-Type Diffuse Large B-Cell Lymphomas

Microenvironment-Induced Expression of PIM Kinases Supports Chronic Lymphocytic Leukemia Cells Survival and Promotes CXCR4-mTOR Pathway Dependent Migration

MiR-155 Amplifies AKT and NFkB Signaling By Targeting Multiple Regulators of BCR Signal in DLBCL

MEK1 Inhibitor Selumetinib Sensitizes Precursor B-Cell Acute Lymphoblastic Leukemia Cells (B-ALL) to Dexamethasone through Modulation of mTOR Activity and Stimulation of Autophagy

FOXO1-p300-Txn Circuit Regulates Oxidative Stress Responses in Diffuse Large B-Cell Lymphomas Characterized By Enhanced Oxidative Phosphorylation

FOXO1 Activation Is an Effector of SYK and AKT Inhibition in Tonic BCR Signal-Dependent Diffuse Large B-Cell Lymphomas

Expression of PIM Kinases in Reed-Sternberg Cells Fosters Immune Privilege and Tumor Cell Survival in Classical Hodgkin Lymphoma

Activity of PIM Kinases in Chronic Lymphocytic Leukemia Modulates Tumor Cell Survival and Stromal Interactions through a Pleiotropic Mechanism Involving Modulation of CXCR4 - mTOR Pathway

HIF1-Alpha and MYC Transcription Factor Signatures in B-Cell Acute Lymphoblastic Leukemia Are Associated with Positive Minimal Residual Disease Status: Therapeutic Implications

A Novel Pan-PIM Kinase Inhibitor, SEL24-B489, Induces Apoptosis and Inhibits Proliferation of Diffuse Large B-Cell Lymphoma Cells through Inhibition of Protein Translation and Attenuation of Myc and NFkB Activity

CXCR4 Upregulation Is a Biomarker Of Sensitivity To Targeted Inhibition Of B-Cell Receptor Signaling In Diffuse Large B-Cell Lymphoma

The BBAP E3 Ligase Monoubiquitylates Histone H4 at Lysine 91 and Selectively Modulates the DNA Damage Response in Chemotherapy-Resistant Lymphomas.

Expression and Targeted Inhibition of the Immunoregulatory Carbohydrate-Binding Lectin, Galectin 1, in EBV-Driven Post-Transplant Lymphoproliferative Disorders.

Selective Expression of the Immunoregulatory Lectin, Galectin-1, in Precursor B Cell Acute Lymphoblastic Leukemias (ALLs) with MLL Rearrangements

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American Society of Hematology

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American Society of Hematology

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