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Prem Ponka, MD, PhD
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Journal Articles

Heme Synthesis Is Inhibited in Erythroid Cells Derived from Beta-Thalassemic Mice

Daniel Garcia dos Santos, PhD, Amel Hamdi, PhD, Prem Ponka, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3494.
https://doi.org/10.1182/blood.V130.Suppl_1.3494.3494
Published: 2017
Journal Articles

Role of Heme in the Regulation of Transferrin Receptor Expression in Erythroid Cells

Amel Hamdi, PhD, Daniel Garcia dos Santos, PhD, Chun-Nam Lok, PhD, Matthias Schranzhofer, PhD, Prem Ponka, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3495.
https://doi.org/10.1182/blood.V130.Suppl_1.3495.3495
Published: 2017
Journal Articles

Heme Oxygenase 1 Inhibition Reverses Anemia in β-Thalassemia Mice

Daniel Garcia-Santos, PhD, Amel Hamdi, PhD, Zuzana Zidova, MSc, Monika Horvathova, PhD, Prem Ponka, MD PhD FCMA
Journal: Blood
Blood (2016) 128 (22): 2462.
https://doi.org/10.1182/blood.V128.22.2462.2462
Published: 2016
Journal Articles

Endosome-Mitochondria Interface Controls Intracellular Iron Trafficking in Erythroid Cells

Amel Hamdi, PhD, Daniel Garcia-Santos, PhD, Tariq Roshan, MD, Alex Sheftel, PhD, Prem Ponka, MD PhD FCMA
Journal: Blood
Blood (2016) 128 (22): 75.
https://doi.org/10.1182/blood.V128.22.75.75
Published: 2016
Journal Articles

Pathophysiology and Treatment of Beta-Thalassemia: Investigations of Heme Oxygenase 1 and Its Inhibitors

Daniel Garcia dos Santos, PhD, Zuzana Zidova, MSc, Marc Mikhael, PhD, Amel Hamdi, PhD, Monika Horvathova, PhD, Prem Ponka, MD PhD FCMA
Journal: Blood
Blood (2015) 126 (23): 3373.
https://doi.org/10.1182/blood.V126.23.3373.3373
Published: 2015
Journal Articles

Interaction of Transferrin-Endosomes with Mitochondria: Implications for Iron Transport to Ferrochelatase in Erythroid Cells

Amel Hamdi, PhD, Tariq Roshan, MD, Alex Sheftel, PhD, Prem Ponka, MD PhD FCMA
Journal: Blood
Blood (2015) 126 (23): 407.
https://doi.org/10.1182/blood.V126.23.407.407
Published: 2015
Journal Articles

Transcriptional Induction of Transferrin Receptors By Heme in Erythroid Cells

Daniel Garcia dos Santos, PhD, Matthias Schranzhofer, MSc, PhD, Nam Lok Chun, PhD, Amel Hamdi, PhD, Prem Ponka, MD PhD FCMA
Journal: Blood
Blood (2015) 126 (23): 3352.
https://doi.org/10.1182/blood.V126.23.3352.3352
Published: 2015
Journal Articles

Further Elucidation of the Mechanism of Iron Transport Form Plasma Transferrin to Mitochondrial Ferrochelatase: Further Evidence for the “Kiss and Run” Hypothesis

Amel Hamdi, PhD, Tariq Roshan, MD, Alex Sheftel, PhD, Prem Ponka, MD PhD FCMA
Journal: Blood
Blood (2014) 124 (21): 4023.
https://doi.org/10.1182/blood.V124.21.4023.4023
Published: 2014
Journal Articles

Oxidative Stress and Increased Destruction of Red Blood Cells Contribute to the Pathophysiology of Anemia Caused By DMT1 Deficiency

Zuzana Zidova, MSc, Daniel Garcia-Santos, PhD, Katarina Kapralova, MSc, Pavla Koralkova, MSc, Renata Mojzikova, PhD, Dalibor Dolezal, DVM, Prem Ponka, MD PhD FCMA, Vladimir Divoky, PhD, Monika Horvathova, PhD
Journal: Blood
Blood (2014) 124 (21): 4027.
https://doi.org/10.1182/blood.V124.21.4027.4027
Published: 2014
Journal Articles

Uncovering the Role of Heme Oxygenase 1 in the Pathophysiology of β-Thalassemia

Daniel Garcia-Santos, PhD, Marc Mikhael, PhD, Monika Horvathova, PhD, Prem Ponka, MD PhD
Journal: Blood
Blood (2014) 124 (21): 1364.
https://doi.org/10.1182/blood.V124.21.1364.1364
Published: 2014
Journal Articles

Exogenous Apo-Transferrin Increases Monoferric Transferrin, Decreasing Cytosolic Iron Uptake and Heme and Globin Synthesis in β-Thalassemic Mice

Tenzin Choesang, Huihui Li, MS, Michael Dussiot, Thiago Maciel, PhD, Laura Breda, PhD, Daniel Garcia Santos, PhD, Huiyong Chen, PhD, Maria Feola, Weili Bao, Petra Pham, Antonia Follenzi, Guiyuan Li, Ivan Cruz Moura, PhD, Prem Ponka, MD PhD, Robert E Fleming, MD, Stefano Rivella, PhD, Yelena Ginzburg, MD
Journal: Blood
Blood (2014) 124 (21): 4037.
https://doi.org/10.1182/blood.V124.21.4037.4037
Published: 2014
Journal Articles

Heme Oxygenase 1 Plays a Role In The Pathophysiology Of β-Thalassemia

Daniel Garcia Santos, Ph.D., Marc Mikhael, PhD, Stefano Rivella, PhD, Monika Horvathova, PhD, Prem Ponka, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 3449.
https://doi.org/10.1182/blood.V122.21.3449.3449
Published: 2013
Journal Articles

The Erythropoietin Receptor Regulates The Number Of Cell Divisions and The Duration Of Erythroblast Terminal Differentiation By Regulating Erythroblast Iron

Daniel Hidalgo, MA, Ramona Pop, Prem Ponka, MD, PhD, Merav Socolovsky, MBBS, PhD
Journal: Blood
Blood (2013) 122 (21): 428.
https://doi.org/10.1182/blood.V122.21.428.428
Published: 2013
Journal Articles

SNX3 Regulates Recycling of the Transferrin Receptor and Iron Assimilation in Developing Erythrocytes*

Caiyong Chen, Ph.D., Daniel Garcia Santos, Ph.D., Yuichi Ishikawa, Ph.D., Alexandra Seguin, Liangtao Li, Ph.D., Katherine H. Fegan, MS, Gordon J. Hildick-Smith, Jeffrey D. Cooney, MA, Wen Chen, Ph.D., Matthew J. King, Iman J. Schultz, Ph.D., Yvette Y. Yien, Ph.D., Arthur J. Dalton, Paul D Kingsley, Ph.D., James Palis, MD, Shilpa Hattangadi, MD, Harvey F. Lodish, PhD, Diane M. Ward, Ph.D., Jerry Kaplan, Ph.D., Takahiro Maeda, M.D., Ph.D., Prem Ponka, MD, PhD, Barry H. Paw, M.D., Ph.D.
Journal: Blood
Blood (2012) 120 (21): 607.
https://doi.org/10.1182/blood.V120.21.607.607
Published: 2012
Journal Articles

Heme Oxygenase 1 Plays An Unexpected Role During Erythroid Differentiation

Daniel Garcia Santos, Phd, Matthias Schranzhofer, MSc, PhD, José Artur Bogo Chies, Msc, Phd, Prem Ponka, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 344.
https://doi.org/10.1182/blood.V118.21.344.344
Published: 2011
Journal Articles

Glycine Transporter 1 Plays a Crucial Role in Hemoglobinization

Matthias Schranzhofer, MSc, PhD, Richard Bergeron, MD, PhD, Prem Ponka, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 345.
https://doi.org/10.1182/blood.V118.21.345.345
Published: 2011
Journal Articles

Further Evidence for the “Kiss and Run” Hypothesis of Iron Delivery to Mitochondria in Erythroid Cells,

Tariq Roshan, MD, Tanya Kahawita, MSc, Matthias Schranzhofer, MSc, PhD, Marc Mikhael, PhD, Anne B Mason, Alex Sheftel, PhD, Prem Ponka, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 3178.
https://doi.org/10.1182/blood.V118.21.3178.3178
Published: 2011
Journal Articles

Transcriptional Regulation of Transferrin Receptor by Heme in Erythroid Cells

Matthias Schranzhofer, MSc, PhD, Nam-Chun Lok, PhD, Manfred Schifrer, MSc, Ernst W Muellner, PhD, Prem Ponka, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 2049.
https://doi.org/10.1182/blood.V116.21.2049.2049
Published: 2010
Journal Articles

Nitrogen Monoxide Inhibits Heme Synthesis In Reticulocytes

Marc Mikhael, PhD, Sameer Apte, BSc, Shan Soe-Lin, PhD, Prem Ponka, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 4252.
https://doi.org/10.1182/blood.V116.21.4252.4252
Published: 2010
Journal Articles

Intraendosomal Transferrin Saturation Governs Interorganellar Association for Iron Delivery In Erythroid Cells

Tariq Roshan, MD, Tanya Kahawita, MSc, Matthias Schranzhofer, MSc, PhD, Marc Mikhael, PhD, Alex Sheftel, PhD, Prem Ponka, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 4253.
https://doi.org/10.1182/blood.V116.21.4253.4253
Published: 2010