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Pauline Rimmelé
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Zinc Finger Nuclease-Mediated Disruption of the BCL11A Erythroid Enhancer Results in Enriched Biallelic Editing, Increased Fetal Hemoglobin, and Reduced Sickling in Erythroid Cells Derived from Sickle Cell Disease Patients

Samuel Lessard, PhD, Pauline Rimmele, PhD, Hui Ling, PhD, Kevin Moran, MSc, Benjamin Vieira, BS, Yi-Dong Lin, PhD, Vu Hong, PhD, Andreas Reik, PhD, Denny Dang, Naoya Uchida, MD, John F. Tisdale, MD, Pablo Rendo, MD, Ahmed Daak, PhD, Alexandra Hicks, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 974.
https://doi.org/10.1182/blood-2019-126048
Published: 2019
Journal Articles

Ex Vivo Gene-Edited Cell Therapy for Sickle Cell Disease: Disruption of the BCL11A Erythroid Enhancer with Zinc Finger Nucleases Increases Fetal Hemoglobin in Plerixafor Mobilized Human CD34+ Cells

Kevin Moran, MSc, Hui Ling, PhD, Samuel Lessard, PhD, Benjamin Vieira, Vu Hong, PhD, Michael C. Holmes, PhD, Andreas Reik, PhD, Denny Dang, David Gray, Dana Levasseur, PhD, Pauline Rimmele, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2190.
https://doi.org/10.1182/blood-2018-99-116998
Published: 2018
Journal Articles

Spi-1/PU.1 Accelerates Replication Fork Elongation through PP1a Phosphatase-Associated Dephosphorylation of CHK1 in Erythroleukemic Cells

Pauline Rimmelé, Jean-Hugues Guervilly, Filippo Rosselli, Françoise Moreau-Gachelin, Christel Guillouf
Journal: Blood
Blood (2014) 124 (21): 2193.
https://doi.org/10.1182/blood.V124.21.2193.2193
Published: 2014
Journal Articles

A Systems Approach Identifies Essential FOXO3 Functions in Erythroblast Enucleation Process

Raymond Liang, Genís Campreciós, PhD, Yan Kou, Ms, Kathleen E McGrath, PhD, Roberta Novak, Seana C Catherman, B.S., Pauline Rimmele, PhD, Carolina L. Bigarella, PhD, Emery H Bresnick, PhD, Dmitri Papatsenko, PhD, Avi Ma'ayan, Velia M. Fowler, PhD, James Palis, MD, Saghi Ghaffari, MD PhD
Journal: Blood
Blood (2014) 124 (21): 445.
https://doi.org/10.1182/blood.V124.21.445.445
Published: 2014
Journal Articles

Loss Of p53 Rescues The Defective Function Of Foxo3 -/- Hematopoietic Stem Cells But Enhances Their Predisposition To Malignancy

Carolina L. Bigarella, PhD, Pauline Rimmele, PhD, Rebeca Dieguez-Gonzalez, PhD, Raymond Liang, Brigitte Izac, MSc, Dmitri Papatsenko, PhD, Saghi Ghaffari, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 4199.
https://doi.org/10.1182/blood.V122.21.4199.4199
Published: 2013
Journal Articles

Foxo3-Mediated Redox Regulation Is Required for DNA Damage Response in Hematopoietic Stem Cells.

Carolina L. Bigarella, PhD, Pauline Rimmele, PhD, Brigitte Izac, MSc, Valentina d'Escamard, MSc, Saghi Ghaffari, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 2295.
https://doi.org/10.1182/blood.V120.21.2295.2295
Published: 2012
Journal Articles

Acetylation Is Critical for Foxo3 Protein Stability and Activity in Hematopoietic Stem and Progenitor Cells

Carolina L. Bigarella, PhD, Pauline Rimmele, PhD, Raymond Liang, Yasaman Azodi, Brigitte Izac, MSc, Valentina d'Escamard, MSc, Saghi Ghaffari, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 1198.
https://doi.org/10.1182/blood.V120.21.1198.1198
Published: 2012
Journal Articles

Resveratrol Induces Erythroid Maturation by Activating FOXO3 and Improves in Vivo Erythropoiesis in Normal and Beta -Thalassemic Mice

Sara Santos Franco, PhD student, Luigia De Falco, PhD, Saghi Ghaffari, MD, PhD, Carlo Brugnara, M.D., David Sinclair, PhD, Achille Iolascon, MD, PhD, Mohandas Narla, DSc, Mariarita Bertoldi, PhD, Christophe Lebouf, PhD, Anne Janin, MD, PhD, Angela Siciliano, Mrs, Pauline Rimmele, PhD, Maria Domenica Cappellini, MD, Shady Michan, PhD, Elisa Zoratti, PhD, Lucia De Franceschi, MD
Journal: Blood
Blood (2012) 120 (21): 3191.
https://doi.org/10.1182/blood.V120.21.3191.3191
Published: 2012
Journal Articles

Metabolic Cross Talk Between Foxo3 and mTOR Is Essential for Hematopoietic Stem Cell Function

Pauline Rimmele, PhD, Valentina d'Escamard, MSc, Kocabas Fatih, Ph.D, Chengcheng Zhang, Ph.D, Hesham A. Sadek, M.D., Ph.D, Saghi Ghaffari, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 856.
https://doi.org/10.1182/blood.V120.21.856.856
Published: 2012
Journal Articles

Metabolic Pathways Control Normal and Beta-Thalassemic Erythroid Cell Maturation

Geníis Camprecióos, PhD, Xin Zhang, MD, PhD, Valentina D'Escamard, MSc, Pauline Rimmele, PhD, Carolina L. Bigarella, PhD, Brigitte Izac, MSc, Carlo Brugnara, M.D., Emery H Bresnick, PhD, Stefano Rivella, PhD, Saghi Ghaffari, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 369.
https://doi.org/10.1182/blood.V120.21.369.369
Published: 2012
Journal Articles

SIRT1 Deacetylase Is Essential for Hematopoietic Stem Cell Activity Via Regulation of Foxo3.

Pauline Rimmele, PhD, Carolina L. Bigarella, PhD, Valentina d'Escamard, MSc, Brigitte Izac, MSc, David Sinclair, PhD, Saghi Ghaffari, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 2315.
https://doi.org/10.1182/blood.V120.21.2315.2315
Published: 2012
Journal Articles

Regulation of Erythroid Cell Maturation Is Mediated by a Foxo3-mTOR Cross Talk: Outcome for Beta-Thalassemic Erythropoiesis

Xin Zhang, MD, PhD, Valentina D'Escamard, MSc, Pauline Rimmele, PhD, Saghi Ghaffari, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 176.
https://doi.org/10.1182/blood.V118.21.176.176
Published: 2011