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Paul Tamburini
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Journal Articles

First in Human Single-Ascending Dose Study: Safety, Biomarker, Pharmacokinetics and Exposure-Response Relationships of ALXN1210, a Humanized Monoclonal Antibody to C5, with Marked Half-Life Extension and Potential for Significantly Longer Dosing Intervals

Leonardo Sahelijo, MD, Arshad Mujeebuddin, MD, David Mitchell, PhD, Richard Larouche, MD, Zhao-Xue Yu, PhD, Yuchun Zhang, MD, Rekha Patel, Melissa Lasaro, PhD, Keith Bouchard, Bruce Andrien, PhD, Yi Wang, MD, Paul Tamburini, PhD, Susan Macdonald, PhD, Douglas Sheridan, PhD, Paresh Soni, MD PhD
Journal: Blood
Blood (2015) 126 (23): 4777.
https://doi.org/10.1182/blood.V126.23.4777.4777
Published: 2015
Journal Articles

A Rare Genetic Polymorphism In C5 Confers Poor Response To The Anti-C5 Monoclonal Antibody Eculizumab In 11 Japanese Patients With PNH

Jun-ichi Nishimura, MD, PhD, Masaki Yamamoto, MD, Shin Hayashi, MD, PhD, Kazuma Ohyashiki, MD, PhD, Kiyoshi Ando, MD, PhD, Hideyoshi Noji, MD, PhD, Kunio Kitamura, MD, PhD, Tetsuya Eto, MD, PhD, Toru Takahashi, MD, Masayoshi Masuko, MD, PhD, Takuro Matsumoto, MD, Yuji Wano, MD, PhD, Tsutomu Shichishima, MD, PhD, Hirohiko Shibayama, Masakazu Hase, PhD, Li Lan, MD, Krista Johnson, Paul Tamburini, PhD, Johji Inazawa, MD, PhD, Taroh Kinoshita, PhD, Yuzuru Kanakura
Journal: Blood
Blood (2013) 122 (21): 3709.
https://doi.org/10.1182/blood.V122.21.3709.3709
Published: 2013
Journal Articles

A Rare Genetic Polymorphism in C5 Confers Poor Response to the Anti-C5 Monoclonal Antibody Eculizumab by Nine Japanese Patients with PNH

Jun-ichi Nishimura, MD, PhD, Masaki Yamamoto, MD, Shin Hayashi, MD, PhD, Kazuma Ohyashiki, MD, Kiyoshi Ando, MD, Hideyoshi Noji, MD, PhD, Kunio Kitamura, MD, Tetsuya Eto, MD, Toshihiko Ando, MD, Masayoshi Masuko, MD, PhD, Hirohiko Shibayama, Masakazu Hase, PhD, Li Lan, Paul Tamburini, Johji Inazawa, MD, PhD, Taroh Kinoshita, PhD, Yuzuru Kanakura, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 3197.
https://doi.org/10.1182/blood.V120.21.3197.3197
Published: 2012