1-9 of 9
Olivier Humbert, PhD
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Multiplex CRISPR/Cas9 Genome Editing Targeting the BCL11A/HBG Axis Maximizes Fetal Hemoglobin Reinduction but Generates Chromosomal Translocations Which Persist In Vivo

Clare Samuelson, Olivier Humbert, PhD, Stefan Radtke, PhD, Haiying Zhu, Mallory J Llewellyn, BS, Emily Fields, BS, Savannah Cook, BS, Meei-Li W Huang, Olivier Negre, PhD, Keith Jerome, MDPhD, Hans-Peter Kiem, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 47–48.
https://doi.org/10.1182/blood-2020-138539
Published: 2020
Journal Articles

CRISPR/Cas9-Mediated Protection of Normal Hematopoiesis Combined with the CD33/CD3 Bispecific T-Cell Engager (BiTE) Antibody AMG330 for Improved AML Therapy

Olivier Humbert, PhD, Mallory J Llewellyn, George S. Laszlo, PhD, Roland B. Walter, MD PhD MS, Hans-Peter Kiem, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4427.
https://doi.org/10.1182/blood-2019-129399
Published: 2019
Journal Articles

Engineering Resistance to CD33-Targeted Immunotherapy in Normal Hematopoiesis By CRISPR/Cas9-Deletion of CD33 Exon 2

Roland B. Walter, MD PhD MS, Olivier Humbert, PhD, George S. Laszlo, PhD, Sophie R. Sichel, BS, Christina M. Ironside, BS, Kevin G. Haworth, PhD, Olivia M. Bates, BA, Mary E. Beddoe, BS, Ray R. Carillo, BS, Hans-Peter Kiem, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2200.
https://doi.org/10.1182/blood-2018-99-117856
Published: 2018
Journal Articles

Persistence of CRISPR/Cas9-Edited Hematopoietic Stem and Progenitor Cells and Reactivation of Fetal Hemoglobin in Nonhuman Primates

Olivier Humbert, PhD, Stefan Radtke, PhD, Ray R Carillo, Anai M Perez, Sowmya Somashekar Reddy, Lauren E Schefter, Christopher Lux, MDPhD, Sowmya Pattabhi, PhD, Olivier Negre, PhD, Ciaran M Lee, PhD, Jennifer Adair, PhD, Christopher Peterson, PhD, Gang Bao, PhD, David J. Rawlings, MD, Andrew M. Scharenberg, MD, Hans-Peter Kiem, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 806.
https://doi.org/10.1182/blood-2018-99-112996
Published: 2018
Journal Articles

Talen Mediated Therapeutic Gene Editing Strategy for ß-Hemoglobinopathies

Christopher Lux, MDPhD, Kyle Jacoby, PhD, Sowmya Pattabhi, PhD, Julia Yang, BS, Olivier Humbert, PhD, Brian Gordon, MS, Irwin D. Bernstein, MD, David J. Rawlings, MD, Andrew M. Scharenberg, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3340.
https://doi.org/10.1182/blood.V130.Suppl_1.3340.3340
Published: 2017
Journal Articles

Rapid Expansion of Gene-Marked Lymphocytes in X-SCID Dogs after AMD3100+G-CSF-Based Hematopoietic Stem/Progenitor Cell Mobilization and Intravenous Injection of a Common γ-Chain Expressing Foamy Viral Vector

Frieda Chan, PhD, Olivier Humbert, PhD, Troy Torgerson, MD PhD, Nicholas Hubbard, Patricia O'Donnell, Daniel R Humphrys, B.S., Jennifer E Adair, PhD, Peter Felsburg, Grant D. Trobridge, PhD, Andrew M. Scharenberg, MD, David J. Rawlings, MD, Hans-Peter Kiem, MD FACP
Journal: Blood
Blood (2016) 128 (22): 1348.
https://doi.org/10.1182/blood.V128.22.1348.1348
Published: 2016
Journal Articles

Long-Term Increase in Fetal Hemoglobin Expression in Nonhuman Primates Following Transplantation of Autologous Bcl11a Nuclease-Edited HSCs

Olivier Humbert, PhD, Hans-Peter Kiem, MD
Journal: Blood
Blood (2015) 126 (23): 2035.
https://doi.org/10.1182/blood.V126.23.2035.2035
Published: 2015
Journal Articles

Pgk-Mediated Expression of Common Gamma Chain Is More Effective Than EF1a for Therapeutic Immune Reconstitution of X-SCID Dogs after In Vivo Gene Therapy with Foamy Virus Vector

Olivier Humbert, PhD, Christopher R Burtner, PhD, Patricia O'Donnell, Daniel R Humphrys, B.S., Nicholas Hubbard, Frieda Chan, PhD, Jennifer E Adair, PhD, Grant D. Trobridge, PhD, Troy Torgerson, MD PhD, Andrew M. Scharenberg, MD, David J. Rawlings, MD, Peter Felsburg, Hans-Peter Kiem, MD
Journal: Blood
Blood (2015) 126 (23): 262.
https://doi.org/10.1182/blood.V126.23.262.262
Published: 2015
Journal Articles

Robust Therapeutic Expression of the Common Gamma Chain with the Human Pgk Promoter Using Foamy Virus in Vivo Gene Therapy in a Canine Model of Severe Combined Immunodeficiency

Christopher R Burtner, PhD, Olivier Humbert, PhD, Patricia O'Donnell, Nicholas Hubbard, Daniel Humphrys, Jennifer E Adair, PhD, Grant D Trobridge, PhD, Troy R Torgerson, MD PhD, Andrew M Scharenberg, MD, David Rawlings, MD, Peter J Felsburg, VMD, PhD, Hans-Peter Kiem, MD
Journal: Blood
Blood (2014) 124 (21): 4794.
https://doi.org/10.1182/blood.V124.21.4794.4794
Published: 2014