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Journal Articles

Defining the Differentiation States of Multiple Myeloma at Single Cell Resolution Reveals Opportunities for Immunotherapy

Julia Frede, PhD MPhil, Praveen Anand, PhD, Andrew J. Yee, MD, Tushara Vijaykumar, Monica S. Nair, Johannes M. Waldschmidt, MD, Sayalee V. Potdar, Jake A. Kloeber, Antonis Kokkalis, PhD MSc, Guangwu Guo, PhD, Samantha J. Shapiro, Mason L. Mann, Robb S Friedman, MD, Brea C. Lipe, MD, Erica L. Campagnaro, MD, Craig E. Cole, MD, Elizabeth K. O'Donnell, MD, Thomas Guerrero, MD, Omar Nadeem, MD, Jacob P. Laubach, MD, Nikhil C. Munshi, MD, Paul G. Richardson, MD, Kenneth C. Anderson, MD, Noopur Raje, MD, Birgit Knoechel, MD PhD, Jens G. Lohr, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3091.
https://doi.org/10.1182/blood-2019-130247
Published: 2019
Journal Articles

Osteoclast-Induced Immunosuppression Occurs through Dysregulation of Immune Checkpoint Axes in Multiple Myeloma

Kenta Mukaihara, MD PhD, Mattia D'Agostino, MD, Cristina Panaroni, PhD, Keertik Fulzele, PhD, Tomoaki Mori, MD PhD, Ka Tat Siu, PhD, Shrikanta Chattopadhyay, MBBS, Noopur Raje, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4382.
https://doi.org/10.1182/blood-2019-130462
Published: 2019
Journal Articles

A Phase I, Open-Label Study to Evaluate the Safety, Pharmacokinetic, Pharmacodynamic, and Clinical Activity of PF-06863135, a B-Cell Maturation Antigen/CD3 Bispecific Antibody, in Patients with Relapsed/Refractory Advanced Multiple Myeloma

Alexander M. Lesokhin, MD, Noopur Raje, MD, Cristina J Gasparetto, MD, Justine Walker, MD, Heike I. Krupka, PhD PMP, Tenshang Joh, PhD, Carrie T. Taylor, PhD MHS, Andrzej Jakubowiak, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3229.
https://doi.org/10.1182/blood-2018-99-110427
Published: 2018
Journal Articles

Renal Response in Carfilzomib (K)- Versus Bortezomib (V)-Treated Patients (Pts) with Relapsed or Refractory Multiple Myeloma (RRMM) in the Real-World Practice Setting

Shaji K. Kumar, MD, Alan Fu, PhD MPH, Khalid Mezzi, Megan Braunlin, Christopher Kim, PhD, Karim Iskander, Ruben Niesvizky, MD, Sundar Jagannath, MD, Ralph Boccia, MD, Noopur Raje, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3253.
https://doi.org/10.1182/blood-2018-99-113519
Published: 2018
Journal Articles

Progression-Free Survival Subset Analysis - Denosumab Vs Zoledronic Acid in Bone Disease Treatment of Newly Diagnosed Multiple Myeloma: An International, Double-Blind, Double-Dummy, Randomized Controlled Phase 3 Study

Evangelos Terpos, MD PhD, Wolfgang Willenbacher, MD, Kazuyuki Shimizu, MD PhD, Ramon García-Sanz, MD PhD, Anthony Glennane, MD, Xuesong Guan, Daniela Niepel, Noopur Raje, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1969.
https://doi.org/10.1182/blood-2018-99-113587
Published: 2018
Journal Articles

Mature Osteoblasts Provide a Protective Niche Against Multiple Myeloma Growth and Survival within the Tumor Microenvironment

Keertik Fulzele, PhD, Cristina Panaroni, PhD, Rosemary Soucy, Ka Tat Siu, PhD, Kenta Mukaihara, MD PhD, Noopur Raje, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4476.
https://doi.org/10.1182/blood-2018-99-118377
Published: 2018
Journal Articles

The Pleiotropic Immunosuppressive Role of Osteoclasts in Multiple Myeloma

Kenta Mukaihara, MD PhD, Ka Tat Siu, PhD, Cristina Panaroni, PhD, Keertik Fulzele, PhD, Rosemary Soucy, Cherrie Huang, Shrikanta Chattopadhyay, MBBS, Noopur Raje, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4447.
https://doi.org/10.1182/blood-2018-99-114922
Published: 2018
Journal Articles

Arachidonic Acid Induces Ferroptosis-Mediated Cell-Death in Multiple Myeloma

Cristina Panaroni, PhD, Keertik Fulzele, PhD, Rosemary Soucy, Ka Tat Siu, PhD, Kenta Mukaihara, MD PhD, Cherrie Huang, Shrikanta Chattopadhyay, MBBS, Noopur Raje, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4498.
https://doi.org/10.1182/blood-2018-99-118482
Published: 2018
Journal Articles

Overcoming MCL1 Resistance in Multiple Myeloma

Ka Tat Siu, PhD, Cherrie Huang, Cristina Panaroni, PhD, Kenta Mukaihara, MD PhD, Keertik Fulzele, PhD, Rosemary Soucy, Justin Cidado, PhD, Lisa Drew, PhD, Shrikanta Chattopadhyay, MBBS, Noopur Raje, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 472.
https://doi.org/10.1182/blood-2018-99-116377
Published: 2018
Journal Articles

Evolving Areas of Consensus and Disagreement Among Experts in Treatment of Patients with Multiple Myeloma (MM)

Kristen M Rosenthal, PhD, Irene M. Ghobrial, MD, Carol Ann Huff, MD, Sagar Lonial, MD, Noopur Raje, MD, Kevin L Obholz, PhD, Shaji K. Kumar, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5664.
https://doi.org/10.1182/blood-2018-99-118941
Published: 2018
Journal Articles

Initial Results from a Phase 1 Clinical Study of bb21217, a Next-Generation Anti Bcma CAR T Therapy

Nina Shah, MD, Melissa Alsina, MD, David S Siegel, MD PhD, Sundar Jagannath, MD, Deepu Madduri, MD, Jonathan L Kaufman, MD, Ashley Turka, Lyh Ping Lam, PharmD, RPh, Monica Massaro, MPH, Kristen Hege, MD, Fabio Petrocca, MD, Jesus G. Berdeja, MD, Noopur Raje, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 488.
https://doi.org/10.1182/blood-2018-99-116953
Published: 2018
Journal Articles

Analysis of Hospitalization and Readmissions after CAR T Cell Therapy

Elizabeth O'Donnell, MD, Hao Deng, MD, Kyan Safavi, William Driscoll, MD, Milcho Nikolov, Andrew J Yee, MD, Noopur Raje, MD, Matthiew Frigault, MD MSc, Dusan Handiziar, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2301.
https://doi.org/10.1182/blood-2018-99-112254
Published: 2018
Journal Articles

Patient Preferences for Multiple Myeloma (MM) Treatment: Interim Analysis of a Discrete Choice Experiment

Caroline McKay, PhD, Eric M Maiese, PhD, Joseph Chiarappa, PhD, M. Janelle Cambron-Mellott, PhD, Martine Maculaitis, PhD, Nicole Alunni, MS, Noopur Raje, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3586.
https://doi.org/10.1182/blood-2018-99-112921
Published: 2018
Journal Articles

Genomic Discovery and Clonal Tracking in Multiple Myeloma By Cell Free DNA Sequencing

Guangwu Guo, PhD, Noopur Raje, MD, Charles M Seifer, Jake Kloeber, Randi Isenhart, Gavin Ha, PhD, Andrew J. Yee, MD, Elizabeth K. O'Donnell, MD, Yu-Tzu Tai, PhD, Jordan Voisine, Julia Frede, PhD, Antonis Kokkalis, PhD, Huiyoung Yun, PhD, Valeriya Dimitrova, PhD, Erica Gemme, Matthew Meyerson, MD PhD, Nikhil C Munshi, MD, Kenneth C. Anderson, MD, Birgit Knoechel, MDPhD, Jens G Lohr, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 329.
https://doi.org/10.1182/blood.V130.Suppl_1.329.329
Published: 2017
Journal Articles

Expression of B Cell Maturation Antigen (BCMA) and Transmembrane Activator and Caml Interactor (TACI) Are Correlated and Can be Targeted at Multiple Points during the Course of Multiple Myeloma

Allison O. Taylor, Matthew J. Frigault, MD, Felipe Bedoya, PhD, Michelle E. DeLelys, Alexandra J. Shay, Rachel T. Nicholson, Noopur Raje, MD, Fredric I. Preffer, PhD, Timothy A. Graubert, MD, Marcela V. Maus, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 5363.
https://doi.org/10.1182/blood.V130.Suppl_1.5363.5363
Published: 2017
Journal Articles

Role of Sclerostin in Multiple Myeloma Progression

Cristina Panaroni, PhD, Keertik Fulzele, PhD, Ka Tat Siu, PhD, Peter Wang, BS, Noopur Raje, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4341.
https://doi.org/10.1182/blood.V130.Suppl_1.4341.4341
Published: 2017
Journal Articles

Updated Results from a Phase Ib Study of Isatuximab Plus Pomalidomide (Pom) and Dexamethasone (dex) in Relapsed/Refractory Multiple Myeloma (RRMM)

Paul G Richardson, MD, Joseph Mikhael, MD, Saad Z Usmani, MD, Noopur Raje, MD, William Bensinger, MD, Dheepak Kanagavel, MD PhD, Lei Gao, Samira Ziti-Ljajic, Kenneth C Anderson, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1887.
https://doi.org/10.1182/blood.V130.Suppl_1.1887.1887
Published: 2017
Journal Articles

Durable Clinical Responses in Heavily Pretreated Patients with Relapsed/Refractory Multiple Myeloma: Updated Results from a Multicenter Study of bb2121 Anti-Bcma CAR T Cell Therapy

Jesus G. Berdeja, MD, Yi Lin, MD PhD, Noopur Raje, MD, Nikhil Munshi, MD, David Siegel, MD PhD, Michaela Liedtke, MD, Sundar Jagannath, MD, Marcela V. Maus, MD PhD, Ashley Turka, Lyh Ping Lam, PharmD, RPh, Kristen Hege, MD, Richard A. Morgan, PhD, Michael Travis Quigley, James N. Kochenderfer, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 740.
https://doi.org/10.1182/blood.V130.Suppl_1.740.740
Published: 2017
Journal Articles

High Rate of Sustained Minimal Residual Disease Negativity Predicts Prolonged Survival for the Overall Patient Population in the Phase 2 KRd Plus Autologous Stem Cell Transplantation MMRC Trial

Andrzej J. Jakubowiak, MD, Noopur Raje, MD, Ravi Vij, MDMBA, Donna Reece, MD FRCP(C), Jesus G. Berdeja, MD, Leonor Stephens, Kathryn M. Tinari, Cara A. Rosenbaum, Jagoda K. Jasielec, Paul G Richardson, MD, Sandeep Gurbuxani, Jennifer Nam, Erica Severson, Amanda McIver, Brittany Wolfe, Sarah Major, Shaun Rosebeck, Andrew Stefka, MS, David Johnson, Dominik Dytfeld, Kent Griffith, Agata Turowski, Tyler Hycner, Todd M. Zimmerman
Journal: Blood
Blood (2017) 130 (Supplement 1): 4533.
https://doi.org/10.1182/blood.V130.Suppl_1.4533.4533
Published: 2017
Journal Articles

Ibrutinib Is Highly Active As First Line Therapy in Symptomatic Waldenstrom's Macroglobulinemia

Steven P Treon, MDPhDFRCP, Joshua Gustine, Kirsten Meid, MPH, Toni Dubeau, NP, Patricia Severns, NP, Christopher Patterson, MAcc, Lian Xu, Guang Yang, PhD, Xia Liu, MD, Maria Demos, BS, Amanda Kofides, BS, Jiaji Chen, BS, Manit Munshi, MS, Nickolas Tsakmaklis, BA, Gloria Chan, MS, Andrew J Yee, MD, Noopur Raje, MD, Elizabeth O'Donnell, MD, Zachary Hunter, PhD, Jorge J. Castillo, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2767.
https://doi.org/10.1182/blood.V130.Suppl_1.2767.2767
Published: 2017