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Journal Articles

Targeted Deletion of Pparβ/δ in Myeloid Cells Enhances Their Tumor-Promoting Function

Anthos Christofides, Rinku Pal, Nikolaos Patsoukis, Vassiliki A Boussiotis

Blood (2023) 142 (Supplement 1): 3908.

https://doi.org/10.1182/blood-2023-178186

Published: 2023

Journal Articles

Specific PD-1 Deletion on Regulatory T Cells Leads to Enhanced Anti-Tumor Responses

Konstantinos Aliazis, Anthos Christofides, Halil-Ibrahim Aksoylar, Rushil Shah, Rinku Pal, Nikolaos Patsoukis, Vassiliki A Boussiotis

Blood (2023) 142 (Supplement 1): 2551.

https://doi.org/10.1182/blood-2023-174422

Published: 2023

Journal Articles

Loss of the Nuclear Receptor Pparγ Primes T Effector (T EFF ) Differentiation of Antigen-Specific CD8 + T Cells

Rushil Shah, Xanthi-Leda Katopodi, Anthos Christofides, Rinku Pal, Ioannis Vlachos, Nikolaos Patsoukis, Vassiliki A Boussiotis

Blood (2022) 140 (Supplement 1): 2637–2638.

https://doi.org/10.1182/blood-2022-170612

Published: 2022

Journal Articles

SHP-2 Regulates Myeloid Cell Differentiation, Anti-Tumor Responses and Innate Immune Memory

Anthos Christofides, Xanthi-Leda Katopodi, Carol Cao, Dimitra Karagkouni, Konstantinos Aliazis, Sasitorn Yenyuwadee, Rinku Pal, John Asara, Ioannis Vlachos, Nikolaos Patsoukis, Vassiliki A Boussiotis

Blood (2022) 140 (Supplement 1): 1403–1404.

https://doi.org/10.1182/blood-2022-170307

Published: 2022

Journal Articles

Pparα Ablation Suppresses T Cell Responses and Anti-Tumor Immunity By Compromising the Antigen-Presenting Properties of Tumor-Associated Macrophages

Anthos Christofides, Carol Cao, Qi Wang, Natalia M Tijaro-Ovalle, Eirini Konstantinidou, Rushil Shah, Chinmay Jani, Rinku Pal, Halil-Ibrahim Aksoylar, Nikolaos Patsoukis, Vassiliki A Boussiotis

Blood (2021) 138 (Supplement 1): 438.

https://doi.org/10.1182/blood-2021-149071

Published: 2021

Journal Articles

Myeloid-Specific SHP-2 Ablation Induces Robust Anti-Tumor Immunity That Is Not Further Enhanced By PD-1 Blockade

Anthos Christofides, MD, Natalia M Tijaro-Ovalle, MD, Halil-Ibrahim Aksoylar, PhD, Rinku Pal, MS, Abdelrahman AA Mahmoud, Laura Strauss, PhD, Nikolaos Patsoukis, PhD, Vassiliki A Boussiotis, MD PhD

Blood (2020) 136 (Supplement 1): 25–26.

https://doi.org/10.1182/blood-2020-138975

Published: 2020

Journal Articles

The Rap1-RIAM Pathway Regulates the Expression of Integrins αEβ7(CD103) and α4β7, Which Guide T Cell Homing to Intestinal Compartments

Yavuz-Furkan Yazicioglu, Halil-Ibrahim Aksoylar, PhD, Rinku Pal, MS, Nikolaos Patsoukis, PhD, Vassiliki A Boussiotis, MD PhD

Blood (2018) 132 (Supplement 1): 864.

https://doi.org/10.1182/blood-2018-99-119450

Published: 2018

Journal Articles

Metabolic Reprogramming of Myeloid Cells in Response to Factors of "Emergency" Myelopoiesis By Myeloid-Specific PD-1 Ablation, Regulates Myeloid Lineage Fate Commitment and Anti-Tumor Immunity

Laura Strauss, PhD, Jessica D Weaver, PhD, Rinku Pal, MS, John Asara, PhD, Nikolaos Patsoukis, PhD, Vassiliki A Boussiotis, MD PhD

Blood (2018) 132 (Supplement 1): 14.

https://doi.org/10.1182/blood-2018-99-117438

Published: 2018

Journal Articles

The Two SH2 Domains of SHP-2 Bridge Two PD-1 Molecules Resulting in SHP-2 Activation and PD-1-Mediated Inhibition

Nikolaos Patsoukis, PhD, Jonathan Duke-Cohan, PhD, Apoorvi Chaudhri, Eunyoung Park, PhD, Council Asia, Anders Berg, MD PhD, Gordon J Freeman, PhD, Michael Eck, Vassiliki A Boussiotis, MD PhD

Blood (2018) 132 (Supplement 1): 862.

https://doi.org/10.1182/blood-2018-99-117486

Published: 2018

Journal Articles

PD-1 Mediates Lineage Fate Determination and Function of Myeloid Cells in Response to Tumor-Mediated "Emergency" Myelopoiesis

Laura Strauss, PhD, Jessica D Weaver, PhD, Nikolaos Patsoukis, PhD, Vassiliki A Boussiotis, MD PhD

Blood (2017) 130 (Supplement 1): 445.

https://doi.org/10.1182/blood.V130.Suppl_1.445.445

Published: 2017

Journal Articles

Interaction of Both SH2 Domains of SHP-2 with a PD-1 Homodimer Is Required for PD-1-Mediated Inhibition of T Cell Responses

Nikolaos Patsoukis, PhD, Asia Council, Anders Berg, MD PhD, Kankana Bardhan, PhD, Jessica D Weaver, PhD, Kathleen M. Mahoney, MD PhD, Gordon J. Freeman, PhD, Vassiliki A. Boussiotis, MD PhD

Blood (2016) 128 (22): 859.

https://doi.org/10.1182/blood.V128.22.859.859

Published: 2016

Journal Articles

Prostaglandin E 2 Alters the Differentiation and Function of Antigen-Specific T Cells By Targeting the Metabolic Gene Regulatory Network Downstream of mTORC1

Christoph Herbel, PhD, Nikolaos Patsoukis, PhD, Jessica D Weaver, PhD, Vassiliki A. Boussiotis, MD PhD

Blood (2016) 128 (22): 552.

https://doi.org/10.1182/blood.V128.22.552.552

Published: 2016

Journal Articles

PD-1 Inhibits TCR Proximal Signaling By Sequestering SHP-2 Phosphatase and Facilitating Csk-Mediated Inhibitory Phosphorylation of Lck

Kankana Bardhan, PhD, Nikolaos Patsoukis, PhD, Duygu Sari, Theodore Anagnostou, Pranam Chatterjee, Gordon J. Freeman, PhD, Lequn Li, MD PhD, Vassiliki A. Boussiotis, MD PhD

Blood (2015) 126 (23): 283.

https://doi.org/10.1182/blood.V126.23.283.283

Published: 2015

Journal Articles

Rap1-GTP Augments TGF-b-Mediated Signaling in T Lymphocytes Via a Mechanism Dependent on the b Chain of LFA-1 Integrin

Kankana Bardhan, PhD, Nikolaos Patsoukis, PhD, Alexandra Plessa, Niko Tsopoulidis, Duygu Sari, Lequn Li, MD PhD, Vassiliki A. Boussiotis, MD PhD

Blood (2015) 126 (23): 3422.

https://doi.org/10.1182/blood.V126.23.3422.3422

Published: 2015

Journal Articles

RIAM Interacts with the Hematopoietic-Specific Adaptor Protein Gads and Forms a LAT-Independent Node of Signal Integration That Regulates Activation of PLC-γ1

Kankana Bardhan, PhD, Nikolaos Patsoukis, PhD, Donna M Berry, Jane McGlade, Vassiliki A. Boussiotis, MD PhD

Blood (2014) 124 (21): 4138.

https://doi.org/10.1182/blood.V124.21.4138.4138

Published: 2014

Journal Articles

Phosphorylation of Tyrosine 340 in the Plekstrin Homology Domain of RIAM Is Required for Translocation of RIAM to the Plasma Membrane, Phosphorylation of RIAM-Associated PLC-g1 and LFA-1 Activation

Duygu Sari, Niko Tsopoulidis, John M. Asara, PhD, Nikolaos Patsoukis, PhD, Vassiliki A. Boussiotis, MD PhD

Blood (2014) 124 (21): 2743.

https://doi.org/10.1182/blood.V124.21.2743.2743

Published: 2014

Journal Articles

Distinct Roles Of PD-1 Itsm and ITIM In Regulating Interactions With SHP-2, ZAP-70 and Lck, and PD-1-Mediated Inhibitory Function

Pranam Chatterjee, Nikolaos Patsoukis, PhD, Gordon J. Freeman, PhD, Vassiliki A. Boussiotis, MD, PhD

Blood (2013) 122 (21): 191.

https://doi.org/10.1182/blood.V122.21.191.191

Published: 2013

Journal Articles

PD-1 Induces Metabolic Reprogramming Of Activated T Cells From Glycolysis To Lipid Oxidation

Nikolaos Patsoukis, PhD, Pranam Chatterjee, Duygu Sari, Victoria Petkova, Lequn Li, MD, PhD, Vassiliki A. Boussiotis, MD, PhD

Blood (2013) 122 (21): 187.

https://doi.org/10.1182/blood.V122.21.187.187

Published: 2013

Journal Articles

Inhibition Of Cdk2 Promotes The Generation Of Inducible CD8 + T Regulatory Cells By Modulating The Epigenetic Regulator EZH2

Lequn Li, MD, PhD, Nikolaos Patsoukis, PhD, Anoma Nellore, MD, Vassiliki A. Boussiotis, MD, PhD

Blood (2013) 122 (21): 138.

https://doi.org/10.1182/blood.V122.21.138.138

Published: 2013

Journal Articles

PD-1 Decreases PTEN Protein Stability While Increasing PTEN Phosphatase Activity by Inhibiting CK2.

Nikolaos Patsoukis, PhD, Lequn Li, MD, PhD, Duygu Sari, Vassiliki A. Boussiotis, MD, PhD

Blood (2012) 120 (21): 2145.

https://doi.org/10.1182/blood.V120.21.2145.2145

Published: 2012

NARROW

Targeted Deletion of Pparβ/δ in Myeloid Cells Enhances Their Tumor-Promoting Function

Specific PD-1 Deletion on Regulatory T Cells Leads to Enhanced Anti-Tumor Responses

Loss of the Nuclear Receptor Pparγ Primes T Effector (T EFF ) Differentiation of Antigen-Specific CD8 + T Cells

SHP-2 Regulates Myeloid Cell Differentiation, Anti-Tumor Responses and Innate Immune Memory

Pparα Ablation Suppresses T Cell Responses and Anti-Tumor Immunity By Compromising the Antigen-Presenting Properties of Tumor-Associated Macrophages

Myeloid-Specific SHP-2 Ablation Induces Robust Anti-Tumor Immunity That Is Not Further Enhanced By PD-1 Blockade

The Rap1-RIAM Pathway Regulates the Expression of Integrins αEβ7(CD103) and α4β7, Which Guide T Cell Homing to Intestinal Compartments

Metabolic Reprogramming of Myeloid Cells in Response to Factors of "Emergency" Myelopoiesis By Myeloid-Specific PD-1 Ablation, Regulates Myeloid Lineage Fate Commitment and Anti-Tumor Immunity

The Two SH2 Domains of SHP-2 Bridge Two PD-1 Molecules Resulting in SHP-2 Activation and PD-1-Mediated Inhibition

PD-1 Mediates Lineage Fate Determination and Function of Myeloid Cells in Response to Tumor-Mediated "Emergency" Myelopoiesis

Interaction of Both SH2 Domains of SHP-2 with a PD-1 Homodimer Is Required for PD-1-Mediated Inhibition of T Cell Responses

Prostaglandin E 2 Alters the Differentiation and Function of Antigen-Specific T Cells By Targeting the Metabolic Gene Regulatory Network Downstream of mTORC1

PD-1 Inhibits TCR Proximal Signaling By Sequestering SHP-2 Phosphatase and Facilitating Csk-Mediated Inhibitory Phosphorylation of Lck

Rap1-GTP Augments TGF-b-Mediated Signaling in T Lymphocytes Via a Mechanism Dependent on the b Chain of LFA-1 Integrin

RIAM Interacts with the Hematopoietic-Specific Adaptor Protein Gads and Forms a LAT-Independent Node of Signal Integration That Regulates Activation of PLC-γ1

Phosphorylation of Tyrosine 340 in the Plekstrin Homology Domain of RIAM Is Required for Translocation of RIAM to the Plasma Membrane, Phosphorylation of RIAM-Associated PLC-g1 and LFA-1 Activation

Distinct Roles Of PD-1 Itsm and ITIM In Regulating Interactions With SHP-2, ZAP-70 and Lck, and PD-1-Mediated Inhibitory Function

PD-1 Induces Metabolic Reprogramming Of Activated T Cells From Glycolysis To Lipid Oxidation

Inhibition Of Cdk2 Promotes The Generation Of Inducible CD8 + T Regulatory Cells By Modulating The Epigenetic Regulator EZH2

PD-1 Decreases PTEN Protein Stability While Increasing PTEN Phosphatase Activity by Inhibiting CK2.

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American Society of Hematology

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American Society of Hematology

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