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Journal Articles

A Novel Therapeutic Approach In Acute Myeloid Leukemia (AML): In Vivo Preclinical Pharmacokinetic (PK), Pharmacodynamic (PD) and Antileukemia Activities Of Synthetic 2’-O-Methylphosphorothioate Mir-29b

Hongyan Wang, PhD, Ramasamy Santhanam, Ph.D, Zhiliang Xie, MD, Xiaomeng Huang, Ming Chiu, Mitch A. Phelps, PhD, Alison R Walker, MD, Michael A. Caligiuri, MD, Ramiro Garzon, MD, James Lee, PhD, Natarajan Muthusamy, DVM, Ph.D, Kenneth K. Chan, Ph.D, Guido Marcucci, MD

Blood (2013) 122 (21): 3933.

https://doi.org/10.1182/blood.V122.21.3933.3933

Published: 2013

Journal Articles

Changing The Treatment Paradigm For Previously Treated Chronic Lymphocytic Leukemia Patients With Del(17p) Karyotype

Deborah M Stephens, DO, Amy Stark, MAS, Jeffrey A. Jones, MD, MPH, Jennifer A. Woyach, MD, Kami Maddocks, Samantha M. Jaglowski, MD, MPH, Leslie A. Andritsos, MD, Joseph M. M. Flynn, DO, MPH, Michael R. Grever, MD, Gerard Lozanski, MD, Amy J. Johnson, PhD, Natarajan Muthusamy, DVM, Ph.D, Nyla A. Heerema, PhD, John C. Byrd, MD

Blood (2013) 122 (21): 2872.

https://doi.org/10.1182/blood.V122.21.2872.2872

Published: 2013

Journal Articles

B-1239, a Novel Anti-BAFF-R Afucosylated Human Antibody, Promotes Potent Natural Killer Cell- Mediated Antibody Dependent Cellular Cytotoxicity In Chronic Lymphocytic Leukemia Cells In- Vitro and Depletion Of Circulating Leukemic CLL B Cells In-Vivo

Emily M. McWilliams, B.S., Carolyn Cheney, B.S, Jeffrey A. Jones, MD, MPH, Joseph M. M. Flynn, DO, MPH, Kami Maddocks, MD, Leslie A. Andritsos, MD, Heather Huet, PhD, Hermann Gram, Ph.D., Johan Baeck, MD, Natarajan Muthusamy, DVM, Ph.D, John C. Byrd, MD

Blood (2013) 122 (21): 4185.

https://doi.org/10.1182/blood.V122.21.4185.4185

Published: 2013

Journal Articles

Prognostic Significance Of Cytogenetic Complexity and Del(17p) At Diagnosis Of Chronic Lymphocytic Leukemia (CLL)

Nyla A. Heerema, PhD, Natarajan Muthusamy, DVM, Ph.D, Amy S. Ruppert, MAS, Leslie A Andritsos, MD, Michael R. Grever, MD, Jeffrey A. Jones, MD, MPH, Kami Maddocks, MD, John C. Byrd, MD

Blood (2013) 122 (21): 1321.

https://doi.org/10.1182/blood.V122.21.1321.1321

Published: 2013

Journal Articles

Tumor Antigen ROR1 Targeted Delivery Of FTY720 Derivative OSU-2S Prolongs Survival In ROR1 Engineered Mouse Model Of Chronic Lymphocytic Leukemia

Rajeswaran Mani, DVM, Yicheng Mao, PhD, Frank W Frissora, M.S., Chi-ling Chiang, Jiang Wang, Yuan Zhao, Yun Wu, Bo Yu, Ph.D., Ribai Yan, Xiaokui Mo, PhD, Sivasubramanian Baskar, PhD, Christoph Rader, Ph.D., Mitch A. Phelps, PhD, Robert J. Lee, Ph.D, Ching-Shih Chen, PhD, James Lee, PhD, John C. Byrd, MD, Natarajan Muthusamy, DVM, Ph.D

Blood (2013) 122 (21): 4168.

https://doi.org/10.1182/blood.V122.21.4168.4168

Published: 2013

Journal Articles

Ibrutinib (PCI-32765) Antagonizes Rituximab-Dependent NK-Cell Mediated Cytotoxicity

Holbrook E Kohrt, MD, PhD, Idit Sagiv-Barfi, PhD, Sarwish Rafiq, MS, Sarah E.M. Herman, Jonathan P Butchar, Ph.D., Carolyn Cheney, B.S, Xiaoli Zhang, PhD, MS, Joseph J. Buggy, PhD, Natarajan Muthusamy, DVM, Ph.D, Ronald Levy, MD, Amy J Johnson, PhD, John C. Byrd, MD

Blood (2013) 122 (21): 373.

https://doi.org/10.1182/blood.V122.21.373.373

Published: 2013

Journal Articles

Decitabine Or 5-Azacitidine Pre-Treatment Does Not Compromise The Novel Fc-Engineered Antibody Mab 33.1-Mediated ADCC Against Primary AML Blasts - A Rationale For Combination Therapy

Shun He, PhD, Carolyn Cheney, Susan P. Whitman, PhD, Jianhua Yu, PhD, Sumithira Vasu, MBBS, William Blum, MD, Karl-Heinz Heider, PhD, Guido Marcucci, MD, Natarajan Muthusamy, DVM, Ph.D

Blood (2013) 122 (21): 3959.

https://doi.org/10.1182/blood.V122.21.3959.3959

Published: 2013

Journal Articles

Externally Validated Predictive Clinical Model For Untreated Del(17p13.1) Chronic Lymphocytic Leukemia Patients

Deborah M Stephens, DO, Amy Stark, MAS, William G. Wierda, MD, PhD, Jeffrey A. Jones, MD, MPH, Jennifer A. Woyach, MD, Kami Maddocks, Samantha M. Jaglowski, MD, MPH, Leslie A Andritsos, MD, Joseph M. M. Flynn, DO, MPH, Michael R. Grever, MD, Gerard Lozanski, MD, Constantine S Tam, MBBS, FRACP, FRCPA, MD, Susan O'Brien, MD, Michael J. Keating, MD, Natarajan Muthusamy, DVM, Ph.D, Lynne V. Abruzzo, MD, PhD, Nyla A. Heerema, PhD, John C. Byrd, MD

Blood (2013) 122 (21): 4128.

https://doi.org/10.1182/blood.V122.21.4128.4128

Published: 2013

Journal Articles

Therapeutic Targeting of the RAS-Pathway by Synthetic Mir-181a Nanoparticles in Acute Myeloid Leukemia (AML).

Blood (2012) 120 (21): 2422.

https://doi.org/10.1182/blood.V120.21.2422.2422

Published: 2012

Journal Articles

TLR7/8 Agonists Overcome the Suppression of FcγR Activity in Monocytes From Chronic Lymphocytic Leukemia Patients

Jonathan P. Butchar, Ph.D., Prexy Shah, B. Sci, Hemal Patel, B. Sci, Kavin Fatehchand, Sarwish Rafiq, MS, Carolyn Cheney, B.S, John P Vasilakos, Ph.D., Natarajan Muthusamy, DVM, Ph.D, John C. Byrd, MD, Susheela Tridandapani, PhD

Blood (2012) 120 (21): 4595.

https://doi.org/10.1182/blood.V120.21.4595.4595

Published: 2012

Journal Articles

Immune Reconstitution At Days 30 and 100 Following Allogeneic Stem Cell Transplant and Association with Subsequent Development of Chronic Graft-Versus-Host Disease

Samantha M. Jaglowski, MD, MPH, Sumithira Vasu, MBBS, Susan Geyer, PhD, Anissa Bingman, M.S., Patrick Elder, MS, Jianhua Yu, PhD, William Blum, MD, Rebecca B Klisovic, MD, Sam Penza, MD, Yvonne A Efebera, M.D., Craig C. Hofmeister, MD, Don M. Benson, Jr., MD, PhD, Natarajan Muthusamy, DVM, Ph.D, Steven M. Devine, MD, Leslie A Andritsos, MD, Gerard Lozanski, MD

Blood (2012) 120 (21): 1949.

https://doi.org/10.1182/blood.V120.21.1949.1949

Published: 2012

Journal Articles

A Transgenic Mouse Model of Aggressive B-Cell Malignancy for Evaluating Anti-Human CD37 Therapeutics

Kyle A Beckwith, B.S., Frank W Frissora, M.S., Matthew R Stefanovski, B.S., Jutta Deckert, Ph.D., Carlo M Croce, M.D., Xiaokui Mo, PhD, David Jarjoura, PhD, John C. Byrd, MD, Natarajan Muthusamy, DVM, Ph.D

Blood (2012) 120 (21): 188.

https://doi.org/10.1182/blood.V120.21.188.188

Published: 2012

Journal Articles

Ibrutinib Is an Irreversible Molecular Inhibitor of Interleukin-2 Inducible Kinase: Expanding Therapeutic Potential and Modulating a Th1 Selective Pressure in CD4 T-Cells

Blood (2012) 120 (21): 775.

https://doi.org/10.1182/blood.V120.21.775.775

Published: 2012

Journal Articles

Lymphocyte Cytosolic Protein 1 (LCP1) Is a Membrane Associated Molecular Target in Chronic Lymphocytic Leukemia and Is Activated in Microenvironment Signaling

Danielle L Chappell, Jason A Dubovsky, Ph.D, Leslie A Andritsos, MD, Joseph M. Flynn, DO, MPH, Jeffrey A. Jones, MD, MPH, John C. Byrd, MD, Natarajan Muthusamy, DVM, Ph.D

Blood (2012) 120 (21): 3866.

https://doi.org/10.1182/blood.V120.21.3866.3866

Published: 2012

Journal Articles

Differential Distribution of Activated Innate and Adaptive Immune Subsets in G-CSF Mobilized Hematopoietic Stem Cell Allografts May Influence Incidence of Acute (aGVHD) and Chronic Graft-Versus-Host Disease (cGVHD)

Sumithira Vasu, MBBS, Samantha M. Jaglowski, MD, MPH, Susan Geyer, PhD, Anissa Bingman, M.S., Patrick Elder, M.S., Jianhua Yu, PhD, Leslie A Andritsos, MD, William Blum, MD, Rebecca B Klisovic, MD, Sam Penza, MD, Yvonne A Efebera, M.D., Craig C. Hofmeister, MD, Don M. Benson, Jr., MD, PhD, Natarajan Muthusamy, DVM, Ph.D, Steven M. Devine, MD, Gerard Lozanski, M.D.

Blood (2012) 120 (21): 4192.

https://doi.org/10.1182/blood.V120.21.4192.4192

Published: 2012

Journal Articles

Tetraspanin CD37 Directly Mediates Transduction of Survival and Apoptotic Signals

Rosa Lapalombella, PhD, Asha Ramanunni, MD, Yuh-Ying Yeh, PhD, Liwen Wang, PhD, Shruti Jha, Justin Staubli, Sarah E. M. Herman, PhD, Leslie A Andritsos, MD, Jeffrey A. Jones, MD, MPH, Joseph M. Flynn, DO, MPH, Xiaokui Mo, PhD, MAS, Amy J. Johnson, PhD, Peter Thompson, MD, Paul A. Algate, PhD, Scott Stromatt, MD, Michael A Freitas, Ph.D., Natarajan Muthusamy, DVM, Ph.D, John C. Byrd, MD

Blood (2011) 118 (21): 622.

https://doi.org/10.1182/blood.V118.21.622.622

Published: 2011

Journal Articles

Targeted Delivery of MicroRNA-29b by Nanoparticles Provides Antileukemic Activity and Increases Sensitivity to the Hypomethylating Agent Decitabine (DAC) in Acute Myeloid Leukemia (AML)

Xiaomeng Huang, Sebastian Schwind, MD, Bo Yu, Ph.D, Jiuxia Pang, Ramasamy Santhanam, Ph.D, Kenneth K. Chan, Ph.D, Ramiro Garzon, MD, William Blum, MD, Clara D. Bloomfield, MD, Shujun Liu, Ph.D, Danilo Perrotti, MD, Ph.D, Robert J. Lee, Ph.D, John C. Byrd, MD, Natarajan Muthusamy, DVM, Ph.D, L. James Lee, Ph.D, Guido Marcucci, MD

Blood (2011) 118 (21): 81.

https://doi.org/10.1182/blood.V118.21.81.81

Published: 2011

Journal Articles

OSU-2S, A Novel FTY720 derivative, Mediates Cytotoxicity In Chronic Lymphocytic Leukemia Through PKC Dependent Modulation of SHP1 Tyrosine Phosphatase

Rajeswaran Mani, DVM, Frank W Frissora, M.S., Ching-Shih Chen, Ph.D, John C. Byrd, MD, Natarajan Muthusamy, DVM, Ph.D

Blood (2011) 118 (21): 2499.

https://doi.org/10.1182/blood.V118.21.2499.2499

Published: 2011

Journal Articles

Comparative Assessment of Different Clinically Utilized CD20 Directed Antibodies in Chronic Lymphocytic Leukemia (CLL) Cells Reveals Divergent NK-Cell, Monocyte and Macrophage Properties,

Sarwish Rafiq, MS, Jonathan P. Butchar, PhD, Carolyn Cheney, Xiaokui Mo, PhD, David Jarjoura, PhD, Susheela Tridandapani, PhD, Natarajan Muthusamy, DVM, Ph.D, John C. Byrd, MD

Blood (2011) 118 (21): 3717.

https://doi.org/10.1182/blood.V118.21.3717.3717

Published: 2011

Journal Articles

Juxtaposing CD20 and CD74 with Novel Bispecific Antibodies Evokes Potent Cytotoxicity in Mantle Cell Lymphoma (MCL)

Pankaj Gupta, Ph.D, David M. Goldenberg, ScD, MD, Edmund A Rossi, Ph.D, Thomas M. Cardillo, Ph.D, John C. Byrd, MD, Natarajan Muthusamy, DVM, Ph.D, Richard R. Furman, MD, Chien-Hsing Chang, Ph.D

Blood (2011) 118 (21): 599.

https://doi.org/10.1182/blood.V118.21.599.599

Published: 2011

NARROW

A Novel Therapeutic Approach In Acute Myeloid Leukemia (AML): In Vivo Preclinical Pharmacokinetic (PK), Pharmacodynamic (PD) and Antileukemia Activities Of Synthetic 2’-O-Methylphosphorothioate Mir-29b

Changing The Treatment Paradigm For Previously Treated Chronic Lymphocytic Leukemia Patients With Del(17p) Karyotype

B-1239, a Novel Anti-BAFF-R Afucosylated Human Antibody, Promotes Potent Natural Killer Cell- Mediated Antibody Dependent Cellular Cytotoxicity In Chronic Lymphocytic Leukemia Cells In- Vitro and Depletion Of Circulating Leukemic CLL B Cells In-Vivo

Prognostic Significance Of Cytogenetic Complexity and Del(17p) At Diagnosis Of Chronic Lymphocytic Leukemia (CLL)

Tumor Antigen ROR1 Targeted Delivery Of FTY720 Derivative OSU-2S Prolongs Survival In ROR1 Engineered Mouse Model Of Chronic Lymphocytic Leukemia

Ibrutinib (PCI-32765) Antagonizes Rituximab-Dependent NK-Cell Mediated Cytotoxicity

Decitabine Or 5-Azacitidine Pre-Treatment Does Not Compromise The Novel Fc-Engineered Antibody Mab 33.1-Mediated ADCC Against Primary AML Blasts - A Rationale For Combination Therapy

Externally Validated Predictive Clinical Model For Untreated Del(17p13.1) Chronic Lymphocytic Leukemia Patients

Therapeutic Targeting of the RAS-Pathway by Synthetic Mir-181a Nanoparticles in Acute Myeloid Leukemia (AML).

TLR7/8 Agonists Overcome the Suppression of FcγR Activity in Monocytes From Chronic Lymphocytic Leukemia Patients

Immune Reconstitution At Days 30 and 100 Following Allogeneic Stem Cell Transplant and Association with Subsequent Development of Chronic Graft-Versus-Host Disease

A Transgenic Mouse Model of Aggressive B-Cell Malignancy for Evaluating Anti-Human CD37 Therapeutics

Ibrutinib Is an Irreversible Molecular Inhibitor of Interleukin-2 Inducible Kinase: Expanding Therapeutic Potential and Modulating a Th1 Selective Pressure in CD4 T-Cells

Lymphocyte Cytosolic Protein 1 (LCP1) Is a Membrane Associated Molecular Target in Chronic Lymphocytic Leukemia and Is Activated in Microenvironment Signaling

Differential Distribution of Activated Innate and Adaptive Immune Subsets in G-CSF Mobilized Hematopoietic Stem Cell Allografts May Influence Incidence of Acute (aGVHD) and Chronic Graft-Versus-Host Disease (cGVHD)

Tetraspanin CD37 Directly Mediates Transduction of Survival and Apoptotic Signals

Targeted Delivery of MicroRNA-29b by Nanoparticles Provides Antileukemic Activity and Increases Sensitivity to the Hypomethylating Agent Decitabine (DAC) in Acute Myeloid Leukemia (AML)

OSU-2S, A Novel FTY720 derivative, Mediates Cytotoxicity In Chronic Lymphocytic Leukemia Through PKC Dependent Modulation of SHP1 Tyrosine Phosphatase

Comparative Assessment of Different Clinically Utilized CD20 Directed Antibodies in Chronic Lymphocytic Leukemia (CLL) Cells Reveals Divergent NK-Cell, Monocyte and Macrophage Properties,

Juxtaposing CD20 and CD74 with Novel Bispecific Antibodies Evokes Potent Cytotoxicity in Mantle Cell Lymphoma (MCL)

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American Society of Hematology

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American Society of Hematology

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