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Journal Articles

Loss of Function RUNX1 Mutations Restrict Protein Biosynthesis during Pre-Leukemia and MDS Transition but Not after Leukemic Transformation

Xiongwei Cai, PhD, Yoshihiro Hayashi, MD PhD, Mark Wunderlich, MS, Nancy A. Speck, PhD, James C. Mulloy, PhD, Gang Huang, PhD, Yi Zheng, PhD

Blood (2016) 128 (22): 3860.

https://doi.org/10.1182/blood.V128.22.3860.3860

Published: 2016

Journal Articles

Direct Conversion of Adult Endothelial Cells into Immunecompetent Long-Term Engraftable Clinically Scalable Hematopoietic Stem Cells: Pathway to Therapeutic Translation

Raphael Lis, PhD, Charles Harrasch, Michael Gustave Poulos, PhD, Jose Gabriel Duran, William Schachterle, PhD, Michael Ginsberg, PhD, Arash Rafii, Koji Shido, Nancy A. Speck, PhD, Jason M. Butler, PhD, Joseph M. Scandura, MD PhD, Shahin Rafii

Blood (2016) 128 (22): 372.

https://doi.org/10.1182/blood.V128.22.372.372

Published: 2016

Journal Articles

Inflammatory Signaling Regulates Embryonic Hematopoietic Stem and Lymphoid Progenitor Cell Formation

Yan Li, Virginie Esain, PhD, Li Teng, Jian Xu, PhD, Isaura Frost, Wanda Kwan, PhD, Amanda D Yzaguirre, Marijke W Maijenberg, Stuart H. Orkin, MD, Kai Tan, PhD, Trista E North, PhD, Nancy A. Speck, PhD

Blood (2014) 124 (21): 2902.

https://doi.org/10.1182/blood.V124.21.2902.2902

Published: 2014

Journal Articles

Inherited and Acquired RUNX1 Mutations in Hematologic Disorders

Nancy A. Speck, PhD, Xiongwei Cai, Ph.D., Jingping Ge, Philip J. Mason

Blood (2013) 122 (21): SCI-5.

https://doi.org/10.1182/blood.V122.21.SCI-5.SCI-5

Published: 2013

Journal Articles

Chromatin Remodeling Enzyme CHD7 Negatively Regulate Hematopoietic Stem Cell Function

Jingmei Hsu, MD, PhD, Hsuan-Ting Huang, Ph.D, Chung-Tsai Lee, Shuqian Yu, MS, Leonard I. Zon, MD, Nancy A. Speck, PhD

Blood (2013) 122 (21): 2413.

https://doi.org/10.1182/blood.V122.21.2413.2413

Published: 2013

Journal Articles

CHD7 Negatively Regulates Hematopoietic Stem Cell Potency

Jingmei Hsu, MD, PhD, Hsuan-Ting Huang, Chung-Tsai Lee, Shuqian Yu, MS, Scott Gerber, PhD, Leonard I. Zon, MD, Nancy A. Speck, PhD

Blood (2012) 120 (21): 850.

https://doi.org/10.1182/blood.V120.21.850.850

Published: 2012

Journal Articles

Runx1-Cbfb Interacts with CHD7, a Chromatin Modifying Enzyme with a Potential Role in Hematopoiesis

Jingmei Hsu, MD, PhD, Chung-Tsai Lee, Scott Gerber, PhD, Shuqian Yu, MS, Nancy A. Speck, PhD

Blood (2011) 118 (21): 1300.

https://doi.org/10.1182/blood.V118.21.1300.1300

Published: 2011

Journal Articles

Hemogenic Endothelium

Nancy A. Speck, PhD, Joanna Tober, Ph.D., Michael Chen, Ph.D., Marella de Bruijn, Ph.D., Mun Chiang Chan

Blood (2010) 116 (21): SCI-44.

https://doi.org/10.1182/blood.V116.21.SCI-44.SCI-44

Published: 2010

Journal Articles

Runx1 Interactions in Stem Cell Biology.

Nancy A. Speck, PhD, Michael Chen, Tomomasa Yokomizo, Brandon Zeigler, Elaine Dzierzak

Blood (2008) 112 (11): sci-15.

https://doi.org/10.1182/blood.V112.11.sci-15.sci-15

Published: 2008

Journal Articles

Development of Small Molecule Inhibitors of the AML1-ETO and CBFβ-SMMHC Oncoproteins.

Jolanta E. Grembecka, PhD, Kristin Graf, Yali Kong, PhD, Michael Douvas, MD, Tomasz Cierpicki, PhD, Anuradha Illendula, PhD, Gwen Baber, Izabela Bielnicka, Liya Roudaia, Nancy A. Speck, PhD, Milton L. Brown, PhD, MD, John H. Bushweller, PhD

Blood (2007) 110 (11): 1591.

https://doi.org/10.1182/blood.V110.11.1591.1591

Published: 2007

Journal Articles

A Role for Twist in Thymocyte Development.

Daisuke Sugiyama, MD, PhD, Hiroko Sugiyama, MD, PhD, Nancy A. Speck, PhD

Blood (2005) 106 (11): 4252.

https://doi.org/10.1182/blood.V106.11.4252.4252

Published: 2005

Journal Articles

Structural and Functional Characterization of the NHR2 and Runt Domains of AML1/ETO.

Matthew D. Cheney, AB, Yizhou Liu, MS, Justin J. Gaudet, BS, Maksymilian Chruszcz, PhD, Stephen M. Lukasik, BS, Daisuke Sugiyama, MD, PhD, Jeff Lary, PhD, James Cole, PhD, Zbyszek Dauter, PhD, Wladek Minor, PhD, Nancy A. Speck, PhD, John H. Bushweller, PhD

Blood (2005) 106 (11): 2854.

https://doi.org/10.1182/blood.V106.11.2854.2854

Published: 2005

Journal Articles

The CBFb-SMMHC Oncoprotein Inhibits Binding of the Runx1 Runt Domain to DNA.

John H. Bushweller, PhD, Stephen M. Lukasik, BS, Nancy A. Speck, PhD

Blood (2005) 106 (11): 2709.

https://doi.org/10.1182/blood.V106.11.2709.2709

Published: 2005

Journal Articles

A Hypomorphic Cbfb Allele Reveals a Critical Dosage-Sensitive Function of Core Binding Factors at the Earliest Stages of T Cell Development.

Ivan Maillard, MD, PhD, Laleh Talebian, PhD, Zhe Li, PhD, Yalin Guo, MD, Daisuke Sugiyama, MD-PhD, Maren E. Speck, BA, Warren S. Pear, MD-PhD, Nancy A. Speck, PhD

Blood (2005) 106 (11): 124.

https://doi.org/10.1182/blood.V106.11.124.124

Published: 2005

Journal Articles

Development of Small Molecule Inhibitor of the AML1-ETO Oncoprotein.

Jolanta Grembecka, PhD, Kristin Graf, Miki Newman, Yunpeng Zhou, Mathew Cheney, Nancy A. Speck, PhD, Milton L. Brown, PhD, John H. Bushweller, PhD

Blood (2005) 106 (11): 1515.

https://doi.org/10.1182/blood.V106.11.1515.1515

Published: 2005

Journal Articles

Loss of Runx1 Perturbs Adult Hematopoiesis and Is Associated with a Myeloproliferative Phenotype.

Joseph D. Growney, PhD, Hirokazu Shigematsu, PhD, Zhe Li, PhD, Benjamin H. Lee, MD, Jennifer Adelsperger, Rebecca Rowan, David P. Curley, Koichi Akashi, MD PhD, Ifor R. Williams, MD PhD, Nancy A. Speck, PhD, D. Gary Gilliland, MD PhD

Blood (2004) 104 (11): 227.

https://doi.org/10.1182/blood.V104.11.227.227

Published: 2004

Journal Articles

Runx1 Deficiency Predisposes Mice to T-Cell Lymphoblastic Lymphoma.

Mondira Kundu, MD, PhD, Sheila Compton, MS, Lisa Garrett, MS, Terryl Stacy, PhD, Mathew Starost, DVM, Michael Eckhaus, DVM, Nancy A. Speck, PhD, Pu Paul Liu, MD, PhD

Blood (2004) 104 (11): 3490.

https://doi.org/10.1182/blood.V104.11.3490.3490

Published: 2004

Journal Articles

PU.1 Is a Critical Downstream Target of AML1.

Gang Huang, PhD, Pu Zhang, MD, Steffen Koschmieder, MD, Joseph D. Growney, PhD, D. Gary Gilliland, MD, Nancy A. Speck, PhD, Daniel G. Tenen, MD

Blood (2004) 104 (11): 358.

https://doi.org/10.1182/blood.V104.11.358.358

Published: 2004

NARROW

Loss of Function RUNX1 Mutations Restrict Protein Biosynthesis during Pre-Leukemia and MDS Transition but Not after Leukemic Transformation

Direct Conversion of Adult Endothelial Cells into Immunecompetent Long-Term Engraftable Clinically Scalable Hematopoietic Stem Cells: Pathway to Therapeutic Translation

Inflammatory Signaling Regulates Embryonic Hematopoietic Stem and Lymphoid Progenitor Cell Formation

Inherited and Acquired RUNX1 Mutations in Hematologic Disorders

Chromatin Remodeling Enzyme CHD7 Negatively Regulate Hematopoietic Stem Cell Function

CHD7 Negatively Regulates Hematopoietic Stem Cell Potency

Runx1-Cbfb Interacts with CHD7, a Chromatin Modifying Enzyme with a Potential Role in Hematopoiesis

Hemogenic Endothelium

Runx1 Interactions in Stem Cell Biology.

Development of Small Molecule Inhibitors of the AML1-ETO and CBFβ-SMMHC Oncoproteins.

A Role for Twist in Thymocyte Development.

Structural and Functional Characterization of the NHR2 and Runt Domains of AML1/ETO.

The CBFb-SMMHC Oncoprotein Inhibits Binding of the Runx1 Runt Domain to DNA.

A Hypomorphic Cbfb Allele Reveals a Critical Dosage-Sensitive Function of Core Binding Factors at the Earliest Stages of T Cell Development.

Development of Small Molecule Inhibitor of the AML1-ETO Oncoprotein.

Loss of Runx1 Perturbs Adult Hematopoiesis and Is Associated with a Myeloproliferative Phenotype.

Runx1 Deficiency Predisposes Mice to T-Cell Lymphoblastic Lymphoma.

PU.1 Is a Critical Downstream Target of AML1.

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American Society of Hematology

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American Society of Hematology

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