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Journal Articles

A CX3CR1 (fractalkine receptor) Small Molecular Antagonist (KAND567) Suppressed the Growth Promoting Effect of Monocytes on Chronic Lymphocytic Leukemia Cells

Mohammad Hojjat-Farsangi, Wen Zhong, Tom Mulder, Ann Svensson, Jeanette Lundin, Marzia Palma, Johan Schultz, Thomas Olin, Bjorn Wahlin, Anders Osterborg, Parviz Kokhaei, Hakan Mellstedt

Blood (2023) 142 (Supplement 1): 5716.

https://doi.org/10.1182/blood-2023-185953

Published: 2023

Journal Articles

ROR1 Small Molecule Inhibitor (KAN0441571C) Induced Significant Apoptosis of Mantle Cell Lymphoma (MCL) Cells

Håkan Mellstedt, MD PhD Prof., Amineh Ghaderi, MSc, Johanna Aschan, MSc, Fariba Mozaffari, MSc,PhD, Ali Moshfegh, MSc,PhD, Birgitta Sander, MD PhD Prof., Johan Schultz, MSc,PhD, Martin Norin, MSc,PhD, Thomas Olin, MSc,PhD, Elias Drakos, MD PhD Prof., George Z. Rassidakis, MD PhD Prof., Anders Österborg, MD PhD, Mohammad Hojjat-Farsangi, MSc,PhD

Blood (2019) 134 (Supplement_1): 5312.

https://doi.org/10.1182/blood-2019-129773

Published: 2019

Journal Articles

Diffuse Large B Cell Lymphoma (DLBCL) Expresses ROR1 and a ROR1 Small Molecule Inhibitor (KAN0441571C) Induced Significant Apoptosis of Tumor Cells

Mohammad Hojjat-Farsangi, MSc,PhD, Amineh Ghaderi, MSc, AmirHossein Daneshmanesh, MD PhD, Jemina Lehto, MSc, Ali Moshfegh, MSc,PhD, Parviz Kokhaei, MSc,PhD, Jan Vågberg, MSc,PhD, Elisabeth Olsson, MSc,PhD, Charlotta Löfberg, MSc,PhD, Charlotta Carina Norström, MSc,PhD, Johan Schultz, MSc,PhD, Martin Norin, MSc,PhD, Thomas Olin, MSc,PhD, Elias Drakos, MD PhD Prof., George Z. Rassidakis, MD PhD Prof., Anders Österborg, MD PhD, Håkan Mellstedt, MD PhD Prof.

Blood (2019) 134 (Supplement_1): 2565.

https://doi.org/10.1182/blood-2019-126801

Published: 2019

Journal Articles

First-in-Class Oral Small Molecule Against the Tyrosine Kinase ROR1 (KAN0439834) Induced Significant Apoptosis of Chronic Lymphocytic Leukemia Cells

Mohammad Hojjat-Farsangi, MSc, PhD Assist. Prof., Amir Hossein Daneshmanesh, MD PhD, Fariba Mozaffari, MSc, PhD, Lotta Hansson, Jan Vågberg, PhD, Styrbjörn Byström, PhD, Elisabeth Olsson, PhD, Charlotta Löfberg, PhD, Charlotta Carina Norström, PhD, Johan Schultz, PhD, Martin Norin, PhD, Thomas Olin, PhD, Anders Österborg, MD PhD Prof., Ali Moshfegh, PhD, Hakan Mellstedt, MD PhD Prof.

Blood (2017) 130 (Supplement 1): 4320.

https://doi.org/10.1182/blood.V130.Suppl_1.4320.4320

Published: 2017

Journal Articles

First-in-Class ROR1 Small Molecule Inhibitor (KAN0439834) Downregulated Wnt-Canonical and Non-Canonical Signaling Pathways and Induced Apoptosis of CLL Cells

Mohammad Hojjat-Farsangi, PhD, Ali Moshfegh, PhD, Amir Hossein Daneshmanesh, MD PhD, Jan Vågberg, Byström Styrbjörn, Johan Schultz, Elisabeth Olsson, Charlotta Löfberg, Carina Norström, Martin Norin, Thomas Olin, PhD, Anders Österborg, MD PhD, Håkan Mellstedt, MD PhD

Blood (2015) 126 (23): 2912.

https://doi.org/10.1182/blood.V126.23.2912.2912

Published: 2015

Journal Articles

Monoclonal Antibody Against ROR1 in Chronic Lymphocytic Leukemia Cells Induced Apoptosis Via PI3-Kinase/AKT/CREB Pathway

Amir Hossein Daneshmanesh, MD, PhD, Mohammad Hojjat-Farsangi, PhD, Asa Sandin, PhD, Abdul Salam Khan, Msc, Ali Moshfegh, PhD, Mahmood Jeddi-Tehrani, PhD, Anders Österborg, MD, PhD, Håkan Mellstedt, MD, PhD

Blood (2012) 120 (21): 1769.

https://doi.org/10.1182/blood.V120.21.1769.1769

Published: 2012

Journal Articles

Dishevelled Proteins of Wnt Signaling Pathways Are Highly Expressed in Chronic Lymphocytic Leukemia

Abdul Salam Khan, Åsa Sandin, Anders Österborg, MD, PhD, Mohammad Hojjat-Farsangi, Håkan Mellstedt, MD, PhD, Ali Moshfegh, PhD

Blood (2012) 120 (21): 4583.

https://doi.org/10.1182/blood.V120.21.4583.4583

Published: 2012

Journal Articles

Phosphorylation of Receptor Tyrosine Kinase ROR1 At Tyrosine 641, 646 and Serine 652 residues Might Be of Importance for the Survival of CLL Leukemic Cells

Mohammad Hojjat-Farsangi, Ph.D, Amir Hossein Daneshmanesh, MD, PhD, Martin Norin, Ph.D, Åsa Sandin, Ph.D, Abdul Salam Khan, Msc, Ali Moshfegh, PhD, Eva Rossmann, MD, Ph.D, Anders Osterborg, MD, PhD, Hakan Mellstedt, MD, Ph.D

Blood (2012) 120 (21): 3885.

https://doi.org/10.1182/blood.V120.21.3885.3885

Published: 2012

Journal Articles

ROR1 Isoforms Are Constitutively Phosphorylated in Chronic Lymphocytic Leukemia (CLL) - a Survival Factor for CLL Cells

Hakan Mellstedt, MD, PhD., Mohammad Hojjat-Farsangi, PhD, Ladan Mansouri, MD, Anders Osterborg, MD, PhD, Hodjattallah Rabbani, PhD

Blood (2011) 118 (21): 1778.

https://doi.org/10.1182/blood.V118.21.1778.1778

Published: 2011

Journal Articles

Patients with Chronic Lymphocyte Leukemia (CLL) Have Naturally Occurring Antibodies Against the Receptor Tyrosine Kinase (ROR1)

Mohammad Hojjat-Farsangi, PhD, Fariba Mozaffari, Ph.D, Amir Hossein Daneshmanesh, MD, Ph.D, Anders Osterborg, MD, PhD, Fazel Shokri, Ph.D, Håkan Mellstedt, MD, Ph.D

Blood (2011) 118 (21): 1771.

https://doi.org/10.1182/blood.V118.21.1771.1771

Published: 2011

Journal Articles

Ror1 Targeting Monoclonal Antibodies Induced Apoptosis of Chronic Lymphocytic Leukemia Cells– A Potential Novel Therapeutic Approach

Hodjattallah Rabbani, PhD, Amir Hossein Daneshmanesh, MD, Abdul Salam Khan, MSc, Mohammad Hojjat-Farsangi, PhD, Mahmood Jeddi-Tehrani, PhD, Mohammad Mehdi Akhondi, PhD, Anders Österborg, MD, PhD, Fazel Shokri, PhD, Håakan Mellstedt, MD, PhD

Blood (2010) 116 (21): 916.

https://doi.org/10.1182/blood.V116.21.916.916

Published: 2010

Journal Articles

T Cells From CLL Patients Recognize Spontaneously Peptides Derived of the Receptor Tyrosine Kinase Ror1

Mohammad Hojjat -Farsangi, Ph.D, Amir Hossein Daneshmanesh, MD, Mahmood Jeddi-Tehrani, Ph.D, Anders Osterborg, MD, PhD, Fazel Shokri, Ph.D, Håkan Mellstedt, MD, Ph.D, Hodjattallah Rabbani, Ph.D

Blood (2010) 116 (21): 3603.

https://doi.org/10.1182/blood.V116.21.3603.3603

Published: 2010

NARROW

A CX3CR1 (fractalkine receptor) Small Molecular Antagonist (KAND567) Suppressed the Growth Promoting Effect of Monocytes on Chronic Lymphocytic Leukemia Cells

ROR1 Small Molecule Inhibitor (KAN0441571C) Induced Significant Apoptosis of Mantle Cell Lymphoma (MCL) Cells

Diffuse Large B Cell Lymphoma (DLBCL) Expresses ROR1 and a ROR1 Small Molecule Inhibitor (KAN0441571C) Induced Significant Apoptosis of Tumor Cells

First-in-Class Oral Small Molecule Against the Tyrosine Kinase ROR1 (KAN0439834) Induced Significant Apoptosis of Chronic Lymphocytic Leukemia Cells

First-in-Class ROR1 Small Molecule Inhibitor (KAN0439834) Downregulated Wnt-Canonical and Non-Canonical Signaling Pathways and Induced Apoptosis of CLL Cells

Monoclonal Antibody Against ROR1 in Chronic Lymphocytic Leukemia Cells Induced Apoptosis Via PI3-Kinase/AKT/CREB Pathway

Dishevelled Proteins of Wnt Signaling Pathways Are Highly Expressed in Chronic Lymphocytic Leukemia

Phosphorylation of Receptor Tyrosine Kinase ROR1 At Tyrosine 641, 646 and Serine 652 residues Might Be of Importance for the Survival of CLL Leukemic Cells

ROR1 Isoforms Are Constitutively Phosphorylated in Chronic Lymphocytic Leukemia (CLL) - a Survival Factor for CLL Cells

Patients with Chronic Lymphocyte Leukemia (CLL) Have Naturally Occurring Antibodies Against the Receptor Tyrosine Kinase (ROR1)

Ror1 Targeting Monoclonal Antibodies Induced Apoptosis of Chronic Lymphocytic Leukemia Cells– A Potential Novel Therapeutic Approach

T Cells From CLL Patients Recognize Spontaneously Peptides Derived of the Receptor Tyrosine Kinase Ror1

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American Society of Hematology

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American Society of Hematology

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