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Mingjun Huang, PhD
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Journal Articles

Phase 3 Study of Danicopan, an Oral Complement Factor D Inhibitor, As Add-on Therapy to a C5 Inhibitor in Patients with Paroxysmal Nocturnal Hemoglobinuria with Clinically Evident Extravascular Hemolysis

Austin Kulasekararaj, MDMBBS,MRCP,FRCPath, Antonio Risitano, Jong Wook Lee, MD, PhD, Mingjun Huang, PhD, Jun-Ichi Nishimura, MD PhD, Alejandra Ramirez-Santiago, Robert Brodsky
Journal: Blood
Blood (2020) 136 (Supplement 1): 6–7.
https://doi.org/10.1182/blood-2020-134388
Published: 2020
Journal Articles

Comparative Evaluation of Complement Factor D, C3, and C5 Inhibitors on Serum Bactericidal Activity Against Neisseria Meningitidis Isolates

Yongsen Zhao, Dharaben Patel, MS, Jane A Thanassi, BS, Mingjun Huang, PhD, Steven D Podos, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5763.
https://doi.org/10.1182/blood-2019-132253
Published: 2019
Journal Articles

Mechanistic Evaluation of Efficacy Using Biomarkers of the Oral, Small Molecule Factor D Inhibitor, Danicopan (ACH-4471), in Untreated Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH)

Antonio M. Risitano, MD PhD, Jong Wook Lee, MD PhD, Rosario Notaro, MD, Robert A. Brodsky, MD, Austin Kulasekararaj, MBBS MDMRCP FRCPath, Jaroslaw P. Maciejewski, MD PhD, Mingjun Huang, PhD, Michael Geffner, MD, Peter Browett, BMedSci, MBChB, FRACP, FRCPA
Journal: Blood
Blood (2019) 134 (Supplement_1): 2226.
https://doi.org/10.1182/blood-2019-124837
Published: 2019
Journal Articles

A Phase 2 Open-Label Study of Danicopan (ACH-0144471) in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Who Have an Inadequate Response to Eculizumab Monotherapy

Austin Kulasekararaj, MBBS MDMRCP FRCPath, Antonio M. Risitano, MD PhD, Jaroslaw P. Maciejewski, MD PhD, Rosario Notaro, MD, Peter Browett, BMedSci, MBChB, FRACP, FRCPA, Jong-Wook Lee, MD, Mingjun Huang, PhD, Michael Geffner, MD, Robert A. Brodsky, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3514.
https://doi.org/10.1182/blood-2019-124748
Published: 2019
Journal Articles

In Vitro Combination Studies of ACH-4471 with Eculizumab to Assess a Potential "Switch" Treatment Approach for Paroxysmal Nocturnal Hemoglobinuria

Dharaben Patel, MS, Jane A Thanassi, BS, Guangwei Yang, PhD, Xuan Yuan, MD MSc, Robert A. Brodsky, MD, Mingjun Huang, PhD, Steven D Podos, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2198.
https://doi.org/10.1182/blood.V130.Suppl_1.2198.2198
Published: 2017
Journal Articles

Evaluation of Bacteria-Mediated Potential "Bystander" Hemolysis of PNH RED CELLS I n Vitro : NO Evidence of Significant Complement Classical or Lectin Pathway-Mediated Hemolysis Induced by Microorganisms

Xuan Yuan, MD MSc, Guangwei Yang, PhD, Jane A Thanassi, Manuel D Galvan, PhD, Steven D Podos, PhD, Mingjun Huang, PhD, Robert A. Brodsky, MD
Journal: Blood
Blood (2016) 128 (22): 2431.
https://doi.org/10.1182/blood.V128.22.2431.2431
Published: 2016
Journal Articles

Novel Small-Molecule Inhibitors Targeting Complement Factor D for Therapy of Paroxysmal Nocturnal Hemoglobinuria

B. Paul Morgan, PhD, Jane Thanassi, Steven Podos, PhD, Avinash Phadke, PhD, Venkat Gadhachanda, PhD, Godwin Pais, PhD, Akihiro Hashimoto, PhD, Qiuping Wang, PhD, Dawei Chen, PhD, Xiangzhu Wang, PhD, Atul Agarwal, PhD, Milind Deshpande, PhD, Yongqing Huang, PhD, Jason Wiles, PhD, Mingjun Huang, PhD
Journal: Blood
Blood (2014) 124 (21): 4817.
https://doi.org/10.1182/blood.V124.21.4817.4817
Published: 2014
Journal Articles

Preclinical Evaluation of Orally Bioavailable Small-Molecule Inhibitors of Complement Factor D As a Potential Treatment for Paroxysmal Nocturnal Hemoglobinuria

Jason Wiles, PhD, Steven Podos, PhD, Jane Thanassi, Avinash Phadke, PhD, Venkat Gadhachanda, PhD, Godwin Pais, PhD, Akihiro Hashimoto, PhD, Qiuping Wang, PhD, Dawei Chen, PhD, Xiangzhu Wang, PhD, Atul Agarwal, PhD, Jose Rivera, Michael Elliot, Christopher Marlor, Jay Zhang, Milind Deshpande, PhD, Mingjun Huang, PhD, Yongqing Huang, PhD
Journal: Blood
Blood (2014) 124 (21): 4819.
https://doi.org/10.1182/blood.V124.21.4819.4819
Published: 2014