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Journal Articles

Targeting Nicotinamide Adenine Dinucleotide (NAD) Glycohydrase Activity of CD38 Exerts Anti-Myeloma Effect Accompanying Intracellular NAD Elevation

Saki Kushima, Takayuki Sasano, Masao Matsuoka, MD PhD, Hiroyuki Hata, MD PhD, Yawara Kawano, MD PhD

Blood (2019) 134 (Supplement_1): 1810.

https://doi.org/10.1182/blood-2019-123624

Published: 2019

Journal Articles

JX06, a Novel PDK1 Inhibitor, Induces Myeloma Cell Apoptosis By Metabolic Reprogramming and Works Synergistically with Bortezomib

Takayuki Sasano, Saki Kushima, Matsushita Yutaka, Masao Matsuoka, MD PhD, Hiroyuki Hata, MD PhD, Yawara Kawano, MD PhD

Blood (2019) 134 (Supplement_1): 1814.

https://doi.org/10.1182/blood-2019-123619

Published: 2019

Journal Articles

Targeting the Plasma Cell Specific Purine Metabolic Enzyme, AMPD1, Induces Multiple Myeloma Cell Death Accompanying NAD Depletion

Yawara Kawano, MD PhD, Takayuki Sasano, Saki Kushima, Yuki Inada, Nao Nishimura, MD, Hiroyuki Hata, MD PhD, Masao Matsuoka, MD PhD

Blood (2019) 134 (Supplement_1): 3097.

https://doi.org/10.1182/blood-2019-125756

Published: 2019

Journal Articles

HTLV-1 Dysregulates IL-6 and IL-10-JAK/STAT Signaling and Induces Leukemia/Lymphoma of Mature CD4+ T Cells with Regulatory T-Cell-like Signatures

Yusuke Higuchi, MD, Jun-ichirou Yasunaga, MD PhD, Yu Mitagami, PhD, Koichi Ohshima, MD PhD, Masao Matsuoka, MD PhD

Blood (2019) 134 (Supplement_1): 1516.

https://doi.org/10.1182/blood-2019-125546

Published: 2019

Journal Articles

Dynamic Changes of Chromatin Structure and Transcriptome By Transient Expression of HTLV-1 Tax in ATL Cells

Daisuke Kurita, MD PhD, Jun-ichirou Yasunaga, MD PhD, Azusa Tanaka, PhD, Mahgoub Mohamed, MD PhD, Masao Matsuoka, MD PhD

Blood (2018) 132 (Supplement 1): 4094.

https://doi.org/10.1182/blood-2018-99-111125

Published: 2018

Journal Articles

The Purine Metabolic Enzyme AMPD1 Is a Novel Therapeutic Target for Multiple Myeloma

Yawara Kawano, MD PhD, Yuki Inada, Takayuki Sasano, Nao Nishimura, MD, Hiroyuki Hata, MD PhD, Masao Matsuoka, MD PhD

Blood (2018) 132 (Supplement 1): 5614.

https://doi.org/10.1182/blood-2018-99-118603

Published: 2018

Journal Articles

Hematopoietic Stem Cell Infected with HTLV-1 Functions As a Viral Reservoir In Vivo

Jun-ichirou Yasunaga, MDPhD, Rie Furuta, Michi Miura, Kenji Sugata, Akatsuki Saito, Akari Hirofumi, Takaharu Ueno, Norihiro Takenouchi, Jun-ichi Fujisawa, Masakazu Shimizu, Fumihiko Matsuda, MD PhD, Anat Melamed, Charles R. M. Bangham, Masao Matsuoka, MD PhD

Blood (2016) 128 (22): 1343.

https://doi.org/10.1182/blood.V128.22.1343.1343

Published: 2016

Journal Articles

Functional Impairment of Co-Inhibitory Receptors Promotes T-Cell Proliferation in HTLV-1 Associated Adult T-Cell Leukemia Cells

Haruka Kinosada, Jun-ichirou Yasunaga, MDPhD, Kazuya Shimura, PhD, Masao Matsuoka, MD PhD

Blood (2016) 128 (22): 2516.

https://doi.org/10.1182/blood.V128.22.2516.2516

Published: 2016

Journal Articles

Prognostic Relevance of Integrated Genetic Profiling in Adult T-Cell Leukemia/Lymphoma

Keisuke Kataoka, MD PhD, Yasunobu Nagata, MDPhD, Akira Kitanaka, MD PhD, Jun-ichirou Yasunaga, MDPhD, Masako Iwanaga, MD, PhD, Yuichi Shiraishi, MD PhD, Kenichi Chiba, BA, Aiko Sato-Otsubo, PhD, Masashi Sanada, MD PhD, Hiroko Tanaka, BA, Hiromichi Suzuki, MD PhD, Yusuke Sato, MD PhD, Yusuke Shiozawa, MD, Tetsuichi Yoshizato, MD, Kenichi Yoshida, MD PhD, Hideki Makishima, MD PhD, Kisato Nosaka, MD PhD, Masakatsu Hishizawa, Hidehiro Itonaga, MD PhD, Yoshitaka Imaizumi, MD PhD, Wataru Munakata, MD, Kotaro Shide, MD PhD, Yoko Kubuki, Tomonori Hidaka, Takuro Kameda, Tsuyoshi Nakamaki, MD, Ken Ishiyama, MD PhD, Shuichi Miyawaki, MD, Kensei Tobinai, MD PhD, Yasushi Miyazaki, MD PhD, Akifumi Takaori-Kondo, MD PhD, Tatsuhiro Shibata, Satoru Miyano, MD PhD, Masao Matsuoka, MD PhD, Kazuya Shimoda, MD PhD, Toshiki Watanabe, MD, PhD, Seishi Ogawa, MD PhD

Blood (2015) 126 (23): 2643.

https://doi.org/10.1182/blood.V126.23.2643.2643

Published: 2015

Journal Articles

Frequent Activating Somatic Alterations in T-Cell Receptor / NF-κb Signaling in Adult T-Cell Leukemia/Lymphoma

Keisuke Kataoka, MD PhD, Yasunobu Nagata, MDPhD, Akira Kitanaka, MD PhD, Yuichi Shiraishi, MD PhD, Jun-ichirou Yasunaga, MDPhD, Yasushi Totoki, Kenichi Chiba, BA, Aiko Sato-Otsubo, PhD, Shinichi Kotani, Masashi Sanada, MD PhD, Hiroko Tanaka, BA, Hiromichi Suzuki, MD PhD, Yusuke Sato, MD PhD, Yusuke Shiozawa, MD, Tetsuichi Yoshizato, MD, Kenichi Yoshida, MD PhD, Hideki Makishima, MD PhD, Guangyong Ma, Kisato Nosaka, MD PhD, Masakatsu Hishizawa, MD PhD, Hidehiro Itonaga, MD PhD, Yoshitaka Imaizumi, MD PhD, Wataru Munakata, MD, Nakamura Hiromi, Natsuko Hama, Kotaro Shide, MD PhD, Yoko Kubuki, Tomonori Hidaka, Takuro Kameda, Tsuyoshi Nakamaki, MD, Ken Ishiyama, MD PhD, Shuichi Miyawaki, MD, Kensei Tobinai, MD PhD, Yasushi Miyazaki, MD PhD, Akifumi Takaori-Kondo, MD PhD, Toshiki Watanabe, MD, PhD, Tatsuhiro Shibata, Masao Matsuoka, MD PhD, Satoru Miyano, MD PhD, Kazuya Shimoda, MD PhD, Seishi Ogawa, MD PhD

Blood (2015) 126 (23): 113.

https://doi.org/10.1182/blood.V126.23.113.113

Published: 2015

Journal Articles

Next-Generation Sequencing Reveal Proviral Genome and Transcriptome in Adult T-Cell Leukemia/Lymphoma

Blood (2015) 126 (23): 3882.

https://doi.org/10.1182/blood.V126.23.3882.3882

Published: 2015

Journal Articles

Landscape of Genetic Alterations in Adult T-Cell Leukemia/Lymphoma

Keisuke Kataoka, MD PhD, Yasunobu Nagata, MD PhD, Akira Kitanaka, MD PhD, Yasushi Totoki, Jun-ichirou Yasunaga, MDPhD, Shinichi Kotani, MD, Aiko Sato-Otsubo, PhD, Masashi Sanada, MD PhD, Yuichi Shiraishi, PhD, Teppei Shimamura, MD PhD, Kenichi Chiba, PhD, Hiroko Tanaka, BA, Hiromichi Suzuki, MD, Yusuke Sato, MD, Yusuke Shiozawa, MD, Tetsuichi Yoshizato, MD, Ayana Kon, MD, Kenichi Yoshida, MD PhD, Masakatsu Hishizawa, MD PhD, Wataru Munakata, MD, Hiromi Nakamura, Natsuko Hama, Kotaro Shide, MD PhD, Yoko Kubuki, MD, Tomonari Hidaka, Takuro Kameda, MD, Ken Ishiyama, MD PhD, Shuichi Miyawaki, MD PhD, Ryohei Ishii, PhD, Osamu Nureki, PhD, Genta Nagae, MD PhD, Hiroyuki Aburatani, MD PhD, Satoru Miyano, PhD, Akifumi Takaori-Kondo, MD, PhD, Toshiki Watanabe, MD PhD, Masao Matsuoka, MD PhD, Tatsuhiro Shibata, Kazuya Shimoda, MD PhD, Seishi Ogawa, MD PhD

Blood (2014) 124 (21): 75.

https://doi.org/10.1182/blood.V124.21.75.75

Published: 2014

Journal Articles

A Therapeutic Vaccine In Adult T-Cell Leukemia Patients With Autologous Dendritic Cells Pulsed With Peptides Corresponding To Tax-Specific Cytotoxic T Lymphocyte Epitopes

Tadafumi Iino, MD, Youko Suehiro, MD, PhD, Atsuhiko Hasegawa, PhD, Nobukazu Watanabe, MD, PhD, Ryuji Tanosaki, MD, PhD, Atae Utsunomiya, M.D., PhD, Masao Matsuoka, MD, PhD, Takanori Teshima, MD, PhD, Koichi Akashi, MD, PhD, Naokuni Uike, MD, PhD, Jun Okamura, MD, PhD, Mari Kannagi, MD, PhD

Blood (2013) 122 (21): 5130.

https://doi.org/10.1182/blood.V122.21.5130.5130

Published: 2013

Journal Articles

Discrepant Expression Between mRNA and Protein of HTLV-I Basic Leucine Zipper Factor (HBZ) Makes HTLV-I Infected CD4 Lymphocytes and Adult T Cell Leukemia Cells Less Susceptible to HBZ-Specific Cytotoxic T Lymphocytes

Koichiro Suemori, MD, Hiroshi Fujiwara, MD, PhD, Toshiki Ochi, MD, Masao Matsuoka, MD, PhD, Jean Michel Mesnard, PhD, Masaki Yasukawa, MD, PhD

Blood (2008) 112 (11): 4995.

https://doi.org/10.1182/blood.V112.11.4995.4995

Published: 2008

Journal Articles

Establishment of Novel Disease Models for Human Acute Type ATL and HTLV-I Carrier Using NOD-scid/IL2rg null Mouse.

Chika Iwamoto, Fumihiko Ishikawa, MD, PhD, Noriaki Kawano, MD, PhD, Noriyuki Saito, MD, Shen M. Yang, MD, PhD, Mitsuhiro Fukata, MD, Yoriko Saito, MD, PhD, Leonard D. Shultz, PhD, Masao Matsuoka, MD, PhD, Mine Harada, MD, PhD

Blood (2007) 110 (11): 2797.

https://doi.org/10.1182/blood.V110.11.2797.2797

Published: 2007

Journal Articles

HTLV-I bZIP Factor Gene, Encoded by the Minus Strand of HTLV-I Provirus, Is Critical for Pathogenesis of HTLV-I Associated Diseases.

Yorifumi Satou, MD, PhD, Jun-ichirou Yasunaga, MD, PhD, Mika Yoshida, MD, PhD, Koichi Ohshima, MD, PhD, Masao Matsuoka, MD, PhD

Blood (2006) 108 (11): 1410.

https://doi.org/10.1182/blood.V108.11.1410.1410

Published: 2006

Journal Articles

Methylation Profile of B-Chronic Lymphocytic Leukemia Cells.

Jun Fan, MS, Asou Norio, MD, Masao Matsuoka, MD, PhD

Blood (2005) 106 (11): 2951.

https://doi.org/10.1182/blood.V106.11.2951.2951

Published: 2005

NARROW

Targeting Nicotinamide Adenine Dinucleotide (NAD) Glycohydrase Activity of CD38 Exerts Anti-Myeloma Effect Accompanying Intracellular NAD Elevation

JX06, a Novel PDK1 Inhibitor, Induces Myeloma Cell Apoptosis By Metabolic Reprogramming and Works Synergistically with Bortezomib

Targeting the Plasma Cell Specific Purine Metabolic Enzyme, AMPD1, Induces Multiple Myeloma Cell Death Accompanying NAD Depletion

HTLV-1 Dysregulates IL-6 and IL-10-JAK/STAT Signaling and Induces Leukemia/Lymphoma of Mature CD4+ T Cells with Regulatory T-Cell-like Signatures

Dynamic Changes of Chromatin Structure and Transcriptome By Transient Expression of HTLV-1 Tax in ATL Cells

The Purine Metabolic Enzyme AMPD1 Is a Novel Therapeutic Target for Multiple Myeloma

Hematopoietic Stem Cell Infected with HTLV-1 Functions As a Viral Reservoir In Vivo

Functional Impairment of Co-Inhibitory Receptors Promotes T-Cell Proliferation in HTLV-1 Associated Adult T-Cell Leukemia Cells

Prognostic Relevance of Integrated Genetic Profiling in Adult T-Cell Leukemia/Lymphoma

Frequent Activating Somatic Alterations in T-Cell Receptor / NF-κb Signaling in Adult T-Cell Leukemia/Lymphoma

Next-Generation Sequencing Reveal Proviral Genome and Transcriptome in Adult T-Cell Leukemia/Lymphoma

Landscape of Genetic Alterations in Adult T-Cell Leukemia/Lymphoma

A Therapeutic Vaccine In Adult T-Cell Leukemia Patients With Autologous Dendritic Cells Pulsed With Peptides Corresponding To Tax-Specific Cytotoxic T Lymphocyte Epitopes

Discrepant Expression Between mRNA and Protein of HTLV-I Basic Leucine Zipper Factor (HBZ) Makes HTLV-I Infected CD4 Lymphocytes and Adult T Cell Leukemia Cells Less Susceptible to HBZ-Specific Cytotoxic T Lymphocytes

Establishment of Novel Disease Models for Human Acute Type ATL and HTLV-I Carrier Using NOD-scid/IL2rg null Mouse.

HTLV-I bZIP Factor Gene, Encoded by the Minus Strand of HTLV-I Provirus, Is Critical for Pathogenesis of HTLV-I Associated Diseases.

Methylation Profile of B-Chronic Lymphocytic Leukemia Cells.

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American Society of Hematology

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American Society of Hematology

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