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Journal Articles

A Novel Underappreciated Role for the Extracellular Adenosine Triphosphate (ATP)-P2X4 Purinergic Receptor Axis in the Homing and Engraftment of HSPCs

Mateusz Adamiak, PhD, Arjun Thapa, Kamila Bujko, MSc, Valentina Pensato, Magdalena Kucia, PhD DSci, Janina Ratajczak, MD PhD DSci, Mariusz Z Ratajczak, MD PhD DSc

Blood (2020) 136 (Supplement 1): 32.

https://doi.org/10.1182/blood-2020-137123

Published: 2020

Journal Articles

The ACE2 Receptor for COVID-19 Entry Is Expressed on the Surface of Hematopoietic Stem/Progenitor Cells and Endothelial Progenitors As Well As Their Precursor Cells and Becomes Activated in Nlrp3 Inflammasome-Dependent Manner By Virus Spike Protein - a Potential Pathway Leading to a "Cytokine Storm"

Magdalena Kucia, PhD DSci, Kamila Bujko, MSc, Andrzej Ciechanowicz, PhD, Monika Cymer, MS, Katarzyna Sielatycka, PhD, Janina Ratajczak, MD PhD DSci, Mariusz Z Ratajczak, MD PhD DSc

Blood (2020) 136 (Supplement 1): 8.

https://doi.org/10.1182/blood-2020-137083

Published: 2020

Journal Articles

Unexpected Novel Findings That Caspase-1-KO Mice Are Poor Mobilizers and Engraft Poorly with Wild Type Bone Marrow Cells - Indicating a Presence of an Autocrine Feedback Loop Involving Interleukin 1b and Interleukin 18 Signaling That Potentiates Nlrp3 Inflammasome Activity, Both in HSPCs and in the BM Microenvironment for Optimal Stem Cell Trafficking

Arjun Thapa, Janina Ratajczak, MD PhD DSci, Magdalena Kucia, PhD DSci, Mariusz Z Ratajczak, MD PhD DSc

Blood (2020) 136 (Supplement 1): 30–31.

https://doi.org/10.1182/blood-2020-137495

Published: 2020

Journal Articles

A Novel View of the Role of Prostaglandin E2 (PGE2) in Facilitating Engraftment of HSPCs By Activating the NOX2-ROS-Nlrp3 Inflammasome Axis to Incorporate the CXCR4 Receptor into Membrane Lipid Rafts

Magdalena Kucia, PhD DSci, Kamila Bujko, MSc, Arjun Thapa, PhD, Janina Ratajczak, MD PhD DSci, Mariusz Z Ratajczak, MD PhD DSc

Blood (2020) 136 (Supplement 1): 3.

https://doi.org/10.1182/blood-2020-137102

Published: 2020

Journal Articles

Nlrp3 Inflammasome Activation in Bone Marrow-Residing Innate Immunity Cells Governs Circadian Changes in the Number of Circulating Hematopoietic Stem/Progenitor Cells in Peripheral Blood

Mateusz Adamiak, PhD, Andrzej Ciechanowicz, PhD, Monika Cymer, MS, Marta Skoda, PhD, Mariusz Z Ratajczak, MD PhD DSc

Blood (2019) 134 (Supplement_1): 1033.

https://doi.org/10.1182/blood-2019-125853

Published: 2019

Journal Articles

Novel Evidence That the Nlrp3 Inflammasome Plays a Role in Bone Marrow As a "Cogwheel" Connecting Purinergic Signaling with Activation of the Complement Cascade to Induce "Sterile Inflammation", Which Is Required for Optimal Mobilization of Hematopoietic Stem/Progenitor Cells

Mateusz Adamiak, PhD, Anna Lenkiewicz, PhD, Kamila Bujko, MS, Arjun Thapa, PhD, Magdalena Kucia, PhD DSci, Ahmed Abdel-Latif, MD PhD, Janina Ratajczak, MD PhD DSci, Mariusz Z Ratajczak, MD PhD DSc

Blood (2019) 134 (Supplement_1): 4468.

https://doi.org/10.1182/blood-2019-125838

Published: 2019

Journal Articles

Novel Evidence That Extracellular Adenosine Triphosphate (ATP), As a Purinergic Signaling Mediator, Activates Mobilization By Engaging a P2X4 Ligand-Gated Cation Channel Receptor Expressed on the Surface of Hematopoietic and Innate Immunity Cells

Kamila Bujko, MS, Mateusz Adamiak, PhD, Arjun Thapa, PhD, Magdalena Kucia, PhD DSci, Janina Ratajczak, MD PhD DSci, Mariusz Z Ratajczak, MD PhD DSc

Blood (2019) 134 (Supplement_1): 4472.

https://doi.org/10.1182/blood-2019-125858

Published: 2019

Journal Articles

Novel Evidence That the Pannexin 1 Channel Is Involved in Adenosine Triphosphate (ATP) Release from Cells for Optimal Mobilization of Hematopoietic Stem Progenitor Cells, and the Pannexin 1 SNP 5 (Rs3020015) T/C Polymorphism Characterizes Poor Mobilizer Status in Patients

Monika Cymer, MS, Mateusz Adamiak, PhD, Marta Skoda, PhD, Marta Antonina Libura, MD PhD, Elzbieta Urbanowska, PhD, Magdalena Kucia, PhD DSci, Mariusz Z Ratajczak, MD PhD DSc

Blood (2019) 134 (Supplement_1): 3248.

https://doi.org/10.1182/blood-2019-125883

Published: 2019

Journal Articles

Efficient Ex Vivo Expansion of Highly Purified Human Umbilical Cord Blood-Derived Very Small CD34 + lin - CD45 - Stem Cells into Functional Endothelial Cells in Vitro in Chemically Identified, Feeder Layer-Free Medium Supplemented with Nicotinamide

Alison Domingues, MS, Kamila Bujko, MS, Magdalena Kucia, PhD DSci, Janina Ratajczak, MD PhD DSci, Mariusz Z Ratajczak, MD PhD DSc

Blood (2019) 134 (Supplement_1): 4882.

https://doi.org/10.1182/blood-2019-125819

Published: 2019

Journal Articles

Inhibition of the C5a-C5aR Axis By the L-Aptamer Aon-D21 As a New Strategy to Ameliorate Uncontrolled Migration/Motility of Hematopoietic Stem Cells - Potential Therapeutic Implications for Paroxysmal Nocturnal Hemoglobinuria

Kamila Bujko, MS, Sylwia Rzeszotek, PhD, Janina Ratajczak, MD PhD DSci, Kai Hoehlig, PhD, Axel Vater, PhD, Mariusz Z Ratajczak, MD PhD DSc

Blood (2017) 130 (Supplement 1): 1188.

https://doi.org/10.1182/blood.V130.Suppl_1.1188.1188

Published: 2017

Journal Articles

Efficient Ex Vivo Expansion of Human Umbilical Cord Blood-Derived Small CD133 + lin - CD45 - Stem Cells Expressing Pluripotency Markers in Presence of Histone Deacethylase Inhibitors—As a New Challenging Strategy to Obtain Multipotent Cells for Regenerative Medicine

Janina Ratajczak, MD PhD DSci, Malwina Suszynska, PhD, Kamila Bujko, MS, Donald M Miller, MD PhD, Magdalena Kucia, PhD DSci, Mariusz Z Ratajczak, MD PhD DSc

Blood (2017) 130 (Supplement 1): 3761.

https://doi.org/10.1182/blood.V130.Suppl_1.3761.3761

Published: 2017

Journal Articles

The Effect of Bioactive Phospholipids on Normal and Malignant Hematopoiesis—Modulation of Their Effects By Downregulating the Activities of Heme Oxygenase 1 (HO-1) and Inducible Nitric Oxygenase Synthase (iNOS)

Ahmed Abdelbaset-Ismail, PhD, Magdalena Kucia, PhD DSci, Janina Ratajczak, MD PhD DSci, Mariusz Z Ratajczak, MD PhD DSc

Blood (2017) 130 (Supplement 1): 3803.

https://doi.org/10.1182/blood.V130.Suppl_1.3803.3803

Published: 2017

Journal Articles

Sphingosine Kinase 2 (SphK2) Deficiency Does Not Lower but Instead Surprisingly Increases the Level of Sphingosine-1-Phosphate (S1P) in Peripheral Blood, Providing a Novel Strategy for Stimulating Hematopoietic Stem Cell Mobilization By Inhibiting SphK2 Activity

Mateusz Adamiak, PhD, Lakshman Chelvarajan, Webster Santos, PhD, Kevin R Lynch, PhD, Ahmed Abdel-Latif, MD PhD, Mariusz Z Ratajczak, MD PhD DSc

Blood (2017) 130 (Supplement 1): 4477.

https://doi.org/10.1182/blood.V130.Suppl_1.4477.4477

Published: 2017

Journal Articles

A Novel View of Umbilical Cord Blood Versus Maternal Peripheral Blood — Evidence for an Increase in the Number of Circulating Stem Cells on Both Sides of the Fetal–Maternal Circulation Barrier.

Kasia Sielatycka, PhD, Agata Poniewierska-Baran, PhD, Karolina Nurek, MD, Andrzej Torbe, MD, Mariusz Z Ratajczak, MD PhD DSc

Blood (2017) 130 (Supplement 1): 4950.

https://doi.org/10.1182/blood.V130.Suppl_1.4950.4950

Published: 2017

Journal Articles

A Novel View of Paroxysmal Nocturnal Hemoglobinuria (PNH) Pathogenesis: Do Pathologic PNH Hematopoietic Stem/Progenitor Cells (HSPCs) Displace Normal HSPCs From Their Niches in Bone Marrow Because They Are More Motile Due to Defective Adhesion and Enhanced Migratory Properties?

Janina Ratajczak, MD, PhD, Rui Liu, Ph.D., Nagendra Natarajan, MD, MPH, Jaroslaw P. Maciejewski, MD, PhD, Vivek R. Sharma, MD, FRCPA, Mariusz Z Ratajczak, MD, PhD, DSc

Blood (2011) 118 (21): 732.

https://doi.org/10.1182/blood.V118.21.732.732

Published: 2011

Journal Articles

Long-Term In Vivo Studies in Mice Unexpectedly Reveal That Prolonged Growth Hormone (GH) and Insulin/Insulin-Like Growth Factor-1 (IGF-1) Signaling Have a Negative Effect on Normal Bone Marrow Hematopoiesis – Implications for GH-Based “rejuvenation” Therapies,

Janina Ratajczak, MD, PhD, Rui Liu, Ph.D., Magda Kucia, Ph.D., Andrzej Bartke, Ph.D., Mariusz Z Ratajczak, MD, PhD, DSc

Blood (2011) 118 (21): 3422.

https://doi.org/10.1182/blood.V118.21.3422.3422

Published: 2011

Journal Articles

A Novel Perspective on Stem Cell Homing – Emerging Interplay Between Bioactive Lipids As Potent Chemoattractants and Cationic Peptides As Underappreciated Modulators of Responsiveness to SDF-1 Gradients

Chihwa Kim, Ph.D, Wu Wan, MS, Nicholas J. Greco, PhD, Magda Kucia, Ph.D., Janina Ratajczak, MD, PhD, Mary J. Laughlin, MD, Mariusz Z Ratajczak, MD, PhD, DSc

Blood (2011) 118 (21): 2957.

https://doi.org/10.1182/blood.V118.21.2957.2957

Published: 2011

Journal Articles

Differential Responsiveness of HSPCs Harvested From Bone Marrow (BM), Mobilized Peripheral Blood (mPB) and Umbilical Cord Blood (UCB) to the BM Homing Factors Stromal-Derived Factor-1 (SDF-1), Sphingosine-1 Phosphate (S1P) and Ceramide-1 Phosphate (C1P) Is Related to the Desensitization of mPB and UCB HSPCs by S1P and C1P Present in mPB and UCB Plasma

Ahmed Abdel-Latif, MD, Anush V Karapetyan, PhD, Chihwa Kim, PhD, Mariusz Z Ratajczak, MD, PhD, DSc

Blood (2011) 118 (21): 2958.

https://doi.org/10.1182/blood.V118.21.2958.2958

Published: 2011

Journal Articles

A Novel Observation That Heme Oxygenase-1 (HO-1) Deficient Mice Are Easy Mobilizers and That HO-1 Plays An Important Role in Maintaining Expression of SDF-1 in Bone Marrow (BM) Stroma and Promotes Retention of Hematopoietic Stem/Progenitor Cells (HSPCs) in the Bone Marrow Microenvironment

Marcin Wysoczynski, PhD, Janina Ratajczak, MD, PhD, Gregg Rokosh, Ph.D., Roberto Bolli, MD, PhD, Mariusz Z Ratajczak, MD, PhD, DSc

Blood (2011) 118 (21): 315.

https://doi.org/10.1182/blood.V118.21.315.315

Published: 2011

Journal Articles

Unexpected Evidence That Chronic IGF-1 Deficiency In Laron Dwarf Mice Maintains High Levels of Hematopoietic Stem Cells (HSCs) In BM - Are HSCs Gradually Depleted From BM with Age In An IGF-1–dependent Manner? Implications for the Novel Effect of Caloric Restriction on the Hematopoietic Stem Cell Compartment and Longevity.

Janina Ratajczak, MD, PhD, Wu Wan, MS, Rui Liu, MB, BS, Dong-Myung Shin, Ph.D., Magdalena Kucia, PhD, Andrzej Bartke, Ph.D., Mariusz Z Ratajczak, MD, PhD, DSc

Blood (2010) 116 (21): 1551.

https://doi.org/10.1182/blood.V116.21.1551.1551

Published: 2010

NARROW

A Novel Underappreciated Role for the Extracellular Adenosine Triphosphate (ATP)-P2X4 Purinergic Receptor Axis in the Homing and Engraftment of HSPCs

The ACE2 Receptor for COVID-19 Entry Is Expressed on the Surface of Hematopoietic Stem/Progenitor Cells and Endothelial Progenitors As Well As Their Precursor Cells and Becomes Activated in Nlrp3 Inflammasome-Dependent Manner By Virus Spike Protein - a Potential Pathway Leading to a "Cytokine Storm"

A Novel View of the Role of Prostaglandin E2 (PGE2) in Facilitating Engraftment of HSPCs By Activating the NOX2-ROS-Nlrp3 Inflammasome Axis to Incorporate the CXCR4 Receptor into Membrane Lipid Rafts

Nlrp3 Inflammasome Activation in Bone Marrow-Residing Innate Immunity Cells Governs Circadian Changes in the Number of Circulating Hematopoietic Stem/Progenitor Cells in Peripheral Blood

Novel Evidence That the Nlrp3 Inflammasome Plays a Role in Bone Marrow As a "Cogwheel" Connecting Purinergic Signaling with Activation of the Complement Cascade to Induce "Sterile Inflammation", Which Is Required for Optimal Mobilization of Hematopoietic Stem/Progenitor Cells

Novel Evidence That Extracellular Adenosine Triphosphate (ATP), As a Purinergic Signaling Mediator, Activates Mobilization By Engaging a P2X4 Ligand-Gated Cation Channel Receptor Expressed on the Surface of Hematopoietic and Innate Immunity Cells

Novel Evidence That the Pannexin 1 Channel Is Involved in Adenosine Triphosphate (ATP) Release from Cells for Optimal Mobilization of Hematopoietic Stem Progenitor Cells, and the Pannexin 1 SNP 5 (Rs3020015) T/C Polymorphism Characterizes Poor Mobilizer Status in Patients

Efficient Ex Vivo Expansion of Highly Purified Human Umbilical Cord Blood-Derived Very Small CD34 + lin - CD45 - Stem Cells into Functional Endothelial Cells in Vitro in Chemically Identified, Feeder Layer-Free Medium Supplemented with Nicotinamide

Inhibition of the C5a-C5aR Axis By the L-Aptamer Aon-D21 As a New Strategy to Ameliorate Uncontrolled Migration/Motility of Hematopoietic Stem Cells - Potential Therapeutic Implications for Paroxysmal Nocturnal Hemoglobinuria

Efficient Ex Vivo Expansion of Human Umbilical Cord Blood-Derived Small CD133 + lin - CD45 - Stem Cells Expressing Pluripotency Markers in Presence of Histone Deacethylase Inhibitors—As a New Challenging Strategy to Obtain Multipotent Cells for Regenerative Medicine

The Effect of Bioactive Phospholipids on Normal and Malignant Hematopoiesis—Modulation of Their Effects By Downregulating the Activities of Heme Oxygenase 1 (HO-1) and Inducible Nitric Oxygenase Synthase (iNOS)

Sphingosine Kinase 2 (SphK2) Deficiency Does Not Lower but Instead Surprisingly Increases the Level of Sphingosine-1-Phosphate (S1P) in Peripheral Blood, Providing a Novel Strategy for Stimulating Hematopoietic Stem Cell Mobilization By Inhibiting SphK2 Activity

A Novel View of Umbilical Cord Blood Versus Maternal Peripheral Blood — Evidence for an Increase in the Number of Circulating Stem Cells on Both Sides of the Fetal–Maternal Circulation Barrier.

A Novel View of Paroxysmal Nocturnal Hemoglobinuria (PNH) Pathogenesis: Do Pathologic PNH Hematopoietic Stem/Progenitor Cells (HSPCs) Displace Normal HSPCs From Their Niches in Bone Marrow Because They Are More Motile Due to Defective Adhesion and Enhanced Migratory Properties?

Long-Term In Vivo Studies in Mice Unexpectedly Reveal That Prolonged Growth Hormone (GH) and Insulin/Insulin-Like Growth Factor-1 (IGF-1) Signaling Have a Negative Effect on Normal Bone Marrow Hematopoiesis – Implications for GH-Based “rejuvenation” Therapies,

A Novel Perspective on Stem Cell Homing – Emerging Interplay Between Bioactive Lipids As Potent Chemoattractants and Cationic Peptides As Underappreciated Modulators of Responsiveness to SDF-1 Gradients

A Novel Observation That Heme Oxygenase-1 (HO-1) Deficient Mice Are Easy Mobilizers and That HO-1 Plays An Important Role in Maintaining Expression of SDF-1 in Bone Marrow (BM) Stroma and Promotes Retention of Hematopoietic Stem/Progenitor Cells (HSPCs) in the Bone Marrow Microenvironment

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American Society of Hematology

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American Society of Hematology

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