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Journal Articles

Adoptively-Transferred EBV-Specific T Cells to Prevent or Treat EBV-Related Lymphoproliferative Disease in Allogeneic HSCT Recipients - a Single Center Experience Spanning 22 Years

Ifigeneia Tzannou, MD, Bilal Omer, MD, Anastasia Papadopoulou, PhD, Ulrike Gerdemann, MD, Colton Smith, PhD, Adrian P. Gee, PhD, Bambi J Grilley, Malcolm K. Brenner, MB, PhD FRCP, FRCPath, Catherine M. Bollard, MD, Ann M. Leen, PhD, Cliona M. Rooney, PhD, Helen E. Heslop, MD

Blood (2015) 126 (23): 1926.

https://doi.org/10.1182/blood.V126.23.1926.1926

Published: 2015

Journal Articles

Multi-Virus-Specific T-Cell Therapy For Patients After Hematopoietic Stem Cell and Cord Blood Transplantation

Patrick Hanley, PhD, Ann Leen, PhD, Adrian P. Gee, PhD, Kathryn Leung, MD, Caridad Martinez, MD, Robert A. Krance, MD, Hao Liu, PhD, Malcolm K. Brenner, MB, PhD, FRCP, FRCPath, Helen E. Heslop, MD, Cliona M. Rooney, PhD, Catherine M. Bollard, MBChB, MD

Blood (2013) 122 (21): 140.

https://doi.org/10.1182/blood.V122.21.140.140

Published: 2013

Journal Articles

Improving Immune Reconstitution After Cord Blood Transplantation Using Ex Vivo Expanded Virus-Specific T Cells: A Phase I Clinical Study

Patrick J Hanley, PhD, Caridad Martinez, MD, Kathryn Leung, MD, Barbara Savoldo, MD, PhD, Gianpietro Dotti, MD, Malcolm K. Brenner, MB, PhD, FRCP, FRCPath, Cliona M. Rooney, PhD, Helen E. Heslop, MD, Robert A. Krance, MD, Elizabeth J Shpall, MD, Catherine M. Bollard, MD, FRACP, FRCPA

Blood (2012) 120 (21): 224.

https://doi.org/10.1182/blood.V120.21.224.224

Published: 2012

Journal Articles

Genetic Modification of Multi Leukemia Antigen-Specific Cytotoxic T Lymphocytes (CTL) to Enhance In Vivo Safety and Persistency

Fabian Zohren, MD, Maria R Imperato, Anurathapan Usanarat, MD, David M Spencer, PhD, Helen E. Heslop, MD, Malcolm K. Brenner, MB, PhD, FRCP, FRCPath, Cliona M. Rooney, PhD, Ann M. Leen, PhD, Juan F Vera, MD, Ulrike Gerdemann, MD

Blood (2011) 118 (21): 644.

https://doi.org/10.1182/blood.V118.21.644.644

Published: 2011

Journal Articles

Infusion of CD19-Directed and Multivirus Specific Cytotoxic T Lymphocytes After Allogeneic Hematopoietic Stem Cell Transplantation for B Cell Malignancies,

Conrad Russell Y. Cruz, MD, Kenneth P. Micklethwaite, MD, PhD, Barbara Savoldo, MD, PhD, Stephanie Ku, BS, Robert A. Krance, MD, Oumar Diouf, BS, Rammurti Kamble, MD, A. John Barrett, MD, Elizabeth J. Shpall, MD, Helen E. Heslop, MD, Cliona M. Rooney, PhD, Malcolm K. Brenner, MB, PhD, FRCP, FRCPath, Catherine M. Bollard, MD, Gianpietro Dotti, MD

Blood (2011) 118 (21): 4083.

https://doi.org/10.1182/blood.V118.21.4083.4083

Published: 2011

Journal Articles

Complete Tumor Responses in Lymphoma Patients Receiving Autologous Cytotoxic T Lymphocytes Targeting Epstein Barr Virus (EBV) - Latent Membrane Proteins

Catherine M. Bollard, MD, Stephen Gottschalk, Andrea M. Sheehan, MD, George Carrum, MD, Hao Liu, PhD, Barbara Pro, MD, Luis Fayad, MD, Anas Younes, MD, Martha Mims, MD, Adrian P. Gee, PhD, Malcolm K. Brenner, MB, PhD, FRCP, FRCPath, Cliona M. Rooney, PhD, Helen E. Heslop, MD

Blood (2011) 118 (21): 956.

https://doi.org/10.1182/blood.V118.21.956.956

Published: 2011

Journal Articles

Most Closely HLA-Matched Allogeneic Virus Specific Cytotoxic T-Lymphocytes (CTL) to Treat Persistent Reactivation or Infection with Adenovirus, CMV and EBV After Hemopoietic Stem Cell Transplantation (HSCT)

Ann M. Leen, PhD, Catherine M Bollard, MD, Adam M Mendizabal, Elizabeth J. Shpall, MD, Paul Szabolcs, MD, Joseph H. Antin, MD, Neena Kapoor, MD, Callie Heaton, Bambi J Grilley, Adrian P. Gee, PhD, Malcolm K. Brenner, MB, PhD, FRCP, FRCPath, Cliona M Rooney, PhD, Helen E. Heslop, MD

Blood (2010) 116 (21): 829.

https://doi.org/10.1182/blood.V116.21.829.829

Published: 2010

Journal Articles

CASPALLO: Phase I Clinical Trial of Allodepleted T Cells Transduced with Inducible Caspase 9 Suicide Gene After Haploidentical Stem Cell Transplantation

Blood (2010) 116 (21): 559.

https://doi.org/10.1182/blood.V116.21.559.559

Published: 2010

Journal Articles

Administration of Tumor-Specific Cytotoxic T Lymphocytes Engineered to Resist TGF-ß to Patients with EBV-Associated Lymphomas

Catherine M Bollard, MD, Gianpietro Dotti, MD, Stephen Gottschalk, Enli Liu, MD, MS, Andrea Sheehan, MD, Martha Mims, MD, Hao Liu, PhD, Adrian P. Gee, PhD, Malcolm K. Brenner, MB, PhD, FRCP, FRCPath, Helen E. Heslop, MD, Cliona M Rooney, PhD

Blood (2010) 116 (21): 560.

https://doi.org/10.1182/blood.V116.21.560.560

Published: 2010

Journal Articles

The Effects of Co-Stimulatory Endodomains on the Fate of T Cells Expressing a Tumor Directed Chimeric Antigen Receptor (CAR) In Human Subjects with B Cell Malignancies

Barbara Savoldo, MD, PhD, Carlos A. Ramos, MD, Catherine M. Bollard, MBChB, MD, Enli Liu, MD, MS, Martha Mims, MD, Michael Keating, MD, Adrian P. Gee, PhD, Zhuyong Mei, MD, Cliona M Rooney, PhD, Helen E Heslop, MD, Malcolm K. Brenner, MB, PhD, FRCP, FRCPath, Gianpietro Dotti, MD

Blood (2010) 116 (21): 3949.

https://doi.org/10.1182/blood.V116.21.3949.3949

Published: 2010

Journal Articles

Allogeneic Virus-Specific T Cells with HLA Alloreactivity Do Not Produce Graft-Versus-Host Disease In Human Subjects

J. Joseph Melenhorst, PhD, Ann M. Leen, PhD, Catherine M. Bollard, MBChB, MD, Máire F Quigley, PhD, David A Price, MD, PhD, Cliona M Rooney, PhD, Malcolm K. Brenner, MB, PhD, FRCP, FRCPath, A. John Barrett, MD, Helen E. Heslop, MD

Blood (2010) 116 (21): 1252.

https://doi.org/10.1182/blood.V116.21.1252.1252

Published: 2010

Journal Articles

An Inducible Caspase 9 Suicide Gene to Improve the Safety of Mesenchymal Stromal Cell Therapies.

Carlos A. Ramos, MD, Zahra Asgari, MA, Eric Yvon, PhD, Cliona M. Rooney, PhD, Helen E. Heslop, MD, Malcolm K. Brenner, MB, PhD, FRCP, FRCPath, Gianpietro Dotti, MD

Blood (2009) 114 (22): 1444.

https://doi.org/10.1182/blood.V114.22.1444.1444

Published: 2009

Journal Articles

Rapid High Titer Retroviral Production Using a Concentrated Retrovirus Expansion Device (CRED).

Juan F Vera, MD, Gianpietro Dotti, MD, John Wilson, Malcolm K. Brenner, MB, PhD, FRCP, FRCPath

Blood (2009) 114 (22): 2468.

https://doi.org/10.1182/blood.V114.22.2468.2468

Published: 2009

Journal Articles

Adverse Events Following Infusion of T Cells for Adoptive Immunotherapy: A 10 Year Experience.

Conrad Russell Y. Cruz, MD, Patrick Hanley, Hao Liu, PhD, Vicky Torrano, Yu-Feng Lin, Stephen Gottschalk, MD, Barbara Savoldo, MD, PhD, Gianpietro Dotti, MD, Chrystal Louis, M.D., Ann M. Leen, PhD, Cliona M. Rooney, PhD, Adrian P. Gee, PhD, Malcolm K. Brenner, MB, PhD, FRCP, FRCPath, Catherine M. Bollard, MD, FRACP, FRCPA, Helen E. Heslop, MD

Blood (2009) 114 (22): 3212.

https://doi.org/10.1182/blood.V114.22.3212.3212

Published: 2009

Journal Articles

Broad Spectrum Tumor Antigen-Specific Cytotoxic T Lymphocytes (CTL) for Therapy of Hematological Malignancy.

Ulrike Gerdemann, MD, Anne S. Christin, MD, Conrad Russell Cruz, MD, Carlos A. Ramos, MD, Donald R. Shaffer, Stephen Gottschalk, MD, Helen E. Heslop, MD, Malcolm K. Brenner, MB, PhD, FRCP, FRCPath, Catherine M. Bollard, MD, FRACP, FRCPA, Cliona M. Rooney, PhD, Ann M. Leen, PhD

Blood (2009) 114 (22): 4083.

https://doi.org/10.1182/blood.V114.22.4083.4083

Published: 2009

Journal Articles

IL15 Enhances Proliferation and Effector Function of Antigen-Specific Cytotoxic T Lymphocytes (CTLs) and Mitigates the Suppressive Action of Regulatory T Cells (Tregs).

Serena Kimi Perna, MD, Biagio De Angelis, PhD, Daria Pagliara, MD, Lan Zhan, Cliona M Rooney, PhD, Helen E. Heslop, MD, Malcolm K Brenner, MB, PhD, FRCP, FRCPath, Gianpietro Dotti, MD, Barbara Savoldo, MD, PhD

Blood (2009) 114 (22): 4088.

https://doi.org/10.1182/blood.V114.22.4088.4088

Published: 2009

Journal Articles

Cytotoxic T Lymphocytes (CTL) Specific for CMV, Adenovirus, and EBV Can Be Generated From Naive T Cells for Adoptive Immunotherapy.

Patrick Hanley, Barbara Savoldo, MD, PhD, Conrad Russell Young Cruz, MD, Ann M. Leen, PhD, Jeffrey J. Molldrem, M.D., Hao Liu, Adrian P. Gee, PhD, Helen E. Heslop, MD, Gianpietro Dotti, MD, John Rodgers, PhD, Cliona M Rooney, PhD, Malcolm K. Brenner, MB, PhD, FRCP, FRCPath, Elizabeth J. Shpall, MD, Catherine M. Bollard, MD, FRACP, FRCPA

Blood (2009) 114 (22): 504.

https://doi.org/10.1182/blood.V114.22.504.504

Published: 2009

NARROW

Adoptively-Transferred EBV-Specific T Cells to Prevent or Treat EBV-Related Lymphoproliferative Disease in Allogeneic HSCT Recipients - a Single Center Experience Spanning 22 Years

Multi-Virus-Specific T-Cell Therapy For Patients After Hematopoietic Stem Cell and Cord Blood Transplantation

Improving Immune Reconstitution After Cord Blood Transplantation Using Ex Vivo Expanded Virus-Specific T Cells: A Phase I Clinical Study

Genetic Modification of Multi Leukemia Antigen-Specific Cytotoxic T Lymphocytes (CTL) to Enhance In Vivo Safety and Persistency

Infusion of CD19-Directed and Multivirus Specific Cytotoxic T Lymphocytes After Allogeneic Hematopoietic Stem Cell Transplantation for B Cell Malignancies,

Complete Tumor Responses in Lymphoma Patients Receiving Autologous Cytotoxic T Lymphocytes Targeting Epstein Barr Virus (EBV) - Latent Membrane Proteins

Most Closely HLA-Matched Allogeneic Virus Specific Cytotoxic T-Lymphocytes (CTL) to Treat Persistent Reactivation or Infection with Adenovirus, CMV and EBV After Hemopoietic Stem Cell Transplantation (HSCT)

CASPALLO: Phase I Clinical Trial of Allodepleted T Cells Transduced with Inducible Caspase 9 Suicide Gene After Haploidentical Stem Cell Transplantation

Administration of Tumor-Specific Cytotoxic T Lymphocytes Engineered to Resist TGF-ß to Patients with EBV-Associated Lymphomas

The Effects of Co-Stimulatory Endodomains on the Fate of T Cells Expressing a Tumor Directed Chimeric Antigen Receptor (CAR) In Human Subjects with B Cell Malignancies

Allogeneic Virus-Specific T Cells with HLA Alloreactivity Do Not Produce Graft-Versus-Host Disease In Human Subjects

An Inducible Caspase 9 Suicide Gene to Improve the Safety of Mesenchymal Stromal Cell Therapies.

Rapid High Titer Retroviral Production Using a Concentrated Retrovirus Expansion Device (CRED).

Adverse Events Following Infusion of T Cells for Adoptive Immunotherapy: A 10 Year Experience.

Broad Spectrum Tumor Antigen-Specific Cytotoxic T Lymphocytes (CTL) for Therapy of Hematological Malignancy.

IL15 Enhances Proliferation and Effector Function of Antigen-Specific Cytotoxic T Lymphocytes (CTLs) and Mitigates the Suppressive Action of Regulatory T Cells (Tregs).

Cytotoxic T Lymphocytes (CTL) Specific for CMV, Adenovirus, and EBV Can Be Generated From Naive T Cells for Adoptive Immunotherapy.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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