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Journal Articles

Detection of Actionable BCR-ABL1 Kinase Domain (KD) Mutations in Chronic Myeloid Leukemia (CML) Patients with Failure and Warning Response to Tyrosine Kinase Inhibitors (TKIs): Potential Impact of Next-Generation Sequencing (NGS) and Droplet Digital PCR (ddPCR) on Clinical Decision Making

Simona Soverini, PhD, Margherita Martelli, Dr, Luana Bavaro, Dr, Caterina De Benedittis, Alessandra Iurlo, MD PhD, Sara Galimberti, MD PhD, Patrizia Pregno, Massimiliano Bonifacio, MD, Francesca Lunghi, MD, Fausto Castagnetti, MD PhD, Gabriele Gugliotta, MD PhD, Gianantonio Rosti, MD, Mario Tiribelli, Vanessa Velotta, Fabio Stagno, MD, Antonella Russo Rossi, Mariella D'Adda, MD, Claudia Baratè, Monica Crugnola, MD, Luigiana Luciano, Maria Antonella Laginestra, PhD, Adam S Corner, PhD, Dianna Maar, PhD, Antonio Percesepe, MD PhD, Stefano Pileri, MD, Fabrizio Pane, MD, Giuseppe Saglio, MD, Michele Baccarani, MD, Giovanni Martinelli, MD, Michele Cavo
Journal: Blood
Blood (2019) 134 (Supplement_1): 661.
https://doi.org/10.1182/blood-2019-126767
Published: 2019
Journal Articles

Aurora Kinase a/MDM2-Mediated SETD2 Loss of Function in Chronic Myeloid Leukemia Patients in Blast Crisis Can be Therapeutically Targeted Inducing Apoptotic Cell Death in a Caspase-Dependent Way

Manuela Mancini, PhD, Sara De Santis, Dr, Cecilia Monaldi, Dr, Luana Bavaro, Dr, Margherita Martelli, Dr, Gabriele Gugliotta, MD PhD, Fausto Castagnetti, MD PhD, Gianantonio Rosti, MD, Maria Chiara Fontana, PhD, Samantha Bruno, Dr, Elisa Dan, PhD, Barbara Sinigaglia, Dr, Alessandra Iurlo, MD PhD, Nicola Orofino, MD, Elisabetta Abruzzese, MD, Marzia Salvucci, MD, Patrizia Pregno, Antonella Gozzini, MD, Monica Crugnola, MD, Francesco Albano, MD, Massimiliano Bonifacio, MD, Elisabetta Calistri, MD, Mario Tiribelli, Gianni Binotto, MD, Annalisa Imovilli, Elena Trabacchi, MD, Sara Galimberti, MD PhD, Claudia Baratè, Elena Tenti, Michele Baccarani, MD, Giovanni Martinelli, MD, Michele Cavo, Simona Soverini, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4142.
https://doi.org/10.1182/blood-2019-126500
Published: 2019
Journal Articles

In Systemic Masocytosis, Midostaurin Targets Both Kit and Aurora Kinase a Reverting H3K36Me3 Deficiency and Synergizes with Second-Generation Tyrosine Kinase Inhibitors

Manuela Mancini, PhD, Cecilia Monaldi, Dr, Sara De Santis, Dr, Cristina Papayannidis, Michela Rondoni, MD, Luana Bavaro, Dr, Margherita Martelli, Dr, Antonio Curti, MD PhD, Maria Chiara Fontana, PhD, Samantha Bruno, Dr, Roberta Zanotti, MD, Massimiliano Bonifacio, MD, Luigi Scaffidi, MD, Livio Pagano, MD, Marianna Criscuolo, MD, Francesco Albano, MD, Fabio Ciceri, MD, Chiara Elena, MD, Patrizia Tosi, Massimo Delledonne, Carla Avanzato, Luciano Xumerle, Peter Valent, MD, Giovanni Martinelli, Michele Cavo, Simona Soverini, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4204.
https://doi.org/10.1182/blood-2019-126538
Published: 2019
Journal Articles

Droplet Digital PCR Phasing (DROP-PHASE): A Novel Method for Straightforward Detection of BCR-ABL1 Compound Mutations in Tyrosine Kinase Inhibitors Resistant Chronic Myeloid Leukemia (CML) and Acute Lymphoblastic Leukemia (ALL)

Pascal Vannuffel, PhD, Luana Bavaro, Dr, Friedel Nollet, PhD, Asena Aynaci, Margherita Martelli, Dr, Helena Devos, Céline De Rop, Simona Soverini, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4660.
https://doi.org/10.1182/blood-2019-123409
Published: 2019