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Journal Articles

Modelling FVIII Levels for Prediction of Zero Spontaneous-Joint Bleeding in a Cohort of Severe Hemophilia a Subjects with Target Joints Initiated on Tertiary Prophylaxis

Kathelijn Fischer, MD PhD MSc, Pratima Chowdary, FRCPath, MRCPath, MRCP, MD, Peter Collins, MD, Amy Cotterill, PhD, Barbara Konkle, MD, Victor S. Blanchette, FRCP, FRCPC, Steven W. Pipe, MD, Martin Wolfsegger, Cstat (RSS), Werner Engl, PhD Cstat, Jimena V Goldstine, PhD, Leonard A. Valentino, MD FAAP, Gerald Spotts, PhD

Blood (2016) 128 (22): 2576.

https://doi.org/10.1182/blood.V128.22.2576.2576

Published: 2016

Journal Articles

Increased Risk of Adverse Bone Health Outcomes in People with Bleeding Disorders

Jason Booth, MPH, Mei Lu, MS, Daniel Gallo, PhD, Diane Ito, MA, Leonard A. Valentino, MD FAAP

Blood (2016) 128 (22): 250.

https://doi.org/10.1182/blood.V128.22.250.250

Published: 2016

Journal Articles

Modeling Minimally-Effective FVIII Trough Levels in Hemophilia a Patients on PK-Guided Prophylaxis

Gerald Spotts, PhD, Steven W. Pipe, MD, Erik Berntorp, MD PhD, Peter W. Collins, MD, Victor S. Blanchette, MD FRCPC, Kathelijn Fischer, MD PhD MSC, MyungShin Oh, Leonard A. Valentino, MD FAAP

Blood (2014) 124 (21): 689.

https://doi.org/10.1182/blood.V124.21.689.689

Published: 2014

Journal Articles

Vitamin D Deficiency and Osteoporosis In Hemophilia: An Underappreciated Risk

Mindy L. Simpson, MD, FAAP, Leonard A. Valentino, MD, FAAP

Blood (2013) 122 (21): 3593.

https://doi.org/10.1182/blood.V122.21.3593.3593

Published: 2013

Journal Articles

Is Bleeding In Hemophilia Really Spontaneous Or Activity Related: Analysis Of US Patient/Caregiver Data From The Hemophilia Experiences, Results and Opportunities (HERO) Study

Leonard A. Valentino, MD, FAAP, Angela Forsyth, Michelle Witkop, DNP, FNP-BC, Christine Guelcher, Angela Lambing, David L. Cooper, MD, MBA

Blood (2013) 122 (21): 2364.

https://doi.org/10.1182/blood.V122.21.2364.2364

Published: 2013

Journal Articles

Biologic Response and Adverse Events To Stimate In Patients With Von Willebrand Disease

Xiangqian Song, MD. PhD., Leonard A. Valentino, MD, FAAP, Mindy L. Simpson, MD, FAAP, Lisa Boggio, MD

Blood (2013) 122 (21): 2365.

https://doi.org/10.1182/blood.V122.21.2365.2365

Published: 2013

Journal Articles

Pharmacokinetics Of Recombinant Factor VIII Fc Fusion Protein (rFVIIIFc) in Pediatric Subjects With Hemophilia A: An Interim Analysis Of The Kids A-LONG Study

Guy Young, MD, Johnny Mahlangu, MD, Beatrice Nolan, MB, MRCPI, FRCPATH, Simon Brown, MD, FRACP, FRCPA, MBBS, FRCP, FRCPath, Leonard A. Valentino, MD, FAAP, Raina Liesner, MA, MBBChir, MD, FRCP, FRCPath, MRCPCH, Yingwen Dong, PhD, Lei Diao, PhD, Haiyan Jiang, PhD, Karen Nugent, MSc, Glenn F. Pierce, MD, PhD, Geoffrey Allen, MD

Blood (2013) 122 (21): 3609.

https://doi.org/10.1182/blood.V122.21.3609.3609

Published: 2013

Journal Articles

Association Of Bleeding Tendency With Time Under Target FIX Activity Levels In Severe Hemophilia B Patients Treated With Recombinant Factor IX Fc Fusion Protein

Amy Shapiro, MD, James Potts, Ph.D, MPH, Shuanglian Li, Ph.D., Leonard A. Valentino, MD, FAAP, Lei Diao, PhD, Ping Wang, Ph.D., Brian Robinson, M.D., Glenn F Pierce, MD, PhD, Haiyan Jiang, PhD

Blood (2013) 122 (21): 2349.

https://doi.org/10.1182/blood.V122.21.2349.2349

Published: 2013

Journal Articles

Pharmacokinetics, Safety, and Efficacy Of Long-Lasting Recombinant Factor IX Fc Fusion Protein (rFIXFc) In Adolescent Subjects With Hemophilia B: A Subgroup Analysis Of The B-LONG Study

Amy Shapiro, MD, John Pasi, MBChB, PhD, FRCP, FRCPath, Johnny Mahlangu, MD, David J. Perry, MD, PhD, FRCP, FRCPath, Jerry S Powell, MD, Margaret V. Ragni, MD, MPH, Leonard A. Valentino, MD, FAAP, Margareth Ozelo, MD, PhD, Karen Nugent, MSc, Shuanglian Li, MD, PhD, Aoife Brennan, MB, BCh, BAO, MMSC, Glenn F Pierce, MD, PhD, Geoffrey Allen, MD

Blood (2013) 122 (21): 2350.

https://doi.org/10.1182/blood.V122.21.2350.2350

Published: 2013

Journal Articles

Phase II Trial of Rituximab in the Treatment of Inhibitors in Congenital Hemophilia A: Results of the RICH Study

Cindy A. Leissinger, MD, Rebecca Kruse-Jarres, MD, Suzanne Granger, MS, Barbara A Konkle, MD, Margaret V. Ragni, MD, MPH, Janna M. Journeycake, MD, Ellis J. Neufeld, MD, PhD, Cassandra Josephson, MD, Carolyn M. Bennett, MD, MS, Leonard A. Valentino, MD, FAAP, Nigel S. Key, MBChB, Leslie Raffini, MD, Marcela Torres, MD, Joan Cox Gill, MD, Susan Assmann, PhD

Blood (2011) 118 (21): 27.

https://doi.org/10.1182/blood.V118.21.27.27

Published: 2011

Journal Articles

Development of a Scoring System for Assessment of Phenotypic Variability in a Mouse Model of Hemophilia A,

Narine Hakobyan, PhD, Leonard A. Valentino, MD, FAAP, Lin Cong, MD, Candace Enockson, MA, Xiagqian Song, PhD

Blood (2011) 118 (21): 3328.

https://doi.org/10.1182/blood.V118.21.3328.3328

Published: 2011

Journal Articles

A Prospective, Multi-Center, Randomized Clinical Trial to Compare the Pharmacokinetic Properties of Human-Cl rhFVIII, a New Human-Cell Line Derived Recombinant Factor VIII, with Those of a Full-Length Recombinant Factor VIII Expressed in Baby Hamster Kidney Cells,

Sigurd Knaub, PhD, Andreas Tiede, MD, PhD, Toshko Lissitchkov, MD, PhD, Leonard A. Valentino, MD, FAAP, Jerry Sherman Powell, MD, Marilyn J. Manco-Johnson, MD

Blood (2011) 118 (21): 3309.

https://doi.org/10.1182/blood.V118.21.3309.3309

Published: 2011

Journal Articles

The Biological Efficacy Profile of a Chemically Modified Recombinant Factor VIII Molecule,

Leonard A. Valentino, MD, FAAP, Narine Hakobyan, PhD, Candace Enockson, MA, Lin Cong, MD, Friedrich Scheiflinger, PhD, Eva M Muchitsch, PhD, Peter L Turecek, PhD

Blood (2011) 118 (21): 3324.

https://doi.org/10.1182/blood.V118.21.3324.3324

Published: 2011

Journal Articles

Pharmacokinetic/Pharmacodynamic Assessment of Reformulated Recombinant Coagulation Factor IX in Adults and Children with Severe Hemophilia B

JM Korth-Bradley, Leonard A. Valentino, MD, FAAP, Pablo Rendo, MD, Frank E. Shafer, MD, Lynne Smith, James A. Baumann, Robert Charnigo

Blood (2011) 118 (21): 1190.

https://doi.org/10.1182/blood.V118.21.1190.1190

Published: 2011

Journal Articles

Surgical Experience with Recombinant FVIIa (rFVIIa) in Patients with Hemophilia and Inhibitors to Factors VIII or IX.

Leonard A. Valentino, MD, FAAP, David L. Cooper, MD, MBA

Blood (2009) 114 (22): 1304.

https://doi.org/10.1182/blood.V114.22.1304.1304

Published: 2009

Journal Articles

Effects of Age on the Development of Arthropathy in Mice with Hemophilia.

Leonard A. Valentino, MD, FAAP, Narine Hakobyan, PhD, D. Rick Sumner, PhD, Candace Enockson

Blood (2008) 112 (11): 3393.

https://doi.org/10.1182/blood.V112.11.3393.3393

Published: 2008

NARROW

Modelling FVIII Levels for Prediction of Zero Spontaneous-Joint Bleeding in a Cohort of Severe Hemophilia a Subjects with Target Joints Initiated on Tertiary Prophylaxis

Increased Risk of Adverse Bone Health Outcomes in People with Bleeding Disorders

Modeling Minimally-Effective FVIII Trough Levels in Hemophilia a Patients on PK-Guided Prophylaxis

Vitamin D Deficiency and Osteoporosis In Hemophilia: An Underappreciated Risk

Is Bleeding In Hemophilia Really Spontaneous Or Activity Related: Analysis Of US Patient/Caregiver Data From The Hemophilia Experiences, Results and Opportunities (HERO) Study

Biologic Response and Adverse Events To Stimate In Patients With Von Willebrand Disease

Pharmacokinetics Of Recombinant Factor VIII Fc Fusion Protein (rFVIIIFc) in Pediatric Subjects With Hemophilia A: An Interim Analysis Of The Kids A-LONG Study

Association Of Bleeding Tendency With Time Under Target FIX Activity Levels In Severe Hemophilia B Patients Treated With Recombinant Factor IX Fc Fusion Protein

Pharmacokinetics, Safety, and Efficacy Of Long-Lasting Recombinant Factor IX Fc Fusion Protein (rFIXFc) In Adolescent Subjects With Hemophilia B: A Subgroup Analysis Of The B-LONG Study

Phase II Trial of Rituximab in the Treatment of Inhibitors in Congenital Hemophilia A: Results of the RICH Study

Development of a Scoring System for Assessment of Phenotypic Variability in a Mouse Model of Hemophilia A,

A Prospective, Multi-Center, Randomized Clinical Trial to Compare the Pharmacokinetic Properties of Human-Cl rhFVIII, a New Human-Cell Line Derived Recombinant Factor VIII, with Those of a Full-Length Recombinant Factor VIII Expressed in Baby Hamster Kidney Cells,

The Biological Efficacy Profile of a Chemically Modified Recombinant Factor VIII Molecule,

Pharmacokinetic/Pharmacodynamic Assessment of Reformulated Recombinant Coagulation Factor IX in Adults and Children with Severe Hemophilia B

Surgical Experience with Recombinant FVIIa (rFVIIa) in Patients with Hemophilia and Inhibitors to Factors VIII or IX.

Effects of Age on the Development of Arthropathy in Mice with Hemophilia.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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