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Kyle Crassini
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Journal Articles

Dual Inhibition of PIM and PI3-Kinase By Ibl-202 Is Highly Synergistic Compared to Mono-Molecular Inhibition and Represents a Novel Treatment Strategy for Chronic Lymphocytic Leukemia

Oliver Giles Best, PhDBSc, Kyle Crassini, MBBS BSc, Michael O'Neill, PhD, Michael E O'Dwyer, MD FRCPI, FRCPath, Stephen P. Mulligan, MBBS (Hons), PhD, FRACP, FRCPA
Journal: Blood
Blood (2014) 124 (21): 4693.
https://doi.org/10.1182/blood.V124.21.4693.4693
Published: 2014
Journal Articles

The Oxazolidinone Derivative Locostatin Induces Apoptosis in CLL Cells through Inhibition of AKT and MAPK-ERK1/2 Signaling Under Conditions That Mimic the Tumor Microenvironment

Oliver Giles Best, PhDBSc, Tahni Pyke, BSc (Hons), Kyle Crassini, MBBS,BSc, William S Stevenson, MBBS, PhD, Stephen P. Mulligan, MBBS (Hons), PhD, FRACP, FRCPA
Journal: Blood
Blood (2014) 124 (21): 3326.
https://doi.org/10.1182/blood.V124.21.3326.3326
Published: 2014
Journal Articles

MEK1/2 Inhibition By MEK162 Is Effective Against Chronic Lymphocytic Leukaemia Cells Under Conditions That Mimic Stimulation of B-Cell Receptor-Mediated Signaling

Kyle Crassini, MBBS,BSc, William S Stevenson, MBBS, PhD, Stephen P. Mulligan, MBBS (Hons), PhD, FRACP, FRCPA, Oliver Giles Best, PhDBSc
Journal: Blood
Blood (2014) 124 (21): 3330.
https://doi.org/10.1182/blood.V124.21.3330.3330
Published: 2014
Journal Articles

MAPK-Erk1/2 Pathway Activation and Survival Of Chronic Lymphocytic Leukemia (CLL) Cells Is Induced By In Vitro Modeling Of The Tumor Microenvironment and Can Be Effectively Inhibited Using The MEK1 Inhibitor MEK162

O. Giles Best, BSc, PhD, Kyle Crassini, William s Stevenson, MBBS, PhD, Stephen P Mulligan, MBBS, PhD, FRACP, FRCPA
Journal: Blood
Blood (2013) 122 (21): 4192.
https://doi.org/10.1182/blood.V122.21.4192.4192
Published: 2013
Journal Articles

Inhibition of Mitogen Activated Protein Kinase Kinase (MEK1) Is Effective Against CLL Cells Cultured in Media Alone or in a Supportive Microenvironment and Is Synergistic with Fludarabine in a Mechanism That Involves Decreased Levels of Reactive Oxygen Species and MCL-1 Protein

Giles Best, BSc (Hons) Ph.D., Kyle Crassini, Williams Stevenson, MBBS, PhD, Stephen P. Mulligan, MBBS, PhD, FRACP, FRCPA
Journal: Blood
Blood (2012) 120 (21): 1804.
https://doi.org/10.1182/blood.V120.21.1804.1804
Published: 2012