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Kenneth Wen, BS
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Journal Articles

TNF-α Confers Resistance of Myeloma Cells to IMiDs through TRAF2 Degradation

Jiye Liu, PhD, Teru Hideshima, MD PhD, Lijie Xing, MD, Kenneth Wen, BS, Yu-Tzu Tai, PhD, Yong Cang, PhD, Kenneth C. Anderson, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1809.
https://doi.org/10.1182/blood-2019-123141
Published: 2019
Journal Articles

Anti-Bcma PBD MEDI2228 Combats Drug Resistance and Synergizes with Bortezomib and Inhibitors to DNA Damage Response in Multiple Myeloma

Lijie Xing, MD, Liang Lin, PhD, Tengteng Yu, MD PhD, Yuyin Li, PhD, Kenneth Wen, BS, Shih-Feng Cho, MD PhD, Phillip A Hsieh, Krista Kinneer, Nikhil C. Munshi, MD, Kenneth C. Anderson, MD, Yu-Tzu Tai, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1817.
https://doi.org/10.1182/blood-2019-127163
Published: 2019
Journal Articles

APRIL Is Significantly Elevated at All Stages of Multiple Myeloma (MM) and Interferes with Anti-Bcma Monoclonal Antibody-Mediated Cytolysis, Supporting the Clinical Evaluation of Bion-1301 As a Novel Therapeutic Approach in MM

Yu-Tzu Tai, PhD, John Dulos, PhD, Lars Guelen, Liang Lin, PhD, Lijie Xing, MD, Shih-Feng Cho, MD PhD, Kenneth Wen, BS, Tengteng Yu, MD, Phillip A Hsieh, Peter van Zandvoort, Bsc, Guido van de Wiel, Jos van de Crommert, Bsc, Bonny Lejeune, Hamid Namini, Hans Eenennaam, PhD, Andrea van Elsas, PhD, Paul Richardson, Nikhil Munshi, MD, Kenneth C. Anderson, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3209.
https://doi.org/10.1182/blood-2018-99-117296
Published: 2018
Journal Articles

Dysregulated Translational Control Is a Central Feature of MM Mediated By 14-3-3ε Interactome Promoting Multiple Myeloma Cell Growth and Viability

Yan Xu, MD, Mariateresa Fulciniti, PhD, Matthew Ho, Mehmet Kemal Samur, PhD, Michael A Lopez, Na Li, MD, Giada Bianchi, MD, Raphael Szalat, MD, Jianhong Lin, MD MSc, Tommaso Perini, MD, Srikanth Talluri, PhD, Tengteng Yu, MD, Kenneth Wen, BS, Jiye Liu, PhD, Li Zhang, MD, Liang Lin, PhD, Lijie Xing, MD, Gang An, MD, Yu-Tzu Tai, PhD, Kenneth Anderson, MD, Lugui Qiu, MD PhD, Nikhil Munshi, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3176.
https://doi.org/10.1182/blood-2018-99-118994
Published: 2018
Journal Articles

APOBEC3B Is Induced By Activation of DNA Repair Pathway and Modulates the Survival and Treatment Response in Human Multiple Myeloma

Lijie Xing, MD, Jiye Liu, PhD, Liang Lin, PhD, Shih-Feng Cho, MD PhD, Kenneth Wen, BS, Tengteng Yu, MD, Phillip Hsieh, Gang An, MD, Lugui Qiu, MD PhD, Nikhil Munshi, MD, Kenneth Anderson, MD, Yu-Tzu Tai, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 407.
https://doi.org/10.1182/blood-2018-99-110317
Published: 2018
Journal Articles

Genome-Wide CRISPR-Cas9 Screening Reveals a Role for TRAF2 in Resistance to IMiDs in Multiple Myeloma

Jiye Liu, PhD, Wenrong Zhou, PhD, Lijie Xing, MD, Liang Lin, PhD, Kenneth Wen, BS, Yu-Tzu Tai, PhD, Teru Hideshima, MD PhD, Yong Cang, PhD, Kenneth C. Anderson, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1917.
https://doi.org/10.1182/blood-2018-99-111962
Published: 2018
Journal Articles

Inhibitor of DNA Binding 2 (ID2) Plays a Key Tumor Suppressor Role in Promoting Oncogenic Transformation in Multiple Myeloma

Tommaso Perini, MD, Raphael Szalat, MD, Mehmet Kemal Samur, PhD, Mariateresa Fulciniti, PhD, Michael A Lopez, Matthew Lawlor, Christopher J. Ott, PhD, Na Li, MD, Yan Xu, MD, Kenneth Wen, BS, Nicola Amodio, PhD, Eugenio Morelli, MD, Kenneth Anderson, MD, Fabio Ciceri, MD, Nikhil Munshi, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 60.
https://doi.org/10.1182/blood-2018-99-118401
Published: 2018
Journal Articles

An Immune Based, Anti-CD138 Targeting Antibody for the Treatment of Multiple Myeloma

Tengteng Yu, MD, Lijie Xing, MD, Liang Lin, PhD, Jiye Liu, PhD, Kenneth Wen, BS, Shih-Feng Cho, MD PhD, Phillip Hsieh, James Myette, Bharat Chaganty, Hedy Adari, Hamid Tissire, Ketan Deotale, Zach Shriver, Nikhil Munshi, MD, Yu-Tzu Tai, PhD, Kenneth Anderson, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5617.
https://doi.org/10.1182/blood-2018-99-119112
Published: 2018
Journal Articles

Chromatin Accessibility Profiling Reveals Cis-Regulatory Heterogeneity and Novel Transcription Factor Dependencies in Multiple Myeloma

Christopher J. Ott, PhD, Raphael Szalat, MD, Matthew Lawlor, Mehmet Kemal Samur, PhD, Yan Xu, MD, Charles B Epstein, Charles Y Lin, PhD, Rao Prabhala, PhD, Nina Farrell, Lauren D Walter, Logan Schwartz, Kenneth Wen, BS, Yu-Tzu Tai, PhD, Mariateresa Fulciniti, PhD, Jinhua Wang, PhD, Nathanael Gray, PhD, Kenneth Anderson, MD, Richard A. Young, PhD, Nikhil Munshi, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1313.
https://doi.org/10.1182/blood-2018-99-119941
Published: 2018
Journal Articles

Anti-BCMA BiTE ® AMG 701 Potently Induces Specific T Cell Lysis of Human Multiple Myeloma (MM) Cells and Immunomodulation in the Bone Marrow Microenvironment

Shih-Feng Cho, MD PhD, Liang Lin, PhD, Lijie Xing, MD, Jiye Liu, PhD, Tengteng Yu, MD, Kenneth Wen, BS, Phillip Hsieh, Nikhil Munshi, MD, Kenneth Anderson, MD, Yu-Tzu Tai, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 592.
https://doi.org/10.1182/blood-2018-99-118425
Published: 2018
Journal Articles

Novel Mechanisms Underlying IMiDs Resistance in Multiple Myeloma: Therapeutic Implications

Jiye Liu, PhD, Wenrong Zhou, PhD, Lijie Xing, MD, Matthew Ho, Kenneth Wen, BS, Tianyu Song, Yu-Tzu Tai, PhD, Teru Hideshima, MD PhD, Yong Cang, PhD, Kenneth C Anderson, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 594.
https://doi.org/10.1182/blood.V130.Suppl_1.594.594
Published: 2017
Journal Articles

Bone Marrow Microenvironment Induces Genomic Instability and Enables Clonal Evolution in Multiple Myeloma

Tommaso Perini, MD, Raphael Szalat, MD, Mariateresa Fulciniti, PhD, Mehmet Kemal Samur, PhD, Michael A Lopez, BS, Puru Nanjappa, Kenneth Wen, BS, Na Li, MD, Yan Xu, MD, Yu-Tzu Tai, PhD, Masood A. Shammas, PhD, Kenneth C Anderson, MD, Fabio Ciceri, MD, Nikhil Munshi, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4408.
https://doi.org/10.1182/blood.V130.Suppl_1.4408.4408
Published: 2017
Journal Articles

A Proliferation Inducing Ligand (APRIL) Directly Impacts Immune Regulatory Subsets to Regulate Suppressive Multiple Myeloma Bone Marrow Microenvironment

Yu-Tzu Tai, PhD, Liang Lin, PhD, Lijie Xing, MD, Kenneth Wen, BS, Phillip Hsieh, An Gang, MD, Lugui Qiu, MD, Nikhil Munshi, MD, Paul G Richardson, MD, Kenneth C Anderson, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3066.
https://doi.org/10.1182/blood.V130.Suppl_1.3066.3066
Published: 2017
Journal Articles

CD8+ Anti-BCMA mRNA CAR T-Cells Effectively Kill Human Multiple Myeloma Cells In Vitro and In Vivo

Liang Lin, PhD, Lijie Xing, MD, Chirag M Acharya, MBBS, Kenneth Wen, BS, Jiye Liu, PhD, Phillip Hsieh, Metin Kurtoglu, MD PhD, Jeffrey Holderness, MD, Murat Kalayoglu, MD PhD, Nikhil Munshi, MD, Paul G Richardson, MD, Kenneth C Anderson, MD, Yu-Tzu Tai, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3067.
https://doi.org/10.1182/blood.V130.Suppl_1.3067.3067
Published: 2017
Journal Articles

Perturbation in B Cell-Subsets Can Explain the Observed Suppression of Uninvolved Immunoglobulins and Their Impact on T Tell-Subsets As Well As Patients Outcome in Myeloma

Rao Prabhala, PhD, Shree Acharya, MS, Megan Stekla, BS, Srikanth Talluri, PhD, Raphael Szalat, MD, Puru Nanjappa, Michael A Lopez, BS, Kenneth Wen, BS, Chaitanya Yenumula, MD, Alexander Heubeck, BS, Yu-Tzu Tai, PhD, Ansh Mehta, MBBS, Mariateresa Fulciniti, PhD, Suzan Lazo-Kallanian, BS, John Daley, PhD, Paul G Richardson, MD, Kenneth C Anderson, MD, Nikhil Munshi, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3049.
https://doi.org/10.1182/blood.V130.Suppl_1.3049.3049
Published: 2017
Journal Articles

Ywhae Located on Chromosome 17p13 Promotes Myeloma Cells Proliferation Via Induction of Anti-Apoptosis and Survival Signaling Pathways

Yan Xu, MD, Mariateresa Fulciniti, PhD, Mehmet Kemal Samur, PhD, Raphael Szalat, MD, Matthew Ho, Michael A Lopez, BS, Na Li, MD, Jianhong Lin, MD MSc, Tommaso Perini, MD, Srikanth Talluri, PhD, Jiye Liu, PhD, Kenneth Wen, BS, Giada Bianchi, MD, Li Zhang, MD, Lijie Xing, MD, An Gang, MD, Liang Lin, PhD, Yu-Tzu Tai, PhD, Lugui Qiu, MD, Kenneth C Anderson, MD, Nikhil Munshi, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1755.
https://doi.org/10.1182/blood.V130.Suppl_1.1755.1755
Published: 2017
Journal Articles

A First in Class APRIL Fully Blocking Antibody Targets Novel Immune Regulation of APRIL in Multiple Myeloma: Further Therapeutic Implication

Liang Lin, PhD, Lijie Xing, MD, Chirag M Acharya, MBBS, Kenneth Wen, BS, Phillip Hsieh, John Dulos, PhD, Andrea Van Elsas, PhD, Nikhil Munshi, MD, Paul G Richardson, MD, Kenneth C Anderson, MD, Yu-Tzu Tai, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 499.
https://doi.org/10.1182/blood.V130.Suppl_1.499.499
Published: 2017
Journal Articles

Blocking HDAC3 in Bone Marrow Stromal Cells Has Direct Anti-Multiple Myeloma Effect and Modulates T Cell Function

Matthew Ho, Jiye Liu, PhD, Alireza Kalbasi, PharmD, Takeshi Harada, MDPhD, Teru Hideshima, MD PhD, Paul Dowling, BSc, PhD, Yu-Tzu Tai, PhD, Li Zhang, MD, Kenneth Wen, BS, Ralph Mazitschek, Amanda McCann, Kenneth C Anderson, MD, Peter O'Gorman, MD PhD FRCP, FRCPath, Giada Bianchi, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4429.
https://doi.org/10.1182/blood.V130.Suppl_1.4429.4429
Published: 2017