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Kenneth L. McClain, MD, PhD
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Journal Articles

Comprehensive Cell Specific Transcriptome Profiling of a Pediatric Hodgkin Lymphoma Cohort

Free
Jennifer Agrusa, MD, Elmoataz A Abdel Fattah, MBBCh, Howard Lin, BS, Rikhia Chakraborty, PhD, Brooks Scull, MS, Harshal Abhyankar, MS, Nmazuo Wudo Ozuah, MBBS, Olive S. Eckstein, MD, Terzah M Horton, MD PhD, Kala Kamdar, MD, Kenneth L. McClain, MD PhD, Chris Tsz-Kwong Man, PhD, Carl E. Allen, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2773.
https://doi.org/10.1182/blood-2019-125982
Published: 2019
Journal Articles

Genomic Characterization of a Pediatric Cohort with Non-Malignant Lymphoproliferative Disorders

Free
Olive S. Eckstein, MD, Nitya Gulati, MBBS, Lisa Forbes, MD, Erin Peckham-Gregory, PhD MPH, Nmazuo Wudo Ozuah, MBBS, M. Cecilia Poli, MD, PhD, Tiphanie Vogel, Emily M Mace, PhD, Jordan S Orange, MD PhD, Jason Caldwell, D.O., Stephen Jolles, Fracesco Saettini, Hey J Chong, Asbjørg Stray-Pedersen, Helen E. Heslop, MD DSc, Kala Kamdar, MD, Robert A. Krance, MD, Swati Naik, MBBS, Tami D John, MD, Rayne H. Rouce, MD, Donna Muzny, Shalini Jhangiani, Richard Gibbs, Zeynep Coban-Akdemir, James Lupski, Kenneth L. McClain, MD PhD, Carl E. Allen, MD PhD, Ivan Chinn
Journal: Blood
Blood (2019) 134 (Supplement_1): 83.
https://doi.org/10.1182/blood-2019-131884
Published: 2019
Journal Articles

Blocking MAPK Activation and Immune Checkpoints Reverse Immune Dysfunction and Reduce Disease in a Mouse Model of LCH

Free
Amel Sengal, BS, Meryl Hahne, Jessica Velasquez, Harshal Abhyankar, MS, Thomas Burke, BS, Walter Olea, Robert Reyes, Brooks Scull, MS, Camille Bigenwald, Catherine M. Bollard, MD, Wendong Yu, Miriam Merad, MD, Kenneth L. McClain, MD PhD, Carl E. Allen, MD PhD, Rikhia Chakraborty, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3602.
https://doi.org/10.1182/blood-2019-128253
Published: 2019
Journal Articles

Inherited Genetic Risk Factors and Langerhans Cell Histiocytosis Relapse Events

Free
Erin Peckham-Gregory, PhD, Michael Scheurer, MPH, PhD, Rikhia Chakraborty, PhD, Harshal Abhyankar, MS, Kenneth L. McClain, MD PhD, Carl E. Allen, MD PhD, Philip J Lupo, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4278.
https://doi.org/10.1182/blood-2018-99-118743
Published: 2018
Journal Articles

Clinical Outcomes and Molecular Responses in Children with Langerhans Cell Histiocytosis Treated with MAPK Pathway Inhibitors

Free
Olive S. Eckstein, MD, Daniel Zinn, MD, Carolyn Fein Levy, MD, Michael M. Henry, MD, Patrick Campbell, MD, Michael B. Jordan, MD, Ashish R Kumar, MD PhD, Carlos Rodriguez-Galindo, MD PhD, Nobuko Hijiya, MD, Oussama Abla, MD, Kenneth L. McClain, MD PhD, Carl E. Allen, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3684.
https://doi.org/10.1182/blood-2018-99-120393
Published: 2018
Journal Articles

Evaluating Anti-TNF-Alpha Therapy in Patients with Relapsed and Refractory Langerhans Cell Histiocytosis

Free
Thomas Burke, BS, Alejandra Legarreta, MD, Howard Lin, Brooks Scull, Olive S. Eckstein, MD, Kenneth L. McClain, MD PhD, Carl E. Allen, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4941.
https://doi.org/10.1182/blood-2018-99-114295
Published: 2018
Journal Articles

An Evaluation of Parental and Perinatal Characteristics and Risk of Langerhans Cell Histiocytosis in Texas Identifies Risk Disparities By Racial/Ethnic Group

Free
Erin Peckham-Gregory, PhD MPH, Michael Scheurer, MPH, PhD, Kenneth L. McClain, MD PhD, Carl E. Allen, MD PhD, Philip J Lupo, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4187.
https://doi.org/10.1182/blood.V130.Suppl_1.4187.4187
Published: 2017
Journal Articles

Transcriptional Profiles, Lineage Tracing with BRAF-V600E and HLA-DQB2 Expression Support a Model of Blood CD1c+ Cells As Precursors to LCH Lesion CD207+ Cells

Free
Karen Phaik Har Lim, Paul Milne, PhD BSc, Michael Poidinger, PhD, Kaibo Duan, PhD, Howard Lin, Harshal Abhyankar, MS, Daniel Zinn, MD, Olive S. Eckstein, MD, Rikhia Chakraborty, PhD BSc, MSc, Evan Newell, PhD, Miriam Merad, MD, Kenneth L. McClain, MD PhD, Chris Tsz-Kwong Man, PhD, Florent Ginhoux, PhD, Matthew P. Collin, MD PhD, Carl E. Allen, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4218.
https://doi.org/10.1182/blood.V130.Suppl_1.4218.4218
Published: 2017
Journal Articles

Immune Checkpoint Inhibitors Restore Function of Lesion Infiltrating T Lymphocytes in Langerhans Cell Histiocytosis

Free
Rikhia Chakraborty, PhD BSc, MSc, Carl E. Allen, MD PhD, Amel Sengal, BS, Amos S. Gaikwad, PhD, Harshal Abhyankar, MS, Brooks Scull, Olive S. Eckstein, MD, Miriam Merad, MD, Kenneth L. McClain, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2280.
https://doi.org/10.1182/blood.V130.Suppl_1.2280.2280
Published: 2017
Journal Articles

Plasma Inflammatory Protein Profiles Distinguish Hemophagocytic Lymphohistiocytosis from Sepsis and SIRS

Free
Harshal Abhyankar, MS, Carl E. Allen, MD PhD, Howard Lin, Baruch Goldberg, Brooks Scull, Kenneth L. McClain, MD PhD, Jordana Goldman, Trung Nguyen, Michael B. Jordan, MD, Tsz-kwong Man, Olive S. Eckstein, MD, Joseph Lubega, Dalia Bashir, Rikhia Chakraborty, PhD BSc, MSc, Hector Wong, Eyal Muscal, Daniel Zinn, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1011.
https://doi.org/10.1182/blood.V130.Suppl_1.1011.1011
Published: 2017
Journal Articles

BRAF-V600E in Peripheral Mononuclear Cells and Microglia-like Brain Cells Suggest Hematopoietic Origin of Langerhans Cell Histiocytosis-Associated Neurodegeneration

Free
Daniel Zinn, MD, Jennifer Picarsic, Rikhia Chakraborty, PhD BSc, MSc, Howard Lin, Harshal Abhyankar, MS, Brooks Scull, Albert Shih, Karen Phaik Har Lim, Olive S. Eckstein, MD, Tricia L. Peters, MD, Walter Olea, Thomas Burke, Nabil Ahmed, MD, John Hicks, Brandon Tran, Jeremy Jones, Robert Dauser, Michael R. Jeng, MD, Robert A Baiocchi, MD PhD, Deborah E. Schiff, MD, Stanton Goldman, MD, Kenneth Matthew Heym, MD, Harry Wilson, Benjamin Carcamo, Ashish Kumar, MBBS, Carlos Rodriguez-Galindo, MD, Nicholas Whipple, Patrick Campbell, MD PhD, Geoffrey Murdoch, Simon Heales, Marian Malone, Randy Woltjer, Joseph Quinn, Paul Orchard, MD, Michael Kruer, Ronald Jaffe, Markus G Manz, MD, Sergio Lira, Donald Will Parsons, MD PhD, Miriam Merad, MD, Tsz-kwong Man, Kenneth L. McClain, MD PhD, Carl E. Allen, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2930.
https://doi.org/10.1182/blood.V130.Suppl_1.2930.2930
Published: 2017
Journal Articles

Efficacy and Toxicity Profile of Clofarabine in Patients with Recurrent/Refractory Langerhans Cell Histiocytosis and Other Histiocytic Disorders

Free
Olive S. Eckstein, MD, Racheal Bingham, CPNP, Erin Christine Peckham, PhD MPH, Austin Brown, MPH, PhD, Carl E. Allen, MD PhD, Kenneth L. McClain, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1329.
https://doi.org/10.1182/blood.V128.22.1329.1329
Published: 2016
Journal Articles

Elevated Ferritin Predicts for Inferior Survival in Patients with Acute Leukemia and May be an Early Marker of a Underlying Systemic Pathologic Inflammation

Free
Preetesh Jain, MBBS, MDDM, PhD, Kelly Casteel, MD, Carl E. Allen, MD PhD, Kenneth L. McClain, MD PhD, Sa Wang, MD, Sergej Konoplev, MD PhD, Elias J. Jabbour, MD, Graciela Nogueras Gonzalez, Xuelin Huang, PhD, Sarah Miller, Waleed Abdelall, MD, Gevorg Tamamyan, MD MSc, Tapan M. Kadia, MD, Gautam Borthakur, MD, Zeev Estrov, MD, Farhad Ravandi, MD, Guillermo Garcia-Manero, MD, Jorge E. Cortes, MD, Hagop M. Kantarjian, MD, Naval Daver, MD
Journal: Blood
Blood (2016) 128 (22): 2791.
https://doi.org/10.1182/blood.V128.22.2791.2791
Published: 2016
Journal Articles

A Genome-Wide Assessment of Inherited Genetic Variants and the Risk of Langerhans Cell Histiocytosis

Free
Erin Peckham, PhD, Philip J Lupo, PhD MPH, Michael E Scheurer, PhD MPH, Rikhia Chakraborty, PhD BSc, MSc, John Belmont, MDPhD, Spiridon Tsavachidis, MS, Albert Shih, BS, Harshal Abhyankar, MS, Karen Phaik Har Lim, MS, Brooks Scull, MS, Kenneth L. McClain, MD PhD, Carl Allen, MD PhD
Journal: Blood
Blood (2015) 126 (23): 4059.
https://doi.org/10.1182/blood.V126.23.4059.4059
Published: 2015
Journal Articles

Evaluation Of Afuresertib, An Oral Pan-AKT Inhibitor, In Patients With Langerhans Cell Histiocytosis

Free
Robert J. Arceci, M.D., Ph.D., Carl E. Allen, MD, PhD, Ira Dunkel, M.D., Eric D. Jacobsen, MD, James Whitlock, Robert Vassallo, M.D., Ivan M. Borrello, MD, Allen Oliff, MD, Shannon R. Morris, MD, PhD, Beth Ann M Reedy, Alison Portnoy, Deborah A. Smith, PharmD, Bob Noble, Amy A. Murnane, Stephen A. Szabo, Carlos Rodriguez-Galindo, Mark L. Heaney, MD, PhD, Kenneth L. McClain, MD, PhD, Sarah Vaseilbuh, MD
Journal: Blood
Blood (2013) 122 (21): 2907.
https://doi.org/10.1182/blood.V122.21.2907.2907
Published: 2013
Journal Articles

Frequent BRAF V600E Mutations Are Identified in CD207+ Cells in LCH Lesions, but BRAF Status does not Correlate with Clinical Presentation of Patients or Transcriptional Profiles of CD207+ Cells

Free
Tricia L Peters, MD, MS, Tsz-Kwong Chris Man, PhD, Jeremy Price, Renelle George, Phaik Har Lim, MS, Kenneth Matthew Heym, MD, Miriam Merad, MD, PhD, Kenneth L. McClain, MD, PhD, Carl E Allen, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 1372.
https://doi.org/10.1182/blood.V118.21.1372.1372
Published: 2011
Journal Articles

Langerhans Cells and T Cells in Langerhans Cell Histiocytosis Have Distinct Cytokine and Growth Factor Gene Expression Profiles Depending on the Clinical Risk Groups.

Free
Kenneth L. McClain, MD PhD, Xiao-tian Yan, MD PhD, Liunan Li, MD, John Hicks, MD PhD DDS, Leif E. Peterson, Ph.D.
Journal: Blood
Blood (2004) 104 (11): 3455.
https://doi.org/10.1182/blood.V104.11.3455.3455
Published: 2004