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Journal Articles

ADAMTS13 Plays a Critical Role in Acetaminophen-Induced Acute Liver Injury in Mice, and Can be a Novel Therapeutic Option

Akihiro Sawa, Kohei Tatsumi, Yoko Takabayashi, Yu Onodera, Ayaka Kakiwaki, Satoshi Senzaki, Nobushiro Nishimura, Hiromasa Kawashima, Kiyomi Yoshimoto, Mitsuhiko Sugimoto, Midori Shima, Kenji Nishio

Blood (2022) 140 (Supplement 1): 5516–5517.

https://doi.org/10.1182/blood-2022-169891

Published: 2022

Journal Articles

The Efficacy and Safety of Caplacizumab in Japanese Patients with Immune-Mediated Thrombotic Thrombocytopenic Purpura (iTTP): An Open-Label, Phase 2/3 Study

Yoshitaka Miyakawa, Kazunori Imada, Satoshi Ichikawa, Hitoji Uchiyama, Yasunori Ueda, Akihito Yonezawa, Shigeki Fujitani, Hiroshi Handa, Tadashi Matsushita, Hidesaku Asakura, Kenji Nishio, Kodai Suzuki, Yasuhiro Hashimoto, Shinobu Ohshima, Sayaka Tahara, Tomoyuki Tanaka, Masanori Matsumoto

Blood (2021) 138 (Supplement 1): 1009.

https://doi.org/10.1182/blood-2021-148427

Published: 2021

Journal Articles

HLA loci predisposing to immune TTP in Japanese: potential role of the shared ADAMTS13 peptide bound to different HLA-DR

Blood (2020) 135 (26): 2413–2419.

https://doi.org/10.1182/blood.2020005395

Published: 2020

Includes: Supplemental data

Journal Articles

Functional Relevance of Von Willebrand Factor in Mouse Model of Hepatic Ischemia- Reperfusion Injury

Yasuyuki Urisono, Hideto Matsui, Shogo Kasuda, Shiro Ono, Kenji Nishio, Masashi Akiyama, Toshiyuki Miyata, PhD, Kazuo Okuchi, Mitsuhiko Sugimoto

Blood (2016) 128 (22): 1356.

https://doi.org/10.1182/blood.V128.22.1356.1356

Published: 2016

Journal Articles

Relevant Role of Von Willebrand Factor in Ischemia-Reperfusion Model of Acute Kidney Injury in Mice

Shiro Ono, Hideto Matsui, MD PhD, Masashi Noda, Shogo Kasuda, Yasunori Matsunari, MD, Noritaka Yada, Kenji Nishio, Mitsuhiko Sugimoto, MD PhD

Blood (2015) 126 (23): 2243.

https://doi.org/10.1182/blood.V126.23.2243.2243

Published: 2015

Journal Articles

Investigator-Initiated Phase 2 Trial of Rituximab in Adult Japanese Patients with Treatment-Resistant Acquired Thrombotic Thrombocytopenic Purpura

Yoshitaka Miyakawa, Kazunori Imada, Tatsuo Ichinohe, MDPhD, Yusuke Yamane, MD, Kenji Nishio, Takayuki Abe, Yoshihiro Fujimura, MDPhD, Yasunori Ueda, MD, PhD, Masanori Matsumoto, MD PhD, Shinichiro Okamoto

Blood (2015) 126 (23): 4645.

https://doi.org/10.1182/blood.V126.23.4645.4645

Published: 2015

Journal Articles

Von Willebrand Factor-Dependent Inflammatory Responses in Mouse Septic Model By Cecal Ligation and Puncture

Shogo Kasuda, MD, Hideto Matsui, MD, Shiro Ono, MD, Yasunori Matsunari, MD, Kenji Nishio, MD, Midori Shima, MD PhD, Katsuhiko Hatake, MD, Mitsuhiko Sugimoto, MD

Blood (2014) 124 (21): 2773.

https://doi.org/10.1182/blood.V124.21.2773.2773

Published: 2014

Journal Articles

Flow-Dependent Functions Of Soluble Or Immobilized Tissue Factor In Mural Thrombus Formation Mediated By Von Willebrand Factor

Yasunori Matsunari, MD., Masaaki Doi, MD, Hideto Matsui, MD, Kenji Nishio, MD, Hitoshi Furuya, MD, Masahiko Kawaguchi, MD, Mitsuhiko Sugimoto, MD

Blood (2013) 122 (21): 3521.

https://doi.org/10.1182/blood.V122.21.3521.3521

Published: 2013

Journal Articles

ADAMTS13 Improving the Cell Engraftment Efficacy in Mouse Model of Bone Marrow Transplantation

Hideto Matsui, MD, Masaaki Doi, MD, Yasunori Matsunari, MD, Maiko Takeda, MD, Kenji Nishio, MD, Midori Shima, MD, Kenji Soejima, PhD, Fumiaki Banno, PhD, Masashi Akiyama, PhD, Koichi Kokame, PhD, Toshiyuki Miyata, PhD, Mitsuhiko Sugimoto, MD

Blood (2012) 120 (21): 1077.

https://doi.org/10.1182/blood.V120.21.1077.1077

Published: 2012

Journal Articles

Protective Role of ADAMTS13 for Myocardium in Mouse Model of Experimental Myocardial Infarction.

Masaaki Doi, MD, Hideto Matsui, MD, Yukiji Takeda, MD, Yoshihiko Saito, MD, Maiko Takeda, MD, Yasunori Matsunari, MD, Kenji Nishio, MD, Midori Shima, MD, Fumiaki Banno, PhD, Masashi Akiyama, PhD, Koichi Kokame, PhD, Toshiyuki Miyata, PhD, Mitsuhiko Sugimoto, MD

Blood (2012) 120 (21): 2175.

https://doi.org/10.1182/blood.V120.21.2175.2175

Published: 2012

Journal Articles

A Recombinant Thrombomodulin Improves Haemostatic Disturbance and Inflammation in Setpic Patients with DIC

Noritaka Yada, MD, Kenji Nishio, MD, PhD, Hidetada Fukushima, MD, Tadahiko Seki, MD, Yasuyuki Urizono, MD, Michiaki Hata, MD, Hideki Asai, MD, Masaaki Doi, MD, Hideto Matsui, MD, PhD, Mitsuhiko Sugimoto, MD, PhD, Kazuo Okuchi, MD, PhD

Blood (2011) 118 (21): 2293.

https://doi.org/10.1182/blood.V118.21.2293.2293

Published: 2011

Journal Articles

The Ratio of ADAMTS13 to VWF-Propeptide Can Reflect the Disease Severity and the Extent of Inflammation of the Patients with Severe Sepsis or Septic Shock,

Kenji Nishio, MD, PhD, Hidetada Fukushima, MD, Tomoro Watanabe, MD, Tadahiko Seki, MD, Hideto Matsui, MD, PhD, Mitsuhiko Sugimoto, MD, PhD, Masanori Matsumoto, MD, PhD, Yoshihiro Fujimura, MD, PhD, Kazuo Okuchi, MD, PhD

Blood (2011) 118 (21): 3349.

https://doi.org/10.1182/blood.V118.21.3349.3349

Published: 2011

Journal Articles

ADAMTS13 gene deletion aggravates ischemic brain damage: a possible neuroprotective role of ADAMTS13 by ameliorating postischemic hypoperfusion

Masayuki Fujioka, Kazuhide Hayakawa, Kenichi Mishima, Ai Kunizawa, Keiichi Irie, Sei Higuchi, Takafumi Nakano, Carl Muroi, Hidetada Fukushima, Mitsuhiko Sugimoto, Fumiaki Banno, Koichi Kokame, Toshiyuki Miyata, Michihiro Fujiwara, Kazuo Okuchi, Kenji Nishio

Blood (2010) 115 (8): 1650–1653.

https://doi.org/10.1182/blood-2009-06-230110

Published: 2010

Journal Articles

Decreased Activity of Plasma ADAMTS13 Parallels Enhanced Endotoxemia in Patients with Severe Acute Pancreatitis: Relationship to Multiorgan Failure

Chie Morioka, Masahito Uemura, Tomomi Matsuyama, Masanori Matsumoto, Masao Fujimoto, Seiji Kato, Masatoshi Ishikawa, Hiromichi Ishizashi, Tatsuhiro Tsujimoto, Hideto Kawaratani, Kazuo Okuchi, Kenji Nishio, Yoshihiro Fujimura, Hiroshi Fukui

Blood (2008) 112 (11): 4541.

https://doi.org/10.1182/blood.V112.11.4541.4541

Published: 2008

Journal Articles

ADAMTS13 Gene Deletion Aggravates Ischemic Brain Damage

Kenji Nishio, Masayuki Fujioka, Kazuhide Hayakawa, Kenichi Mishima, Michihiro Fujiwara, Fumiaki Banno, Koichi Kokame, Toshiyuki Miyata, Yasuaki Shida, Mitsuhiko Sugimoto, Hidetada Fukushima, Kazuo Okuchi

Blood (2008) 112 (11): 260.

https://doi.org/10.1182/blood.V112.11.260.260

Published: 2008

Journal Articles

Functional imaging of shear-dependent activity of ADAMTS13 in regulating mural thrombus growth under whole blood flow conditions

Yasuaki Shida, Kenji Nishio, Mitsuhiko Sugimoto, Tomohiro Mizuno, Masaaki Hamada, Seiji Kato, Masanori Matsumoto, Kazuo Okuchi, Yoshihiro Fujimura, Akira Yoshioka

Blood (2008) 111 (3): 1295–1298.

https://doi.org/10.1182/blood-2007-09-110700

Published: 2008

Journal Articles

Plasma ADAMTS13 Activity Markedly Decreases in Patients with Severe Acute Pancreatitis: Its Potential Role on the Development of Multiorgan Failure.

Chie Morioka, MD, Masahito Uemura, MD, Tomomi Matsuyama, MD, Masanori Matsumoto, MD, Seiji Kato, MD, Masatohsi Ishikawa, MD, Hiromichi Ishizashi, MD, Masao Fujimoto, MD, Tatsuhiro Tsujimoto, MD, Kenji Nishio, MD, Kazuo Okuchi, MD, Yoshihiro Fujimura, MD, Hiroshi Fukui, MD

Blood (2007) 110 (11): 2160.

https://doi.org/10.1182/blood.V110.11.2160.2160

Published: 2007

Journal Articles

Cleavage of ultralarge multimers of von Willebrand factor by C -terminal–truncated mutants of ADAMTS-13 under flow

Zhenyin Tao, Yongtao Wang, Huiwei Choi, Aubrey Bernardo, Kenji Nishio, J. Evan Sadler, José A. López, Jing-fei Dong

Blood (2005) 106 (1): 141–143.

https://doi.org/10.1182/blood-2004-11-4188

Published: 2005

NARROW

ADAMTS13 Plays a Critical Role in Acetaminophen-Induced Acute Liver Injury in Mice, and Can be a Novel Therapeutic Option

The Efficacy and Safety of Caplacizumab in Japanese Patients with Immune-Mediated Thrombotic Thrombocytopenic Purpura (iTTP): An Open-Label, Phase 2/3 Study

HLA loci predisposing to immune TTP in Japanese: potential role of the shared ADAMTS13 peptide bound to different HLA-DR

Functional Relevance of Von Willebrand Factor in Mouse Model of Hepatic Ischemia- Reperfusion Injury

Relevant Role of Von Willebrand Factor in Ischemia-Reperfusion Model of Acute Kidney Injury in Mice

Investigator-Initiated Phase 2 Trial of Rituximab in Adult Japanese Patients with Treatment-Resistant Acquired Thrombotic Thrombocytopenic Purpura

Von Willebrand Factor-Dependent Inflammatory Responses in Mouse Septic Model By Cecal Ligation and Puncture

Flow-Dependent Functions Of Soluble Or Immobilized Tissue Factor In Mural Thrombus Formation Mediated By Von Willebrand Factor

ADAMTS13 Improving the Cell Engraftment Efficacy in Mouse Model of Bone Marrow Transplantation

Protective Role of ADAMTS13 for Myocardium in Mouse Model of Experimental Myocardial Infarction.

A Recombinant Thrombomodulin Improves Haemostatic Disturbance and Inflammation in Setpic Patients with DIC

The Ratio of ADAMTS13 to VWF-Propeptide Can Reflect the Disease Severity and the Extent of Inflammation of the Patients with Severe Sepsis or Septic Shock,

ADAMTS13 gene deletion aggravates ischemic brain damage: a possible neuroprotective role of ADAMTS13 by ameliorating postischemic hypoperfusion

Decreased Activity of Plasma ADAMTS13 Parallels Enhanced Endotoxemia in Patients with Severe Acute Pancreatitis: Relationship to Multiorgan Failure

ADAMTS13 Gene Deletion Aggravates Ischemic Brain Damage

Functional imaging of shear-dependent activity of ADAMTS13 in regulating mural thrombus growth under whole blood flow conditions

Plasma ADAMTS13 Activity Markedly Decreases in Patients with Severe Acute Pancreatitis: Its Potential Role on the Development of Multiorgan Failure.

Cleavage of ultralarge multimers of von Willebrand factor by C -terminal–truncated mutants of ADAMTS-13 under flow

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American Society of Hematology

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American Society of Hematology

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