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Keigo Okada, MD
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Journal Articles

FLT3-ITD Enhances Proliferation and Survival of AML Cells through Activation of RSK1 to Upregulate the mTORC1/eIF4F Pathway Cooperatively with PIM or PI3K and to Inhibit Bad and Bim

Ayako Nogami, MD PhD BPharm, Daisuke Watanabe, MD, Keigo Okada, MD, PhD, Hiroki Akiyama, MD, PhD, Yoshihiro Umezawa, MD, PhD, Toshikage Nagao, MD, PhD, Shuji Tohda, MD, PhD, Osamu Miura, MD, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1425.
https://doi.org/10.1182/blood-2019-123183
Published: 2019
Journal Articles

Deubiquitinase Inhibitor WP1130 Blocks FLT3-ITD to Induce Apoptosis in Leukemic Cells

Hiroki Akiyama, MD, Yoshihiro Umezawa, MD, Keigo Okada, MD, Shinya Ishida, MD, Ayako Nogami, MD, PhD, Osamu Miura, MD, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2531.
https://doi.org/10.1182/blood.V130.Suppl_1.2531.2531
Published: 2017
Journal Articles

FLT3-ITD Confers Resistance to Bortezomib By Protecting the mTOR/4EBP1 Pathway through Activation of STAT5 and Induction of Pim-1 Expression

Ayako Nogami, MD PhD, Keigo Okada, MD, Gaku Oshikawa, MD PhD, Shinya Ishida, MD, Hiroki Akiyama, MD, Yoshihiro Umezawa, MD, Tetsuya Kurosu, MD PhD, Osamu Miura, MD PhD
Journal: Blood
Blood (2015) 126 (23): 1270.
https://doi.org/10.1182/blood.V126.23.1270.1270
Published: 2015