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Kavitha Siva, PhD
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Journal Articles

Metformin Upregulates Mir-26a to Improve Erythropoiesis in Preclinical Models of Diamond Blackfan Anemia through Suppression of Nlk Expression

Mark C Wilkes, PhD, Kavitha Siva, PhD, Jacqueline D Mercado, Ethan Patrick Wentworth, Mallika Saxena, Jun Chen, MD PhD, Anupama Narla, MD, Bertil Glader, MD PhD, Shuo Lin, PhD, Manuel Serrano, PhD, Johan Flygare, MD PhD, Kathleen M. Sakamoto, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 7.
https://doi.org/10.1182/blood-2020-137170
Published: 2020
Journal Articles

Pharmacological Inhibition of Nemo-like Kinase Rescues mTOR-Mediated Translation and Primes Progenitors for Leucine-Stimulated Erythroid Expansion in Pre-Clinical Models of Diamond Blackfan Anemia

Mark C Wilkes, PhD, Jacqueline D Mercado, Mallika Saxena, Jun Chen, MD PhD, Kavitha Siva, PhD, Hee-Don Chae, PhD, Minyoung Youn, PhD, Ethan Patrick Wentworth, Kevin Jung, Ryan Sathianathen, Hiral Patel, Bertil Glader, MD PhD, Anupama Narla, MD, Claire E Repellin, PhD, Hanna T Gazda, MD PhD, Manuel Serrano, PhD, Johan Flygare, MD PhD, Kathleen M. Sakamoto, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 455.
https://doi.org/10.1182/blood-2019-129570
Published: 2019
Journal Articles

Pharmacological Inhibition of Nlk (Nemo-like Kinase) Rescues Erythropoietic Defects in Pre-Clinical Models of Diamond Blackfan Anemia

Mark C Wilkes, Jun Chen, MD PhD, Kavitha Siva, PhD, Gianluca Veretti, PhD, Daniel P. Dever, PhD, Minyoung Youn, PhD, Hee-Don Chae, PhD, Jacqueline D Mercado, Mallika Saxena, Anupama Narla, MD, Bertil Glader, MD, Matthew Porteus, MD PhD, Claire E Repellin, PhD, Hanna T Gazda, MD PhD, Manuel Serrano, PhD, Johan Flygare, MD PhD, Kathleen M. Sakamoto, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 754.
https://doi.org/10.1182/blood-2018-99-119954
Published: 2018
Journal Articles

Small Molecule Screens Identify CDK8-Inhibitors As Candidate Diamond-Blackfan Anemia Drugs

Jun Chen, MD PhD, Kavitha Siva, PhD, Tomasz Rzymski, PhD, Lars Johansson, Thomas Lundbäck, Lorena Nunez Villacis, Fredrik Ek, PhD, Bingrui Wang, Amee J George, PhD, Yang Wan, Lihong Shi, Melissa IIsley, Agatheeswaran Subramaniam, PhD, Mayur Jain, PhD, Shubhranshu Debnath, PhD, Abdul Ghani Alattar, Hanna Axelsson, Milena Mazan, PhD, Eliza Majewska, Ulf R. Tedgard, MD PhD, Marcin W. Wlodarski, MD PhD, Anna-Lena Gustavsson, Roger Olsson, Michal Mikula, Xiaofan Zhu, PhD, Krzysztof Brzózka, PhD, Ross Hannan, PhD, Johan Flygare, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 753.
https://doi.org/10.1182/blood-2018-99-114570
Published: 2018
Journal Articles

Calmodulin Inhibition Rescues DBA Models with Ribosomal Protein Deficiency through Reduction of RSK Signaling

Elizabeth R Macari, PhD, Alison M Taylor, PhD, David Raiser, PhD, Kavitha Siva, PhD, Katherine McGrath, Jessica M Humphries, Johan Flygare, MDPhD, Benjamin L. Ebert, MDPhD, Leonard I. Zon, MD
Journal: Blood
Blood (2016) 128 (22): 332.
https://doi.org/10.1182/blood.V128.22.332.332
Published: 2016
Journal Articles

Bile Acids Protect Expanding Hematopoietic Stem Cells from Unfolded Protein Stress in Fetal Liver

Valgardur Sigurdsson, PhD, Hajime Takei, Svetlana Soboleva, Visnja Radulovic, PhD, Roman Galeev, Kavitha Siva, PhD, L. M. Fredrik Leeb-Lundberg, Prof., Takashi Iida, Prof., Hiroshi Nittono, MD PhD, Kenichi Miharada, PhD
Journal: Blood
Blood (2015) 126 (23): 897.
https://doi.org/10.1182/blood.V126.23.897.897
Published: 2015
Journal Articles

Calmodulin Inhibition Rescues the Effects of Ribosomal Protein Deficiency in in Vitro and In Vivo Diamond Blackfan Anemia Models

Elizabeth R Macari, PhD, Alison Taylor, PhD, David Raiser, PhD, Kavitha Siva, PhD, Katherine McGrath, Jessica M Humphries, Johan Flygare, MD PhD, Benjamin L Ebert, MD PhD, Leonard I. Zon, MD
Journal: Blood
Blood (2015) 126 (23): 672.
https://doi.org/10.1182/blood.V126.23.672.672
Published: 2015
Journal Articles

Direct Lineage Reprogramming of Murine Fibroblasts to Erythroid Progenitor Cells By Defined Factors

Sandra Capellera Garcia, Kishori Dhulipala, MD, Kavitha Siva, PhD, Violeta Rayon Estrada, Evelyn Wang, Gregory Hyde, PhD, Sofie Singbrant, PhD, Carl Walkley, PhD BPharm, Shamit Soneji, PhD, Vijay G. Sankaran, MD PhD, Johan Flygare, MD PhD
Journal: Blood
Blood (2014) 124 (21): 246.
https://doi.org/10.1182/blood.V124.21.246.246
Published: 2014
Journal Articles

Cripto Selectively Expands a Distinct Population of Hematopoietic Stem Cells Expressing the Cell Surface Receptor GRP78 and Strongly Induces An Immature Phenotype In Vivo After Ex Vivo Culture

Kenichi Miharada, PhD, Göran Karlsson, PhD, Jonas Larsson, MD, PhD, Emma Larsson, Kavitha Siva, PhD, Stefan Karlsson, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 405.
https://doi.org/10.1182/blood.V116.21.405.405
Published: 2010