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Journal Articles

Aurora Kinase Is a Therapeutic Target in Ibrutinib-Resistant Waldenstrom Macroglobulinemia: In-Silico Target Identification and in-Vitro Validation

Aneel Paulus, MDMS, Kasyapa S. Chitta, PhD, Sharoon Akhtar, MPhil, Hassan Yousaf, Davitte Cogen, Shireen Vali, Ansu Kumar, Neeraj Kumar Singh, Taher Abbasi, James M. Foran, MD, Candido E. Rivera, MD, Taimur Sher, MD, Vivek Roy, MD, Sikander Ailawadhi, MD, Asher Alban Chanan-Khan, MD

Blood (2015) 126 (23): 2754.

https://doi.org/10.1182/blood.V126.23.2754.2754

Published: 2015

Journal Articles

VLX1570, a First in Class Dub Inhibitor, Modulates BCR Signaling and CXCR4 Expression and Demonstrates Significant In Vivo Antitumor Activity in a Murine Model of Human Waldenstrom Macroglobulinemia

Blood (2015) 126 (23): 703.

https://doi.org/10.1182/blood.V126.23.703.703

Published: 2015

Journal Articles

Identification of USP14 and UCHL5 As Druggable Oncotargets in Ibrutinib-Resistant Mantle Cell Lymphoma

Aneel Paulus, MDMS, Sharoon Akhtar, MPhil, Kelara Samuel, Hassan Yousaf, Davitte Cogen, Pooja Advani, MBBS, Thomas E. Witzig, MD, George J Weiner, MD, Sikander Ailawadhi, MD, Joachim Gullbo, MD PhD, Stig Linder, PhD, Geraldo Otero-Colon, Kasyapa S. Chitta, PhD, Asher Alban Chanan-Khan, MD

Blood (2015) 126 (23): 1557.

https://doi.org/10.1182/blood.V126.23.1557.1557

Published: 2015

Journal Articles

A Novel and Personalized Method Using Simulation for Predicting Effective Therapeutics for Waldenströms Macroglobulinemia

Abdel Kareem Azab, BPharm, PhD, Aneel Paulus, MDMS, Feda Azab, B.Pharm, Sharoon Akhtar, MPhil, Shireen Vali, PhD, Ansu Kumar, Neeraj Kumar Singh, Shweta Kapoor, Taher Abbasi, MS, Asher Chanan-Khan, MD, Kasyapa S. Chitta, PhD

Blood (2014) 124 (21): 3024.

https://doi.org/10.1182/blood.V124.21.3024.3024

Published: 2014

Journal Articles

Therapeutic Sensitivity of CD20- Waldenströms Macroglobulinemia Cells Is Determined By Underlying Genomic and Epigenetic Events

Aneel Paulus, MDMS, Sharoon Akhtar, MPhil, Hyejin Yoon, Xue Wang, PhD, Maja Blake-Kuranz, Paul K. Wallace, MS, PhD, Sikander Ailawadhi, MD, Stephen M. Ansell, MD PhD, Anne J. Novak, PhD, Morie A Gertz, MD, Robert A Kyle, MD, Peter Martin, MD, Morton Coleman, MD, Jungsu Kim, PhD, Asher Chanan-Khan, MD, Kasyapa S. Chitta, PhD

Blood (2014) 124 (21): 3115.

https://doi.org/10.1182/blood.V124.21.3115.3115

Published: 2014

Journal Articles

Targeted Disruption of USP14 and UCHL5 with the Novel Deubiquitinase Enzyme (DUB) Inhibitor, VLX1570, Induces Immense Proteotoxicity and Cell Death in Malignant Plasma Cells

Aneel Paulus, MDMS, Sharoon Akhtar, MPhil, Maja Kuranz-Blake, B.S., Anne J. Novak, PhD, Stephen Ansell, MD, Morie A Gertz, MD, Robert A Kyle, MD, Peter Martin, MD, Morton Coleman, MD, Sikander Ailawadhi, MD, Stig Linder, MD PhD, Asher Chanan-Khan, MD, Kasyapa S. Chitta, PhD

Blood (2014) 124 (21): 3116.

https://doi.org/10.1182/blood.V124.21.3116.3116

Published: 2014

Journal Articles

Methylation Patterns in Waldenströms Macroglobulinemia Cells That Are Inherently Resistant or Have Acquired Resistance to Bortezomib, Converge on the TP63 and Cepba Family of Transcription Factors

Aneel Paulus, MDMS, Xue Wang, PhD, Sharoon Akhtar, MPhil, Maja Kuranz-Blake, B.S., Anne Novak, PhD, Stephen M Ansell, MD, PhD, Morie A Gertz, MD, Robert A Kyle, MD, Peter Martin, MD, Morton Coleman, MD, Sikander Ailawadhi, MD, Asher Chanan-Khan, MD, Kasyapa S. Chitta, PhD

Blood (2014) 124 (21): 3551.

https://doi.org/10.1182/blood.V124.21.3551.3551

Published: 2014

Journal Articles

The Selective Bcl-2 Inhibitor ABT-199 Synergizes with BTK or Proteasome Inhibitors to Induce Potent Cell Death in Preclinical Models of Bortezomib or Ibrutinib-Resistant Waldenströms Macroglobulinemia

Kasyapa S. Chitta, PhD, Aneel Paulus, MDMS, Maja Blake-Kuranz, Sharoon Akhtar, MPhil, Anne J. Novak, PhD, Stephen M. Ansell, MD PhD, Robert Kyle, MD MACP, Morie A Gertz, MD, Peter Martin, MD, Morton Coleman, MD, Sikander Ailawadhi, MD, Asher Chanan-Khan, MD

Blood (2014) 124 (21): 1689.

https://doi.org/10.1182/blood.V124.21.1689.1689

Published: 2014

Journal Articles

Acquired in Vitro Resistance to Ibrutinib Is Associated with Transcriptional Re-Programming and Sustained Survival Signaling in Waldenströms Macroglobulinemia and Mantle Cell Lymphoma, Independent of BTK Cys 481 Mutation

Kasyapa S. Chitta, PhD, Aneel Paulus, MDMS, Maja Kuranz-Blake, B.S., Sharoon Akhtar, MPhil, Anne J. Novak, PhD, Stephen M. Ansell, MD PhD, Morie A Gertz, MD, Robert A Kyle, MD, Peter Martin, MD, Morton Coleman, MD, Sikander Ailawadhi, MD, Asher Chanan-Khan, MD

Blood (2014) 124 (21): 2250.

https://doi.org/10.1182/blood.V124.21.2250.2250

Published: 2014

Journal Articles

Heterogeneous Bcl-2 Family Expression In Waldenström Macroglobulinemia Determines Response To Inducers Of Intrinsic Apoptosis

Brian T Gaudette, Kasyapa S. Chitta, PhD, Stephanie Poulain, Kelvin P Lee, MD, Asher Chanan-Khan, MD, Stephen M Ansell, M.D.Ph.D., Xavier Leleu, MD, PhD, Sagar Lonial, M.D., Lawrence H. Boise, PhD

Blood (2013) 122 (21): 4287.

https://doi.org/10.1182/blood.V122.21.4287.4287

Published: 2013

Journal Articles

The Novel Proteasome Inhibitor MLN2238 (Ixazomib) Induces Death In CLL Cells In Vitro and Potentiates Lethality Of Fludarabine and The BCL2 Inhibitor At-101

Kasyapa S. Chitta, PhD, Aneel Paulus, MD, MS, Sharoon Akhtar, Maja Kuranz, Kena Miller, A.R.N.P, Candido E. Rivera, MD, Vivek Roy, M.D., James M. Foran, MD, Aisha Masood, MD, Asher Chanan-Khan, MD

Blood (2013) 122 (21): 4189.

https://doi.org/10.1182/blood.V122.21.4189.4189

Published: 2013

Journal Articles

Waldenströms Macroglobulinemia Cell Lines Display Differential Surface Molecule Expression Reflecting Variability In Disease Biology and Potential Impact Of Therapeutic Stress

Aneel Paulus, MD, MS, Kasyapa S. Chitta, PhD, Sharoon Akhtar, Maja Kuranz, Paul K. Wallace, MS, PhD, Sikander Ailawadhi, M.D., Kena Miller, A.R.N.P, Candido E. Rivera, MD, Gerardo Colon-Otero, MD, Vivek Roy, M.D., Stephen M Ansell, M.D.Ph.D., Anne J. Novak, PhD, Peter Martin, MD, Morton Coleman, MD, Asher Chanan-Khan, MD

Blood (2013) 122 (21): 5091.

https://doi.org/10.1182/blood.V122.21.5091.5091

Published: 2013

Journal Articles

The Deubiquitinating Enzymes Of The 19S Proteasome Offer Novel Therapeutic Opportunity In Bortezomib Resistant Waldenströms Macroglobulinemia

Aneel Paulus, MD, MS, Kasyapa S. Chitta, PhD, Sharoon Akhtar, Maja Kuranz, Vivek Roy, M.D., Stephen M Ansell, M.D.Ph.D., Anne J. Novak, PhD, Peter Martin, MD, Richard R. Furman, MD, Morton Coleman, MD, Stig Linder, MD, PhD, Asher Chanan-Khan, MD

Blood (2013) 122 (21): 4426.

https://doi.org/10.1182/blood.V122.21.4426.4426

Published: 2013

Journal Articles

Interference Of The Tumor Supportive Effects Of BCL2 and MCL1 Sensitize Malignant Plasma Cells To The Lethal Effects Of Lenalidomide and Dexamethasone Regimen: An Important Clinical Path For BCL2 Targeting Drugs

Aneel Paulus, MD, MS, Kasyapa S. Chitta, PhD, Sharoon Akhtar, Maja Kuranz, Shaji Kumar, MD, Vivek Roy, MD, FACP, Stephen M. Ansell, M.D.Ph.D., Joseph R. Mikhael, MD, Angela Dispenzieri, MD, Craig Reeder, MD, Candido E. Rivera, MD, James M. Foran, MD, Francis Buadi, MD, Vincent Rajkumar, MD, Asher Chanan-Khan, MD

Blood (2013) 122 (21): 1928.

https://doi.org/10.1182/blood.V122.21.1928.1928

Published: 2013

Journal Articles

Inhibition Of The Deubiquitinating Enzymes UCHL5 and USP14 Is Lethal To Waldenströms Macroglobulinemia Cells

Kasyapa S. Chitta, PhD, Aneel Paulus, MD, MS, Sharoon Akhtar, Maja Kuranz, Vivek Roy, M.D., Stephen M Ansell, M.D.Ph.D., Anne J. Novak, PhD, Peter Martin, MD, Richard R. Furman, MD, Morton Coleman, MD, Stig Linder, MD, PhD, Asher Chanan-Khan, MD

Blood (2013) 122 (21): 1823.

https://doi.org/10.1182/blood.V122.21.1823.1823

Published: 2013

Journal Articles

Development Of a Human IgM Secreting Model Of Rpci-WM1 Through Xenografting In SCID Mice For In Vivo Drug Evaluation

Kasyapa S. Chitta, PhD, Aneel Paulus, MD, MS, Sharoon Akhtar, Maja Kuranz, Sikander Ailawadhi, M.D., Kena Miller, A.R.N.P, Candido E. Rivera, MD, Gerardo Colon-Otero, MD, Vivek Roy, M.D., Stephen M Ansell, M.D, Ph.D., Anne J. Novak, PhD, Peter Martin, MD, Morton Coleman, MD, Asher Chanan-Khan, MD

Blood (2013) 122 (21): 3081.

https://doi.org/10.1182/blood.V122.21.3081.3081

Published: 2013

Journal Articles

Novel Proteasome Inhibitors Induce Mitochondrial Destabilization and Activate Caspase Mediated Apoptosis In Preclinical Models Of Pediatric B-Cell Cancers

Aneel Paulus, MD, MS, Kasyapa S. Chitta, PhD, Eric Sandler, MD, Sharoon Akhtar, Maja Kuranz, Han Tun, MD, Vivek Roy, M.D., James M. Foran, MD, Kena Miller, A.R.N.P, Candido E. Rivera, MD, Asher Chanan-Khan, MD

Blood (2013) 122 (21): 5140.

https://doi.org/10.1182/blood.V122.21.5140.5140

Published: 2013

NARROW

Aurora Kinase Is a Therapeutic Target in Ibrutinib-Resistant Waldenstrom Macroglobulinemia: In-Silico Target Identification and in-Vitro Validation

VLX1570, a First in Class Dub Inhibitor, Modulates BCR Signaling and CXCR4 Expression and Demonstrates Significant In Vivo Antitumor Activity in a Murine Model of Human Waldenstrom Macroglobulinemia

Identification of USP14 and UCHL5 As Druggable Oncotargets in Ibrutinib-Resistant Mantle Cell Lymphoma

A Novel and Personalized Method Using Simulation for Predicting Effective Therapeutics for Waldenströms Macroglobulinemia

Therapeutic Sensitivity of CD20- Waldenströms Macroglobulinemia Cells Is Determined By Underlying Genomic and Epigenetic Events

Targeted Disruption of USP14 and UCHL5 with the Novel Deubiquitinase Enzyme (DUB) Inhibitor, VLX1570, Induces Immense Proteotoxicity and Cell Death in Malignant Plasma Cells

Methylation Patterns in Waldenströms Macroglobulinemia Cells That Are Inherently Resistant or Have Acquired Resistance to Bortezomib, Converge on the TP63 and Cepba Family of Transcription Factors

The Selective Bcl-2 Inhibitor ABT-199 Synergizes with BTK or Proteasome Inhibitors to Induce Potent Cell Death in Preclinical Models of Bortezomib or Ibrutinib-Resistant Waldenströms Macroglobulinemia

Acquired in Vitro Resistance to Ibrutinib Is Associated with Transcriptional Re-Programming and Sustained Survival Signaling in Waldenströms Macroglobulinemia and Mantle Cell Lymphoma, Independent of BTK Cys 481 Mutation

Heterogeneous Bcl-2 Family Expression In Waldenström Macroglobulinemia Determines Response To Inducers Of Intrinsic Apoptosis

The Novel Proteasome Inhibitor MLN2238 (Ixazomib) Induces Death In CLL Cells In Vitro and Potentiates Lethality Of Fludarabine and The BCL2 Inhibitor At-101

Waldenströms Macroglobulinemia Cell Lines Display Differential Surface Molecule Expression Reflecting Variability In Disease Biology and Potential Impact Of Therapeutic Stress

The Deubiquitinating Enzymes Of The 19S Proteasome Offer Novel Therapeutic Opportunity In Bortezomib Resistant Waldenströms Macroglobulinemia

Interference Of The Tumor Supportive Effects Of BCL2 and MCL1 Sensitize Malignant Plasma Cells To The Lethal Effects Of Lenalidomide and Dexamethasone Regimen: An Important Clinical Path For BCL2 Targeting Drugs

Inhibition Of The Deubiquitinating Enzymes UCHL5 and USP14 Is Lethal To Waldenströms Macroglobulinemia Cells

Development Of a Human IgM Secreting Model Of Rpci-WM1 Through Xenografting In SCID Mice For In Vivo Drug Evaluation

Novel Proteasome Inhibitors Induce Mitochondrial Destabilization and Activate Caspase Mediated Apoptosis In Preclinical Models Of Pediatric B-Cell Cancers

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American Society of Hematology

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American Society of Hematology

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