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Journal Articles

Depletion of PHLPP1 and 2 by Bcr-Abl Promotes CML Cell Proliferation through the Continuous Phosphorylation of Akt.

Isao Hirano, Satoki Nakamura, Tomonari Takemura, Daisuke Yokota, Takaaki Ono, Kazuyuki Shigeno, Shinya Fujisawa, Kaori Shinjo, Kazunori Ohnishi

Blood (2009) 114 (22): 2182.

https://doi.org/10.1182/blood.V114.22.2182.2182

Published: 2009

Journal Articles

Identification of Target Molecules and Anti-Leukemic Effects of Novel Phospha Sugar Derivative, TMPP.

Satoki Nakamura, Mitsuji Yamashita, Tomonari Takemura, Daisuke Yokota, Isao Hirano, Takaaki Ono, Kazuyuki Shigeno, Kiyoshi Shibata, Michio Fujie, Shinya Fujisawa, Kaori Shinjo, Kazunori Ohnishi

Blood (2009) 114 (22): 4814.

https://doi.org/10.1182/blood.V114.22.4814.4814

Published: 2009

Journal Articles

Bcr-Abl Promotes CML Cell Proliferation through the Suppression of PHLPP Expression.

Isao Hirano, Satoki Nakamura, Daisuke Yokota, Takaaki Ono, Kazuyuki Shigeno, Shinya Fujisawa, Kaori Shinjo, Kazunori Ohnishi, MD, PhD

Blood (2008) 112 (11): 1085.

https://doi.org/10.1182/blood.V112.11.1085.1085

Published: 2008

Journal Articles

Cell Cycle Features and Quantitative Alteration of Target Molecules of Malignant B Cells Treated with Inotuzumab Ozogamicin (CMC544) Alone or in Combination with Rituximab.

Nozomi Yamakage, MA, Akihiro Takeshita, PhD, MD, Kaori Shinjo, MD, Takaaki Ono, MD, Hirotaka Matsui, MD, Satoki Nakamura, MD, Kazuyuki Shigeno, MD, Masato Maekawa, PhD, MD, Kazunori Ohnishi, PhD, MD, Ryuzo Ohno, PhD, MD

Blood (2007) 110 (11): 2362.

https://doi.org/10.1182/blood.V110.11.2362.2362

Published: 2007

Journal Articles

Reduced Effect of Inotuzumab Ozogamicin (CMC544) on P-Glycoprotein Positive Malignant B Cells and Its Restoration by Multidrug Resistance Modifiers.

Akihiro Takeshita, PhD, MD, Kaori Shinjo, PhD, MD, Nozomi Yamakage, MA, Takaaki Ono, MD, Isao Hirano, MD, Kenji Okinaka, MD, Hirotaka Matsui, PhD, MD, Satoki Nakamura, MD, Kazuyuki Shigeno, MD, Masato Maekawa, PhD, MD, Kazunori Ohnishi, PhD, MD, Ryuzo Ohno, PhD, MD

Blood (2007) 110 (11): 2378.

https://doi.org/10.1182/blood.V110.11.2378.2378

Published: 2007

Journal Articles

Elevated FoxM1 Expression Promotes Cell Cycle Progression by Induction of KIS Expression and Contributes to the Development of Leukemia Cells.

Okinaka Keiji, Satoki Nakamura, Isao Hirano, Takaaki Ono, Shinya Fujisawa, Kazuyuki Shigeno, Kaori Shinjo, Kazunori Ohnishi

Blood (2007) 110 (11): 888.

https://doi.org/10.1182/blood.V110.11.888.888

Published: 2007

Journal Articles

HOXA10 Expression Induces by Abl Kinase Inhibitors Enhanced Apoptosis through PI3K Pathway in CML Cells.

Isao Hirano, Yuya Sugimoto, Keiji Okinaka, Takaaki Ono, Kaori Shinjo, Kazuyuki Shigeno, Satoki Nakamura, Kazunori Ohnishi

Blood (2007) 110 (11): 4529.

https://doi.org/10.1182/blood.V110.11.4529.4529

Published: 2007

Journal Articles

Development as Anti-Leukemic Agents, a Novel Synthesis of Phospha Sugar Derivatives in Therapy for Leukemias, and Analysis of Their Characterizations.

Satoki Nakamura, MD, PhD, Keiji Okinaka, MD, Isao Hirano, MD, Takaaki Ono, MD, Kazuyuki Shigeno, MD, Kaori Shinjo, MD,PhD, Michio Fujie, Yukiko Iguchi, PhD, Taishi Niimi, PhD, Satoru Ito, PhD, Takuya Suyama, PhD, Kazuhide Asai, PhD, Mitsuji Yamashita, PhD, Kazunori Ohnishi, MD, PhD

Blood (2007) 110 (11): 4174.

https://doi.org/10.1182/blood.V110.11.4174.4174

Published: 2007

Journal Articles

Analysis of FoxM1 Expression and Regulation of Cell Cycle, and Anti-Leukemic Effectss by FoxM1 Knockdown on Leukemia Cells Transfected with siRNA FoxM1.

Satoki Nakamura, MD, PhD, Takaaki Ono, MD, Yuya Sugimoto, MD, Miki Kobayashi, MD,PhD, Naohi Sahara, MD,PhD, Kazuyuki Shigeno, MD,PhD, Kaori Shinjo, MD,PhD, Shinya Fujisawa, MD,PhD, Kazunori Ohnishi, MD,PhD

Blood (2006) 108 (11): 4320.

https://doi.org/10.1182/blood.V108.11.4320.4320

Published: 2006

Journal Articles

Bcr-Abl Inhibitors Induce Expression of HoxA10, Playing a Role as an Inhibitor of the Proliferation through PI3K/PKB Pathway in Chronic Myelogenous Leukemia Cells.

Yuya Sugimoto, MD, Satoki Nakamura, MD,PhD, Takaaki Ono, MD, Miki Kobayashi, MD,PhD, Naohi Sahara, MD,PhD, Kaori Shinjo, MD,PhD, Kazuyuki Shigeno, MD,PhD, Kazunori Ohnishi, MD,PhD

Blood (2006) 108 (11): 1363.

https://doi.org/10.1182/blood.V108.11.1363.1363

Published: 2006

Journal Articles

Analysis of Aurora Kinase Expressions and Cell Cycle Regulation by Aurora-C in Leukemia Cells.

Miki Kobayashi, MD, PhD, Satoki Nakamura, MD, PhD, Takaaki Ono, MD, Yuya Sugimoto, MD, Naohi Sahara, MD, PhD, Kaori Shinjo, MD, PhD, Kazuyuki Shigeno, MD, PhD, Kazunori Ohnishi, MD, PhD

Blood (2006) 108 (11): 1366.

https://doi.org/10.1182/blood.V108.11.1366.1366

Published: 2006

Journal Articles

Analysis of the Expression of an Endogenous Tumor Suppressor Gene, PHLPP, and Elevation of PHLPP as an Ideal Target for MRD Monitoring in Leukemia.

Takaaki Ono, MD, Satoki Nakamura, MD,PhD, Yuya Sugimoto, MD, Miki Kobayashi, MD,PhD, Naohi Sahara, MD,PhD, Kaori Shinjo, MD,PhD, Kazuyuki Shigeno, MD,PhD, Shinya Fujisawa, MD, Kazunori Ohnishi, MD,PhD

Blood (2006) 108 (11): 4327.

https://doi.org/10.1182/blood.V108.11.4327.4327

Published: 2006

Journal Articles

Arsenic Trioxide Inhibited Bacterial Growth but Increased the Incidence of Herpes Zoster among Patients with APL; Results from In Vitro and Clinical Studies.

Akihiro Takeshita, MD, PhD, Kaori Shinjo, MD, Kazuyuki Shigeno, MD, Naohi Sahara, MD, Takaaki Ono, MD, Satoki Nakamura, MD, Masato Maekawa, MD, Kazunori Ohnishi, MD,PhD, Ryuzo Ohno, MD,PhD

Blood (2006) 108 (11): 4559.

https://doi.org/10.1182/blood.V108.11.4559.4559

Published: 2006

Journal Articles

Etodolac Inhibits EBER Expression and Induces Bcl-2-Regulated Apoptosis in Burkitt’s Lymphoma Cells.

Miki Kobayashi, MD, Satoki Nakamura, MD, PhD, Kiyoshi Shibata, Naohi Sahara, MD, PhD, Kazuyuki Shigeno, MD, PhD, Kaori Shinjo, MD, PhD, Kensuke Naito, MD, PhD, Kazunori Ohnishi, MD, PhD

Blood (2005) 106 (11): 4825.

https://doi.org/10.1182/blood.V106.11.4825.4825

Published: 2005

Journal Articles

Elevation of Kinase Interacting with Stathmin (KIS) and Promotion of Cellcycle Progression by KIS in Leukemia Cells.

Satoki Nakamura, MD, PhD, Takaaki Ono, MD., Yuya Sugimoto, MD., Miki Kobayashi, MD., Naohi Sahara, MD.PhD, Kaori Shinjo, MD.PhD, Kazuyuki Shigeno, MD.PhD, Kazunori Ohnishi, MD.PhD

Blood (2005) 106 (11): 1365.

https://doi.org/10.1182/blood.V106.11.1365.1365

Published: 2005

Journal Articles

Pharmacokinetics of Arsenic Species with Relapsed or Refractory Acute Promyelocytic Leukemia (APL) Treated with Arsenic Trioxide (ATO) in Japanese Patients.

Kazuyuki Shigeno, MD, Miki Kobayashi, MD, Naohi Sahara, MD, Satoki Nakamura, MD, Shinya Fujisawa, MD, Kensuke Naito, MD, Kaori Shinjo, MD, Akihiro Takeshita, MD, Ryuzo Ohno, MD, Kenji Kinoshita, PhD, Masahito Shimoya, PhD, Toshikazu Kaise, PhD, Kazunori Ohnishi, MD

Blood (2005) 106 (11): 4426.

https://doi.org/10.1182/blood.V106.11.4426.4426

Published: 2005

Journal Articles

Etodolac Induces Apoptosis and Inhibits Cell Adhesion to Bone Marrow Stromal Cells in Human Myeloma Cells.

Satoki Nakamura, MD, PhD, Miki Kobayashi, MD, Kiyoshi Shibata, Naohi Sahara, MD, Kazuyuki Shigeno, MD, PhD, Kaori Shinjo, MD, PhD, Kensuke Naito, MD, PhD, Kazunori Ohnishi, MD, PhD

Blood (2004) 104 (11): 4836.

https://doi.org/10.1182/blood.V104.11.4836.4836

Published: 2004

Journal Articles

Role for Interleukin-6 and Insulin like Growth Factor-I Via PI3-K/Akt Pathway in the Proliferation of CD56-Negative and Positive Multiple Myeloma Cells.

Naohi Sahara, Akihiro Takeshita, Miki Kobayashi, Kazuyuki Shigeno, Satoki Nakamura, Kaori Shinjo, Kensuke Naito, Takemi Otsuki, Kazunori Ohnishi, Ryuzo Ohno

Blood (2004) 104 (11): 3365.

https://doi.org/10.1182/blood.V104.11.3365.3365

Published: 2004

NARROW

Depletion of PHLPP1 and 2 by Bcr-Abl Promotes CML Cell Proliferation through the Continuous Phosphorylation of Akt.

Identification of Target Molecules and Anti-Leukemic Effects of Novel Phospha Sugar Derivative, TMPP.

Bcr-Abl Promotes CML Cell Proliferation through the Suppression of PHLPP Expression.

Cell Cycle Features and Quantitative Alteration of Target Molecules of Malignant B Cells Treated with Inotuzumab Ozogamicin (CMC544) Alone or in Combination with Rituximab.

Reduced Effect of Inotuzumab Ozogamicin (CMC544) on P-Glycoprotein Positive Malignant B Cells and Its Restoration by Multidrug Resistance Modifiers.

Elevated FoxM1 Expression Promotes Cell Cycle Progression by Induction of KIS Expression and Contributes to the Development of Leukemia Cells.

HOXA10 Expression Induces by Abl Kinase Inhibitors Enhanced Apoptosis through PI3K Pathway in CML Cells.

Development as Anti-Leukemic Agents, a Novel Synthesis of Phospha Sugar Derivatives in Therapy for Leukemias, and Analysis of Their Characterizations.

Analysis of FoxM1 Expression and Regulation of Cell Cycle, and Anti-Leukemic Effectss by FoxM1 Knockdown on Leukemia Cells Transfected with siRNA FoxM1.

Bcr-Abl Inhibitors Induce Expression of HoxA10, Playing a Role as an Inhibitor of the Proliferation through PI3K/PKB Pathway in Chronic Myelogenous Leukemia Cells.

Analysis of Aurora Kinase Expressions and Cell Cycle Regulation by Aurora-C in Leukemia Cells.

Analysis of the Expression of an Endogenous Tumor Suppressor Gene, PHLPP, and Elevation of PHLPP as an Ideal Target for MRD Monitoring in Leukemia.

Arsenic Trioxide Inhibited Bacterial Growth but Increased the Incidence of Herpes Zoster among Patients with APL; Results from In Vitro and Clinical Studies.

Etodolac Inhibits EBER Expression and Induces Bcl-2-Regulated Apoptosis in Burkitt’s Lymphoma Cells.

Elevation of Kinase Interacting with Stathmin (KIS) and Promotion of Cellcycle Progression by KIS in Leukemia Cells.

Pharmacokinetics of Arsenic Species with Relapsed or Refractory Acute Promyelocytic Leukemia (APL) Treated with Arsenic Trioxide (ATO) in Japanese Patients.

Etodolac Induces Apoptosis and Inhibits Cell Adhesion to Bone Marrow Stromal Cells in Human Myeloma Cells.

Role for Interleukin-6 and Insulin like Growth Factor-I Via PI3-K/Akt Pathway in the Proliferation of CD56-Negative and Positive Multiple Myeloma Cells.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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